DK2377550T3 - Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner - Google Patents

Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner Download PDF

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Publication number
DK2377550T3
DK2377550T3 DK11173797T DK11173797T DK2377550T3 DK 2377550 T3 DK2377550 T3 DK 2377550T3 DK 11173797 T DK11173797 T DK 11173797T DK 11173797 T DK11173797 T DK 11173797T DK 2377550 T3 DK2377550 T3 DK 2377550T3
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Denmark
Prior art keywords
leptospira
heat
bacterin
bacterins
treated
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DK11173797T
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English (en)
Inventor
Michael John Huether
Ramasamy Mannar Mannan
Mark Davis Goodyear
Nancee Lois Oien
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Zoetis P Llc
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Publication of DK2377550T3 publication Critical patent/DK2377550T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0225Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (9)

1. Varmebehandlet Leptospira-baVXem til anvendelse i en emulsionsvaccine, der omfatter en suspension af dræbte bakterier, som har en lipaseaktivitet på 50% eller mindre end lipaseaktiviteten af bakterinet før varmebehandlingen, hvor varmebehandlingen omfatter opvarmning af bakterinet, som har en lipaseaktivitet, til en temperatur på 60 til 70°C i 5 til 10 timer.
2. Varmebehandlet bakterin ifølge krav 1, hvor det varmebehandlede Lepto-spira- bakte ri n fremstilles ved en fremgangsmåde, der omfatter opvarmning af bakterinet til en temperatur på 65°C i 8 timer.
3. Varmebehandlet bakterin ifølge krav 1 eller 2, hvor de dræbte bakterier er 1 til 5 Leptospira-arter valgt fra gruppen bestående af Leptospira canicola, Leptospira grippotyposa, Leptospira hardjo, Leptospira icterohaemorrhagiae, og Leptospira pomona.
4. Varmebehandlet bakterin ifølge et hvilket som helst af kravene 1 til 3, der yderligere omfatter levende vira.
5. Varmebehandlet bakterin ifølge krav 1, yderligere omfattende et lecithin-præparat, Quil A og kolesterol.
6. Varmebehandlet bakterin ifølge et hvilket som helst af kravene 1 til 3, der yderligere omfatter dræbte vira.
7. Varmebehandlet bakterin ifølge krav 5, der yderligere omfatter dræbte vira.
8. Varmebehandlet bakterin ifølge krav 4, hvor de levende vira er 1 til 3 vira, der er valgt fra gruppen bestående af bovint rhinotracheitis (IBR) virus, parainfluenza 3 (PI3) virus og bovint respiratorisk syncytialvirus (BRSV).
9. Varmebehandlet bakterin ifølge krav 7, hvor de dræbte vira er et eller to vira, der er valgt fra gruppen bestående af Type 1 bovin viral diarré (BVD) og Type 2 bovin viral diarré (BVD).
DK11173797T 2006-09-11 2007-08-30 Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner DK2377550T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84366506P 2006-09-11 2006-09-11
EP07804880.8A EP2066340B1 (en) 2006-09-11 2007-08-30 Heat treated bacterins, and emulsion vaccines prepared from such heat treated bacterins

Publications (1)

Publication Number Publication Date
DK2377550T3 true DK2377550T3 (da) 2015-04-07

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Family Applications (2)

Application Number Title Priority Date Filing Date
DK11173797T DK2377550T3 (da) 2006-09-11 2007-08-30 Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner
DK07804880.8T DK2066340T3 (da) 2006-09-11 2007-08-30 Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK07804880.8T DK2066340T3 (da) 2006-09-11 2007-08-30 Varmebehandlede bakteriner og emulsionsvacciner fremstillet af sådanne varmebehandlede bakteriner

Country Status (27)

Country Link
US (1) US8491915B2 (da)
EP (2) EP2066340B1 (da)
JP (2) JP5550341B2 (da)
KR (1) KR101238486B1 (da)
CN (1) CN101516393B (da)
AR (1) AR062758A1 (da)
AU (1) AU2007297287B2 (da)
BR (1) BRPI0716548B1 (da)
CA (1) CA2663166C (da)
CL (1) CL2007002621A1 (da)
CO (1) CO6160333A2 (da)
DK (2) DK2377550T3 (da)
ES (2) ES2432392T3 (da)
HK (1) HK1130202A1 (da)
ME (1) ME00598B (da)
MX (1) MX2009001849A (da)
NO (1) NO339147B1 (da)
NZ (2) NZ595748A (da)
PL (2) PL2377550T3 (da)
PT (1) PT2066340E (da)
RS (1) RS54981B1 (da)
RU (2) RU2425692C2 (da)
SI (1) SI2066340T1 (da)
TW (1) TWI361077B (da)
UA (1) UA98115C2 (da)
WO (1) WO2008032158A2 (da)
ZA (1) ZA200902493B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101903041A (zh) * 2007-12-21 2010-12-01 辉瑞大药厂 经热处理的菌苗,及由这些经热处理的菌苗制备的乳剂疫苗
EP2717055A1 (en) * 2012-10-04 2014-04-09 Institut Pasteur Use of Leptospira fainei serovar Hurstbridge bacteria for diagnosing leptospirosis
JP2024510057A (ja) * 2020-05-26 2024-03-06 サイラス トェンティファースト センチュリー アントレプレナーシップ エルエルシー ハキムプールシナの除染手順

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DE3721169A1 (de) * 1986-06-30 1988-01-14 Lion Corp Orale zubereitung
US5084269A (en) 1986-11-06 1992-01-28 Kullenberg Fred W Adjuvant for dose treatment with antigens
US6248329B1 (en) * 1998-06-01 2001-06-19 Ramaswamy Chandrashekar Parasitic helminth cuticlin nucleic acid molecules and uses thereof
AU2001234616A1 (en) 2000-01-31 2001-08-07 Vic Jira Vaccine composition, process and methods
US20030147914A1 (en) 2001-07-02 2003-08-07 Pfizer Inc. Mycoplasma bovis vaccine and methods of reducing pneumonia in animals
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WO2004026024A2 (en) 2002-09-20 2004-04-01 The United States Of America As Represented By The Secretary Of Agriculture Vaccine compositions and adjuvant
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CA2513352C (en) * 2003-01-29 2010-10-12 Pfizer Products Inc. Canine vaccines against bordetella bronchiseptica
WO2004087204A2 (en) * 2003-04-04 2004-10-14 Pfizer Products Inc. Microfluidized oil-in-water emulsions and vaccine compositions

Also Published As

Publication number Publication date
NO339147B1 (no) 2016-11-14
EP2377550A1 (en) 2011-10-19
BRPI0716548A2 (pt) 2013-09-24
PL2066340T3 (pl) 2013-12-31
CA2663166A1 (en) 2008-03-20
DK2066340T3 (da) 2013-10-14
RS54981B1 (sr) 2016-11-30
US8491915B2 (en) 2013-07-23
KR101238486B1 (ko) 2013-03-04
RU2009108004A (ru) 2010-10-20
WO2008032158A2 (en) 2008-03-20
CL2007002621A1 (es) 2008-03-14
HK1130202A1 (en) 2009-12-24
CN101516393B (zh) 2014-05-14
AU2007297287B2 (en) 2013-03-14
MEP7509A (en) 2011-12-20
CA2663166C (en) 2015-11-03
NZ595748A (en) 2013-07-26
ME00598B (me) 2011-12-20
NZ574896A (en) 2011-11-25
SI2066340T1 (sl) 2013-11-29
RU2569457C2 (ru) 2015-11-27
PT2066340E (pt) 2013-10-30
JP5643906B2 (ja) 2014-12-17
RU2011115400A (ru) 2012-10-27
ES2535977T3 (es) 2015-05-19
EP2377550B1 (en) 2015-03-04
TW200820990A (en) 2008-05-16
EP2066340A2 (en) 2009-06-10
ZA200902493B (en) 2010-03-31
JP2010502238A (ja) 2010-01-28
AU2007297287A1 (en) 2008-03-20
UA98115C2 (ru) 2012-04-25
US20080112970A1 (en) 2008-05-15
RS20090088A (en) 2010-06-30
NO20090745L (no) 2009-03-11
RU2425692C2 (ru) 2011-08-10
WO2008032158A3 (en) 2008-07-03
PL2377550T3 (pl) 2015-07-31
TWI361077B (en) 2012-04-01
JP5550341B2 (ja) 2014-07-16
JP2014088428A (ja) 2014-05-15
MX2009001849A (es) 2009-03-02
AR062758A1 (es) 2008-12-03
KR20090039840A (ko) 2009-04-22
CN101516393A (zh) 2009-08-26
ES2432392T3 (es) 2013-12-03
CO6160333A2 (es) 2010-05-20
BRPI0716548B1 (pt) 2020-10-06
EP2066340B1 (en) 2013-07-31

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