DK2348114T3 - Knogleafgivelseskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle - Google Patents

Knogleafgivelseskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle Download PDF

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DK2348114T3
DK2348114T3 DK11000196.3T DK11000196T DK2348114T3 DK 2348114 T3 DK2348114 T3 DK 2348114T3 DK 11000196 T DK11000196 T DK 11000196T DK 2348114 T3 DK2348114 T3 DK 2348114T3
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DK11000196.3T
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Philippe Crine
Guy Boileau
Isabelle Lemire
Thomas P Loisel
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Alexion Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (9)

1. Isoleret nukleinsyremolekyle, der omfatter en polynukleotidsekvens, som er valgt fra gruppen bestående af: a. et polynukleotid, der omfatter nukleotidsekvensen som angivet i SEQ ID NO: 7; b. et polynukleotid, der koder for et polypeptid, der omfatter en aminosyresekvens som angivet i SEQ ID NO: 8; c. en nukleotidsekvens, som er fuldstændig komplementær til en hvilken som helst af nukleotidsekvenserne i a) eller b); og d. en nukleotidsekvens, der under højstringensbetingelser er hybridiserbar til nukleotidsekvensen i c), hvor højstringensbetingelserne omfatter: præhybridisering og hybridisering i 6 x SSC, 5 x Denhardts reagens, 0,5 % SDS og 100 mg/ml denatureret fragmenteret laksesperma-DNA ved 68 °C; og vaskninger i 2 x SSC og 0,5 % SDS ved stuetemperatur i 10 min.; i 2 x SSC og 0,1 % SDS ved stuetemperatur i 10 min.; og i 0,1 x SSC og 0,5 % SDS ved 65 °C tre gange i 5 min.; hvor nukleinsyremolekylet koder for en aktiv opløselig alkalisk phosphatase, der i den C-terminale ende omfatter en polyaspartatsekvens Dn, hvor n=10 til 16.
2. Isoleret nukleinsyremolekyle ifølge krav 1, som omfatter en polynukleotidsekvens, der koder for den aktive opløselige alkaliske phosphatase, som i den C-terminale ende omfatter en polyaspartatsekvens Dw (sALP- Dw).
3. Rekombinant vektor, der omfatter en isoleret nukleotidsekvens ifølge kravene 1 eller 2.
4. Rekombinant værtscelle, der omfatter den rekombinante vektor ifølge krav 3.
5. Rekombinant vektor ifølge krav 3, som er pCDNA3-RSV-sALP-Di0-NEO, hvor sALP-Dio har nukleotidsekvensen som angivet i SEQ ID NO: 7.
6. Rekombinant værtscelle, der omfatter den rekombinante vektor ifølge krav 5, hvor værtscellen er en HEK293-celle.
7. Isoleret nukleinsyremolekyle ifølge krav 1, hvor polypeptidet i b) er den opløselige alkaliske phosphatase, der i den C-terminale ende omfatter en polyaspartatsekvens Dio (sALP-D-io).
8. Isoleret nukleinsyremolekyle ifølge krav 1, hvor den aktive opløselige alkaliske phosphatase nedsætter ekstracellulære PPi-niveauer.
9. Isoleret nukleinsyremolekyle ifølge krav 1, hvor den aktive opløselige alkaliske phosphatase er en biologisk aktiv alkalisk phosphatase.
DK11000196.3T 2004-04-21 2005-04-21 Knogleafgivelseskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle DK2348114T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56382804P 2004-04-21 2004-04-21
US59034704P 2004-07-23 2004-07-23
US61498404P 2004-10-04 2004-10-04
EP05739065A EP1759001B1 (en) 2004-04-21 2005-04-21 Bone delivery conjugates and method of using same to target proteins to bone

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DK2348114T3 true DK2348114T3 (da) 2018-09-03

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DK11000196.3T DK2348114T3 (da) 2004-04-21 2005-04-21 Knogleafgivelseskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle
DK05739065.0T DK1759001T3 (da) 2004-04-21 2005-04-21 Konjugat til tilførsel til knogler og fremgangsmåde til fremstilling deraf ved at målrette proteiner til knoglen
DK18173111.8T DK3404102T3 (da) 2004-04-21 2005-04-21 Knogletilførselskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle

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DK05739065.0T DK1759001T3 (da) 2004-04-21 2005-04-21 Konjugat til tilførsel til knogler og fremgangsmåde til fremstilling deraf ved at målrette proteiner til knoglen
DK18173111.8T DK3404102T3 (da) 2004-04-21 2005-04-21 Knogletilførselskonjugater og fremgangsmåde til anvendelse heraf til målretning af proteiner mod knogle

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US (5) US7763712B2 (da)
EP (3) EP2348114B1 (da)
JP (1) JP4874954B2 (da)
AT (1) ATE505551T1 (da)
AU (1) AU2005235635B2 (da)
CA (1) CA2559228C (da)
DE (1) DE602005027461D1 (da)
DK (3) DK2348114T3 (da)
ES (3) ES2687786T3 (da)
HK (1) HK1255900A1 (da)
HU (2) HUE055861T2 (da)
PL (3) PL3404102T3 (da)
PT (3) PT1759001E (da)
SI (2) SI3404102T1 (da)
WO (1) WO2005103263A1 (da)

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