DK175372B1 - 1,3-dioxolanderivater - Google Patents
1,3-dioxolanderivater Download PDFInfo
- Publication number
- DK175372B1 DK175372B1 DK198901720A DK172089A DK175372B1 DK 175372 B1 DK175372 B1 DK 175372B1 DK 198901720 A DK198901720 A DK 198901720A DK 172089 A DK172089 A DK 172089A DK 175372 B1 DK175372 B1 DK 175372B1
- Authority
- DK
- Denmark
- Prior art keywords
- dioxolane
- compound according
- trans
- cis
- isomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Secondary Cells (AREA)
- Peptides Or Proteins (AREA)
- Paints Or Removers (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK200200474A DK200200474A (da) | 1988-04-11 | 2002-03-27 | 1,3-dioxolanderivater |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17961588A | 1988-04-11 | 1988-04-11 | |
US17961588 | 1988-04-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK172089D0 DK172089D0 (da) | 1989-04-10 |
DK172089A DK172089A (da) | 1989-10-12 |
DK175372B1 true DK175372B1 (da) | 2004-09-13 |
Family
ID=22657287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198901720A DK175372B1 (da) | 1988-04-11 | 1989-04-10 | 1,3-dioxolanderivater |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0337713B1 (ja) |
JP (1) | JP3085675B2 (ja) |
KR (1) | KR0137023B1 (ja) |
AT (1) | ATE129247T1 (ja) |
AU (1) | AU631786B2 (ja) |
CA (1) | CA1339609C (ja) |
DE (1) | DE68924549T2 (ja) |
DK (1) | DK175372B1 (ja) |
ES (1) | ES2078234T3 (ja) |
GR (1) | GR3017812T3 (ja) |
HK (1) | HK5996A (ja) |
IE (1) | IE71225B1 (ja) |
IL (1) | IL89921A (ja) |
NZ (1) | NZ228645A (ja) |
OA (1) | OA09470A (ja) |
ZA (1) | ZA892645B (ja) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5597824A (en) * | 1987-11-03 | 1997-01-28 | Abbott Laboratories | Analogs of oxetanyl purines and pyrimidines |
US7119202B1 (en) | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US5041449A (en) * | 1988-04-11 | 1991-08-20 | Iaf Biochem International, Inc. | 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections |
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US5270315A (en) * | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
US5684164A (en) * | 1988-04-11 | 1997-11-04 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6350753B1 (en) | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
UA45942A (uk) * | 1989-02-08 | 2002-05-15 | Біокем Фарма, Інк. | 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція |
IE904378A1 (en) | 1989-12-20 | 1991-07-03 | Abbott Lab | Analogs of oxetanyl purines and pyrimidines |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US6642245B1 (en) | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
ES2091948T3 (es) * | 1990-11-13 | 1996-11-16 | Iaf Biochem Int | 1,3-oxatiolanos sustituidos con propiedades antiviricas. |
US6228860B1 (en) | 1990-11-13 | 2001-05-08 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
US6369066B1 (en) | 1990-11-13 | 2002-04-09 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5179104A (en) * | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
US5248776A (en) * | 1990-12-05 | 1993-09-28 | University Of Georgia Research Foundation, Inc. | Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides |
US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
US6005107A (en) * | 1992-12-23 | 1999-12-21 | Biochem Pharma, Inc. | Antiviral compounds |
GB9226879D0 (en) * | 1992-12-23 | 1993-02-17 | Iaf Biochem Int | Anti-viral compounds |
US6444656B1 (en) | 1992-12-23 | 2002-09-03 | Biochem Pharma, Inc. | Antiviral phosphonate nucleotides |
JPH09504785A (ja) | 1993-09-10 | 1997-05-13 | エモリー、ユニバーシティー | 抗b型肝炎ウイルス活性を有するヌクレオシド |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL115156A (en) * | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
CA2219132C (en) | 1995-06-07 | 2007-03-06 | Emory University | Nucleosides with anti-hepatitis b virus activity |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
US5792773A (en) * | 1996-11-15 | 1998-08-11 | Yale University | L-β-dioxolane uridine analog administration for treating Epstein-Barr virus infection |
US6022876A (en) * | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
ES2221164T3 (es) * | 1997-03-19 | 2004-12-16 | Emory University | Sintesis y actividad de la inmunodeficiencia humana y antivirus de la hepatitis b de nucleosidos de 1,3-oxaselenolano. |
