DK1805163T3 - 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister - Google Patents

1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister

Info

Publication number
DK1805163T3
DK1805163T3 DK05772622T DK05772622T DK1805163T3 DK 1805163 T3 DK1805163 T3 DK 1805163T3 DK 05772622 T DK05772622 T DK 05772622T DK 05772622 T DK05772622 T DK 05772622T DK 1805163 T3 DK1805163 T3 DK 1805163T3
Authority
DK
Denmark
Prior art keywords
pentalenes
cyclopropa
thia
tetrahydro
receptor agonists
Prior art date
Application number
DK05772622T
Other languages
Danish (da)
English (en)
Inventor
Martin Bolli
Daniel Bur
Martine Clozel
Walter Fischli
David Lehmann
Boris Mathys
Claus Mueller
Oliver Nayler
Michael Scherz
Thomas Weller
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK1805163T3 publication Critical patent/DK1805163T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK05772622T 2004-07-29 2005-07-20 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister DK1805163T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2004/008501 WO2006010379A1 (fr) 2004-07-29 2004-07-29 Nouveaux derives du thiophene utilises comme agents immunosupresseurs
PCT/EP2005/007892 WO2006010544A2 (fr) 2004-07-29 2005-07-20 Nouveaux derives du thiophene

Publications (1)

Publication Number Publication Date
DK1805163T3 true DK1805163T3 (da) 2008-12-15

Family

ID=34958296

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05772622T DK1805163T3 (da) 2004-07-29 2005-07-20 1,1A,5,5A-tetrahydro-3-thia-cyclopropa[A]pentalener: Tricykliske thiophenderivater som S1P1/Edg1-receptoragonister

Country Status (23)

Country Link
US (1) US7750040B2 (fr)
EP (1) EP1805163B1 (fr)
JP (1) JP4807884B2 (fr)
KR (1) KR20070046849A (fr)
CN (1) CN1993346B (fr)
AR (1) AR050273A1 (fr)
AT (1) ATE409697T1 (fr)
AU (1) AU2005266529A1 (fr)
BR (1) BRPI0513841A (fr)
CA (1) CA2574305A1 (fr)
DE (1) DE602005010109D1 (fr)
DK (1) DK1805163T3 (fr)
ES (1) ES2313391T3 (fr)
IL (1) IL180962A0 (fr)
MX (1) MX2007000972A (fr)
NO (1) NO20071095L (fr)
PL (1) PL1805163T3 (fr)
PT (1) PT1805163E (fr)
RU (1) RU2386626C2 (fr)
SI (1) SI1805163T1 (fr)
TW (1) TW200616994A (fr)
WO (2) WO2006010379A1 (fr)
ZA (1) ZA200700535B (fr)

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Also Published As

Publication number Publication date
RU2386626C2 (ru) 2010-04-20
PL1805163T3 (pl) 2009-04-30
CN1993346B (zh) 2011-04-27
JP4807884B2 (ja) 2011-11-02
AR050273A1 (es) 2006-10-11
SI1805163T1 (sl) 2009-02-28
KR20070046849A (ko) 2007-05-03
US7750040B2 (en) 2010-07-06
CN1993346A (zh) 2007-07-04
AU2005266529A1 (en) 2006-02-02
DE602005010109D1 (de) 2008-11-13
US20080064740A1 (en) 2008-03-13
BRPI0513841A (pt) 2008-05-20
WO2006010379A1 (fr) 2006-02-02
ATE409697T1 (de) 2008-10-15
NO20071095L (no) 2007-02-27
ZA200700535B (en) 2008-10-29
IL180962A0 (en) 2007-07-04
ES2313391T3 (es) 2009-03-01
TW200616994A (en) 2006-06-01
WO2006010544A3 (fr) 2006-03-30
CA2574305A1 (fr) 2006-02-02
PT1805163E (pt) 2008-12-05
WO2006010544A2 (fr) 2006-02-02
MX2007000972A (es) 2007-04-10
JP2008508210A (ja) 2008-03-21
EP1805163A2 (fr) 2007-07-11
RU2007107164A (ru) 2008-09-10
EP1805163B1 (fr) 2008-10-01

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