DK2204383T3 - Fremgangsmåde til fremstilling af eptifibatid og relevante mellemproduktforbindelser - Google Patents
Fremgangsmåde til fremstilling af eptifibatid og relevante mellemproduktforbindelserInfo
- Publication number
- DK2204383T3 DK2204383T3 DK09075233.8T DK09075233T DK2204383T3 DK 2204383 T3 DK2204383 T3 DK 2204383T3 DK 09075233 T DK09075233 T DK 09075233T DK 2204383 T3 DK2204383 T3 DK 2204383T3
- Authority
- DK
- Denmark
- Prior art keywords
- eptifibatide
- preparation
- fragment
- novel compounds
- intermediate compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Combined Means For Separation Of Solids (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56045304P | 2004-04-08 | 2004-04-08 | |
EP05735068A EP1735345B1 (en) | 2004-04-08 | 2005-04-08 | Processes for preparing eptifibatide and pertinent intermediate compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2204383T3 true DK2204383T3 (da) | 2011-10-17 |
Family
ID=34956145
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05735068T DK1735345T3 (da) | 2004-04-08 | 2005-04-08 | Fremgangsmåde til fremstilling af eptifibatid og relevante mellemproduktforbindelser |
DK09075233.8T DK2204383T3 (da) | 2004-04-08 | 2005-04-08 | Fremgangsmåde til fremstilling af eptifibatid og relevante mellemproduktforbindelser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05735068T DK1735345T3 (da) | 2004-04-08 | 2005-04-08 | Fremgangsmåde til fremstilling af eptifibatid og relevante mellemproduktforbindelser |
Country Status (21)
Country | Link |
---|---|
US (2) | US7674768B2 (da) |
EP (2) | EP1735345B1 (da) |
JP (2) | JP4926942B2 (da) |
KR (1) | KR101238133B1 (da) |
CN (1) | CN1972960B (da) |
AT (2) | ATE433997T1 (da) |
AU (1) | AU2005233603B2 (da) |
CA (1) | CA2562157C (da) |
CY (2) | CY1109357T1 (da) |
DE (1) | DE602005014956D1 (da) |
DK (2) | DK1735345T3 (da) |
ES (2) | ES2369872T3 (da) |
HK (2) | HK1099313A1 (da) |
HR (2) | HRP20090490T1 (da) |
ME (2) | ME01260B (da) |
MX (1) | MXPA06011904A (da) |
PL (2) | PL2204383T3 (da) |
PT (2) | PT1735345E (da) |
RS (2) | RS51929B (da) |
SI (2) | SI1735345T1 (da) |
WO (1) | WO2005100381A2 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007513192A (ja) * | 2004-10-04 | 2007-05-24 | ノベタイド,リミティド | ペプチド用の対イオン交換法 |
NL2000126C2 (nl) * | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
US20100317827A1 (en) * | 2008-02-06 | 2010-12-16 | Biocon Limited | Method of Purifying a Peptide |
WO2009150657A1 (en) * | 2008-06-09 | 2009-12-17 | Natco Pharma Limited | Improved process for preparation of eptifibatide by fmoc solid phase synthesis |
CN101538314B (zh) * | 2009-01-13 | 2012-10-03 | 深圳翰宇药业股份有限公司 | 一种纯化爱啡肽的方法 |
CN101747412A (zh) * | 2009-12-30 | 2010-06-23 | 江苏诺泰制药技术有限公司 | 一种依替非巴肽的合成制备工艺 |
CN102174081B (zh) * | 2011-03-09 | 2013-05-29 | 杭州华津允上医药有限公司 | 埃替非巴肽及其前体的制备方法 |
CN102827249A (zh) * | 2011-06-14 | 2012-12-19 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种依替巴肽的液相合成方法 |
CN103408637B (zh) | 2013-06-27 | 2015-12-02 | 深圳翰宇药业股份有限公司 | 一种爱啡肽的制备方法 |
CN104710509B (zh) * | 2013-12-11 | 2018-01-02 | 深圳翰宇药业股份有限公司 | 一种爱啡肽的制备方法 |
CN108250265A (zh) * | 2016-12-29 | 2018-07-06 | 北京中科亚光生物科技有限公司 | 一种合成含有分子内二硫键的多肽的新工艺 |
CN110894212B (zh) * | 2018-08-24 | 2021-06-04 | 翰宇药业(武汉)有限公司 | 一种合成依替巴肽硫醚的方法 |
CN109251234A (zh) * | 2018-10-08 | 2019-01-22 | 重庆科脉生物化工有限公司 | 一种抗血小板聚集药物爱啡肽的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2616785B1 (fr) | 1987-06-19 | 1989-10-06 | Solvay | Composes guanidiniques comprenant un ion tetraphenylborate substitue et procede d'obtention de ces composes et utilisation des composes lors de la synthese peptidique |
US5686567A (en) | 1989-06-16 | 1997-11-11 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5318899A (en) | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
US5747447A (en) | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
BE1007184A3 (fr) | 1993-06-18 | 1995-04-18 | Solvay | Procede de preparation d'un amide d'alpha-aminoacide, utilisable en synthese peptidique. |
US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
MXPA04010910A (es) * | 2002-05-03 | 2005-01-25 | Avecia Ltd | Procedimiento para la sintesis de peptidos. |
DK1511761T3 (da) * | 2003-04-07 | 2006-11-27 | Novetide Ltd | Fremgangsmåde til fremstilling af cykliske peptider |
NL2000126C2 (nl) | 2005-07-15 | 2008-01-29 | Solvay | Werkwijze voor de vervaardiging van eptifibatide. |
-
2005
- 2005-04-08 WO PCT/US2005/011873 patent/WO2005100381A2/en active Application Filing
- 2005-04-08 DK DK05735068T patent/DK1735345T3/da active
- 2005-04-08 RS RS20110463A patent/RS51929B/en unknown
- 2005-04-08 SI SI200530776T patent/SI1735345T1/sl unknown
- 2005-04-08 ME MEP-2011-175A patent/ME01260B/me unknown
- 2005-04-08 MX MXPA06011904A patent/MXPA06011904A/es active IP Right Grant
- 2005-04-08 KR KR1020067020842A patent/KR101238133B1/ko not_active IP Right Cessation
- 2005-04-08 PT PT05735068T patent/PT1735345E/pt unknown
- 2005-04-08 PL PL09075233T patent/PL2204383T3/pl unknown
- 2005-04-08 DK DK09075233.8T patent/DK2204383T3/da active
- 2005-04-08 AU AU2005233603A patent/AU2005233603B2/en not_active Ceased
- 2005-04-08 ME MEP-2009-347A patent/ME01063B/me unknown
- 2005-04-08 DE DE602005014956T patent/DE602005014956D1/de active Active
- 2005-04-08 EP EP05735068A patent/EP1735345B1/en active Active
- 2005-04-08 ES ES09075233T patent/ES2369872T3/es active Active
- 2005-04-08 PT PT09075233T patent/PT2204383E/pt unknown
- 2005-04-08 PL PL05735068T patent/PL1735345T3/pl unknown
- 2005-04-08 CA CA2562157A patent/CA2562157C/en not_active Expired - Fee Related
- 2005-04-08 SI SI200531388T patent/SI2204383T1/sl unknown
- 2005-04-08 JP JP2007507520A patent/JP4926942B2/ja not_active Expired - Fee Related
- 2005-04-08 ES ES05735068T patent/ES2328713T3/es active Active
- 2005-04-08 CN CN2005800107525A patent/CN1972960B/zh not_active Expired - Fee Related
- 2005-04-08 EP EP09075233A patent/EP2204383B1/en active Active
- 2005-04-08 AT AT05735068T patent/ATE433997T1/de active
- 2005-04-08 AT AT09075233T patent/ATE519781T1/de active
- 2005-04-08 US US11/101,983 patent/US7674768B2/en not_active Expired - Fee Related
- 2005-04-08 RS RSP-2009/0399A patent/RS51182B/sr unknown
-
2007
- 2007-05-22 HK HK07105387.3A patent/HK1099313A1/xx not_active IP Right Cessation
-
2009
- 2009-09-07 CY CY20091100931T patent/CY1109357T1/el unknown
- 2009-09-15 HR HR20090490T patent/HRP20090490T1/xx unknown
- 2009-10-23 US US12/604,600 patent/US20100105609A1/en not_active Abandoned
-
2010
- 2010-12-30 HK HK10112216.1A patent/HK1145691A1/xx not_active IP Right Cessation
-
2011
- 2011-10-31 CY CY20111101038T patent/CY1111904T1/el unknown
- 2011-11-02 HR HR20110812T patent/HRP20110812T1/xx unknown
- 2011-12-06 JP JP2011266478A patent/JP2012111756A/ja active Pending
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