DK1787980T3 - Krystallint og rent modafinil og fremgangsmåde til atfremstille dette - Google Patents

Krystallint og rent modafinil og fremgangsmåde til atfremstille dette

Info

Publication number
DK1787980T3
DK1787980T3 DK07000780.2T DK07000780T DK1787980T3 DK 1787980 T3 DK1787980 T3 DK 1787980T3 DK 07000780 T DK07000780 T DK 07000780T DK 1787980 T3 DK1787980 T3 DK 1787980T3
Authority
DK
Denmark
Prior art keywords
crystalline
making
pure modafinil
modafinil
pure
Prior art date
Application number
DK07000780.2T
Other languages
English (en)
Inventor
Claude Singer
Neomi Gershon
Arina Ceausu
Judith Aronhime
Anita Lieberman
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of DK1787980T3 publication Critical patent/DK1787980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Laminated Bodies (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
DK07000780.2T 2000-07-27 2001-07-27 Krystallint og rent modafinil og fremgangsmåde til atfremstille dette DK1787980T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US22649100P 2000-08-18 2000-08-18
US22916000P 2000-08-30 2000-08-30
US23008800P 2000-09-05 2000-09-05
US25933201P 2001-01-02 2001-01-02
EP01961766A EP1309547B1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (1)

Publication Number Publication Date
DK1787980T3 true DK1787980T3 (da) 2010-04-26

Family

ID=27539819

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07000780.2T DK1787980T3 (da) 2000-07-27 2001-07-27 Krystallint og rent modafinil og fremgangsmåde til atfremstille dette
DK01961766T DK1309547T3 (da) 2000-07-27 2001-07-27 Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01961766T DK1309547T3 (da) 2000-07-27 2001-07-27 Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme

Country Status (24)

Country Link
US (3) US6849120B2 (da)
EP (3) EP2168946A1 (da)
JP (2) JP4302977B2 (da)
KR (8) KR100729298B1 (da)
CN (2) CN101186590A (da)
AT (1) ATE453618T1 (da)
AU (1) AU2001283008A1 (da)
CA (3) CA2416792C (da)
CY (1) CY1110234T1 (da)
CZ (1) CZ2003529A3 (da)
DE (3) DE20122504U1 (da)
DK (2) DK1787980T3 (da)
ES (2) ES2337838T3 (da)
HR (2) HRP20030131B1 (da)
HU (1) HUP0400927A3 (da)
IL (2) IL154122A0 (da)
IS (1) IS6699A (da)
MX (1) MXPA03000747A (da)
NZ (1) NZ524359A (da)
PL (1) PL206371B1 (da)
PT (2) PT1309547E (da)
SK (1) SK2242003A3 (da)
WO (1) WO2002010125A1 (da)
ZA (1) ZA200300672B (da)

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US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
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US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ATE442352T1 (de) * 2003-05-16 2009-09-15 Cephalon France Verfahren zur herstellung von modafinil
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
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US7368591B2 (en) * 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
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BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
JP2009518398A (ja) * 2005-12-09 2009-05-07 マリンクロッド・インコーポレイテッド モダフィニルおよびその類似体の製造方法
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WO2009045488A2 (en) * 2007-10-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
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CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
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Also Published As

Publication number Publication date
EP1787980B1 (en) 2009-12-30
KR20070097131A (ko) 2007-10-02
KR20100098462A (ko) 2010-09-06
ES2277937T3 (es) 2007-08-01
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
KR20030029636A (ko) 2003-04-14
EP2168946A1 (en) 2010-03-31
CA2685310C (en) 2012-10-16
HRP20030131B1 (en) 2011-03-31
US20020043207A1 (en) 2002-04-18
KR101019448B1 (ko) 2011-03-07
HUP0400927A3 (en) 2007-11-28
AU2001283008A1 (en) 2002-02-13
EP1787980A3 (en) 2007-08-08
KR20090103962A (ko) 2009-10-01
KR101081212B1 (ko) 2011-11-07
JP2004509080A (ja) 2004-03-25
PL365613A1 (en) 2005-01-10
EP1787980A2 (en) 2007-05-23
HUP0400927A2 (hu) 2004-07-28
US20050034652A1 (en) 2005-02-17
DE60126099D1 (de) 2007-03-08
ATE453618T1 (de) 2010-01-15
KR20060097771A (ko) 2006-09-15
IL154122A0 (en) 2003-07-31
CA2416792A1 (en) 2002-02-07
JP4302977B2 (ja) 2009-07-29
EP1309547A1 (en) 2003-05-14
CA2416792C (en) 2010-02-09
KR20090106661A (ko) 2009-10-09
KR101098749B1 (ko) 2011-12-23
HRP20080373A2 (en) 2008-12-31
CZ2003529A3 (cs) 2003-09-17
KR20060024028A (ko) 2006-03-15
CN1466570A (zh) 2004-01-07
ES2337838T3 (es) 2010-04-29
US7235691B2 (en) 2007-06-26
CY1110234T1 (el) 2015-01-14
DK1309547T3 (da) 2007-05-21
KR100729292B1 (ko) 2007-06-18
PT1787980E (pt) 2010-03-18
EP1309547A4 (en) 2005-03-02
US8048222B2 (en) 2011-11-01
IS6699A (is) 2003-01-24
IL154122A (en) 2009-07-20
SK2242003A3 (en) 2003-10-07
CA2634702C (en) 2011-07-19
CN101186590A (zh) 2008-05-28
US6849120B2 (en) 2005-02-01
CA2634702A1 (en) 2002-02-07
JP4980309B2 (ja) 2012-07-18
ZA200300672B (en) 2004-02-18
CA2685310A1 (en) 2002-02-07
JP2009024006A (ja) 2009-02-05
NZ524359A (en) 2005-06-24
CN100500651C (zh) 2009-06-17
DE60140973D1 (de) 2010-02-11
DE20122504U1 (de) 2005-12-29
MXPA03000747A (es) 2003-06-04
KR20070007970A (ko) 2007-01-16
HRP20030131A2 (en) 2005-04-30
DE60126099T2 (de) 2007-11-15
WO2002010125A1 (en) 2002-02-07
EP1309547B1 (en) 2007-01-17
PL206371B1 (pl) 2010-07-30
US20050038124A1 (en) 2005-02-17

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