DK2402754T4 - Ustrukturerede rekombinante polymerer og anvendelser deraf - Google Patents
Ustrukturerede rekombinante polymerer og anvendelser deraf Download PDFInfo
- Publication number
- DK2402754T4 DK2402754T4 DK11172812.7T DK11172812T DK2402754T4 DK 2402754 T4 DK2402754 T4 DK 2402754T4 DK 11172812 T DK11172812 T DK 11172812T DK 2402754 T4 DK2402754 T4 DK 2402754T4
- Authority
- DK
- Denmark
- Prior art keywords
- unstructured recombinant
- recombinant polymers
- polymers
- unstructured
- recombinant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74341006P | 2006-03-06 | 2006-03-06 | |
US74362206P | 2006-03-21 | 2006-03-21 | |
US11/528,927 US20070191272A1 (en) | 2005-09-27 | 2006-09-27 | Proteinaceous pharmaceuticals and uses thereof |
US11/528,950 US20070212703A1 (en) | 2005-09-27 | 2006-09-27 | Proteinaceous pharmaceuticals and uses thereof |
EP07752636.6A EP1996220B2 (en) | 2006-03-06 | 2007-03-06 | Unstructured recombinant polymers and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DK2402754T3 DK2402754T3 (da) | 2015-01-12 |
DK2402754T4 true DK2402754T4 (da) | 2023-08-28 |
Family
ID=38475542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11172812.7T DK2402754T4 (da) | 2006-03-06 | 2007-03-06 | Ustrukturerede rekombinante polymerer og anvendelser deraf |
Country Status (6)
Country | Link |
---|---|
EP (3) | EP1996220B2 (da) |
AU (2) | AU2007223888A1 (da) |
CA (1) | CA2644712C (da) |
DK (1) | DK2402754T4 (da) |
SI (1) | SI2402754T2 (da) |
WO (2) | WO2007103455A2 (da) |
Families Citing this family (79)
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PT1583562E (pt) | 2003-01-06 | 2011-09-19 | Angiochem Inc | Angiopep-1, compostos relacionados, e suas utilizações |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
US7846445B2 (en) | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
CA2634034A1 (en) | 2005-12-20 | 2007-06-28 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
WO2007103455A2 (en) | 2006-03-06 | 2007-09-13 | Amunix, Inc. | Genetic packages and uses thereof |
US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
SI2173890T1 (sl) | 2007-06-21 | 2011-06-30 | Univ Muenchen Tech | Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost |
MX2010001684A (es) * | 2007-08-15 | 2010-04-21 | Amunix Inc | Composiciones y metodos para modificar propiedades de polipeptidos biologicamente activos. |
EP2926825A1 (en) | 2008-06-27 | 2015-10-07 | Duke University | Therapeutic agents comprising elastin-like peptides |
JP2012505637A (ja) | 2008-10-15 | 2012-03-08 | アンジオケム,インコーポレーテッド | Glp−1アゴニストのコンジュゲート及びその使用 |
CN102307904A (zh) | 2008-12-05 | 2012-01-04 | 安吉奥开米公司 | 神经降压素或神经降压素类似物的缀合物及其用途 |
AU2014206217B2 (en) * | 2009-02-03 | 2015-09-17 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
AU2015218510B2 (en) * | 2009-02-03 | 2016-11-10 | Amunix Pharmaceuticals, Inc. | Extended recombinant polypeptides and compositions comprising same |
US8703717B2 (en) | 2009-02-03 | 2014-04-22 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
MX362028B (es) | 2009-02-03 | 2019-01-04 | Amunix Pharmaceuticals Inc | Polipeptidos recombinantes extendidos y composiciones que comprenden los mismos. |
US8680050B2 (en) | 2009-02-03 | 2014-03-25 | Amunix Operating Inc. | Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same |
