DE602006003651D1 - Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K - Google Patents

Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K

Info

Publication number
DE602006003651D1
DE602006003651D1 DE602006003651T DE602006003651T DE602006003651D1 DE 602006003651 D1 DE602006003651 D1 DE 602006003651D1 DE 602006003651 T DE602006003651 T DE 602006003651T DE 602006003651 T DE602006003651 T DE 602006003651T DE 602006003651 D1 DE602006003651 D1 DE 602006003651D1
Authority
DE
Germany
Prior art keywords
pi3k
phenylthiazole ligand
immobilized
phenylthiazole
ligand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006003651T
Other languages
English (en)
Inventor
Moore Giovanna Bergamini
Andrew Cansfield
Nigel Ramsden
Gitte Neubauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellzome GmbH
Original Assignee
Cellzome GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome GmbH filed Critical Cellzome GmbH
Publication of DE602006003651D1 publication Critical patent/DE602006003651D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
DE602006003651T 2006-08-03 2006-08-03 Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K Active DE602006003651D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06016205A EP1887359B1 (de) 2006-08-03 2006-08-03 Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K

Publications (1)

Publication Number Publication Date
DE602006003651D1 true DE602006003651D1 (de) 2008-12-24

Family

ID=37635850

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006003651T Active DE602006003651D1 (de) 2006-08-03 2006-08-03 Verfahren zur Identifizierung von Molekülen die mit PI3K interagieren und Verfahren zur Reinigung von PI3K

Country Status (12)

Country Link
US (1) US8153389B2 (de)
EP (1) EP1887359B1 (de)
JP (1) JP5234668B2 (de)
CN (1) CN101563612B (de)
AT (1) ATE414281T1 (de)
AU (1) AU2007280631B2 (de)
CA (1) CA2658904A1 (de)
DE (1) DE602006003651D1 (de)
DK (1) DK1887359T3 (de)
ES (1) ES2317382T3 (de)
HK (1) HK1111218A1 (de)
WO (1) WO2008015013A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5336375B2 (ja) 2006-08-30 2013-11-06 セルゾーム リミテッド キナーゼ阻害剤としてのトリアゾール誘導体
MX2010005700A (es) 2007-11-27 2010-06-11 Cellzome Ltd Amino triazoles como inhibidores pi3k.
EP2410062A1 (de) 2008-02-04 2012-01-25 Cellzome Ag Selektive Profilierung von PI3K-Interaktionsmolekülen gegen mehrere Ziele
ATE547707T1 (de) * 2008-05-16 2012-03-15 Cellzome Ag Verfahren zur identifizierung von mit parp wechselwirkenden molekülen und zur aufreinigung von parp-proteinen
WO2010092015A1 (en) 2009-02-10 2010-08-19 Cellzome Limited Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors
CA2755061A1 (en) 2009-03-13 2010-09-16 Cellzome Limited Pyrimidine derivatives as mtor inhibitors
WO2010112210A1 (en) 2009-04-03 2010-10-07 Cellzome Ag Methods for the identification of kinase interacting molecules and for the purification of kinase proteins
EP2432782A1 (de) 2009-05-20 2012-03-28 Cellzome Ag Verfahren zur identifizierung von mit phosphatidylinositkinase wechselwirkenden molekülen und zur aufreinigung von phosphatidylinositkinaseproteinen
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
US20140163023A1 (en) 2011-04-04 2014-06-12 Cellzome Limited Dihydropyrrolo pyrimidine derivatives as mtor inhibitors
CN103917530B (zh) 2011-09-21 2016-08-24 塞尔佐姆有限公司 作为mtor抑制剂的吗啉代取代的脲或氨基甲酸衍生物
RU2609208C2 (ru) 2011-10-07 2017-01-31 Селлзоум Лимитед МОРФОЛИНО-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ БИЦИКЛИЧЕСКИХ ПИРИМИДИНМОЧЕВИНЫ ИЛИ КАРБАМАТА В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
US20160022757A1 (en) * 2013-03-15 2016-01-28 Icahn School Of Medicine At Mount Sinai Therapeutic methods for treating solid tumors and related diagnostic methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952512A (en) * 1984-06-22 1990-08-28 Loskutoff David J Gene encoding an inhibitor of tissue-type and urokinase-type plasminogen activators
US5994082A (en) * 1994-08-26 1999-11-30 Mach; Bernard Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity
CA2239463A1 (en) * 1996-11-01 1998-05-14 Onyx Pharmaceuticals, Inc. Nucleotide sequences that encode phosphatidylinositol-3' kinase associated proteins and uses thereof
PE20030968A1 (es) * 2002-02-28 2004-01-12 Novartis Ag Derivados de 5-feniltiazol como inhibidores de cinasas
US7138402B2 (en) * 2003-09-18 2006-11-21 Conforma Therapeutics Corporation Pyrrolopyrimidines and related analogs as HSP90-inhibitors
SE0402735D0 (sv) * 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
PL1891446T3 (pl) 2005-06-14 2013-08-30 Cellzome Gmbh Sposób identyfikacji nowych związków oddziałujących z enzymami
EP2410062A1 (de) 2008-02-04 2012-01-25 Cellzome Ag Selektive Profilierung von PI3K-Interaktionsmolekülen gegen mehrere Ziele

Also Published As

Publication number Publication date
JP5234668B2 (ja) 2013-07-10
EP1887359A1 (de) 2008-02-13
HK1111218A1 (en) 2008-08-01
US8153389B2 (en) 2012-04-10
JP2010500870A (ja) 2010-01-14
EP1887359B1 (de) 2008-11-12
ATE414281T1 (de) 2008-11-15
CN101563612A (zh) 2009-10-21
WO2008015013A1 (en) 2008-02-07
CA2658904A1 (en) 2008-02-07
US20100055711A1 (en) 2010-03-04
DK1887359T3 (da) 2009-03-02
AU2007280631A1 (en) 2008-02-07
AU2007280631B2 (en) 2013-02-21
CN101563612B (zh) 2013-05-29
ES2317382T3 (es) 2009-04-16

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