DK1974017T4 - Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler - Google Patents

Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler Download PDF

Info

Publication number
DK1974017T4
DK1974017T4 DK06824300.5T DK06824300T DK1974017T4 DK 1974017 T4 DK1974017 T4 DK 1974017T4 DK 06824300 T DK06824300 T DK 06824300T DK 1974017 T4 DK1974017 T4 DK 1974017T4
Authority
DK
Denmark
Prior art keywords
affecting
stability
methods
producing cells
antibody producing
Prior art date
Application number
DK06824300.5T
Other languages
English (en)
Other versions
DK1974017T3 (da
Inventor
Hergen Spits
Ferenc Alexander Scheeren
Tim Beaumont
Sean Andrew Diehl
Original Assignee
Academisch Medisch Centrum Bij De Univ Van Amsterdam
Kling Biotherapeutics B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37714656&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1974017(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/NL2005/000848 external-priority patent/WO2007067032A1/en
Application filed by Academisch Medisch Centrum Bij De Univ Van Amsterdam, Kling Biotherapeutics B V filed Critical Academisch Medisch Centrum Bij De Univ Van Amsterdam
Publication of DK1974017T3 publication Critical patent/DK1974017T3/da
Application granted granted Critical
Publication of DK1974017T4 publication Critical patent/DK1974017T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0635B lymphocytes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/231Interleukin-10 (IL-10)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2321Interleukin-21 (IL-21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/52CD40, CD40-ligand (CD154)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60Transcription factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/99Coculture with; Conditioned medium produced by genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/04Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK06824300.5T 2005-12-09 2006-12-08 Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler DK1974017T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/NL2005/000848 WO2007067032A1 (en) 2005-12-09 2005-12-09 Means and methods for influencing the stability of cells
EP06076211 2006-06-12
PCT/NL2006/000625 WO2007067046A1 (en) 2005-12-09 2006-12-08 Means and methods for influencing the stability of antibody producing cells

Publications (2)

Publication Number Publication Date
DK1974017T3 DK1974017T3 (da) 2014-02-10
DK1974017T4 true DK1974017T4 (da) 2023-09-25

Family

ID=37714656

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12175198.6T DK2540820T3 (da) 2005-12-09 2006-12-08 Midler og fremgangsmåder til påvirkning af stabiliteten af antistofproducerende celler
DK06824300.5T DK1974017T4 (da) 2005-12-09 2006-12-08 Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK12175198.6T DK2540820T3 (da) 2005-12-09 2006-12-08 Midler og fremgangsmåder til påvirkning af stabiliteten af antistofproducerende celler

Country Status (14)

Country Link
US (3) US9127251B2 (da)
EP (3) EP2540820B1 (da)
JP (2) JP5753339B2 (da)
AU (2) AU2006323315B2 (da)
BR (2) BR122021001906B1 (da)
CA (2) CA3015416C (da)
DK (2) DK2540820T3 (da)
ES (2) ES2660899T3 (da)
FI (1) FI1974017T4 (da)
HU (1) HUE037580T2 (da)
NZ (3) NZ569543A (da)
PL (2) PL1974017T5 (da)
PT (2) PT2540820T (da)
WO (1) WO2007067046A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2540820T (pt) 2005-12-09 2018-03-02 Academisch Medisch Centrum Bij De Univ Van Amsterdam Meios e métodos para influenciar a establidade de células produtoras de anticorpos
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
JP5205597B2 (ja) * 2007-06-01 2013-06-05 静岡県 1細胞レベルでの抗体遺伝子の解析・同定方法
WO2009020923A1 (en) * 2007-08-03 2009-02-12 Musc Foundation For Research Development Human monoclonal antibodies and methods for producing the same
US20110171688A1 (en) * 2008-06-16 2011-07-14 Christoph Esslinger Method of providing immunoglobulin secreting b lymphocytes and human antibodies
BRPI1012749B1 (pt) 2009-05-11 2022-01-11 Janssen Vaccines & Prevention B.V. Anticorpo monoclonal humano, seu uso e seu método de produção, imunoconjugado, e composição farmacêutica
JP5781508B2 (ja) 2009-07-15 2015-09-24 アイム・セラピューティクス・べー・フェー 高親和性抗体を産生させるための手段および方法
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
EP3037435B1 (en) 2009-11-17 2019-08-07 MUSC Foundation for Research Development Human monoclonal antibodies to human nucleolin
PL2400298T3 (pl) * 2010-05-28 2014-01-31 Hoffmann La Roche Sposób hodowania pojedynczych komórek b oraz wytwarzania swoistych przeciwciał
CN103429615B (zh) 2010-12-02 2018-03-16 埃姆医疗有限公司 用于生产高亲和力抗体的方式和方法
KR20140112495A (ko) 2011-12-02 2014-09-23 에임 쎄라퓨틱스 비.브이. 인플루엔자 a 바이러스 특이적 항체
US10017739B2 (en) * 2012-09-06 2018-07-10 Duke University Methods of expanding and assessing B cells and using expanded B cells to treat disease
US10240125B2 (en) 2013-03-14 2019-03-26 Immusoft Corporation Methods for in vitro memory B cell differentiation and transduction with VSV-G pseudotyped viral vectors
MX2016008109A (es) 2013-12-17 2017-01-13 Aimm Therapeutics Bv Medios y metodos para contrarrestar trastornos mieloproliferativos o linfoproliferativos.
ES2927905T3 (es) * 2013-12-24 2022-11-11 Kling Biotherapeutics B V Producción de anticuerpos ex vivo
EP3099709B1 (en) 2014-01-31 2019-12-25 AIMM Therapeutics B.V. Means and methods for producing stable antibodies
AU2015268982B2 (en) * 2014-06-05 2021-11-04 Kling Biotherapeutics B.V. Means and methods for determining T cell recognition
WO2016002760A1 (ja) 2014-07-02 2016-01-07 学校法人東京理科大学 B細胞集団の製造方法
WO2016100932A1 (en) * 2014-12-19 2016-06-23 Immusoft Corporation B cells for in vivo delivery of therapeutic agents
EP3277823B1 (en) * 2015-04-03 2023-09-13 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
EP3307070A4 (en) * 2015-06-12 2019-01-02 Emory University Growth and survival compositions for cells capable of producing antibodies and methods related thereto
MX2017016258A (es) 2015-06-24 2018-04-20 Aimm Therapeutics Bv Antigenos de leucemia mieloide aguda (aml) y usos de los mismos.
JP7036729B2 (ja) 2016-01-08 2022-03-15 クリング・バイオセラピューティックス・べー・フェー 治療用抗cd9抗体
WO2018102612A1 (en) 2016-12-02 2018-06-07 Juno Therapeutics, Inc. Engineered b cells and related compositions and methods
CA3051466A1 (en) 2017-01-31 2018-08-09 Vanderbilt University Generation of human allergen-and helminth-specific ige monoclonal antibodies for diagnostic and therapeutic use
US11125757B2 (en) 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
US20210317187A1 (en) * 2017-12-05 2021-10-14 Sqz Biotechnologies Company Intracellular delivery of biomolecules to modulate antibody production

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997764A (en) * 1987-04-23 1991-03-05 New York University Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors
AU636573B2 (en) 1988-02-26 1993-05-06 Worcester Foundation For Biomedical Research, Inc. Inhibition of htlv-iii by exogenous oligonucleotides
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
WO1994007367A1 (en) 1992-09-29 1994-04-14 Apollon, Inc. Anti-viral oligomers that bind polypurine tracts of single-stranded rna or rna-dna hybrids
DK0664833T3 (da) 1992-10-05 1997-04-14 Hybridon Inc Terapeutisk anti-HIV oligonukletid og lægemiddel
WO1994017086A1 (en) 1993-01-25 1994-08-04 Apollon, Inc. Gene regulation by targeting putative intramolecular triple helix
US5550019A (en) * 1993-05-26 1996-08-27 La Jolla Cancer Research Foundation Methods of identifying compounds which alter apoptosis
US5866755A (en) 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
CA2170980A1 (en) 1993-09-03 1995-03-09 James Mule Genetically modified human hematopoietic stem cells and their progeny
US6265556B1 (en) * 1994-12-02 2001-07-24 The Burnham Institute Nucleic acid encoding CD40 associated proteins
GB9425060D0 (en) * 1994-12-13 1995-02-08 Univ Birmingham Carcinoma treatment
US5811524A (en) * 1995-06-07 1998-09-22 Idec Pharmaceuticals Corporation Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
US6001558A (en) 1997-06-25 1999-12-14 Ortho Clinical Diagnostics, Inc. Amplification and detection of HIV-1 and/or HIV 2
EP1214399B1 (en) * 1999-09-08 2007-07-11 Genetrol Biotherapeutics High level cytokine production with enhanced cell viability
EP1083230A1 (en) 1999-09-10 2001-03-14 Academisch Medisch Centrum Amsterdam Viral replicons and viruses dependent on inducing agents
US7122180B2 (en) 2000-10-23 2006-10-17 Children's Medical Center Corporation DNA vectors containing mutated HIV proviruses
US20030175950A1 (en) 2001-05-29 2003-09-18 Mcswiggen James A. RNA interference mediated inhibition of HIV gene expression using short interfering RNA
US20050009180A1 (en) 2001-12-10 2005-01-13 Lili Yang Method for the generation of antigen-specific lymphocytes
ATE515189T1 (de) 2001-12-10 2011-07-15 California Inst Of Techn Verfahren zur herstellung von antigenspezifischen lymphozyten
EP2141228A1 (en) * 2001-12-18 2010-01-06 Cancer Research Technology Limited Method for the generation of proliferating and differentiating B cell lines
US7741077B2 (en) 2001-12-22 2010-06-22 4-Antibody Ag Method for the generation of genetically modified vertebrate precursor lymphocytes and use thereof for the production of heterologous binding proteins
EP1495141A4 (en) 2002-03-20 2006-03-22 Massachusetts Inst Technology HIV THERAPEUTIC
JP2004121237A (ja) * 2002-09-05 2004-04-22 Japan Science & Technology Agency 体外免疫末梢血リンパ球を用いた抗原特異的抗体
WO2004040969A1 (ja) * 2002-11-07 2004-05-21 Kumamoto Technology & Industry Foundation Ganp導入トランスジェニック哺乳動物及びその利用
GB2398783A (en) * 2003-02-26 2004-09-01 Antonio Lanzavecchia A method for producing immortalised human B memory lymphocytes
CN1777621A (zh) * 2003-03-14 2006-05-24 Wyeth公司 抗人il-21受体的抗体及其应用
PT1682178E (pt) 2003-11-04 2010-10-21 Novartis Vaccines & Diagnostic Métodos de terapêutica para cancros que expressam o antigénio cd40
GB2422845B (en) * 2003-11-19 2007-08-01 Us Gov Health & Human Serv Method of inducing memory B cell development and terminal differentiation
GB0327384D0 (en) 2003-11-25 2003-12-31 Queen Mary & Westfield College Gene therapy
US20050238626A1 (en) 2004-04-01 2005-10-27 Lili Yang Antigen specific T cell therapy
WO2005123923A2 (en) 2004-06-17 2005-12-29 Wolfgang Hillen Inducer specific tetracycline repressor proteins and methods of use thereof
EP1627563A1 (en) 2004-08-10 2006-02-22 Academisch Medisch Centrum bij de Universiteit van Amsterdam Means and methods for producing a stabilized cell of interest
EP1647595A1 (en) 2004-10-15 2006-04-19 Academisch Medisch Centrum bij de Universiteit van Amsterdam Nucleic acids against viruses, in particular HIV
US7393923B2 (en) 2004-11-08 2008-07-01 The Regents Of The University Of California Red-shifted fluorescent proteins mPlum and mRaspberry and polynucleotides encoding the same
US8337851B2 (en) 2005-05-18 2012-12-25 Novartis Ag Methods of monitoring the efficacy of anti-CD40 antibodies in treating a subject for a CD40-expressing cancer
EP1891209A1 (en) 2005-06-06 2008-02-27 Academisch Medisch Centrum bij de Universiteit van Amsterdam Means and methods for generating a t cell against an antigen of interest.
CA2630348C (en) 2005-11-17 2016-01-12 Stichting Voor De Technische Wetenschappen Inducible expression systems
PT2540820T (pt) 2005-12-09 2018-03-02 Academisch Medisch Centrum Bij De Univ Van Amsterdam Meios e métodos para influenciar a establidade de células produtoras de anticorpos
WO2007067032A1 (en) 2005-12-09 2007-06-14 Academisch Medisch Cemtrum Bij De Universiteit Van Amsterdam Means and methods for influencing the stability of cells
WO2008103475A1 (en) 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
RU2537264C2 (ru) 2009-04-03 2014-12-27 Медикал Рисерч Каунсил Мутанты индуцируемой активацией цитидиндеаминазы (aid) и способы их применения
CN105440133A (zh) 2009-07-15 2016-03-30 Aimm医疗股份公司 ***特异性结合化合物
JP5781508B2 (ja) 2009-07-15 2015-09-24 アイム・セラピューティクス・べー・フェー 高親和性抗体を産生させるための手段および方法
NZ599148A (en) 2009-10-06 2014-08-29 Medimmune Ltd Rsv-specific binding molecule
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
CN103429615B (zh) 2010-12-02 2018-03-16 埃姆医疗有限公司 用于生产高亲和力抗体的方式和方法
KR20140112495A (ko) 2011-12-02 2014-09-23 에임 쎄라퓨틱스 비.브이. 인플루엔자 a 바이러스 특이적 항체

Also Published As

Publication number Publication date
PL1974017T3 (pl) 2014-04-30
ES2444465T3 (es) 2014-02-25
US9127251B2 (en) 2015-09-08
CA2633157C (en) 2018-10-09
EP2540820A1 (en) 2013-01-02
JP5753339B2 (ja) 2015-07-22
PT2540820T (pt) 2018-03-02
CA2633157A1 (en) 2007-06-14
JP2009518033A (ja) 2009-05-07
NZ600075A (en) 2013-12-20
US20170306293A1 (en) 2017-10-26
FI1974017T4 (fi) 2023-09-14
PL2540820T3 (pl) 2018-05-30
CA3015416C (en) 2022-10-11
JP2013099358A (ja) 2013-05-23
JP5753547B2 (ja) 2015-07-22
US20100113745A1 (en) 2010-05-06
DK1974017T3 (da) 2014-02-10
ES2660899T3 (es) 2018-03-26
CA3015416A1 (en) 2007-06-14
EP3327117A1 (en) 2018-05-30
BRPI0619579B8 (pt) 2022-01-25
AU2006323315B2 (en) 2014-02-20
EP1974017B2 (en) 2023-06-21
BR122021001906B1 (pt) 2022-03-29
EP1974017A1 (en) 2008-10-01
ES2444465T5 (es) 2023-11-30
NZ592159A (en) 2012-12-21
EP2540820B1 (en) 2018-01-10
PT1974017E (pt) 2014-02-11
DK2540820T3 (da) 2018-03-12
BRPI0619579B1 (pt) 2021-07-20
US9822339B2 (en) 2017-11-21
NZ569543A (en) 2012-12-21
AU2014202709A1 (en) 2014-06-12
EP1974017B1 (en) 2013-11-06
AU2006323315A1 (en) 2007-06-14
PL1974017T5 (pl) 2023-10-23
US20160060598A1 (en) 2016-03-03
WO2007067046A1 (en) 2007-06-14
HUE037580T2 (hu) 2018-09-28
BRPI0619579A2 (pt) 2011-10-04
US10273454B2 (en) 2019-04-30
AU2014202709B2 (en) 2016-09-08

Similar Documents

Publication Publication Date Title
DK1974017T3 (da) Midler og fremgangsmåder til at påvirke stabiliteten af antistof producerende celler
LTPA2016026I1 (lt) Anti-il-17 antikūnai
DK1748077T3 (da) Fremgangsmåde til fremstilling af protein
DK1828164T3 (da) Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider
DK1778668T3 (da) Fremgangsmåde til fremstilling af dihydropteridion
DK2959774T3 (da) Fremgangsmåde til kryokonservering af sædceller
DK2573166T3 (da) Fremgangsmåder til fremstilling af T-celler til celleterapi
DK1805312T3 (da) Fremgangsmåder og midler til fremstilling af hyaluronan
NO20071430L (no) Anti-OX4OL antistoffer
DK1838874T3 (da) Fremgangsmåder til regulering af stamceller
DK2030476T3 (da) Fremgangsmåde og system til forbedring af forståeligheden af lyde
DK1737891T3 (da) Anti-p-selectin-antistoffer
DK2102398T3 (da) Fremgangsmåde til fremstilling af en ankelsok og ankelsok opnået derved
DE602005017745D1 (de) Brennstoffzellen-auseinanderbauverfahren
DK1952103T3 (da) Fremgangsmåde til at veje med flere vejeceller
DK1948176T3 (da) Diarylurinstoffer til behandling af pulmonær hypertension
DK1954713T3 (da) Modificerede grønfluorescerende proteiner og fremgangsmåder til anvendelse af samme
DK1831223T3 (da) Fremgangsmåde til fremstilling af L-biopterin
DK1768691T3 (da) Aequorinholdige præparater og fremgangsmåder til anvendelse af samme
DK1794111T3 (da) Fremgangsmåde til fremstilling af cyclopentanon
DK1753720T3 (da) Fremgangsmåde til fremstilling af perindopril og salte deraf
DK1870460T3 (da) Fremgangsmåder til fremstilling af proteiner med tripelhelixstruktur
FI20041123A0 (fi) Palkkirakenne
DK1931379T3 (da) Proteiner med forbedret opløselighed samt fremgangsmåder til frembringelse og anvendelse af samme
DK1912961T3 (da) Fremgangsmåde til fremstilling af bepromolin