DK321482A - Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf Download PDF

Info

Publication number
DK321482A
DK321482A DK321482A DK321482A DK321482A DK 321482 A DK321482 A DK 321482A DK 321482 A DK321482 A DK 321482A DK 321482 A DK321482 A DK 321482A DK 321482 A DK321482 A DK 321482A
Authority
DK
Denmark
Prior art keywords
piperazinylphenoxy
octan
imidazolyl
phenyl
compounds
Prior art date
Application number
DK321482A
Other languages
English (en)
Inventor
G E Gymer
K Richardson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK321482A publication Critical patent/DK321482A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK321482A 1981-07-18 1982-07-16 Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf DK321482A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8122246 1981-07-18

Publications (1)

Publication Number Publication Date
DK321482A true DK321482A (da) 1983-01-19

Family

ID=10523357

Family Applications (1)

Application Number Title Priority Date Filing Date
DK321482A DK321482A (da) 1981-07-18 1982-07-16 Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (7)

Country Link
US (1) US4435399A (da)
EP (1) EP0072623B1 (da)
JP (1) JPS5824567A (da)
DE (1) DE3264036D1 (da)
DK (1) DK321482A (da)
GR (1) GR77222B (da)
IE (1) IE53386B1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3402166A1 (de) * 1984-01-23 1985-07-25 Hoechst Ag, 6230 Frankfurt Azolyl-aryl-alkanol-derivate, verfahren zu ihrer herstellung und ihre verwendung
US5091428A (en) * 1987-04-24 1992-02-25 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5043447A (en) * 1987-04-24 1991-08-27 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5010075A (en) * 1987-04-24 1991-04-23 Syntex Pharmaceuticals Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5252736A (en) * 1987-04-24 1993-10-12 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US4935417A (en) * 1987-04-24 1990-06-19 Syntex Pharmaceuticals Ltd. Sustituted imidazolyl-alkyl-piperazine and -diazepine derivatives for treating cerebrovascular disease
US4829065A (en) * 1987-04-24 1989-05-09 Syntex Pharmaceuticals, Ltd. Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives
US5142052A (en) * 1988-04-22 1992-08-25 Laboratoires Syntex Cationic effect-driven carbinol/amine reaction
US4973591A (en) * 1988-10-21 1990-11-27 Syntex Pharmaceuticals, Ltd. Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine
US5063220A (en) * 1988-10-21 1991-11-05 Syntex Pharmaceuticals, Ltd. Parenteral formulations of 1-diphenylmethyl-4-((2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)methyl)piperazine
GB9817197D0 (en) * 1998-08-07 1998-10-07 Lilly Co Eli Pharmaceutical compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001654B1 (de) * 1977-10-13 1981-07-22 Siegfried Aktiengesellschaft Imidazolyläthyl-oxyalkoxy-Derivate und ihre Thio-Analoge, pharmazeutische Zubereitungen mit diesen Stoffen und Verfahren zu ihrer Herstellung
DE2920375A1 (de) * 1979-05-19 1980-11-20 Bayer Ag Fungizide mittel, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
EP0023103A1 (en) * 1979-07-04 1981-01-28 Pfizer Limited Antifungal imidazole derivatives, process for their preparation and pharmaceutical compositions thereof
AU542623B2 (en) * 1980-05-16 1985-02-28 Bayer Aktiengesellschaft 1-hydroxyethyl-azole derivatives

Also Published As

Publication number Publication date
JPS5824567A (ja) 1983-02-14
EP0072623A1 (en) 1983-02-23
IE821721L (en) 1983-01-18
GR77222B (da) 1984-09-11
IE53386B1 (en) 1988-10-26
JPS6121630B2 (da) 1986-05-28
EP0072623B1 (en) 1985-06-05
DE3264036D1 (en) 1985-07-11
US4435399A (en) 1984-03-06

Similar Documents

Publication Publication Date Title
DK74282A (da) Fremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf
DK149895C (da) Fremgangsmaade til fremstilling af alfa-aminoacylprolyl-ng-carboxy-argininaldehydderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK337383D0 (da) Fremgangsmade til fremstilling af 4-amino-6,7-dimethoxyquinolin-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK148795C (da) Anologifremgangsmaade til fremstilling af 3-(2-morpholino-ethyl-amino)-5-phenyl-pyridazin eller farmaceutisk acceptable syreadditionssalte deraf
DK157862C (da) Analogifremgangsmaade til fremstilling af imidazolylphenylamidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK349582A (da) Fremgangsmaade til fremstilling af aromatisk substituerede aminoforbindelser eller syreadditionssalte deraf
DK69382A (da) Fremgangsmaade til fremstilling af azepinderivater eller saltederaf
DK148596C (da) Analogifremgangsmaade til fremstilling af 3-aminosubstituerede pyridaziner eller farmaceutisk acceptable syreadditionssalte deraf
DK335279A (da) Fremgangsmaade til fremstilling af spirofuranohydantoin-forbindelser eller farmaceutisk acceptable metalsalte deraf
DK321482A (da) Fremgangsmaade til fremstilling af 1-imidazolyl-2-phenyl-8-piperazinylphenoxy-octan-2-ol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK157451C (da) Analogifremgangsmaade til fremstilling af 2,4-diamino-6-alkoxybenzyl-5-methylpyridooe2,3-daapyrimidiner eller farmaceutisk acceptable syreadditionssalte deraf
DK134580A (da) Fremgangsmaade til fremstilling af 2,6-diaminonebulariner eller syreadditionssalte deraf
DK15282A (da) Fremgangsmaade til fremstilling af (+)-enantiomere eller (+)(-)-racemiske 4a,9b-trans-hexahydro-1h-pyridoindol-derivater eller farmaceutisk acceptable syreadditionssalte deraf
DK160498C (da) Analogifremgangsmaade til fremstilling af 3-methyl-flavon-8-carboxylsyreestere eller farmaceutisk acceptable syreadditionssalte deraf
DK438482A (da) Fremgangsmaade til fremstilling af indanderivater eller syreadditionssalte deraf
DK157135C (da) Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK152427C (da) Analogifremgangsmaade til fremstilling af 4-thiomethylpyridinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK148281C (da) Analogifremgangsmaade til fremstilling af 8a-substituerede 8,8a-desoxy-8,8a-dihydrooleandomycin-forbindelser eller farmaceutiskacceptable syreadditionssalte deraf
DK157023C (da) Analogifremgangsmaade til fremstilling af imidazodiazepiner eller farmaceutisk acceptable syreadditionssalte deraf
DK319982A (da) Fremgangsmaade til fremstilling af bicykliske forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK553982A (da) Fremgangsmaade til fremstilling af omt-esterderivater eller syreadditionssalte deraf
DK160874C (da) Analogifremgangsmaade til fremstilling af ergol-8-en- eller ergolinforbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DK398283D0 (da) Fremgangsmade til fremstilling af 1,4-dihydropyridinderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK151021C (da) Analogifremgangsmaade til fremstilling af 17,18-dehydro-apovincaminol-3',4',5'-trimethoxybenzoat eller farmaceutisk acceptable syreadditionssalte deraf
DK502682A (da) Fremgangsmaade til fremstilling af benzylalkoholderivater eller farmaceutisk acceptable syreadditionssalte deraf

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment