DK1904477T3 - Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister - Google Patents

Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister

Info

Publication number
DK1904477T3
DK1904477T3 DK06764048T DK06764048T DK1904477T3 DK 1904477 T3 DK1904477 T3 DK 1904477T3 DK 06764048 T DK06764048 T DK 06764048T DK 06764048 T DK06764048 T DK 06764048T DK 1904477 T3 DK1904477 T3 DK 1904477T3
Authority
DK
Denmark
Prior art keywords
piperodome
spiro
indole
carbonyl
derivatives
Prior art date
Application number
DK06764048T
Other languages
English (en)
Inventor
Mark Rogers-Evans
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1904477T3 publication Critical patent/DK1904477T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK06764048T 2005-07-14 2006-07-04 Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister DK1904477T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05106443 2005-07-14
EP05109364 2005-10-07
PCT/EP2006/063846 WO2007006688A1 (en) 2005-07-14 2006-07-04 Indol-3-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists

Publications (1)

Publication Number Publication Date
DK1904477T3 true DK1904477T3 (da) 2009-03-16

Family

ID=37001896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06764048T DK1904477T3 (da) 2005-07-14 2006-07-04 Indol-3-carbonyl-spiro-piperodom-derivater som V1A-receptorantagonister

Country Status (26)

Country Link
US (2) US7332501B2 (da)
EP (1) EP1904477B1 (da)
JP (1) JP4927079B2 (da)
KR (1) KR100974967B1 (da)
CN (1) CN101253164B (da)
AR (1) AR054830A1 (da)
AT (1) ATE421511T1 (da)
AU (1) AU2006268724B2 (da)
BR (1) BRPI0612988A2 (da)
CA (1) CA2615726C (da)
CY (1) CY1108996T1 (da)
DE (1) DE602006004997D1 (da)
DK (1) DK1904477T3 (da)
ES (1) ES2317558T3 (da)
HK (1) HK1123554A1 (da)
IL (1) IL188478A (da)
MX (1) MX2008000585A (da)
MY (1) MY144684A (da)
NO (1) NO20080059L (da)
PL (1) PL1904477T3 (da)
PT (1) PT1904477E (da)
RU (1) RU2414466C2 (da)
SI (1) SI1904477T1 (da)
TW (1) TWI312780B (da)
WO (1) WO2007006688A1 (da)
ZA (1) ZA200800320B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615726C (en) * 2005-07-14 2014-05-27 Caterina Bissantz Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists
ATE488519T1 (de) * 2005-09-28 2010-12-15 Hoffmann La Roche Indol-3-ylcarbonylazaspiroderivate als vasopressinrezeptorantagonisten
US7351706B2 (en) 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
CA2670674A1 (en) 2006-12-07 2008-06-12 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives as via receptor antagonists
EP2089381B1 (en) * 2006-12-08 2010-06-30 F.Hoffmann-La Roche Ag Indoles which act as via receptor antagonists
US20080153863A1 (en) * 2006-12-22 2008-06-26 Caterina Bissantz Spiropiperidine derivatives
ATE536356T1 (de) * 2007-01-12 2011-12-15 Hoffmann La Roche Spiropiperidin-glycinamid-derivate
TW200940547A (en) * 2007-12-13 2009-10-01 Speedel Experimenta Ag Organic compounds
EP2563764B1 (en) * 2010-04-26 2015-02-25 Merck Sharp & Dohme Corp. Novel spiropiperidine prolylcarboxypeptidase inhibitors
ME02412B (me) 2011-03-10 2016-09-20 Zoetis Services Llc Spirociklični derivati izoksazolina kao antiparazitska sredstva
RU2475489C1 (ru) * 2011-10-07 2013-02-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Чувашский государственный университет имени И.Н. Ульянова" Способ получения 8-амино-1-имино-6-морфолин-4-ил-2-окса-7-азаспиро[4,4]нона-3,6,8-триен-9-карбонитрилов
US9006244B2 (en) 2012-03-16 2015-04-14 Vitae Pharmaceuticals, Inc. Liver X receptor modulators
PT2825542T (pt) 2012-03-16 2016-12-20 Vitae Pharmaceuticals Inc Modeladores do recetor x do fígado
JO3109B1 (ar) * 2012-05-10 2017-09-20 Ferring Bv منبهات لمستقبلات v1a
KR101698124B1 (ko) * 2015-05-29 2017-01-19 한국외국어대학교 연구산학협력단 3-(메틸아미노)-3-((r)-피롤리딘-3-일)프로판니트릴 또는 이의 염의 제조방법
CN108884096B (zh) * 2016-02-08 2022-03-22 豪夫迈·罗氏有限公司 作为ddr1抑制剂的螺二氢吲哚酮
US20180002344A1 (en) 2016-06-16 2018-01-04 Genentech, Inc. Heteroaryl estrogen receptor modulators and uses thereof
CA3223869A1 (en) * 2016-09-21 2018-03-29 Vectus Biosystems Limited Compositions for the treatment of hypertension and/or fibrosis
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素V1a受體拮抗劑之三環化合物
CN113563255B (zh) * 2020-04-29 2023-08-18 成都倍特药业股份有限公司 瑞芬沙星中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
EP1410437A2 (en) * 2001-01-22 2004-04-21 Morgan Chemical Products, Inc. Cvd diamond enhanced microprocessor cooling system
CA2615726C (en) * 2005-07-14 2014-05-27 Caterina Bissantz Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists

Also Published As

Publication number Publication date
HK1123554A1 (en) 2009-06-19
SI1904477T1 (sl) 2009-06-30
CN101253164A (zh) 2008-08-27
ES2317558T3 (es) 2009-04-16
CA2615726C (en) 2014-05-27
JP2009501185A (ja) 2009-01-15
EP1904477B1 (en) 2009-01-21
MX2008000585A (es) 2008-03-14
KR100974967B1 (ko) 2010-08-09
US7332501B2 (en) 2008-02-19
RU2008100082A (ru) 2009-08-20
TW200726469A (en) 2007-07-16
PT1904477E (pt) 2009-03-12
BRPI0612988A2 (pt) 2010-12-14
RU2414466C2 (ru) 2011-03-20
IL188478A0 (en) 2008-04-13
AR054830A1 (es) 2007-07-18
MY144684A (en) 2011-10-31
KR20080024231A (ko) 2008-03-17
NO20080059L (no) 2008-04-02
DE602006004997D1 (de) 2009-03-12
AU2006268724B2 (en) 2011-06-02
US20070027173A1 (en) 2007-02-01
CA2615726A1 (en) 2007-01-18
EP1904477A1 (en) 2008-04-02
AU2006268724A1 (en) 2007-01-18
TWI312780B (en) 2009-08-01
JP4927079B2 (ja) 2012-05-09
ATE421511T1 (de) 2009-02-15
CN101253164B (zh) 2012-05-16
US20080146557A1 (en) 2008-06-19
IL188478A (en) 2012-01-31
PL1904477T3 (pl) 2009-07-31
US7629353B2 (en) 2009-12-08
ZA200800320B (en) 2009-02-25
WO2007006688A1 (en) 2007-01-18
CY1108996T1 (el) 2014-07-02

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