DK173528B1 - Koncentreret, stabiliseret ultrasonisk afbildningsmiddel af mikrobobletype og fremgangsmåde til fremstilling af et sådant m - Google Patents

Koncentreret, stabiliseret ultrasonisk afbildningsmiddel af mikrobobletype og fremgangsmåde til fremstilling af et sådant m Download PDF

Info

Publication number: DK173528B1
Authority: DK; Denmark
Prior art keywords: microspheres; imaging agent; dispersion; concentration; solution
Prior art date: 1987-12-29

Application number

DK198807216A

Other languages

Danish (da)

English (en)

Other versions

DK721688A (da

DK721688D0 (da

Inventor

Kenneth J Widder

Peter J Westkaemper

Original Assignee

Molecular Biosystems Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-29

Filing date

1988-12-23

Publication date

2001-01-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26837357&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK173528(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1987-12-29 Priority claimed from US07/139,576 external-priority patent/US4844882A/en

1988-12-23 Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc

1988-12-23 Publication of DK721688D0 publication Critical patent/DK721688D0/da

1989-06-30 Publication of DK721688A publication Critical patent/DK721688A/da

2001-01-29 Application granted granted Critical

2001-01-29 Publication of DK173528B1 publication Critical patent/DK173528B1/da

Links

239000012216 imaging agent Substances 0.000 title claims abstract description 38
238000004519 manufacturing process Methods 0.000 title claims description 6
239000004005 microsphere Substances 0.000 claims abstract description 82
239000006185 dispersion Substances 0.000 claims abstract description 32
238000000034 method Methods 0.000 claims abstract description 16
239000012736 aqueous medium Substances 0.000 claims abstract description 3
239000000243 solution Substances 0.000 claims description 45
238000012545 processing Methods 0.000 claims description 24
238000011282 treatment Methods 0.000 claims description 15
102000009027 Albumins Human genes 0.000 claims description 14
108010088751 Albumins Proteins 0.000 claims description 14
238000005187 foaming Methods 0.000 claims description 14
102000004169 proteins and genes Human genes 0.000 claims description 13
108090000623 proteins and genes Proteins 0.000 claims description 13
102000008100 Human Serum Albumin Human genes 0.000 claims description 12
108091006905 Human Serum Albumin Proteins 0.000 claims description 12
239000007864 aqueous solution Substances 0.000 claims description 6
238000003756 stirring Methods 0.000 claims description 6
239000012141 concentrate Substances 0.000 claims description 4
238000010438 heat treatment Methods 0.000 claims description 4
239000006260 foam Substances 0.000 claims description 3
238000001990 intravenous administration Methods 0.000 claims description 3
238000000527 sonication Methods 0.000 claims description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
238000000605 extraction Methods 0.000 claims 1
239000000560 biocompatible material Substances 0.000 abstract description 4
238000003384 imaging method Methods 0.000 description 12
238000000926 separation method Methods 0.000 description 10
239000012071 phase Substances 0.000 description 9
239000000523 sample Substances 0.000 description 5
238000003860 storage Methods 0.000 description 5
239000000126 substance Substances 0.000 description 5
238000005194 fractionation Methods 0.000 description 4
239000007789 gas Substances 0.000 description 4
238000005259 measurement Methods 0.000 description 4
239000000443 aerosol Substances 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
244000025361 Ficus carica Species 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
239000011324 bead Substances 0.000 description 2
238000009826 distribution Methods 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
238000007654 immersion Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102000001554 Hemoglobins Human genes 0.000 description 1
108010054147 Hemoglobins Proteins 0.000 description 1
102000003839 Human Proteins Human genes 0.000 description 1
108090000144 Human Proteins Proteins 0.000 description 1
238000002583 angiography Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
230000000747 cardiac effect Effects 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
238000001514 detection method Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000000975 dye Substances 0.000 description 1
238000002592 echocardiography Methods 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000003709 heart valve Anatomy 0.000 description 1
238000005286 illumination Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000011325 microbead Substances 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
230000002688 persistence Effects 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000012285 ultrasound imaging Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Radiology & Medical Imaging (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Acoustics & Sound (AREA)
Medical Informatics (AREA)
Biomedical Technology (AREA)
Surgery (AREA)
Engineering & Computer Science (AREA)
Pathology (AREA)
Biophysics (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Surgical Instruments (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Manufacturing Of Micro-Capsules (AREA)

DK198807216A 1987-12-29 1988-12-23 Koncentreret, stabiliseret ultrasonisk afbildningsmiddel af mikrobobletype og fremgangsmåde til fremstilling af et sådant m DK173528B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US13957787A	1987-12-29	1987-12-29
US07/139,576 US4844882A (en)	1987-12-29	1987-12-29	Concentrated stabilized microbubble-type ultrasonic imaging agent
US13957787		1987-12-29
US13957687		1987-12-29

Publications (3)

Publication Number	Publication Date
DK721688D0 DK721688D0 (da)	1988-12-23
DK721688A DK721688A (da)	1989-06-30
DK173528B1 true DK173528B1 (da)	2001-01-29

Family

ID=26837357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198807216A DK173528B1 (da)	1987-12-29	1988-12-23	Koncentreret, stabiliseret ultrasonisk afbildningsmiddel af mikrobobletype og fremgangsmåde til fremstilling af et sådant m

Country Status (7)

Country	Link
EP (1)	EP0324938B2 (no)
AT (1)	ATE97325T1 (no)
DE (1)	DE3885730T2 (no)
DK (1)	DK173528B1 (no)
FI (1)	FI93698C (no)
IE (1)	IE61591B1 (no)
NO (1)	NO176826C (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107519502A (zh) *	2017-08-20	2017-12-29	湖南康润药业有限公司	超声造影微泡的制备方法及超声造影微泡

