DK192982A - Fremgangsmaade til fremstilling af arylalkansyrederivater - Google Patents

Fremgangsmaade til fremstilling af arylalkansyrederivater Download PDF

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Publication number
DK192982A
DK192982A DK192982A DK192982A DK192982A DK 192982 A DK192982 A DK 192982A DK 192982 A DK192982 A DK 192982A DK 192982 A DK192982 A DK 192982A DK 192982 A DK192982 A DK 192982A
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DK
Denmark
Prior art keywords
arylalkanic
procedure
preparation
acid derivatives
acid
Prior art date
Application number
DK192982A
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English (en)
Inventor
George Charles Schloemer
Original Assignee
Syntex Pharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Pharma Int filed Critical Syntex Pharma Int
Publication of DK192982A publication Critical patent/DK192982A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

syre, og α-arylalkansyren eventuelt omdannes til dens farmaceutisk acceptable salt, hvor Ar og er som defineret ovenfor og -0-2 er den anioniske rest af en organisk syre, der er tilstrækkelig labil til at adskilles fra estersubstratet ved kontakt med et prot eller dipolært, aprot opløsningsmiddel.
De fremstillede α-arvlalkansyrer er nyttige som farmaceutiske midler, og udviser anti-inflammatoriske, analgetiske og anti-pyretiske egenskaber.
DK192982A 1981-04-30 1982-04-29 Fremgangsmaade til fremstilling af arylalkansyrederivater DK192982A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25911981A 1981-04-30 1981-04-30
US25911981 1981-04-30

Publications (1)

Publication Number Publication Date
DK192982A true DK192982A (da) 1982-10-31

Family

ID=22983610

Family Applications (1)

Application Number Title Priority Date Filing Date
DK192982A DK192982A (da) 1981-04-30 1982-04-29 Fremgangsmaade til fremstilling af arylalkansyrederivater

Country Status (21)

Country Link
EP (1) EP0064394A1 (da)
JP (1) JPS57192325A (da)
KR (1) KR890002772B1 (da)
AU (1) AU8313382A (da)
CA (1) CA1199646A (da)
CS (1) CS241104B2 (da)
DD (1) DD202688A5 (da)
DK (1) DK192982A (da)
ES (2) ES511816A0 (da)
FI (1) FI821501A0 (da)
GR (1) GR75425B (da)
HU (1) HU189577B (da)
IL (1) IL65629A (da)
IN (1) IN155753B (da)
NO (3) NO821417L (da)
NZ (1) NZ200458A (da)
PH (1) PH24244A (da)
PL (1) PL139818B1 (da)
PT (1) PT74818B (da)
RO (1) RO83840B1 (da)
ZA (1) ZA822955B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
FI82680C (fi) * 1981-12-11 1991-04-10 Syntex Pharma Int Framstaellning av - arylalkansyror.
DE3461525D1 (en) * 1984-02-02 1987-01-15 Zambon Spa Process for preparing alpha-arylalkanoic acids
IT1173216B (it) * 1984-02-03 1987-06-18 Zambon Spa Processo per la preparazione di acidi alfa-idrossiaril-alcanoici
IT1196013B (it) * 1984-02-03 1988-11-10 Zambon Spa Procedimento per preparare acidi alfa-aril-alcanoici
EP0160241B1 (en) * 1984-04-14 1988-11-30 Kyowa Hakko Kogyo Co., Ltd. Process for producing an alpha-aromatic group substituted alkanoic acid derivative
US4608441A (en) * 1984-07-11 1986-08-26 Blaschim S.P.A. Process for the preparation of arylalkanoic acids by oxidative rearrangement of arylalkanones
IT1201443B (it) * 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
JPS62263153A (ja) * 1986-05-28 1987-11-16 エフ・ホフマン―ラ　ロシユ　アーゲー カルバゾ−ル誘導体
IT1197800B (it) * 1986-08-01 1988-12-06 Zambon Spa Processo per la sintesi di acidi carbossilici
US4761497A (en) * 1987-10-13 1988-08-02 Eastman Kodak Company Process for preparing 2-naphthanoic acids and esters thereof
IT1251958B (it) * 1991-10-18 1995-05-27 Zambon Spa Processo per la dealogenazione di derivati del naftalene
JP3744060B2 (ja) * 1996-06-20 2006-02-08 ダイソー株式会社 アシルオキシスルホン酸エステル誘導体の製造法
ES2797777T3 (es) * 2017-04-24 2020-12-03 Igm Group B V Funcionalización oxidante simple de alquil aril cetonas
CN114644554A (zh) * 2020-12-21 2022-06-21 上海医药工业研究院 (s)-氟比洛芬的制备方法及其中间体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50897B1 (en) * 1980-02-26 1986-08-06 Blaschim Spa Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals
JPS5798232A (en) * 1980-11-10 1982-06-18 Sagami Chem Res Center 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
NZ198271A (en) * 1980-09-11 1985-05-31 Syntex Pharma Int Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
JPS57144234A (en) * 1981-03-03 1982-09-06 Sagami Chem Res Center 1-halophenyl-2-oxy-1-alkanone acetal

Also Published As

Publication number Publication date
ES8401007A1 (es) 1983-12-01
ES8601839A1 (es) 1985-12-01
ES511816A0 (es) 1983-12-01
FI821501A0 (fi) 1982-04-29
KR890002772B1 (ko) 1989-07-28
DD202688A5 (de) 1983-09-28
CA1199646A (en) 1986-01-21
KR830010036A (ko) 1983-12-24
ZA822955B (en) 1983-12-28
PL236221A1 (da) 1982-12-06
CS310082A2 (en) 1985-07-16
CS241104B2 (en) 1986-03-13
PT74818B (en) 1983-10-28
IL65629A0 (en) 1982-07-30
PL139818B1 (en) 1987-02-28
PH24244A (en) 1990-05-04
RO83840A2 (ro) 1984-04-02
NO831338L (no) 1982-11-01
RO83840B1 (ro) 1984-04-30
HU189577B (en) 1986-07-28
EP0064394A1 (en) 1982-11-10
IL65629A (en) 1987-08-31
GR75425B (da) 1984-07-17
NO824255L (no) 1982-11-01
NZ200458A (en) 1985-11-08
JPS57192325A (en) 1982-11-26
ES524528A0 (es) 1985-12-01
PT74818A (en) 1982-05-01
AU8313382A (en) 1982-11-04
IN155753B (da) 1985-03-02
NO821417L (no) 1982-11-01

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