DK1809663T3 - Fremgangsmåde til oprensning af FSH - Google Patents

Fremgangsmåde til oprensning af FSH

Info

Publication number
DK1809663T3
DK1809663T3 DK05815953T DK05815953T DK1809663T3 DK 1809663 T3 DK1809663 T3 DK 1809663T3 DK 05815953 T DK05815953 T DK 05815953T DK 05815953 T DK05815953 T DK 05815953T DK 1809663 T3 DK1809663 T3 DK 1809663T3
Authority
DK
Denmark
Prior art keywords
fsh
purification
chromatography
dye
steps
Prior art date
Application number
DK05815953T
Other languages
Danish (da)
English (en)
Inventor
Pascal Valax
Pierre Wenger
Anne Stanley
Lydia Delegrange
Luciano Capponi
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of DK1809663T3 publication Critical patent/DK1809663T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacturing Of Electric Cables (AREA)
  • Detergent Compositions (AREA)
DK05815953T 2004-11-09 2005-11-08 Fremgangsmåde til oprensning af FSH DK1809663T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04105639 2004-11-09
US62871704P 2004-11-17 2004-11-17
PCT/EP2005/055815 WO2006051070A1 (en) 2004-11-09 2005-11-08 Method for purifying fsh

Publications (1)

Publication Number Publication Date
DK1809663T3 true DK1809663T3 (da) 2008-11-17

Family

ID=39560952

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05815953T DK1809663T3 (da) 2004-11-09 2005-11-08 Fremgangsmåde til oprensning af FSH

Country Status (22)

Country Link
US (1) US7741455B2 (de)
EP (1) EP1809663B1 (de)
KR (1) KR101173717B1 (de)
CN (1) CN101087805B (de)
AT (1) ATE408624T1 (de)
AU (1) AU2005303818B2 (de)
BR (1) BRPI0517973B8 (de)
CA (1) CA2579131A1 (de)
CY (1) CY1108602T1 (de)
DE (1) DE602005009856D1 (de)
DK (1) DK1809663T3 (de)
EA (1) EA011673B1 (de)
ES (1) ES2312037T3 (de)
HK (1) HK1108704A1 (de)
HR (1) HRP20080464T3 (de)
IL (1) IL182716A (de)
MX (1) MX2007005327A (de)
NO (1) NO340811B1 (de)
PL (1) PL1809663T3 (de)
PT (1) PT1809663E (de)
SI (1) SI1809663T1 (de)
WO (1) WO2006051070A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754860B2 (en) * 2003-12-22 2010-07-13 Ares Trading S.A. Method for purifying FSH
LT1917276T (lt) 2005-08-26 2018-05-25 Ares Trading S.A. Glikozilinto interferono beta gavimo būdas
JP5199112B2 (ja) * 2005-12-09 2013-05-15 アレス トレーディング ソシエテ アノニム Ｆｓｈ又はｆｓｈ変異体を精製するための方法
US9091695B2 (en) * 2007-06-01 2015-07-28 Laboratory Corporation Of America Holdings Methods and systems for quantification of peptides and other analytes
US8318457B2 (en) 2007-06-28 2012-11-27 Biogenerix Ag FSH producing cell clone
EP2203474A1 (de) * 2007-10-22 2010-07-07 Merck Serono S.A. Verfahren zur reinigung von fc-fusionsproteinen
AU2008314689A1 (en) * 2007-10-22 2009-04-30 Merck Serono S.A. Method for purifying an Fc-containing protein
AU2009211331B2 (en) 2008-02-08 2014-07-03 Theramex HQ UK Limited Liquid formulation of FSH
JP2009273427A (ja) 2008-05-16 2009-11-26 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
DK2414380T3 (en) 2009-04-01 2015-10-19 Ratiopharm Gmbh Process for the purification of recombinant fsh
CN101519445B (zh) * 2009-04-08 2013-03-27 上海天伟生物制药有限公司 一种高比活尿促***及其制备方法
CN101555279B (zh) * 2009-05-19 2013-03-27 上海天伟生物制药有限公司 一种高纯度尿促***及其制备方法
CN101928342B (zh) * 2009-06-18 2013-05-08 上海天伟生物制药有限公司 一种高纯度绝经期促性腺素及其制备方法和用途
EP2325194A1 (de) * 2009-11-24 2011-05-25 Glycotope GmbH Verfahren zur Reinigung von Glykoproteinen
JP2011172602A (ja) * 2011-06-15 2011-09-08 Jcr Pharmaceuticals Co Ltd 組換え体ヒトｆｓｈの製造方法
CN103570820B (zh) * 2012-08-06 2015-11-18 齐鲁制药有限公司 一种重组人促卵泡激素的纯化方法
EP2968391A1 (de) 2013-03-13 2016-01-20 Moderna Therapeutics, Inc. Langlebige polynukleotidmoleküle
JP5750471B2 (ja) * 2013-05-22 2015-07-22 Ｊｃｒファーマ株式会社 組換え体ヒトｆｓｈの製造方法
CN103554269B (zh) * 2013-11-01 2015-02-11 广州联康生物科技有限公司 重组猪促卵泡激素融合蛋白
CN103539860B (zh) * 2013-11-01 2014-12-03 广州优联康医药科技有限公司 一种长效重组人促卵泡激素融合蛋白
CN103539861B (zh) * 2013-11-01 2015-02-18 广州联康生物科技有限公司 长效重组人促卵泡激素融合蛋白
BR112016023680A2 (pt) 2014-04-18 2017-08-15 Cadila Healthcare Ltd ?processo de purificação de gonadotropina?
CN104961821A (zh) * 2014-07-28 2015-10-07 厦门欧瑞捷生物科技有限公司 一种从人尿中提取***的方法
WO2016116966A1 (en) * 2015-01-22 2016-07-28 Jcr Pharmaceuticals Co., Ltd. Method for purification of recombinant human alpha-galactosidase a from material containing contaminant host cell proteins
CN105461799A (zh) * 2015-12-31 2016-04-06 哈药集团技术中心 一种重组人促卵泡生成素的纯化方法
CN107698676B (zh) * 2017-11-07 2020-07-14 江西浩然生物医药有限公司 一种高纯度尿促性素的提取制备方法
CN110563832A (zh) * 2019-07-31 2019-12-13 江苏璟泽生物医药有限公司 一种高纯度重组促***纯化方法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113372433B (zh) * 2021-03-12 2022-10-11 上海景泽生物技术有限公司 纯化fsh方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206302B (it) * 1987-06-26 1989-04-14 Serono Cesare Ist Ricerca Ormone follicolo-stimolante urinario
US5665868A (en) 1990-09-14 1997-09-09 Vittal Mallya Scientific Research Foundation Chromatographic agent and its use for the separation or proteins, polypeptides of metals
SE9201073D0 (sv) * 1992-04-03 1992-04-03 Kabi Pharmacia Ab Protein formulation
CA2223125A1 (en) * 1995-02-17 1996-08-22 Stichting Instituut Voor Dierhouderij En Diergezondheid Production of biologically active recombinant bovine follicle stimulating hormone (recbfsh) in the baculovirus expression system
AUPN801296A0 (en) 1996-02-12 1996-03-07 Csl Limited Stabilised growth hormone formulation and method of preparation thereof
US6162905A (en) * 1996-11-07 2000-12-19 Ibsa Institut Biochimique S.A. FSH and LH separation and purification process
IT1287138B1 (it) * 1996-11-07 1998-08-04 Ibsa Inst Biochimique Sa Procedimento per la separazione e purificazione di fsh e lh
US6414123B1 (en) * 1997-10-21 2002-07-02 Vitro Diagnostics, Inc. Method for purifying FSH
US5990288A (en) * 1997-10-21 1999-11-23 Vitro Diagnostics, Inc. Method for purifying FSH
ATE358139T1 (de) * 1999-04-16 2007-04-15 Inst Massone S A Verfahren zur herstelllung von gonadotropin- zusammensetzungen
SK287041B6 (sk) * 2000-02-22 2009-10-07 Laboratoires Serono Sa Spôsob čistenia luteinizačného hormónu - LH zo vzorky, rekombinantný hLH, jeho použitie a farmaceutický prostriedok s jeho obsahom
EP1803730A1 (de) * 2000-04-12 2007-07-04 Human Genome Sciences, Inc. Albuminfusionsproteine
AU784808B2 (en) * 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
US7754860B2 (en) * 2003-12-22 2010-07-13 Ares Trading S.A. Method for purifying FSH
US7598356B2 (en) 2004-07-08 2009-10-06 Board of Regents of the University of Nebraska by and on behalf of the University of Nebraska Medical Center Method for purifying a protein of the cystine-knot superfamily

Also Published As

Publication number Publication date
EP1809663B1 (de) 2008-09-17
ES2312037T3 (es) 2009-02-16
WO2006051070A1 (en) 2006-05-18
KR20070083618A (ko) 2007-08-24
HRP20080464T3 (en) 2008-10-31
PL1809663T3 (pl) 2009-01-30
BRPI0517973B1 (pt) 2018-02-14
IL182716A (en) 2010-12-30
CY1108602T1 (el) 2014-04-09
EA011673B1 (ru) 2009-04-28
BRPI0517973A (pt) 2008-10-21
MX2007005327A (es) 2007-08-02
DE602005009856D1 (de) 2008-10-30
CA2579131A1 (en) 2006-05-18
BRPI0517973B8 (pt) 2021-05-25
EP1809663A1 (de) 2007-07-25
PT1809663E (pt) 2008-10-02
NO340811B1 (no) 2017-06-19
HK1108704A1 (en) 2008-05-16
IL182716A0 (en) 2007-07-24
SI1809663T1 (sl) 2009-02-28
ATE408624T1 (de) 2008-10-15
NO20072863L (no) 2007-06-05
CN101087805A (zh) 2007-12-12
EA200701040A1 (ru) 2007-10-26
US20080070832A1 (en) 2008-03-20
KR101173717B1 (ko) 2012-08-13
AU2005303818A1 (en) 2006-05-18
AU2005303818B2 (en) 2011-06-23
CN101087805B (zh) 2012-05-23
US7741455B2 (en) 2010-06-22

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