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4957656A (en) *	1988-09-14	1990-09-18	Molecular Biosystems, Inc.	Continuous sonication method for preparing protein encapsulated microbubbles
US5469854A (en) *	1989-12-22	1995-11-28	Imarx Pharmaceutical Corp.	Methods of preparing gas-filled liposomes
US6146657A (en)	1989-12-22	2000-11-14	Imarx Pharmaceutical Corp.	Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5585112A (en)	1989-12-22	1996-12-17	Imarx Pharmaceutical Corp.	Method of preparing gas and gaseous precursor-filled microspheres
US5656211A (en)	1989-12-22	1997-08-12	Imarx Pharmaceutical Corp.	Apparatus and method for making gas-filled vesicles of optimal size
US5705187A (en)	1989-12-22	1998-01-06	Imarx Pharmaceutical Corp.	Compositions of lipids and stabilizing materials
US5773024A (en)	1989-12-22	1998-06-30	Imarx Pharmaceutical Corp.	Container with multi-phase composition for use in diagnostic and therapeutic applications
US5352435A (en)	1989-12-22	1994-10-04	Unger Evan C	Ionophore containing liposomes for ultrasound imaging
US5922304A (en)	1989-12-22	1999-07-13	Imarx Pharmaceutical Corp.	Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5733572A (en)	1989-12-22	1998-03-31	Imarx Pharmaceutical Corp.	Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6088613A (en)	1989-12-22	2000-07-11	Imarx Pharmaceutical Corp.	Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en)	1989-12-22	1996-08-06	Imarx Pharmaceutical Corp.	Therapeutic delivery systems related applications
US6551576B1 (en)	1989-12-22	2003-04-22	Bristol-Myers Squibb Medical Imaging, Inc.	Container with multi-phase composition for use in diagnostic and therapeutic applications
US5305757A (en)	1989-12-22	1994-04-26	Unger Evan C	Gas filled liposomes and their use as ultrasonic contrast agents
US6001335A (en)	1989-12-22	1999-12-14	Imarx Pharmaceutical Corp.	Contrasting agents for ultrasonic imaging and methods for preparing the same
US5776429A (en)	1989-12-22	1998-07-07	Imarx Pharmaceutical Corp.	Method of preparing gas-filled microspheres using a lyophilized lipids
US5580575A (en) *	1989-12-22	1996-12-03	Imarx Pharmaceutical Corp.	Therapeutic drug delivery systems
DE4004430A1 (de) *	1990-02-09	1991-08-14	Schering Ag	Aus polyaldehyden aufgebaute kontrastmittel
US6989141B2 (en)	1990-05-18	2006-01-24	Bracco International B.V.	Ultrasound contrast agents and methods of making and using them
US5578292A (en)	1991-11-20	1996-11-26	Bracco International B.V.	Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (no) *	1990-04-02	1993-05-01	Sint Sa
USRE39146E1 (en)	1990-04-02	2006-06-27	Bracco International B.V.	Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en)	1991-05-03	2006-08-01	Bracco International B.V.	Ultrasound contrast agents and methods of making and using them
US6613306B1 (en)	1990-04-02	2003-09-02	Bracco International B.V.	Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) *	1990-05-18	1993-04-29	Bracco International B.V.	Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
AU635449B2 (en) *	1990-10-05	1993-03-18	Bracco International B.V.	Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5370901A (en)	1991-02-15	1994-12-06	Bracco International B.V.	Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
GB9106686D0 (en) †	1991-03-28	1991-05-15	Hafslund Nycomed As	Improvements in or relating to contrast agents
US5205290A (en)	1991-04-05	1993-04-27	Unger Evan C	Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en)	1991-04-05	1999-02-23	Imarx Pharmaceutical Corp.	Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5993805A (en) *	1991-04-10	1999-11-30	Quadrant Healthcare (Uk) Limited	Spray-dried microparticles and their use as therapeutic vehicles
GB9107628D0 (en) *	1991-04-10	1991-05-29	Moonbrook Limited	Preparation of diagnostic agents
GB9116610D0 (en) *	1991-08-01	1991-09-18	Danbiosyst Uk	Preparation of microparticles
NZ244147A (en) †	1991-09-03	1994-09-27	Hoechst Ag	Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
US6723303B1 (en)	1991-09-17	2004-04-20	Amersham Health, As	Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
CA2119129C (en) *	1991-09-17	1999-11-09	Steven C. Quay	Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
MX9205298A (es) *	1991-09-17	1993-05-01	Steven Carl Quay	Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5409688A (en) *	1991-09-17	1995-04-25	Sonus Pharmaceuticals, Inc.	Gaseous ultrasound contrast media
