DK2245181T3 - Selektivitetsprofilering af PI3K-interagerende molekyler med multiple mål - Google Patents
Selektivitetsprofilering af PI3K-interagerende molekyler med multiple målInfo
- Publication number
- DK2245181T3 DK2245181T3 DK09709335.5T DK09709335T DK2245181T3 DK 2245181 T3 DK2245181 T3 DK 2245181T3 DK 09709335 T DK09709335 T DK 09709335T DK 2245181 T3 DK2245181 T3 DK 2245181T3
- Authority
- DK
- Denmark
- Prior art keywords
- multiple target
- interacting molecules
- selectivity profiling
- target pi3k
- pi3k interacting
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08002053 | 2008-02-04 | ||
| PCT/EP2009/000692 WO2009098021A1 (en) | 2008-02-04 | 2009-02-03 | Selectivity profiling of pi3k interacting molecules against multiple targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2245181T3 true DK2245181T3 (da) | 2012-02-06 |
Family
ID=39561994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09709335.5T DK2245181T3 (da) | 2008-02-04 | 2009-02-03 | Selektivitetsprofilering af PI3K-interagerende molekyler med multiple mål |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110111972A1 (da) |
| EP (2) | EP2410062A1 (da) |
| JP (1) | JP2011514965A (da) |
| CN (1) | CN101965408B (da) |
| AT (1) | ATE528408T1 (da) |
| AU (1) | AU2009211845A1 (da) |
| CA (1) | CA2713276A1 (da) |
| DK (1) | DK2245181T3 (da) |
| ES (1) | ES2375541T3 (da) |
| HK (1) | HK1144705A1 (da) |
| WO (1) | WO2009098021A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602006003651D1 (de) | 2006-08-03 | 2008-12-24 | Cellzome Ag | Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K |
| US8785457B2 (en) | 2009-03-13 | 2014-07-22 | Cellzome Limited | Pyrimidine derivatives as mTOR inhibitors |
| EP2542536B1 (en) | 2010-03-04 | 2015-01-21 | Cellzome Limited | Morpholino substituted urea derivatives as mtor inhibitors |
| US20130210030A1 (en) | 2010-07-19 | 2013-08-15 | Cellzome Ag | In vivo method for the evaluation of a compound-target interaction |
| EP2694511A1 (en) | 2011-04-04 | 2014-02-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| CA2849189A1 (en) | 2011-09-21 | 2013-03-28 | Cellzome Limited | Morpholino substituted urea or carbamate derivatives as mtor inhibitors |
| MX341577B (es) | 2011-10-07 | 2016-08-25 | Cellzome Ltd | Derivados biciclicos de pirimidin-urea o carbamato sustituidos con morfolino como inhibidores del blanco de rapamicina de mamifero. |
| CN102977063A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种2-***啉-8-苯基-4-苯并吡喃-4-酮的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525503A (en) * | 1993-09-28 | 1996-06-11 | Dana-Farber Cancer Institute, Inc. | Signal transduction via CD28 |
| US20030194749A1 (en) * | 2002-02-15 | 2003-10-16 | Wandless Thomas J. | Wortmannin derivatives as probes of cellular proteins and processes |
| MY156407A (en) | 2002-02-28 | 2016-02-26 | Novartis Ag | 5-phenylthiazole derivatives and use as p13 kinase inhibitors |
| SE0402735D0 (sv) * | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| EP1734367A1 (en) * | 2005-06-14 | 2006-12-20 | Cellzome Ag | Process for the identification of novel enzyme interacting compounds |
| AU2006259153B2 (en) | 2005-06-14 | 2012-04-12 | Cellzome Gmbh | Process for the identification of novel enzyme interacting compounds |
| UA96736C2 (ru) * | 2005-09-07 | 2011-12-12 | Мерк Сероно Са | Ингибиторы pi3k для лечения эндометриоза |
| CN101426927B (zh) * | 2006-03-14 | 2012-05-23 | 塞尔卓姆股份公司 | 鉴定lrrk2相互作用分子和纯化lrrk2的方法 |
| DE602006003651D1 (de) * | 2006-08-03 | 2008-12-24 | Cellzome Ag | Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K |
-
2009
- 2009-02-03 CN CN2009801077436A patent/CN101965408B/zh not_active Expired - Fee Related
- 2009-02-03 AT AT09709335T patent/ATE528408T1/de active
- 2009-02-03 DK DK09709335.5T patent/DK2245181T3/da active
- 2009-02-03 US US12/866,000 patent/US20110111972A1/en not_active Abandoned
- 2009-02-03 WO PCT/EP2009/000692 patent/WO2009098021A1/en active Application Filing
- 2009-02-03 JP JP2010544648A patent/JP2011514965A/ja active Pending
- 2009-02-03 EP EP11008204A patent/EP2410062A1/en not_active Withdrawn
- 2009-02-03 AU AU2009211845A patent/AU2009211845A1/en not_active Abandoned
- 2009-02-03 CA CA2713276A patent/CA2713276A1/en not_active Abandoned
- 2009-02-03 ES ES09709335T patent/ES2375541T3/es active Active
- 2009-02-03 EP EP09709335A patent/EP2245181B1/en not_active Not-in-force
-
2010
- 2010-12-01 HK HK10111176.1A patent/HK1144705A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2410062A1 (en) | 2012-01-25 |
| US20110111972A1 (en) | 2011-05-12 |
| CA2713276A1 (en) | 2009-08-13 |
| EP2245181A1 (en) | 2010-11-03 |
| AU2009211845A1 (en) | 2009-08-13 |
| WO2009098021A1 (en) | 2009-08-13 |
| ES2375541T3 (es) | 2012-03-01 |
| CN101965408A (zh) | 2011-02-02 |
| CN101965408B (zh) | 2013-08-28 |
| ATE528408T1 (de) | 2011-10-15 |
| JP2011514965A (ja) | 2011-05-12 |
| HK1144705A1 (en) | 2011-03-04 |
| EP2245181B1 (en) | 2011-10-12 |
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