DK2114903T3 - Bicykliske pyrimidinoner og anvendelser deraf - Google Patents

Bicykliske pyrimidinoner og anvendelser deraf

Info

Publication number: DK2114903T3
Authority: DK; Denmark
Prior art keywords: applications; bicyclic pyrimidinones; pyrimidinones; bicyclic
Prior art date: 2006-12-22

Application number

DK07855368.2T

Other languages

English (en)

Inventor

Eric Dale Jones

Jonathan Alan Victor Coates

David Ian Rhodes

John Joseph Deadman

Nicholas Andrew Vandegraff

Lisa Jane Winfield

Neeranat Thienthong

William Issa

Neil Choi

Katherine Macfarlane

Original Assignee

Avexa Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2007-12-21

Publication date

2011-04-18

2006-12-22 Priority claimed from AU2006907283A external-priority patent/AU2006907283A0/en

2007-12-21 Application filed by Avexa Ltd filed Critical Avexa Ltd

2011-04-18 Application granted granted Critical

2011-04-18 Publication of DK2114903T3 publication Critical patent/DK2114903T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

DK07855368.2T 2006-12-22 2007-12-21 Bicykliske pyrimidinoner og anvendelser deraf DK2114903T3 (da)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
AU2006907283A AU2006907283A0 (en)		2006-12-22	Bicyclic pyrimidinones and uses thereof
AU2007902479A AU2007902479A0 (en)		2007-05-09	Bicyclic pyrimidinones and uses thereof (2)
AU2007903401A AU2007903401A0 (en)		2007-06-25	Bicyclic pyrimidinodes and uses thereof (3)
AU2007904114A AU2007904114A0 (en)		2007-07-31	Bicyclic pyrimidinones and uses thereof (4)
PCT/AU2007/001980 WO2008077188A1 (en)	2006-12-22	2007-12-21	Bicyclic pyrimidinones and uses thereof

Publications (1)

Publication Number	Publication Date
DK2114903T3 true DK2114903T3 (da)	2011-04-18

Family

ID=39562030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07855368.2T DK2114903T3 (da)	2006-12-22	2007-12-21	Bicykliske pyrimidinoner og anvendelser deraf

Country Status (16)

Country	Link
US (3)	US8143268B2 (da)
EP (2)	EP2269992A1 (da)
JP (2)	JP5208962B2 (da)
KR (2)	KR20090097194A (da)
CN (1)	CN101880280B (da)
AR (2)	AR064517A1 (da)
AT (1)	ATE496898T1 (da)
AU (2)	AU2007336703B9 (da)
BR (2)	BRPI0720564A2 (da)
CA (1)	CA2673183C (da)
DE (1)	DE602007012308D1 (da)
DK (1)	DK2114903T3 (da)
HK (1)	HK1131615A1 (da)
MX (1)	MX2009006764A (da)
NZ (1)	NZ577491A (da)
WO (1)	WO2008077188A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8426405B2 (en) *	2008-07-02	2013-04-23	Avexa Limited	Thiazopyrimidinones and uses thereof
EP2759544A1 (en) *	2008-07-02	2014-07-30	Avexa Limited	Compounds having antiviral properties
CA2729656A1 (en) *	2008-07-02	2010-01-07	Avexa Limited	Imidazopyrimidinones and uses thereof
CN102336751A (zh) *	2010-07-16	2012-02-01	爱维艾珂瑟有限公司	新型抗病毒剂
CA2923075C (en)	2013-09-12	2022-07-26	Alios Biopharma, Inc.	Aza-pyridone compounds and uses thereof
EP3082820B1 (en) *	2013-12-19	2022-07-20	PTC Therapeutics, Inc.	Methods for modulating the amount of rna transcripts
EA036776B1 (ru)	2015-03-11	2020-12-21	Янссен Байофарма, Инк.	Соединения азапиридона и способы их применения
WO2016196386A1 (en)	2015-05-30	2016-12-08	Ptc Therapeutics, Inc.	Methods for modulating rna splicing
ES2879995T3 (es)	2015-12-10	2021-11-23	Ptc Therapeutics Inc	Métodos para el tratamiento de la enfermedad de Huntington
US11702646B2 (en)	2016-11-28	2023-07-18	Ptc Therapeutics, Inc.	Methods for modulating RNA splicing
EA201992878A1 (ru)	2017-06-05	2020-05-08	ПиТиСи ТЕРАПЬЮТИКС, ИНК.	Соединения для лечения болезни хантингтона
CN111372611A (zh)	2017-06-14	2020-07-03	Ptc医疗公司	修饰rna剪接的方法
BR112019027717A2 (pt)	2017-06-28	2020-07-28	Ptc Therapeutics, Inc.	métodos para tratar a doença de huntington
MX2019015580A (es)	2017-06-28	2020-07-28	Ptc Therapeutics Inc	Metodos para tratar la enfermedad de huntington.
CN112135815A (zh)	2018-03-27	2020-12-25	Ptc医疗公司	用于治疗亨廷顿氏病的化合物
EP3814360A1 (en)	2018-06-27	2021-05-05	PTC Therapeutics, Inc.	Heteroaryl compounds for treating huntington's disease
AU2019294478B2 (en)	2018-06-27	2023-03-23	Ptc Therapeutics, Inc.	Heterocyclic and heteroaryl compounds for treating Huntington's disease
US20230116403A1 (en)	2019-12-02	2023-04-13	Storm Therapeutics Limited	Polyheterocyclic compounds as mettl3 inhibitors
US20230070337A1 (en) *	2021-08-27	2023-03-09	Wisconsin Alumni Research Foundation	System and assay for monitoring production/release of membrane-lytic toxins in bacteria and compounds for modulating same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2422729A1 (en)	2000-09-20	2002-06-06	Schering Corporation	Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
CZ2004764A3 (cs)	2002-11-20	2005-02-16	Japan Tobacco Inc	4-Oxochinolinová sloučenina a její použití jako inhibitoru HIV-integrázy
US8044073B2 (en)	2003-12-18	2011-10-25	Tibotec Pharmaceuticals	Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
TW200526635A (en) *	2003-12-22	2005-08-16	Shionogi & Co	Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
KR20070084172A (ko)	2004-10-12	2007-08-24	아스트라제네카 아베	퀴나졸린 유도체
EP1866313A1 (en) *	2005-03-31	2007-12-19	Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.	Hiv integrase inhibitors
US7939537B2 (en)	2005-10-04	2011-05-10	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	HIV integrase inhibitors

2007
- 2007-12-21 CN CN201010148170.6A patent/CN101880280B/zh not_active Expired - Fee Related
- 2007-12-21 KR KR1020097014886A patent/KR20090097194A/ko not_active Application Discontinuation
- 2007-12-21 AR ARP070105884A patent/AR064517A1/es not_active Application Discontinuation
- 2007-12-21 WO PCT/AU2007/001980 patent/WO2008077188A1/en active Application Filing
- 2007-12-21 NZ NZ577491A patent/NZ577491A/en not_active IP Right Cessation
- 2007-12-21 AU AU2007336703A patent/AU2007336703B9/en not_active Ceased
- 2007-12-21 CA CA2673183A patent/CA2673183C/en not_active Expired - Fee Related
- 2007-12-21 DK DK07855368.2T patent/DK2114903T3/da active
- 2007-12-21 JP JP2009541695A patent/JP5208962B2/ja not_active Expired - Fee Related
- 2007-12-21 EP EP10164218A patent/EP2269992A1/en not_active Withdrawn
- 2007-12-21 EP EP07855368A patent/EP2114903B1/en active Active
- 2007-12-21 BR BRPI0720564-3A patent/BRPI0720564A2/pt not_active IP Right Cessation
- 2007-12-21 BR BRPI0722411-7A patent/BRPI0722411A2/pt active Search and Examination
- 2007-12-21 AT AT07855368T patent/ATE496898T1/de not_active IP Right Cessation
- 2007-12-21 DE DE602007012308T patent/DE602007012308D1/de active Active
- 2007-12-21 KR KR1020107008711A patent/KR20100049698A/ko not_active Application Discontinuation
- 2007-12-21 US US12/519,273 patent/US8143268B2/en not_active Expired - Fee Related
- 2007-12-21 MX MX2009006764A patent/MX2009006764A/es active IP Right Grant
2009
- 2009-11-12 HK HK09110584.2A patent/HK1131615A1/xx not_active IP Right Cessation
2010
- 2010-03-24 AU AU2010201160A patent/AU2010201160A1/en not_active Abandoned
- 2010-04-23 US US12/766,510 patent/US8207334B2/en not_active Expired - Fee Related
- 2010-06-07 JP JP2010129801A patent/JP2010222370A/ja not_active Withdrawn
- 2010-06-09 AR ARP100102037A patent/AR077043A2/es unknown
2012
- 2012-02-27 US US13/405,511 patent/US8859563B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2008077188A1 (en)	2008-07-03
AU2010201160A1 (en)	2010-04-15
AR077043A2 (es)	2011-07-27
US20100168063A1 (en)	2010-07-01
EP2114903A1 (en)	2009-11-11
US8207334B2 (en)	2012-06-26
AU2007336703B2 (en)	2012-04-12
CN101880280A (zh)	2010-11-10
BRPI0720564A2 (pt)	2011-08-16
AR064517A1 (es)	2009-04-08
US8143268B2 (en)	2012-03-27
US20110009366A1 (en)	2011-01-13
AU2007336703A1 (en)	2008-07-03
BRPI0722411A2 (pt)	2012-06-05
DE602007012308D1 (de)	2011-03-10
CA2673183A1 (en)	2008-07-03
JP2010513322A (ja)	2010-04-30
US20120232035A1 (en)	2012-09-13
KR20100049698A (ko)	2010-05-12
US8859563B2 (en)	2014-10-14
EP2114903B1 (en)	2011-01-26
MX2009006764A (es)	2009-11-26
EP2114903A4 (en)	2009-12-30
CN101880280B (zh)	2014-07-16
JP2010222370A (ja)	2010-10-07
HK1131615A1 (en)	2010-01-29
CA2673183C (en)	2014-06-10
EP2269992A1 (en)	2011-01-05
NZ577491A (en)	2011-06-30
ATE496898T1 (de)	2011-02-15
AU2007336703B9 (en)	2014-03-27
JP5208962B2 (ja)	2013-06-12
KR20090097194A (ko)	2009-09-15

Publication	Publication Date	Title
DK2114903T3 (da)	2011-04-18	Bicykliske pyrimidinoner og anvendelser deraf
DK2059535T3 (da)	2014-01-13	Prlr-specifikt antistof og anvendelser deraf
DK2209806T3 (da)	2012-09-17	Anti-hepcidin-antistoffer og anvendelser deraf
DK1988307T3 (da)	2012-01-16	Reduktionsgear
DK2142529T3 (da)	2014-02-10	Trpv1-antagonister og anvendelser deraf
DK2147096T3 (da)	2015-06-15	Modificerede faktor-VII-polypeptider og anvendelser deraf
DK2068887T3 (da)	2014-05-19	SP35-antistoffer og anvendelser heraf
DK2170827T3 (da)	2013-11-18	Indolin-2-oner og aza-indolin-2-oner
DK2118140T3 (da)	2013-07-01	Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf
BRPI0816617A2 (pt)	2016-10-04	circuitos de led e conjuntos
BRPI0716300A2 (pt)	2014-02-25	Artigo e mistura
DK1866339T3 (da)	2013-09-02	GTR-bindende molekyler og anvendelser heraf
DK2139490T3 (da)	2014-09-08	Diazo-bicykliske smac-mimetiske stoffer og anvendelser deraf
DK2012773T3 (da)	2012-09-24	Lægemidler og anvendelser deraf
NO20085030L (no)	2009-01-06	Pyrrolopyrimidinforbindelser og deres anvendelser
DK1994055T3 (da)	2014-08-25	Anti-5t4-antistoffer og anvendelser deraf
DE502006006338D1 (de)	2010-04-15	Ächen
DK1894567T3 (da)	2012-11-19	Ledsagende farmaceutiske midler og anvendelse deraf
BRPI0719369A2 (pt)	2014-02-04	Porta-prótese e aplicações do mesmo
NO20054709L (no)	2007-04-16	Sammenfoyningssystem og anvendelse av dette
DK2001556T3 (da)	2014-11-10	Thioninium-forbindelser og anvendelse deraf
DK2079485T3 (da)	2012-08-06	Phenylpropionamidforbindelser og anvendelsen deraf
BRPI0811115A2 (pt)	2014-12-23	Compostos de heteroarilamida pirimidona
DK2185175T3 (da)	2013-05-13	MMP-9-regulatorer og anvendelser deraf
DK2099304T3 (da)	2014-10-06	Carboranylporfyriner og anvendelser deraf