US5233995A (en) *	1991-11-21	1993-08-10	Sterling Winthrop Inc.	Encapsulated particles useful as contrast agents in ultrasound and x-ray imaging compositions and methods
IL104084A (en) *	1992-01-24	1996-09-12	Bracco Int Bv	Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US6383470B1 (en)	1992-09-26	2002-05-07	Thomas Fritzsch	Microparticle preparations made of biodegradable copolymers
GB9221329D0 (en)	1992-10-10	1992-11-25	Delta Biotechnology Ltd	Preparation of further diagnostic agents
US5558855A (en) *	1993-01-25	1996-09-24	Sonus Pharmaceuticals	Phase shift colloids as ultrasound contrast agents
IL108416A (en)	1993-01-25	1998-10-30	Sonus Pharma Inc	Colloids with phase difference as contrast ultrasound agents
ES2158892T3 (es) *	1993-01-25	2001-09-16	Sonus Pharma Inc	Coloides de desplazamiento de fase como agentes de contraste de ultrasonidos.
CN1245156C (zh) *	1993-02-22	2006-03-15	美国生物科学有限公司	用于体内传送生物制品的方法及用于该方法的组合物
ES2068151B1 (es)	1993-06-23	1995-11-16	Cabrera Garrido Juan	Microespuma inyectable para esclerosis.
HUT74827A (en) *	1993-07-02	1997-02-28	Molecular Biosystems Inc	Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
JPH10508284A (ja)	1993-12-15	1998-08-18	ブラッコリサーチソシエテアノニム	超音波造影媒体、この媒体を含む造影剤及び方法
US5736121A (en)	1994-05-23	1998-04-07	Imarx Pharmaceutical Corp.	Stabilized homogenous suspensions as computed tomography contrast agents
EP0699445A3 (en) *	1994-08-04	1996-04-17	Gakko Houjin Toin Gakuen	Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant
GB9423419D0 (en)	1994-11-19	1995-01-11	Andaris Ltd	Preparation of hollow microcapsules
US6743779B1 (en)	1994-11-29	2004-06-01	Imarx Pharmaceutical Corp.	Methods for delivering compounds into a cell
US5830430A (en)	1995-02-21	1998-11-03	Imarx Pharmaceutical Corp.	Cationic lipids and the use thereof
US5997898A (en)	1995-06-06	1999-12-07	Imarx Pharmaceutical Corp.	Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en)	1995-06-07	2000-10-31	Imarx Pharmaceutical Corp.	Targeted contrast agents for diagnostic and therapeutic use
US6521211B1 (en)	1995-06-07	2003-02-18	Bristol-Myers Squibb Medical Imaging, Inc.	Methods of imaging and treatment with targeted compositions
US6033645A (en)	1996-06-19	2000-03-07	Unger; Evan C.	Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US5674469A (en) *	1995-06-07	1997-10-07	Molecular Biosystems, Inc.	Gas-exchange method of making gas-filled microspheres
US6231834B1 (en)	1995-06-07	2001-05-15	Imarx Pharmaceutical Corp.	Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
EP0904113B1 (en) *	1996-03-05	2004-05-12	Acusphere, Inc.	Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) *	1996-03-05	1997-03-18	Acusphere, Inc.	Microencapsulated fluorinated gases for use as imaging agents
CA2252617A1 (en)	1996-05-01	1997-11-06	Imarx Pharmaceutical Corp.	Methods for delivering compounds into a cell
US5985309A (en) *	1996-05-24	1999-11-16	Massachusetts Institute Of Technology	Preparation of particles for inhalation
US5874064A (en)	1996-05-24	1999-02-23	Massachusetts Institute Of Technology	Aerodynamically light particles for pulmonary drug delivery
US6652837B1 (en)	1996-05-24	2003-11-25	Massachusetts Institute Of Technology	Preparation of novel particles for inhalation
US5837221A (en) *	1996-07-29	1998-11-17	Acusphere, Inc.	Polymer-lipid microencapsulated gases for use as imaging agents
US6414139B1 (en)	1996-09-03	2002-07-02	Imarx Therapeutics, Inc.	Silicon amphiphilic compounds and the use thereof
US6017310A (en) *	1996-09-07	2000-01-25	Andaris Limited	Use of hollow microcapsules
ATE231004T1 (de)	1996-09-11	2003-02-15	Imarx Pharmaceutical Corp	Verbesserte verfahren zur diagnostischen bilderzeugung unter verwendung eines kontrastmittels und eines vasodilators
US5846517A (en)	1996-09-11	1998-12-08	Imarx Pharmaceutical Corp.	Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6068600A (en) *	1996-12-06	2000-05-30	Quadrant Healthcare (Uk) Limited	Use of hollow microcapsules
US6120751A (en)	1997-03-21	2000-09-19	Imarx Pharmaceutical Corp.	Charged lipids and uses for the same
US6090800A (en)	1997-05-06	2000-07-18	Imarx Pharmaceutical Corp.	Lipid soluble steroid prodrugs
US6143276A (en)	1997-03-21	2000-11-07	Imarx Pharmaceutical Corp.	Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en)	1997-06-18	2003-03-25	Imarx Therapeutics, Inc.	Oxygen delivery agents and uses for the same
US6416740B1 (en)	1997-05-13	2002-07-09	Bristol-Myers Squibb Medical Imaging, Inc.	Acoustically active drug delivery systems
GB9717476D0 (en) *	1997-08-18	1997-10-22	Nycomed Imaging As	Process
GB9717588D0 (en) *	1997-08-19	1997-10-22	Nycomed Imaging As	Improvements in or relating to contrast agents
US6548047B1 (en)	1997-09-15	2003-04-15	Bristol-Myers Squibb Medical Imaging, Inc.	Thermal preactivation of gaseous precursor filled compositions
US6123923A (en)	1997-12-18	2000-09-26	Imarx Pharmaceutical Corp.	Optoacoustic contrast agents and methods for their use
US20010003580A1 (en)	1998-01-14	2001-06-14	Poh K. Hui	Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9912356D0 (en)	1999-05-26	1999-07-28	Btg Int Ltd	Generation of microfoam
US7678364B2 (en)	1999-08-25	2010-03-16	Alkermes, Inc.	Particles for inhalation having sustained release properties
US6749835B1 (en)	1999-08-25	2004-06-15	Advanced Inhalation Research, Inc.	Formulation for spray-drying large porous particles
EP1289565B1 (en)	2000-06-02	2015-04-22	Bracco Suisse SA	Compounds for targeting endothelial cells
GB0028692D0 (en)	2000-11-24	2001-01-10	Btg Int Ltd	Generation of therapeutic microform
AU2002230993B2 (en)	2000-12-29	2006-02-02	Alkermes, Inc.	Particles for inhalation having sustained release properties
US6962071B2 (en)	2001-04-06	2005-11-08	Bracco Research S.A.	Method for improved measurement of local physical parameters in a fluid-filled cavity
US8512680B2 (en)	2001-08-08	2013-08-20	Btg International Ltd.	Injectables in foam, new pharmaceutical applications
JP2005504756A (ja) *	2001-08-08	2005-02-17	マリア・アントニア・ガルシア−オルメド・ドミンゲス	注射可能な泡製剤および新規な医薬的適用
US8623822B2 (en)	2002-03-01	2014-01-07	Bracco Suisse Sa	KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
WO2003074005A2 (en)	2002-03-01	2003-09-12	Dyax Corp.	Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en)	2002-03-01	2007-05-01	Bracco International B.V.	Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en)	2002-03-01	2010-09-14	Bracco International B.V.	Targeting vector-phospholipid conjugates
EP1587944A4 (en)	2002-03-01	2007-03-21	Dyax Corp	KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7261876B2 (en)	2002-03-01	2007-08-28	Bracco International Bv	Multivalent constructs for therapeutic and diagnostic applications
US9364569B2 (en)	2003-02-04	2016-06-14	Bracco Suisse S.A.	Ultrasound contrast agents and process for the preparation thereof
EP2284180B1 (en)	2003-03-03	2015-09-09	Dyax Corp.	Uses of peptides that specifically bind HGF receptor (cMET)
DE602004024925D1 (de)	2003-11-17	2010-02-11	Btg Int Ltd	Verfahren zur herstellung eines schaums mit einem sklerosierenden mittel
US8048439B2 (en)	2003-11-17	2011-11-01	Btg International Ltd.	Therapeutic foam
CA2547024C (en)	2003-12-22	2013-12-17	Bracco Research Sa	Gas-filled microvesicle assembly for contrast imaging
US8012457B2 (en)	2004-06-04	2011-09-06	Acusphere, Inc.	Ultrasound contrast agent dosage formulation
CA2575677C (en)	2004-08-18	2013-01-22	Bracco Research Sa	Gas-filled microvesicles composition for contrast imaging
EP1714642A1 (en)	2005-04-18	2006-10-25	Bracco Research S.A.	Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
GB0509824D0 (en)	2005-05-13	2005-06-22	Btg Int Ltd	Therapeutic foam
EP2117603A2 (en)	2006-12-19	2009-11-18	Bracco International B.V.	Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
US9023321B2 (en)	2008-03-21	2015-05-05	The Board Of Trustees Of The University Of Arkansas	Methods for producing microbubbles
CN102202694B (zh)	2008-10-07	2014-03-12	博莱科瑞士股份有限公司	包含抗-聚合物抗体的靶向构建体和结合它们的脂质体或微泡
KR101893423B1 (ko)	2010-08-09	2018-08-31	브라코 스위스 에스.에이.	표적화 기체-충전 미세소포
CN103269717B (zh)	2010-12-24	2016-08-03	博莱科瑞士股份有限公司	气体填充微囊泡用作疫苗
JP2012246306A (ja) *	2012-08-22	2012-12-13	Btg Internatl Ltd	注射可能な泡製剤および新規な医薬的適用
WO2014052311A1 (en) *	2012-09-25	2014-04-03	The Board Of Trustees Of The University Of Arkansas	Sonolysis with biodegradable nanoparticles
IL296875A (en)	2014-12-31	2022-12-01	Lantheus Medical Imaging Inc	Fat-wrapped gas microsphere preparations and related methods
KR20180104166A (ko)	2016-02-09	2018-09-19	브라코 스위스 에스.에이.	셀렉틴 표적화를 위한 재조합 키메라 단백질
CN115531560B (zh)	2016-05-04	2024-05-17	蓝瑟斯医学影像公司	用于制备超声波造影剂的方法及装置
US9789210B1 (en)	2016-07-06	2017-10-17	Lantheus Medical Imaging, Inc.	Methods for making ultrasound contrast agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4718433A (en) *	1983-01-27	1988-01-12	Feinstein Steven B	Contrast agents for ultrasonic imaging

1988
- 1988-10-14 IE IE312788A patent/IE61591B1/en not_active IP Right Cessation
- 1988-12-06 AT AT88120371T patent/ATE97325T1/de not_active IP Right Cessation
- 1988-12-06 DE DE88120371T patent/DE3885730T2/de not_active Expired - Lifetime
- 1988-12-06 EP EP88120371A patent/EP0324938B2/en not_active Expired - Lifetime
- 1988-12-23 DK DK198807216A patent/DK173528B1/da not_active IP Right Cessation
- 1988-12-28 NO NO885796A patent/NO176826C/no unknown
- 1988-12-28 FI FI886016A patent/FI93698C/fi not_active IP Right Cessation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN107519502A (zh) *	2017-08-20	2017-12-29	湖南康润药业有限公司	超声造影微泡的制备方法及超声造影微泡
CN107519502B (zh) *	2017-08-20	2019-01-15	湖南康润药业有限公司	超声造影微泡的制备方法及超声造影微泡

Also Published As

Publication number	Publication date
IE61591B1 (en)	1994-11-16
NO176826C (no)	1995-06-14
EP0324938B1 (en)	1993-11-18
FI93698C (fi)	1995-05-26
FI886016A (fi)	1989-06-30
NO885796L (no)	1989-06-30
IE883127L (en)	1989-06-29
DE3885730T2 (de)	1994-03-10
ATE97325T1 (de)	1993-12-15
EP0324938B2 (en)	2008-02-27
DE3885730D1 (de)	1993-12-23
NO176826B (no)	1995-02-27
FI93698B (fi)	1995-02-15
NO885796D0 (no)	1988-12-28
DK721688A (da)	1989-06-30
EP0324938A1 (en)	1989-07-26
DK721688D0 (da)	1988-12-23

Legal Events

Date	Code	Title	Description
2001-01-29	B1	Patent granted (law 1993)
2009-01-19	PUP	Patent expired

Publication	Publication Date	Title
DK173528B1 (da)	2001-01-29	Koncentreret, stabiliseret ultrasonisk afbildningsmiddel af mikrobobletype og fremgangsmåde til fremstilling af et sådant m
DK175484B1 (da)	2004-11-08	Fremgangsmåde til kontinuert fremstilling af proteinindkapslede mikrokugler
CA1239092A (en)	1988-07-12	Ultrasound contrast agents containing microparticles and gas micro-bubbles
KR960005709B1 (ko)	1996-05-01	농축안정화된 미세기포형 초음파촬영제
CA1232837A (en)	1988-02-16	Ultrasound contrast agent containing microparticles and gas micro-bubbles
JP2905598B2 (ja)	1999-06-14	熱変性されたタンパク質からカプセル化されたマイクロスフェアを製造する方法
US5855865A (en)	1999-01-05	Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
JPH0737394B2 (ja)	1995-04-26	微小気泡及び微粒子から成る超音波造影剤及びその製法
JPH0443889B2 (no)	1992-07-20
CN106572973B (zh)	2020-11-24	用于使用载体基质的可注射性血管硬化泡沫的装置和方法以及其应用
JPS6075437A (ja)	1985-04-27	超音波コントラスト剤とその製法
JP2000512281A (ja)	2000-09-19	超音波画像化剤としての耐圧性タンパク質ミクロスフェア
JPH08508257A (ja)	1996-09-03	超音波造影媒質としての微粒子
JP2001515055A (ja)	2001-09-18	造影剤に関する改良
AU722742B2 (en)	2000-08-10	Methods for making encapsulated microspheres from heat denatured protein using mechanical cavitation