DK2065388T3 - Pyrazolopyrimidinderivat - Google Patents
PyrazolopyrimidinderivatInfo
- Publication number
- DK2065388T3 DK2065388T3 DK07807337.6T DK07807337T DK2065388T3 DK 2065388 T3 DK2065388 T3 DK 2065388T3 DK 07807337 T DK07807337 T DK 07807337T DK 2065388 T3 DK2065388 T3 DK 2065388T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- compound represented
- hsp90
- compound
- antitumor activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006253465 | 2006-09-19 | ||
PCT/JP2007/067933 WO2008035629A1 (fr) | 2006-09-19 | 2007-09-14 | Dérivé de pyrazolopyrimidine |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2065388T3 true DK2065388T3 (da) | 2012-01-09 |
Family
ID=39200455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07807337.6T DK2065388T3 (da) | 2006-09-19 | 2007-09-14 | Pyrazolopyrimidinderivat |
Country Status (26)
Country | Link |
---|---|
US (1) | US8158638B2 (da) |
EP (1) | EP2065388B1 (da) |
JP (1) | JP5252636B2 (da) |
KR (2) | KR20140127367A (da) |
CN (1) | CN101541811B (da) |
AT (1) | ATE523513T1 (da) |
AU (1) | AU2007298286B2 (da) |
BR (1) | BRPI0717176A2 (da) |
CA (1) | CA2663965C (da) |
CO (1) | CO6210702A2 (da) |
CY (1) | CY1112191T1 (da) |
DK (1) | DK2065388T3 (da) |
ES (1) | ES2373160T3 (da) |
HK (1) | HK1127476A1 (da) |
IL (1) | IL197513A (da) |
MX (1) | MX2009002998A (da) |
MY (1) | MY145041A (da) |
NO (1) | NO20091495L (da) |
NZ (1) | NZ575564A (da) |
PL (1) | PL2065388T3 (da) |
PT (1) | PT2065388E (da) |
RU (1) | RU2420530C2 (da) |
SI (1) | SI2065388T1 (da) |
TW (1) | TWI388563B (da) |
WO (1) | WO2008035629A1 (da) |
ZA (1) | ZA200901921B (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102333781B (zh) | 2009-02-25 | 2014-06-11 | 第一三共株式会社 | 三环吡唑并嘧啶衍生物 |
TW201102390A (en) * | 2009-03-31 | 2011-01-16 | Arqule Inc | Substituted pyrazolo-pyrimidine compounds |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
EP2810945A1 (en) * | 2010-08-23 | 2014-12-10 | Daiichi Sankyo Company, Limited | Dihydrochloride salt of a tricyclic pyrazolopyrimidine derivative |
JPWO2012026433A1 (ja) * | 2010-08-23 | 2013-10-28 | 第一三共株式会社 | 三環性ピラゾロピリミジン誘導体のフリー体結晶 |
CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
CN114380738A (zh) * | 2021-09-28 | 2022-04-22 | 都创(重庆)医药科技有限公司 | 一种3-溴-4-氯-2-甲基吡啶的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9615934D0 (en) | 1996-07-30 | 1996-09-11 | Netlon Ltd | Integral tube |
WO1998043991A1 (en) | 1997-04-02 | 1998-10-08 | Amersham Pharmacia Biotech Uk Limited | Tricyclic base analogues |
JP2001526639A (ja) * | 1997-04-02 | 2001-12-18 | アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド | 三環式塩基類似体 |
US7138402B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | Pyrrolopyrimidines and related analogs as HSP90-inhibitors |
WO2004047755A2 (en) | 2002-11-22 | 2004-06-10 | Japan Tobacco Inc. | Fused bicyclic nitrogen-containing heterocycles |
WO2005021568A2 (en) * | 2003-08-27 | 2005-03-10 | Biota, Inc. | Novel tricyclic nucleosides or nucleotides as therapeutic agents |
WO2006015263A2 (en) | 2004-07-29 | 2006-02-09 | Threshold Pharmaceuticals, Inc. | Lonidamine analogs |
-
2007
- 2007-09-14 MX MX2009002998A patent/MX2009002998A/es active IP Right Grant
- 2007-09-14 US US12/442,094 patent/US8158638B2/en not_active Expired - Fee Related
- 2007-09-14 AT AT07807337T patent/ATE523513T1/de active
- 2007-09-14 JP JP2008535335A patent/JP5252636B2/ja not_active Expired - Fee Related
- 2007-09-14 ES ES07807337T patent/ES2373160T3/es active Active
- 2007-09-14 CA CA2663965A patent/CA2663965C/en not_active Expired - Fee Related
- 2007-09-14 BR BRPI0717176-5A patent/BRPI0717176A2/pt not_active IP Right Cessation
- 2007-09-14 PT PT07807337T patent/PT2065388E/pt unknown
- 2007-09-14 DK DK07807337.6T patent/DK2065388T3/da active
- 2007-09-14 PL PL07807337T patent/PL2065388T3/pl unknown
- 2007-09-14 EP EP07807337A patent/EP2065388B1/en not_active Not-in-force
- 2007-09-14 AU AU2007298286A patent/AU2007298286B2/en not_active Ceased
- 2007-09-14 SI SI200730765T patent/SI2065388T1/sl unknown
- 2007-09-14 RU RU2009114731/04A patent/RU2420530C2/ru not_active IP Right Cessation
- 2007-09-14 KR KR20147027308A patent/KR20140127367A/ko not_active Application Discontinuation
- 2007-09-14 CN CN200780042951.3A patent/CN101541811B/zh not_active Expired - Fee Related
- 2007-09-14 NZ NZ575564A patent/NZ575564A/en not_active IP Right Cessation
- 2007-09-14 WO PCT/JP2007/067933 patent/WO2008035629A1/ja active Application Filing
- 2007-09-14 KR KR1020097005525A patent/KR101485199B1/ko not_active IP Right Cessation
- 2007-09-19 TW TW096134774A patent/TWI388563B/zh not_active IP Right Cessation
-
2009
- 2009-03-10 IL IL197513A patent/IL197513A/en not_active IP Right Cessation
- 2009-03-17 MY MYPI20091088A patent/MY145041A/en unknown
- 2009-03-18 ZA ZA200901921A patent/ZA200901921B/xx unknown
- 2009-04-16 NO NO20091495A patent/NO20091495L/no not_active Application Discontinuation
- 2009-04-17 CO CO09039060A patent/CO6210702A2/es active IP Right Grant
- 2009-07-15 HK HK09106411.9A patent/HK1127476A1/xx not_active IP Right Cessation
-
2011
- 2011-12-07 CY CY20111101220T patent/CY1112191T1/el unknown
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