DE69933860T2 (de) | 1998-02-25 | 2007-05-31 | Emory University | 2'-fluoronukleoside |
EP1754710A3 (en) | 1998-02-25 | 2007-12-19 | Emory University | 2'-Fluoroncucleosides |
EP1361223B1 (en) | 1998-08-12 | 2005-04-06 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
MXPA01004504A (es) | 1998-11-05 | 2005-04-19 | Centre Nat Rech Scient | Nucleosidos con actividad contra virus de la hepatitis b. |
WO2000039143A2 (en) | 1998-12-23 | 2000-07-06 | Shire Biochem Inc. | Antiviral nucleoside analogues |
JP2002540142A (ja) | 1999-03-29 | 2002-11-26 | シャイアー・バイオケム・インコーポレイテッド | 白血病の処置方法 |
US6653318B1 (en) | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
EP1214074B1 (en) * | 1999-09-24 | 2004-06-16 | Shire Biochem Inc. | Dioxolane nucleoside analogs for the treatment or prevention of viral infection |
AU1262001A (en) * | 1999-11-04 | 2001-05-14 | Biochem Pharma Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
EP1634888A3 (en) | 1999-11-12 | 2007-11-21 | Pharmasset, Inc. | Synthesis of 2'-deoxy-L-nucleosides |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
JP2004510832A (ja) * | 2000-10-13 | 2004-04-08 | シャイアー・バイオケム・インコーポレイテッド | 改善された細胞間送達のためのジオキソランアナログ |
AU2002335489B2 (en) | 2001-03-01 | 2008-06-05 | Abbott Laboratories | Polymorphic and other crystalline forms of cis-FTC |
DE10335061B4 (de) * | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
EP1720840B1 (en) | 2004-02-03 | 2016-02-03 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
CN101310021A (zh) | 2005-09-26 | 2008-11-19 | 法莫赛特股份有限公司 | 作为抗病毒剂的修饰的4’-核苷 |
US8895531B2 (en) | 2006-03-23 | 2014-11-25 | Rfs Pharma Llc | 2′-fluoronucleoside phosphonates as antiviral agents |
PT2041071E (pt) | 2006-06-29 | 2014-09-23 | Kinex Pharmaceuticals Llc | Composições de biarilo e processos para a regulação de uma cascata de cinases |
ES2842334T3 (es) | 2007-10-20 | 2021-07-13 | Athenex Inc | Composiciones farmacéuticas para modular una cascada de cinasas y métodos de uso de las mismas |
US9675632B2 (en) | 2014-08-26 | 2017-06-13 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL76546A (en) * | 1984-10-12 | 1988-12-30 | Warner Lambert Co | 9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them |
FI87783C (fi) * | 1985-05-15 | 1993-02-25 | Wellcome Found | Foerfarande foer framstaellning av terapeutiskt anvaendbara 2',3'-dideoxinukleosider |
-
1989
- 1989-04-07 NZ NZ228645A patent/NZ228645A/xx unknown
- 1989-04-10 IE IE113689A patent/IE71225B1/en not_active IP Right Cessation
- 1989-04-10 CA CA000596218A patent/CA1339609C/en not_active Expired - Lifetime
- 1989-04-10 DK DK198901720A patent/DK175372B1/da not_active IP Right Cessation
- 1989-04-11 OA OA59557A patent/OA09470A/xx unknown
- 1989-04-11 IL IL89921A patent/IL89921A/xx unknown
- 1989-04-11 AT AT89303537T patent/ATE129247T1/de not_active IP Right Cessation
- 1989-04-11 EP EP89303537A patent/EP0337713B1/en not_active Expired - Lifetime
- 1989-04-11 KR KR1019890004725A patent/KR0137023B1/ko not_active IP Right Cessation
- 1989-04-11 ZA ZA892645A patent/ZA892645B/xx unknown
- 1989-04-11 AU AU32644/89A patent/AU631786B2/en not_active Expired
- 1989-04-11 ES ES89303537T patent/ES2078234T3/es not_active Expired - Lifetime
- 1989-04-11 JP JP01089893A patent/JP3085675B2/ja not_active Expired - Lifetime
- 1989-04-11 DE DE68924549T patent/DE68924549T2/de not_active Expired - Lifetime
-
1995
- 1995-10-19 GR GR950401393T patent/GR3017812T3/el unknown
-
1996
- 1996-01-11 HK HK5996A patent/HK5996A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA892645B (en) | 1989-12-27 |
OA09470A (en) | 1992-11-15 |
EP0337713A2 (en) | 1989-10-18 |
DE68924549T2 (de) | 1996-04-04 |
AU3264489A (en) | 1989-10-12 |
GR3017812T3 (en) | 1996-01-31 |
KR0137023B1 (ko) | 1998-04-25 |
DK172089D0 (da) | 1989-04-10 |
IL89921A (en) | 1993-08-18 |
ATE129247T1 (de) | 1995-11-15 |
DK172089A (da) | 1989-10-12 |
JP3085675B2 (ja) | 2000-09-11 |
DE68924549D1 (de) | 1995-11-23 |
KR890016046A (ko) | 1989-11-28 |
CA1339609C (en) | 1997-12-30 |
AU631786B2 (en) | 1992-12-10 |
EP0337713B1 (en) | 1995-10-18 |
NZ228645A (en) | 1991-09-25 |
HK5996A (en) | 1996-01-19 |
IL89921A0 (en) | 1989-12-15 |
EP0337713A3 (en) | 1990-11-22 |
ES2078234T3 (es) | 1995-12-16 |
JPH01316375A (ja) | 1989-12-21 |
IE71225B1 (en) | 1997-02-12 |
IE891136L (en) | 1989-10-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |