DK2114888T3 - Tricykliske forbindelser og deres anvendelse som glu-cocorticoid-receptor-modulatorer - Google Patents
Tricykliske forbindelser og deres anvendelse som glu-cocorticoid-receptor-modulatorerInfo
- Publication number
- DK2114888T3 DK2114888T3 DK08702358.6T DK08702358T DK2114888T3 DK 2114888 T3 DK2114888 T3 DK 2114888T3 DK 08702358 T DK08702358 T DK 08702358T DK 2114888 T3 DK2114888 T3 DK 2114888T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptor modulators
- glucocorticoid receptor
- tricyclic compounds
- tricyclic
- compounds
- Prior art date
Links
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88798107P | 2007-02-02 | 2007-02-02 | |
PCT/IB2008/000249 WO2008093236A1 (en) | 2007-02-02 | 2008-01-28 | Tricyclic compounds and their use as glucocorticoid receptor modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2114888T3 true DK2114888T3 (da) | 2011-01-24 |
Family
ID=39887754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08702358.6T DK2114888T3 (da) | 2007-02-02 | 2008-01-28 | Tricykliske forbindelser og deres anvendelse som glu-cocorticoid-receptor-modulatorer |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP2114888B1 (da) |
JP (1) | JP4579333B2 (da) |
AP (1) | AP2411A (da) |
AT (1) | ATE487700T1 (da) |
AU (1) | AU2008211622B2 (da) |
BR (1) | BRPI0807121A2 (da) |
CA (1) | CA2676907C (da) |
DE (1) | DE602008003405D1 (da) |
DK (1) | DK2114888T3 (da) |
EA (1) | EA016001B1 (da) |
HK (1) | HK1135094A1 (da) |
HR (1) | HRP20100726T1 (da) |
IL (1) | IL200044A (da) |
MX (1) | MX2009008286A (da) |
NZ (1) | NZ578661A (da) |
PL (1) | PL2114888T3 (da) |
SI (1) | SI2114888T1 (da) |
UZ (1) | UZ4378C (da) |
WO (1) | WO2008093236A1 (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2114970E (pt) * | 2007-02-02 | 2011-09-22 | Pfizer Prod Inc | Compostos tricíclicos e sua utilização como moduladores de receptor de glucocorticóide |
EA018024B1 (ru) * | 2008-07-28 | 2013-04-30 | Пфайзер Инк. | Фенантреноновые соединения, композиции и способы |
MX2013010576A (es) * | 2011-03-15 | 2014-03-12 | Abbvie Inc | Moduladores de receptores de hormonas nucleares. |
WO2013040233A1 (en) * | 2011-09-13 | 2013-03-21 | New York University | Controlling regulatory t cell function |
TW201422590A (zh) | 2012-09-07 | 2014-06-16 | Abbvie Inc | 雜環核激素受體調節劑 |
EP2935284A4 (en) | 2012-12-21 | 2016-04-27 | Abbvie Inc | HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS |
RU2731618C2 (ru) * | 2015-09-15 | 2020-09-07 | Лео Фарма А/С | Нестероидные модуляторы глюкокортиодидных рецепторов для местной доставки лекарств |
WO2020127685A1 (en) | 2018-12-19 | 2020-06-25 | Leo Pharma A/S | Amino-acid anilides as small molecule modulators of il-17 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01011018A (es) * | 1999-04-30 | 2002-05-06 | Pfizer Prod Inc | Moduladores del receptor glucocorticoide. |
JP4738603B2 (ja) * | 2000-11-06 | 2011-08-03 | ライオン株式会社 | 歯ブラシ |
IL146057A (en) * | 2000-10-27 | 2007-09-20 | Pfizer Prod Inc | A process for the preparation of modulators of a non-steroidal glucocorticoid receptor |
ES2262612T3 (es) * | 2000-10-28 | 2006-12-01 | Pfizer Products Inc. | Moduladpres del receptor de glucocorticoides. |
JP2007511501A (ja) * | 2003-11-13 | 2007-05-10 | ファイザー・プロダクツ・インク | グルココルチコイド受容体調節剤として有用なオクタヒドロフェナンスレンヒドラジド誘導体 |
JP2009535430A (ja) * | 2006-05-02 | 2009-10-01 | コーセプト セラピューティクス, インコーポレイテッド | Il−2を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターiiアンタゴニストの使用 |
-
2008
- 2008-01-28 UZ UZ0900241A patent/UZ4378C/xx unknown
- 2008-01-28 AT AT08702358T patent/ATE487700T1/de active
- 2008-01-28 AP AP2009004941A patent/AP2411A/xx active
- 2008-01-28 EA EA200970662A patent/EA016001B1/ru not_active IP Right Cessation
- 2008-01-28 BR BRPI0807121-7A2A patent/BRPI0807121A2/pt not_active Application Discontinuation
- 2008-01-28 NZ NZ578661A patent/NZ578661A/en not_active IP Right Cessation
- 2008-01-28 DK DK08702358.6T patent/DK2114888T3/da active
- 2008-01-28 WO PCT/IB2008/000249 patent/WO2008093236A1/en active Application Filing
- 2008-01-28 MX MX2009008286A patent/MX2009008286A/es active IP Right Grant
- 2008-01-28 PL PL08702358T patent/PL2114888T3/pl unknown
- 2008-01-28 SI SI200830124T patent/SI2114888T1/sl unknown
- 2008-01-28 CA CA2676907A patent/CA2676907C/en not_active Expired - Fee Related
- 2008-01-28 DE DE602008003405T patent/DE602008003405D1/de active Active
- 2008-01-28 EP EP08702358A patent/EP2114888B1/en active Active
- 2008-01-28 JP JP2009547779A patent/JP4579333B2/ja not_active Expired - Fee Related
- 2008-01-28 AU AU2008211622A patent/AU2008211622B2/en not_active Ceased
-
2009
- 2009-07-23 IL IL200044A patent/IL200044A/en active IP Right Grant
-
2010
- 2010-02-12 HK HK10101644.6A patent/HK1135094A1/xx not_active IP Right Cessation
- 2010-12-27 HR HR20100726T patent/HRP20100726T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2008093236A1 (en) | 2008-08-07 |
EA016001B1 (ru) | 2012-01-30 |
JP4579333B2 (ja) | 2010-11-10 |
EP2114888B1 (en) | 2010-11-10 |
IL200044A0 (en) | 2010-04-15 |
SI2114888T1 (sl) | 2011-02-28 |
UZ4378C (en) | 2011-07-29 |
MX2009008286A (es) | 2009-08-12 |
JP2010517991A (ja) | 2010-05-27 |
DE602008003405D1 (de) | 2010-12-23 |
ATE487700T1 (de) | 2010-11-15 |
BRPI0807121A2 (pt) | 2014-04-08 |
PL2114888T3 (pl) | 2011-04-29 |
AP2009004941A0 (en) | 2009-08-31 |
AP2411A (en) | 2012-05-30 |
NZ578661A (en) | 2010-12-24 |
AU2008211622A1 (en) | 2008-08-07 |
EA200970662A1 (ru) | 2010-02-26 |
HK1135094A1 (en) | 2010-05-28 |
CA2676907C (en) | 2012-03-20 |
AU2008211622B2 (en) | 2012-04-19 |
EP2114888A1 (en) | 2009-11-11 |
CA2676907A1 (en) | 2008-08-07 |
IL200044A (en) | 2015-06-30 |
HRP20100726T1 (hr) | 2011-04-30 |
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