DK1989295T3 - Fremgangsmåde til osteogen differentiering af knoglemarv-stamceller (bmsc) og anvendelser deraf - Google Patents

Fremgangsmåde til osteogen differentiering af knoglemarv-stamceller (bmsc) og anvendelser deraf Download PDF

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Publication number
DK1989295T3
DK1989295T3 DK07711561.6T DK07711561T DK1989295T3 DK 1989295 T3 DK1989295 T3 DK 1989295T3 DK 07711561 T DK07711561 T DK 07711561T DK 1989295 T3 DK1989295 T3 DK 1989295T3
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Denmark
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bmsc
procedure
stem cells
bone marrow
marrow stem
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DK07711561.6T
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English (en)
Inventor
Dominique Egrise
Micheline Lambermont
Michel Toungouz
Valérie Gangji
Jean-Philippe Hauzeur
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Univ Bruxelles
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Publication of DK1989295T3 publication Critical patent/DK1989295T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C12N2500/84—Undefined extracts from animals from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK07711561.6T 2006-02-16 2007-02-16 Fremgangsmåde til osteogen differentiering af knoglemarv-stamceller (bmsc) og anvendelser deraf DK1989295T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2006001427 2006-02-16
PCT/EP2007/001360 WO2007093431A1 (en) 2006-02-16 2007-02-16 A method for osteogenic differentiation of bone marrow stem cells (bmsc) and uses thereof

Publications (1)

Publication Number Publication Date
DK1989295T3 true DK1989295T3 (da) 2020-09-28

Family

ID=36223371

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07711561.6T DK1989295T3 (da) 2006-02-16 2007-02-16 Fremgangsmåde til osteogen differentiering af knoglemarv-stamceller (bmsc) og anvendelser deraf

Country Status (9)

Country Link
US (1) US8337827B2 (da)
JP (1) JP5170443B2 (da)
KR (1) KR20080109726A (da)
CN (1) CN101384707A (da)
CA (1) CA2640794C (da)
DK (1) DK1989295T3 (da)
ES (1) ES2830525T3 (da)
PT (1) PT1989295T (da)
WO (1) WO2007093431A1 (da)

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JP2008109866A (ja) * 2006-10-30 2008-05-15 Jms Co Ltd 培地添加剤、この培地添加剤を含む培地、及びこの培地を用いた細胞の培養方法
US8062364B1 (en) 2007-04-27 2011-11-22 Knee Creations, Llc Osteoarthritis treatment and device
PL2224934T3 (pl) * 2007-12-21 2012-12-31 Bone Therapeutics Sa Zastosowanie osteoblastów w leczeniu zapalnych chorób reumatycznych
US20100278788A1 (en) * 2008-01-11 2010-11-04 Bone Therapeutics, S.A. Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors
CA2722803A1 (en) * 2008-05-07 2009-11-12 Bone Therapeutics S.A. Human bone-forming cells in the treatment of conditions and bone diseases associated with immunodeficiency or immunosuppression
CA2722625A1 (en) * 2008-05-07 2009-11-12 Bone Therapeutics S.A. Novel mesenchymal stem cells and bone-forming cells
SG10201601279SA (en) 2008-08-18 2016-03-30 Mesoblast Inc Monoclonal Antibody STRO-4
WO2010051032A1 (en) * 2008-10-31 2010-05-06 Synthes Usa, Llc Method and device for activating stem cells
WO2010132315A1 (en) * 2009-05-13 2010-11-18 Endgenitor Technologies, Inc. Enhanced hematopoietic stem cell engraftment
EP2258413A1 (en) * 2009-06-04 2010-12-08 Université Catholique de Louvain Multi-dimensional biomaterial and method for producing the same.
WO2012048755A1 (en) 2010-10-15 2012-04-19 Université Libre de Bruxelles Er-alpha-17p peptide, effects on stem cell differentiation
AU2012239874A1 (en) * 2011-04-08 2013-10-31 Neostem, Inc. Autologous human adult pluripotent Very Small Embryonic-Like (hVSEL) Stem Cell regeneration of bone and cartilage
SG11201401434TA (en) 2011-10-11 2014-09-26 Bone Therapeutics Sa Uses of growth and differentiation factor 8 (gdf-8)
US20130243736A1 (en) * 2012-01-27 2013-09-19 Sapporo Medical University Replacement of bone marrow niche cells for treatment of various diseases
US9486483B2 (en) * 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
CN103611193B (zh) * 2013-11-26 2015-05-27 中山大学 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用
KR101518651B1 (ko) * 2013-12-31 2015-05-07 동국대학교 산학협력단 골 및 신생혈관 형성능이 향상된 줄기세포 공배양 방법
WO2016170112A1 (en) 2015-04-23 2016-10-27 Bone Therapeutics S.A. In vitro preservation of therapeutic cells
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant
CA3079439C (en) * 2017-10-20 2022-08-09 Bone Therapeutics Sa Methods for differentiating mesenchymal stem cells
JP2022501053A (ja) 2018-09-25 2022-01-06 ボーン、セラピューティクス、エスアーBone Thrapeutics Sa 間葉系幹細胞を分化させるための方法
WO2020064793A1 (en) 2018-09-25 2020-04-02 Bone Therapeutics Sa Methods and uses for determining osteogenic potential of in vitro differentiated cells
KR20200036459A (ko) 2018-09-28 2020-04-07 (주)링크옵틱스 녹색 형광결합 CD133 단백질의 발현을 통한 전립선암 세포의 in vitro 및 in vivo 골전이 방법
CN116583594A (zh) * 2020-10-14 2023-08-11 奥瑟姆健康公司 用于骨髓的提取和低温保藏的***和方法
CN113599500A (zh) * 2021-08-04 2021-11-05 天津医科大学朱宪彝纪念医院(天津医科大学代谢病医院、天津代谢病防治中心) 一种治疗骨骼代谢性疾病的药物及其应用

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US5736396A (en) * 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US8075880B2 (en) * 1999-01-11 2011-12-13 Steward St. Elizabeth's Medical Center Of Boston, Inc. Compositions and methods for regulating angiogenesis
WO1998033515A1 (en) 1997-02-05 1998-08-06 Case Western Reserve University STIMULATORY EFFECTS OF bFGF AND BMP-2 ON OSTEOGENIC DIFFERENTIATION OF MESENCHYMAL STEM CELLS
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WO2004007697A2 (en) * 2002-07-16 2004-01-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of implanting mesenchymal stem cells for tissue repair and formation

Also Published As

Publication number Publication date
JP2009526534A (ja) 2009-07-23
CA2640794C (en) 2015-04-14
KR20080109726A (ko) 2008-12-17
JP5170443B2 (ja) 2013-03-27
WO2007093431A1 (en) 2007-08-23
ES2830525T3 (es) 2021-06-03
PT1989295T (pt) 2020-10-29
US8337827B2 (en) 2012-12-25
CN101384707A (zh) 2009-03-11
CA2640794A1 (en) 2007-08-23
US20090081169A1 (en) 2009-03-26

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