US9173891B2 (en) | 2009-04-20 | 2015-11-03 | Angiochem, Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
ES2705249T3 (es) * | 2009-06-08 | 2019-03-22 | Amunix Operating Inc | Polipéptidos reguladores de glucosa y métodos para su producción y uso |
KR101813727B1 (ko) * | 2009-06-08 | 2018-01-02 | 아뮤닉스 오퍼레이팅 인코포레이티드 | 성장 호르몬 폴리펩타이드 및 이를 제조하고 사용하는 방법 |
US9849188B2 (en) | 2009-06-08 | 2017-12-26 | Amunix Operating Inc. | Growth hormone polypeptides and methods of making and using same |
MX354555B (es) * | 2009-06-08 | 2018-03-09 | Amunix Operating Inc | Polipeptidos de la hormona de crecimiento y metodos de preparacion y su uso. |
RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
AU2010290077C1 (en) | 2009-08-24 | 2015-12-03 | Bioverativ Therapeutics Inc. | Coagulation factor IX compositions and methods of making and using same |
EP2502939B1 (en) * | 2009-11-19 | 2016-01-27 | Zhejiang University | Nonnatural collagen-like protein and use thereof |
ES2880038T3 (es) | 2009-12-06 | 2021-11-23 | Bioverativ Therapeutics Inc | Polipéptidos quiméricos e híbridos de factor VIII-Fc, y métodos de uso de los mismos |
US8557961B2 (en) | 2010-04-02 | 2013-10-15 | Amunix Operating Inc. | Alpha 1-antitrypsin compositions and methods of making and using same |
EP2552967A4 (en) * | 2010-04-02 | 2014-10-08 | Amunix Operating Inc | BINDING FUSION PROTEINS, BINDING FUSION PROTEIN MEDICINAL CONJUGATES, XTEN MEDICAMENT CONJUGATES, AND METHOD FOR THEIR PREPARATION AND USE |
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
EA024755B1 (ru) | 2010-05-21 | 2016-10-31 | ИксЭль-ПРОТЕИН ГМБХ | Биосинтетические нерегулярные спиральные полипептиды пролина/аланина и их применения |
CA2802635A1 (en) | 2010-06-18 | 2011-12-22 | Xiberscience Gmbh | Peptides as active agents to stabilize biologic barriers |
CN103140237A (zh) | 2010-07-09 | 2013-06-05 | 比奥根艾迪克依蒙菲利亚公司 | 因子ix多肽及其使用方法 |
CA2818990C (en) | 2010-11-26 | 2021-06-15 | Molecular Partners Ag | Designed repeat proteins binding to serum albumin |
PL2717898T3 (pl) | 2011-06-10 | 2019-06-28 | Bioverativ Therapeutics Inc. | Związki o działaniu prokoagulacyjnym i sposoby ich stosowania |
RS58578B1 (sr) | 2011-07-08 | 2019-05-31 | Bioverativ Therapeutics Inc | Faktor viii himernih i hibridnih polipeptida i postupci za njihovu upotrebu |
US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
BR112014017165B1 (pt) * | 2012-01-12 | 2023-05-02 | Bioverativ Therapeutics Inc | Proteína quimérica compreendendo uma proteína de fator viii, composição farmacêutica, e seus usos |
EP3549953A1 (en) | 2012-02-15 | 2019-10-09 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
ES2771208T3 (es) | 2012-02-15 | 2020-07-06 | Bioverativ Therapeutics Inc | Composiciones de factor VIII y métodos de preparación y uso de las mismas |
MX366864B (es) | 2012-02-27 | 2019-07-26 | Amunix Operating Inc | Composiciones de conjugados de xten y métodos para realizarlas. |
ES2753135T3 (es) | 2012-05-07 | 2020-04-07 | Allergan Inc | Método de tratamiento de DMAE en pacientes resistentes a terapia anti-VEGF |
US9289507B2 (en) | 2012-05-17 | 2016-03-22 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
BR112014032316A2 (pt) | 2012-06-28 | 2017-06-27 | Molecular Partners Ag | proteínas de repetição de anquirina projetadas que se ligam ao fator de crescimento derivado de plaqueta |
EP2870250B2 (en) | 2012-07-06 | 2022-06-29 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
CN110054699A (zh) | 2012-07-11 | 2019-07-26 | 比奥贝拉蒂治疗公司 | 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途 |
TWI810729B (zh) | 2012-09-25 | 2023-08-01 | 美商百歐維拉提夫治療公司 | Fix多肽的應用 |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
AU2014228938B2 (en) | 2013-03-15 | 2019-05-02 | Bioverativ Therapeutics Inc. | Factor IX polypeptide formulations |
WO2015022326A1 (en) | 2013-08-12 | 2015-02-19 | Xiber Science Gmbh | Peptides as active agents for treating primary graft dysfunction |
WO2015023891A2 (en) | 2013-08-14 | 2015-02-19 | Biogen Idec Ma Inc. | Factor viii-xten fusions and uses thereof |
EP3065761B1 (en) | 2013-11-05 | 2020-01-08 | Allergan, Inc. | Method of treating conditions of the eye with an anti-vegf darpin |
EP3065769A4 (en) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Procoagulant fusion compound |
CN106456718A (zh) | 2014-01-10 | 2017-02-22 | 比奥根Ma公司 | 因子viii嵌合蛋白及其用途 |
BR112016027897A2 (pt) | 2014-06-18 | 2017-10-24 | Albert Einstein College Medicine Inc | polipeptídio multimérico, ácido nucleico, vetor de expressão recombinante, célula hospedeira geneticamente modificada, composição, método, e, método de tratamento de uma infecção num indivíduo |
US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
EP3220961B1 (en) | 2014-10-22 | 2023-07-05 | Extend Biosciences, Inc. | Therapeutic vitamin d conjugates |
ES2953482T3 (es) | 2015-04-02 | 2023-11-13 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con especificidad de unión para la albúmina sérica |
US11208452B2 (en) | 2015-06-02 | 2021-12-28 | Novo Nordisk A/S | Insulins with polar recombinant extensions |
ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
AU2016315656A1 (en) | 2015-08-28 | 2018-02-01 | Amunix Pharmaceuticals, Inc. | Chimeric polypeptide assembly and methods of making and using the same |
MA43348A (fr) | 2015-10-01 | 2018-08-08 | Novo Nordisk As | Conjugués de protéines |
EP3458095A4 (en) | 2016-05-18 | 2019-11-27 | Albert Einstein College of Medicine | PD-L1 POLYPEPTIDE VARIANTS, T-LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES AND METHODS OF USING SAME |
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EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
CN110505885A (zh) | 2017-04-05 | 2019-11-26 | 诺和诺德股份有限公司 | 寡聚体延伸的胰岛素-Fc缀合物 |
CN111315768A (zh) | 2017-09-07 | 2020-06-19 | 库尔生物制药有限公司 | 具有缀合位点的t细胞调节性多聚体多肽及其使用方法 |
WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
WO2019201855A1 (en) * | 2018-04-16 | 2019-10-24 | Swedish Orphan Biovitrum Ab (Publ) | Lysosomal fusion protein |
TW202039542A (zh) | 2018-12-19 | 2020-11-01 | 美商庫爾生物製藥有限公司 | 多聚體t細胞調節多肽及其使用方法 |
EP3935080A4 (en) | 2019-03-06 | 2023-04-05 | Cue Biopharma, Inc. | T-CELL-MODULATING MULTIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF |
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CN115925995A (zh) | 2020-09-30 | 2023-04-07 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
US20240123031A1 (en) | 2020-11-25 | 2024-04-18 | Bristol-Myers Squibb Company | Methods of treating liver diseases |
WO2022123459A1 (en) | 2020-12-11 | 2022-06-16 | Friedrich Miescher Institute For Biomedical Research | Hdac6 binding proteins and their anti-viral use |
CN115083016A (zh) * | 2022-06-09 | 2022-09-20 | 广州紫为云科技有限公司 | 一种基于单目摄像机的面向小目标手部隔空交互方法与装置 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD257197A1 (de) † | 1987-01-28 | 1988-06-08 | Univ Dresden Tech | Verfahren zur herstellung von immobilisierten, in ihrer biologischen aktivitaet stabilisierten und in ihren pharmakologischen eigenschaften modifizierten insulinpraeparationen |
FR2647677B1 (fr) * | 1989-05-31 | 1991-09-27 | Roussel Uclaf | Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines |
SK60893A3 (en) † | 1990-12-13 | 1993-10-06 | Upjohn Co | Fusion polypeptides |
US5833911A (en) † | 1995-05-31 | 1998-11-10 | Johnson & Johnson Medical, Inc. | Method for forming a glove using a folded glove form |
AU5065198A (en) † | 1996-11-15 | 1998-06-10 | Maria Grazia Masucci | Fusion proteins having increased half-lives |
US20050260605A1 (en) * | 1998-02-11 | 2005-11-24 | Maxygen, Inc. | Targeting of genetic vaccine vectors |
AU3289199A (en) * | 1998-02-11 | 1999-08-30 | Maxygen, Inc. | Antigen library immunization |
US20050287153A1 (en) * | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
US20030049689A1 (en) * | 2000-12-14 | 2003-03-13 | Cynthia Edwards | Multifunctional polypeptides |
PE20020908A1 (es) * | 2001-03-21 | 2002-10-26 | Cell Therapeutics Inc | Produccion recombinante de polimeros polianionicos y uso de de los mismos |
EP1841787A2 (en) * | 2005-01-25 | 2007-10-10 | Cell Therapeutics, Inc. | Conjugates of biologically active proteins having a modified in vivo half-life |
CA2634034A1 (en) † | 2005-12-20 | 2007-06-28 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
WO2007103455A2 (en) | 2006-03-06 | 2007-09-13 | Amunix, Inc. | Genetic packages and uses thereof |
WO2008049711A1 (en) † | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
-
2007
- 2007-03-06 WO PCT/US2007/005857 patent/WO2007103455A2/en active Application Filing
- 2007-03-06 AU AU2007223888A patent/AU2007223888A1/en not_active Abandoned
- 2007-03-06 EP EP07752636.6A patent/EP1996220B2/en active Active
- 2007-03-06 EP EP07752549A patent/EP1996937A4/en not_active Withdrawn
- 2007-03-06 AU AU2007223855A patent/AU2007223855B2/en active Active
- 2007-03-06 DK DK11172812.7T patent/DK2402754T4/da active
- 2007-03-06 SI SI200731588T patent/SI2402754T2/sl unknown
- 2007-03-06 WO PCT/US2007/005952 patent/WO2007103515A2/en active Application Filing
- 2007-03-06 EP EP20140189047 patent/EP2863222A1/en not_active Ceased
- 2007-03-06 CA CA2644712A patent/CA2644712C/en active Active
Also Published As
Publication number | Publication date |
---|---|
DK2402754T3 (da) | 2015-01-12 |
EP2863222A1 (en) | 2015-04-22 |
WO2007103455A3 (en) | 2007-11-29 |
AU2007223888A1 (en) | 2007-09-13 |
EP1996220B2 (en) | 2023-08-16 |
EP1996220B1 (en) | 2013-05-08 |
SI2402754T1 (sl) | 2015-02-27 |
EP1996220A4 (en) | 2009-04-29 |
EP1996937A2 (en) | 2008-12-03 |
CA2644712A1 (en) | 2007-09-13 |
EP1996220A2 (en) | 2008-12-03 |
WO2007103515A3 (en) | 2008-04-03 |
WO2007103515A2 (en) | 2007-09-13 |
CA2644712C (en) | 2016-09-13 |
WO2007103455A2 (en) | 2007-09-13 |
AU2007223855A1 (en) | 2007-09-13 |
AU2007223855B2 (en) | 2013-05-16 |
SI2402754T2 (sl) | 2023-09-29 |
EP1996937A4 (en) | 2009-04-08 |
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