DK17385A - Oxadiazinonforbindelser - Google Patents

Oxadiazinonforbindelser Download PDF

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Publication number
DK17385A
DK17385A DK17385A DK17385A DK17385A DK 17385 A DK17385 A DK 17385A DK 17385 A DK17385 A DK 17385A DK 17385 A DK17385 A DK 17385A DK 17385 A DK17385 A DK 17385A
Authority
DK
Denmark
Prior art keywords
compounds
oxadiazinon
conhnhcoch
nah
halogen
Prior art date
Application number
DK17385A
Other languages
English (en)
Other versions
DK17385D0 (da
Inventor
Ila Sircar
Michael H Cain
John G Topliss
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK17385D0 publication Critical patent/DK17385D0/da
Publication of DK17385A publication Critical patent/DK17385A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

Forbindelserne fremstilles ved at omsætte en forbindelse med formlen Ar-A-CONHNHCOCH2-X, hvor X er halogen* med NaH i et ikke-reaktivt opløsningsmiddel ved hævede temperaturer, hvorefter basen om ønsket kan overføres i et syreadditionssalt.
DK17385A 1984-01-16 1985-01-14 Oxadiazinonforbindelser DK17385A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/571,057 US4508718A (en) 1984-01-16 1984-01-16 Cardiotonic and antihypertensive oxadiazinone compounds
US57105784 1984-01-16

Publications (2)

Publication Number Publication Date
DK17385D0 DK17385D0 (da) 1985-01-14
DK17385A true DK17385A (da) 1985-07-17

Family

ID=24282156

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17385A DK17385A (da) 1984-01-16 1985-01-14 Oxadiazinonforbindelser

Country Status (7)

Country Link
US (1) US4508718A (da)
EP (1) EP0149543A1 (da)
JP (1) JPS60174781A (da)
AU (1) AU566853B2 (da)
DK (1) DK17385A (da)
ES (1) ES8603872A1 (da)
GR (1) GR850110B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
US4804662A (en) * 1987-05-05 1989-02-14 Schering A.G. Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
TW251288B (da) * 1991-06-27 1995-07-11 Takeda Dharm Industry Co Ltd
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
GR1001386B (el) * 1991-12-24 1993-10-29 Takeda Chemical Industries Ltd Ετεροκυκλικές ενώσεις.
JP4827821B2 (ja) * 2004-05-26 2011-11-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド化合物
TWI370130B (en) 2005-11-24 2012-08-11 Eisai R&D Man Co Ltd Two cyclic cinnamide compound
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
EP2559693B1 (en) 2007-08-31 2014-11-26 Eisai R&D Management Co., Ltd. Polycyclic compound
WO2020157201A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Oxadiazinone compounds for the treatment of hyperproliferative diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3172252D1 (en) * 1980-11-14 1985-10-17 Ici Plc Heterocyclic compounds
ZA827641B (en) * 1981-11-12 1983-09-28 Ici Plc Thiadiazine, oxadiazine and triazine derivatives which possess cardiotonic and/or antihypertensive activity
CA1199027A (en) * 1981-11-12 1986-01-07 Stuart D. Mills Heterocyclic derivatives of pyridazinone, thiadiazinone, oxadiazinone and triazinone

Also Published As

Publication number Publication date
EP0149543A1 (en) 1985-07-24
DK17385D0 (da) 1985-01-14
US4508718A (en) 1985-04-02
AU566853B2 (en) 1987-10-29
AU3768585A (en) 1985-07-25
GR850110B (da) 1985-05-16
ES539543A0 (es) 1986-01-01
JPS60174781A (ja) 1985-09-09
ES8603872A1 (es) 1986-01-01

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment