PT1989295T - Processo para diferenciação osteogénica de células estaminais de medula óssea (cemo) e as suas utilizações - Google Patents
Processo para diferenciação osteogénica de células estaminais de medula óssea (cemo) e as suas utilizaçõesInfo
- Publication number
- PT1989295T PT1989295T PT77115616T PT07711561T PT1989295T PT 1989295 T PT1989295 T PT 1989295T PT 77115616 T PT77115616 T PT 77115616T PT 07711561 T PT07711561 T PT 07711561T PT 1989295 T PT1989295 T PT 1989295T
- Authority
- PT
- Portugal
- Prior art keywords
- bmsc
- stem cells
- bone marrow
- marrow stem
- osteogenic differentiation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2006001427 | 2006-02-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1989295T true PT1989295T (pt) | 2020-10-29 |
Family
ID=36223371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT77115616T PT1989295T (pt) | 2006-02-16 | 2007-02-16 | Processo para diferenciação osteogénica de células estaminais de medula óssea (cemo) e as suas utilizações |
Country Status (9)
Country | Link |
---|---|
US (1) | US8337827B2 (pt) |
JP (1) | JP5170443B2 (pt) |
KR (1) | KR20080109726A (pt) |
CN (1) | CN101384707A (pt) |
CA (1) | CA2640794C (pt) |
DK (1) | DK1989295T3 (pt) |
ES (1) | ES2830525T3 (pt) |
PT (1) | PT1989295T (pt) |
WO (1) | WO2007093431A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008109866A (ja) * | 2006-10-30 | 2008-05-15 | Jms Co Ltd | 培地添加剤、この培地添加剤を含む培地、及びこの培地を用いた細胞の培養方法 |
US8062364B1 (en) | 2007-04-27 | 2011-11-22 | Knee Creations, Llc | Osteoarthritis treatment and device |
KR101618380B1 (ko) * | 2007-12-21 | 2016-05-04 | 본 테라퓨틱스 소시에테아노님 | 염증성 류마티스 질환의 치료에 있어서의 인간 골-형성 세포 |
US20100278788A1 (en) * | 2008-01-11 | 2010-11-04 | Bone Therapeutics, S.A. | Osteogenic Differentiation Of Bone Marrow Stem Cells And Mesenchymal Stem Cells Using A Combination Of Growth Factors |
KR20110013450A (ko) * | 2008-05-07 | 2011-02-09 | 본 테라퓨틱스 소시에테아노님 | 간엽 줄기 세포 및 골-형성 세포 |
BE1018578A5 (fr) * | 2008-05-07 | 2011-04-05 | Bone Therapeutics Sa | Cellules formatrices d'os humains dans le traitement d'etats et de maladies osseuses associes a une immunodeficience ou une immunosuppression. |
EP2324359B1 (en) * | 2008-08-18 | 2018-10-31 | Mesoblast, Inc. | Use of heat shock protein 90-beta as marker for the identification and/or enrichment of adult multipotential mesenchymal precursor cells |
EP2344631B1 (en) * | 2008-10-31 | 2019-10-16 | Synthes GmbH | Method and device for activating stem cells |
WO2010132315A1 (en) * | 2009-05-13 | 2010-11-18 | Endgenitor Technologies, Inc. | Enhanced hematopoietic stem cell engraftment |
EP2258413A1 (en) | 2009-06-04 | 2010-12-08 | Université Catholique de Louvain | Multi-dimensional biomaterial and method for producing the same. |
WO2012048755A1 (en) | 2010-10-15 | 2012-04-19 | Université Libre de Bruxelles | Er-alpha-17p peptide, effects on stem cell differentiation |
US20140112891A1 (en) * | 2011-04-08 | 2014-04-24 | Neostem, Inc. | AUTOLOGOUS HUMAN ADULT PLURIPOTENT VERY SMALL EMBRYONIC-LIKE (hVSEL) STEM CELL REGENERATION OF BONE AND CARTILAGE |
SG11201401434TA (en) | 2011-10-11 | 2014-09-26 | Bone Therapeutics Sa | Uses of growth and differentiation factor 8 (gdf-8) |
JP2013153747A (ja) * | 2012-01-27 | 2013-08-15 | Sapporo Medical Univ | 様々な疾患の治療のための骨芽ニッチ細胞の置換 |
US9486483B2 (en) * | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
CN103611193B (zh) * | 2013-11-26 | 2015-05-27 | 中山大学 | 一种碳酸钙微球-细胞外基质复合材料及其制备方法和应用 |
KR101518651B1 (ko) * | 2013-12-31 | 2015-05-07 | 동국대학교 산학협력단 | 골 및 신생혈관 형성능이 향상된 줄기세포 공배양 방법 |
WO2016170112A1 (en) | 2015-04-23 | 2016-10-27 | Bone Therapeutics S.A. | In vitro preservation of therapeutic cells |
AU2017204355B2 (en) | 2016-07-08 | 2021-09-09 | Mako Surgical Corp. | Scaffold for alloprosthetic composite implant |
AU2018351804B2 (en) | 2017-10-20 | 2020-07-09 | Bone Therapeutics Sa | Methods for differentiating mesenchymal stem cells |
KR20210074303A (ko) | 2018-09-25 | 2021-06-21 | 본 테라퓨틱스 소시에테아노님 | 중간엽 줄기 세포의 분화 방법 |
JP2022502034A (ja) | 2018-09-25 | 2022-01-11 | ボーン、セラピューティクス、エスアーBone Thrapeutics Sa | in vitro分化細胞の骨形成能を決定するための方法および使用 |
KR20200036459A (ko) | 2018-09-28 | 2020-04-07 | (주)링크옵틱스 | 녹색 형광결합 CD133 단백질의 발현을 통한 전립선암 세포의 in vitro 및 in vivo 골전이 방법 |
CN116583594A (zh) * | 2020-10-14 | 2023-08-11 | 奥瑟姆健康公司 | 用于骨髓的提取和低温保藏的***和方法 |
CN113599500A (zh) * | 2021-08-04 | 2021-11-05 | 天津医科大学朱宪彝纪念医院(天津医科大学代谢病医院、天津代谢病防治中心) | 一种治疗骨骼代谢性疾病的药物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
US8075880B2 (en) * | 1999-01-11 | 2011-12-13 | Steward St. Elizabeth's Medical Center Of Boston, Inc. | Compositions and methods for regulating angiogenesis |
AU6144698A (en) | 1997-02-05 | 1998-08-25 | Case Western Reserve University | Stimulatory effects of bfgf and bmp-2 on osteogenic differentiation of mesenchymal stem cells |
ES2539105T3 (es) * | 2001-07-06 | 2015-06-26 | Asterias Biotherapeutics, Inc. | Células mesenquimatosas y osteoblastos procedentes de células madre embrionarias humanas |
JP2005532810A (ja) | 2002-07-16 | 2005-11-04 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 組織修復および組織形成のために間葉性幹細胞を移植する方法 |
-
2007
- 2007-02-16 JP JP2008554685A patent/JP5170443B2/ja active Active
- 2007-02-16 US US12/278,557 patent/US8337827B2/en active Active
- 2007-02-16 PT PT77115616T patent/PT1989295T/pt unknown
- 2007-02-16 CA CA2640794A patent/CA2640794C/en active Active
- 2007-02-16 KR KR1020087019628A patent/KR20080109726A/ko not_active Application Discontinuation
- 2007-02-16 WO PCT/EP2007/001360 patent/WO2007093431A1/en active Application Filing
- 2007-02-16 CN CNA2007800057563A patent/CN101384707A/zh active Pending
- 2007-02-16 ES ES07711561T patent/ES2830525T3/es active Active
- 2007-02-16 DK DK07711561.6T patent/DK1989295T3/da active
Also Published As
Publication number | Publication date |
---|---|
CA2640794A1 (en) | 2007-08-23 |
JP2009526534A (ja) | 2009-07-23 |
US20090081169A1 (en) | 2009-03-26 |
WO2007093431A1 (en) | 2007-08-23 |
CA2640794C (en) | 2015-04-14 |
KR20080109726A (ko) | 2008-12-17 |
DK1989295T3 (da) | 2020-09-28 |
ES2830525T3 (es) | 2021-06-03 |
US8337827B2 (en) | 2012-12-25 |
CN101384707A (zh) | 2009-03-11 |
JP5170443B2 (ja) | 2013-03-27 |
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