DK2131845T3 - 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazol-3-carboxylsyre-ethylamid-mesylat, hydrater og polymorfe deraf samt præparater, der omfatter disse former - Google Patents

5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazol-3-carboxylsyre-ethylamid-mesylat, hydrater og polymorfe deraf samt præparater, der omfatter disse former

Info

Publication number: DK2131845T3
Authority: DK; Denmark
Prior art keywords: phenyl; polymorphs; morpholin; isoxazole; ylmethyl
Prior art date: 2007-03-01

Application number

DK08717228.4T

Other languages

English (en)

Inventor

Martin James Drysdale

Brian William Dymock

Christoph Krell

Michael Mutz

Holger Petersen

Weijia Zheng

Original Assignee

Novartis Ag

Vernalis R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-01

Filing date

2008-02-28

Publication date

2012-07-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38134307&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2131845(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-28 Application filed by Novartis Ag, Vernalis R&D Ltd filed Critical Novartis Ag

2012-07-16 Application granted granted Critical

2012-07-16 Publication of DK2131845T3 publication Critical patent/DK2131845T3/da

Links

ZMAQNODASNQSRR-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide methanesulfonic acid Chemical compound CS(O)(=O)=O.CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 ZMAQNODASNQSRR-UHFFFAOYSA-N 0.000 title 1
150000004677 hydrates Chemical class 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

DK08717228.4T 2007-03-01 2008-02-28 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazol-3-carboxylsyre-ethylamid-mesylat, hydrater og polymorfe deraf samt præparater, der omfatter disse former DK2131845T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07103346		2007-03-01
PCT/EP2008/052443 WO2008104595A1 (en)	2007-03-01	2008-02-28	Acid addition salts, hydrates and polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide and formulations comprising these forms

Publications (1)

Publication Number	Publication Date
DK2131845T3 true DK2131845T3 (da)	2012-07-16

Family

ID=38134307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08717228.4T DK2131845T3 (da)	2007-03-01	2008-02-28	5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazol-3-carboxylsyre-ethylamid-mesylat, hydrater og polymorfe deraf samt præparater, der omfatter disse former

Country Status (41)

Country	Link
US (3)	US8163747B2 (da)
EP (2)	EP2545921A3 (da)
JP (1)	JP2010520176A (da)
KR (1)	KR20090122218A (da)
CN (2)	CN102302500A (da)
AR (1)	AR065519A1 (da)
AT (1)	ATE552836T1 (da)
AU (1)	AU2008220800B2 (da)
BR (1)	BRPI0807992A2 (da)
CA (1)	CA2678043A1 (da)
CL (1)	CL2008000618A1 (da)
CO (1)	CO6210828A2 (da)
CR (1)	CR10989A (da)
CY (1)	CY1113805T1 (da)
DK (1)	DK2131845T3 (da)
DO (1)	DOP2009000209A (da)
EA (1)	EA017075B1 (da)
EC (1)	ECSP099602A (da)
ES (1)	ES2384906T3 (da)
GE (1)	GEP20115309B (da)
GT (1)	GT200900236A (da)
HK (1)	HK1139073A1 (da)
HR (1)	HRP20120535T1 (da)
IL (1)	IL200401A0 (da)
MA (1)	MA31204B1 (da)
MX (1)	MX2009009233A (da)
NI (1)	NI200900161A (da)
NZ (1)	NZ578854A (da)
PA (1)	PA8771101A1 (da)
PE (1)	PE20090166A1 (da)
PL (1)	PL2131845T3 (da)
PT (1)	PT2131845E (da)
RS (1)	RS52351B (da)
SI (1)	SI2131845T1 (da)
SM (1)	SMAP200900080A (da)
TN (1)	TN2009000357A1 (da)
TW (1)	TW200844102A (da)
UA (1)	UA101950C2 (da)
UY (1)	UY30943A1 (da)
WO (1)	WO2008104595A1 (da)
ZA (1)	ZA200905417B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200922595A (en) *	2007-10-12	2009-06-01	Novartis Ag	Organic compounds
TWI450898B (zh) *	2008-07-04	2014-09-01	Sigma Tau Res Switzerland Sa	具有抗腫瘤活性之芳基異唑化合物
JP5063815B2 (ja) *	2008-11-25	2012-10-31	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	抗腫瘍および抗神経変性剤としての二環式ピラゾールおよびイソオキサゾール誘導体
CN106963759B (zh) *	2010-01-21	2020-07-07	阿普利亚治疗有限公司	用于治疗过度增生性疾病、自身免疫性疾病和心脏病的包含3-奎宁环酮衍生物的水溶液
JP2013519727A (ja) *	2010-02-17	2013-05-30	イルドンファームシーオー．，エルティーディー．	新規の５員複素環誘導体及びその製造方法
KR20120031854A (ko)	2010-09-27	2012-04-04	한국전자통신연구원	시간 및 주파수 특징을 이용하는 음악 음원 분리 장치 및 방법
WO2013015661A2 (en) *	2011-07-28	2013-01-31	Ildong Pharm Co.,Ltd.	Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide
FR3039401B1 (fr) *	2015-07-31	2018-07-13	Les Laboratoires Servier	Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2393483T3 (es) *	2003-02-11	2012-12-21	Vernalis (R&D) Limited	Compuestos de isoxazol como inhibidores de las proteínas de choque térmico
US20060070405A1 (en) *	2004-10-06	2006-04-06	Anheuser-Busch, Inc.	Method for the production of amber glass with reduced sulfur-containing emissions
CN101626758A (zh)	2007-02-15	2010-01-13	诺瓦提斯公司	用于治疗癌症的lbh589和其他治疗剂的组合
WO2010069458A1 (de)	2008-12-17	2010-06-24	Merck Patent Gmbh	Hexahalochromat(lll)-komplexe

2008
- 2008-02-28 UA UAA200908592A patent/UA101950C2/ru unknown
- 2008-02-28 EA EA200901141A patent/EA017075B1/ru not_active IP Right Cessation
- 2008-02-28 BR BRPI0807992-7A2A patent/BRPI0807992A2/pt not_active IP Right Cessation
- 2008-02-28 NZ NZ578854A patent/NZ578854A/en not_active IP Right Cessation
- 2008-02-28 CN CN201110226727.8A patent/CN102302500A/zh active Pending
- 2008-02-28 JP JP2009551218A patent/JP2010520176A/ja active Pending
- 2008-02-28 CA CA002678043A patent/CA2678043A1/en not_active Abandoned
- 2008-02-28 KR KR1020097018126A patent/KR20090122218A/ko not_active Application Discontinuation
- 2008-02-28 AR ARP080100831A patent/AR065519A1/es not_active Application Discontinuation
- 2008-02-28 DK DK08717228.4T patent/DK2131845T3/da active
- 2008-02-28 EP EP11192158.1A patent/EP2545921A3/en not_active Withdrawn
- 2008-02-28 MX MX2009009233A patent/MX2009009233A/es active IP Right Grant
- 2008-02-28 WO PCT/EP2008/052443 patent/WO2008104595A1/en active Application Filing
- 2008-02-28 GE GEAP200811444A patent/GEP20115309B/en unknown
- 2008-02-28 CN CN200880005490.7A patent/CN101636162A/zh active Pending
- 2008-02-28 PT PT08717228T patent/PT2131845E/pt unknown
- 2008-02-28 EP EP08717228A patent/EP2131845B1/en active Active
- 2008-02-28 AU AU2008220800A patent/AU2008220800B2/en not_active Ceased
- 2008-02-28 UY UY30943A patent/UY30943A1/es not_active Application Discontinuation
- 2008-02-28 PL PL08717228T patent/PL2131845T3/pl unknown
- 2008-02-28 SI SI200830688T patent/SI2131845T1/sl unknown
- 2008-02-28 AT AT08717228T patent/ATE552836T1/de active
- 2008-02-28 RS RS20120263A patent/RS52351B/en unknown
- 2008-02-28 US US12/529,090 patent/US8163747B2/en active Active
- 2008-02-28 ES ES08717228T patent/ES2384906T3/es active Active
- 2008-02-29 PA PA20088771101A patent/PA8771101A1/es unknown
- 2008-02-29 PE PE2008000418A patent/PE20090166A1/es not_active Application Discontinuation
- 2008-02-29 TW TW097107239A patent/TW200844102A/zh unknown
- 2008-02-29 CL CL200800618A patent/CL2008000618A1/es unknown
2009
- 2009-08-03 ZA ZA200905417A patent/ZA200905417B/xx unknown
- 2009-08-13 IL IL200401A patent/IL200401A0/en unknown
- 2009-08-21 CR CR10989A patent/CR10989A/es not_active Application Discontinuation
- 2009-08-28 NI NI200900161A patent/NI200900161A/es unknown
- 2009-08-28 EC EC2009009602A patent/ECSP099602A/es unknown
- 2009-08-28 TN TNP2009000357A patent/TN2009000357A1/fr unknown
- 2009-08-31 GT GT200900236A patent/GT200900236A/es unknown
- 2009-08-31 MA MA32191A patent/MA31204B1/fr unknown
- 2009-08-31 DO DO2009000209A patent/DOP2009000209A/es unknown
- 2009-09-01 CO CO09092694A patent/CO6210828A2/es not_active Application Discontinuation
- 2009-09-30 SM SM200900080T patent/SMAP200900080A/it unknown
2010
- 2010-06-09 HK HK10105737.5A patent/HK1139073A1/xx not_active IP Right Cessation
2012
- 2012-03-08 US US13/415,268 patent/US8487095B2/en active Active
- 2012-06-28 HR HRP20120535AT patent/HRP20120535T1/hr unknown
- 2012-07-09 CY CY20121100610T patent/CY1113805T1/el unknown
2013
- 2013-07-10 US US13/938,659 patent/US20130296556A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ATE552836T1 (de)	2012-04-15
US20120172592A1 (en)	2012-07-05
DOP2009000209A (es)	2009-09-15
ES2384906T3 (es)	2012-07-13
SI2131845T1 (sl)	2013-02-28
MA31204B1 (fr)	2010-02-01
PE20090166A1 (es)	2009-03-14
TW200844102A (en)	2008-11-16
BRPI0807992A2 (pt)	2014-06-17
PL2131845T3 (pl)	2012-09-28
EP2545921A3 (en)	2013-04-10
IL200401A0 (en)	2010-04-29
PA8771101A1 (es)	2009-02-09
EP2545921A2 (en)	2013-01-16
UY30943A1 (es)	2008-10-31
EA200901141A1 (ru)	2010-04-30
EP2131845B1 (en)	2012-04-11
US20130296556A1 (en)	2013-11-07
TN2009000357A1 (en)	2010-12-31
ECSP099602A (es)	2009-12-28
NI200900161A (es)	2010-07-27
PT2131845E (pt)	2012-07-10
EP2131845A1 (en)	2009-12-16
AR065519A1 (es)	2009-06-10
US8487095B2 (en)	2013-07-16
US8163747B2 (en)	2012-04-24
CN102302500A (zh)	2012-01-04
WO2008104595A1 (en)	2008-09-04
ZA200905417B (en)	2010-05-26
CR10989A (es)	2010-03-01
UA101950C2 (ru)	2013-05-27
CO6210828A2 (es)	2010-10-20
US20100093732A1 (en)	2010-04-15
CL2008000618A1 (es)	2008-09-12
CN101636162A (zh)	2010-01-27
JP2010520176A (ja)	2010-06-10
GT200900236A (es)	2011-09-14
GEP20115309B (en)	2011-10-25
SMAP200900080A (it)	2010-01-19
HRP20120535T1 (hr)	2012-07-31
KR20090122218A (ko)	2009-11-26
AU2008220800A1 (en)	2008-09-04
NZ578854A (en)	2012-03-30
HK1139073A1 (da)	2010-09-10
CY1113805T1 (el)	2016-07-27
RS52351B (en)	2012-12-31
EA017075B1 (ru)	2012-09-28
MX2009009233A (es)	2010-06-02
CA2678043A1 (en)	2008-09-04
AU2008220800B2 (en)	2012-02-16

Publication	Publication Date	Title
DK2131845T3 (da)	2012-07-16	5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazol-3-carboxylsyre-ethylamid-mesylat, hydrater og polymorfe deraf samt præparater, der omfatter disse former
DE602006016303D1 (de)	2010-09-30	3,4-dihydro-2H-benzoÄ1,4Üoxazin- und 3,4-dihydro-2H-benzoÄ1,4Üthiazin-VERBINDUNGEN ALS ALPHA2C-ADRENOREZEPTOR-ANTAGONISTEN
BRPI0817101A2 (pt)	2017-05-09	4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas
ZA200804762B (en)	2009-04-29	1,3-oxazolidin-2-one derivatives useful as CETP inhibitors
BRPI0817537A2 (pt)	2015-03-31	4-[3-(4-ciclopropanocarbonil-piperazina-i-carboni-,-fl uoro-benzil]-2h-ftalazin-1-ona
FR2888505B1 (fr)	2007-09-07	Nouvelles compositions cosmetiques amincissantes
FR2932492B1 (fr)	2010-07-30	Compositions a base d'hydrofluoroolefines
FR2932493B1 (fr)	2010-07-30	Compositions a base d'hydrofluoroolefines
DE502005007430D1 (de)	2009-07-16	Akkuschrauber
DK2010501T3 (da)	2014-06-30	Imidazolbaserede forbindelser, sammensætninger omfattende disse og fremgangsmåder for deres anvendelse
DE502005005415D1 (de)	2008-10-30	Akkuschrauber
DK2527714T3 (da)	2014-07-07	Modificeret latexfriktionsformindsker
DK3473101T3 (da)	2021-07-12	Isoxazolinsammensætninger og deres anvendelse som antiparasitik for feliner
FR2932494B1 (fr)	2011-02-25	Compositions a base d'hydrofluoroolefines
ATE536884T1 (de)	2011-12-15	Immunogene zusammensetzung
DE602006013038D1 (de)	2010-04-29	Herbizide zusammensetzung
MA28994B1 (fr)	2007-11-01	Composition immunogene
DE602004026934D1 (de)	2010-06-10	Löschverfahren für nichtflüchtige speicherung und nichtflüchtige speicherung
DK1881377T3 (da)	2010-03-15	Skydelukker og tonertilførselsapparat, der omfatter skydelukkeren
DK2079485T3 (da)	2012-08-06	Phenylpropionamidforbindelser og anvendelsen deraf
DK2139334T3 (da)	2013-09-23	Kondenserede heterocykliske 2-cyanophenylforbindelser og sammensætninger og anvendelser deraf
DK2158199T3 (da)	2011-02-07	Piperidinforbindelser og anvendelser deraf
ATE517878T1 (de)	2011-08-15	Substituierte 5-phenyl-3,6-dihydro-2-oxo-6h-ä1,3, 4üthiadiazine
DK2053921T3 (da)	2010-04-19	Ny antifungal sammensætning
DK1698668T3 (da)	2012-08-20	Stuetemperatur-hærdelige organopolysiloxansammensætninger