DK2065388T3 - Pyrazolopyrimidinderivat - Google Patents

Pyrazolopyrimidinderivat

Info

Publication number
DK2065388T3
DK2065388T3 DK07807337.6T DK07807337T DK2065388T3 DK 2065388 T3 DK2065388 T3 DK 2065388T3 DK 07807337 T DK07807337 T DK 07807337T DK 2065388 T3 DK2065388 T3 DK 2065388T3
Authority
DK
Denmark
Prior art keywords
formula
compound represented
hsp90
compound
antitumor activity
Prior art date
Application number
DK07807337.6T
Other languages
English (en)
Inventor
Satoru Ohsuki
Atsushi Tengeiji
Masahiro Ikeda
Yoshihiro Shibata
Chikahiro Nagata
Takashi Shimada
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Application granted granted Critical
Publication of DK2065388T3 publication Critical patent/DK2065388T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK07807337.6T 2006-09-19 2007-09-14 Pyrazolopyrimidinderivat DK2065388T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006253465 2006-09-19
PCT/JP2007/067933 WO2008035629A1 (fr) 2006-09-19 2007-09-14 Dérivé de pyrazolopyrimidine

Publications (1)

Publication Number Publication Date
DK2065388T3 true DK2065388T3 (da) 2012-01-09

Family

ID=39200455

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07807337.6T DK2065388T3 (da) 2006-09-19 2007-09-14 Pyrazolopyrimidinderivat

Country Status (26)

Country Link
US (1) US8158638B2 (da)
EP (1) EP2065388B1 (da)
JP (1) JP5252636B2 (da)
KR (2) KR20140127367A (da)
CN (1) CN101541811B (da)
AT (1) ATE523513T1 (da)
AU (1) AU2007298286B2 (da)
BR (1) BRPI0717176A2 (da)
CA (1) CA2663965C (da)
CO (1) CO6210702A2 (da)
CY (1) CY1112191T1 (da)
DK (1) DK2065388T3 (da)
ES (1) ES2373160T3 (da)
HK (1) HK1127476A1 (da)
IL (1) IL197513A (da)
MX (1) MX2009002998A (da)
MY (1) MY145041A (da)
NO (1) NO20091495L (da)
NZ (1) NZ575564A (da)
PL (1) PL2065388T3 (da)
PT (1) PT2065388E (da)
RU (1) RU2420530C2 (da)
SI (1) SI2065388T1 (da)
TW (1) TWI388563B (da)
WO (1) WO2008035629A1 (da)
ZA (1) ZA200901921B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102333781B (zh) 2009-02-25 2014-06-11 第一三共株式会社 三环吡唑并嘧啶衍生物
TW201102390A (en) * 2009-03-31 2011-01-16 Arqule Inc Substituted pyrazolo-pyrimidine compounds
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
EP2810945A1 (en) * 2010-08-23 2014-12-10 Daiichi Sankyo Company, Limited Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative
JPWO2012026433A1 (ja) * 2010-08-23 2013-10-28 第一三共株式会社 三環性ピラゾロピリミジン誘導体のフリー体結晶
CA2928568A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Combinatorial methods to improve the therapeutic benefit of bisantrene
CN114380738A (zh) * 2021-09-28 2022-04-22 都创(重庆)医药科技有限公司 一种3-溴-4-氯-2-甲基吡啶的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615934D0 (en) 1996-07-30 1996-09-11 Netlon Ltd Integral tube
WO1998043991A1 (en) 1997-04-02 1998-10-08 Amersham Pharmacia Biotech Uk Limited Tricyclic base analogues
JP2001526639A (ja) * 1997-04-02 2001-12-18 アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド 三環式塩基類似体
US7138402B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation Pyrrolopyrimidines and related analogs as HSP90-inhibitors
WO2004047755A2 (en) 2002-11-22 2004-06-10 Japan Tobacco Inc. Fused bicyclic nitrogen-containing heterocycles
WO2005021568A2 (en) * 2003-08-27 2005-03-10 Biota, Inc. Novel tricyclic nucleosides or nucleotides as therapeutic agents
WO2006015263A2 (en) 2004-07-29 2006-02-09 Threshold Pharmaceuticals, Inc. Lonidamine analogs

Also Published As

Publication number Publication date
KR101485199B1 (ko) 2015-01-22
EP2065388B1 (en) 2011-09-07
US8158638B2 (en) 2012-04-17
TW200823223A (en) 2008-06-01
AU2007298286B2 (en) 2011-02-03
WO2008035629A1 (fr) 2008-03-27
KR20090066274A (ko) 2009-06-23
KR20140127367A (ko) 2014-11-03
SI2065388T1 (sl) 2012-03-30
IL197513A (en) 2014-01-30
JP5252636B2 (ja) 2013-07-31
CA2663965C (en) 2012-06-12
PT2065388E (pt) 2011-11-10
US20100113410A1 (en) 2010-05-06
AU2007298286A1 (en) 2008-03-27
MX2009002998A (es) 2009-04-02
EP2065388A1 (en) 2009-06-03
PL2065388T3 (pl) 2012-02-29
CY1112191T1 (el) 2015-12-09
HK1127476A1 (en) 2009-09-25
CN101541811A (zh) 2009-09-23
JPWO2008035629A1 (ja) 2010-01-28
RU2420530C2 (ru) 2011-06-10
CO6210702A2 (es) 2010-10-20
NZ575564A (en) 2011-02-25
BRPI0717176A2 (pt) 2013-10-15
MY145041A (en) 2011-12-15
RU2009114731A (ru) 2010-10-27
TWI388563B (zh) 2013-03-11
ES2373160T3 (es) 2012-02-01
CN101541811B (zh) 2014-07-09
NO20091495L (no) 2009-06-18
IL197513A0 (en) 2009-12-24
CA2663965A1 (en) 2008-03-27
EP2065388A4 (en) 2009-11-18
ATE523513T1 (de) 2011-09-15
ZA200901921B (en) 2009-12-30

Similar Documents

Publication Publication Date Title
CY1112191T1 (el) Παραγωγο πυραζολοπυριμιδινης
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
DK1853602T3 (da) Kemiske forbindelser
DK1853588T3 (da) Kemiske forbindelser
BRPI0813244B8 (pt) compostos derivados de pirazinona, composições compreendendo ditos compostos, uso dos compostos no tratamento de doenças de pulmão e composto intermediário
BRPI0610850A2 (pt) derivados de Ácido aril alquila, composiÇço farmacÊutica, medicamento, bem como uso dos referidos derivados
BRPI0514841A (pt) inibidores de piridila da sinalização de hedgehog, processo de preparação dos mesmos e composição compreendendo os referidos inibidores
MX2009000657A (es) Composiciones y metodos para el tratamiento de mucositis.
TW200736229A (en) Substituted 1H-benzimidazole-4-carboxamides are potent PARP inhibitors
MX2009005292A (es) Metodo de radiosensibilizacion de tumores usando un agente radiosensibilizante.
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
BRPI0714885B8 (pt) compostos terapêuticos e seu uso
ATE543803T1 (de) 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
EA201170344A1 (ru) Азаиндольные ингибиторы iap
MXPA05010020A (es) Derivados de oxamida.
MX2011008677A (es) Derivados de pirazolopirimidina triciclicos.
EA200870223A1 (ru) Производные бензоизоиндола для лечения боли
MX2009005912A (es) Derivados de etilamina-fenilo heterociclilo sustituidos, su preparacion y uso como medicamentos.
IL191670A0 (en) Compounds for the inhibition of apoptosis
ECSP078015A (es) 4-anilino-3-quinolinocarbonitrilos para el tratamiento de cáncer
ATE540920T1 (de) Aminobenzocycloheptenderivate, verfahren zu deren herstellung und deren verwendung in der therapie
ATE509956T1 (de) Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie
TNSN07283A1 (en) Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EA200870157A1 (ru) Производные 2-карбамид-4-фенилтиазола, их получение и их применение в терапии
GB2452142A (en) Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same