DK1720550T3 - Derivater af piperidinylalkylcarbamater, fremstilling heraf samt anvendelse heraf som inhibitorer for FAAH enzym - Google Patents

Derivater af piperidinylalkylcarbamater, fremstilling heraf samt anvendelse heraf som inhibitorer for FAAH enzym

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Publication number
DK1720550T3
DK1720550T3 DK05732905T DK05732905T DK1720550T3 DK 1720550 T3 DK1720550 T3 DK 1720550T3 DK 05732905 T DK05732905 T DK 05732905T DK 05732905 T DK05732905 T DK 05732905T DK 1720550 T3 DK1720550 T3 DK 1720550T3
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Prior art keywords
piperidinylalkylcarbamates
inhibitors
derivatives
preparation
faah enzyme
Prior art date
Application number
DK05732905T
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Danish (da)
English (en)
Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Jean Jeunesse
Original Assignee
Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
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Publication of DK1720550T3 publication Critical patent/DK1720550T3/da

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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DK05732905T 2004-02-26 2005-02-25 Derivater af piperidinylalkylcarbamater, fremstilling heraf samt anvendelse heraf som inhibitorer for FAAH enzym DK1720550T3 (da)

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FR0401952A FR2866885B1 (fr) 2004-02-26 2004-02-26 Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
PCT/FR2005/000452 WO2005089759A1 (fr) 2004-02-26 2005-02-25 Derives de piperidinylalkylcarbamates, leur preparation et leur application comme inhibiteurs de l’enzyme faah

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FR2866888B1 (fr) * 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
WO2007061862A2 (en) * 2005-11-18 2007-05-31 Janssen Pharmaceutica N.V. 2-keto-oxazoles as modulators of fatty acid amide hydrolase
WO2007070760A2 (en) 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2008014199A2 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 receptor
BRPI0718515A2 (pt) 2006-09-25 2013-11-19 Boehringer Ingelheim Int Compostos que modulam o receptor cb2
CA2704684A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
JP5749162B2 (ja) 2008-07-10 2015-07-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節するスルホン化合物
CN102164917A (zh) 2008-09-25 2011-08-24 贝林格尔.英格海姆国际有限公司 选择性调节cb2受体的磺酰基化合物
FR2941696B1 (fr) * 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945531A1 (fr) * 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
WO2011037795A1 (en) 2009-09-22 2011-03-31 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
EP2523936A1 (de) 2010-01-15 2012-11-21 Boehringer Ingelheim International GmbH Cb2 rezeptor-modulierende verbindungen
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
JP5746764B2 (ja) 2010-07-22 2015-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
EP2803668A1 (de) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole

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DE3235565A1 (de) * 1982-09-25 1984-03-29 Boehringer Ingelheim KG, 6507 Ingelheim Piperidinderivate, ihre herstellung und verwendung
EP1039902B1 (de) * 1997-11-24 2006-03-08 The Scripps Research Institute Hemmer der "gap junction communication"
MXPA03009850A (es) * 2001-04-27 2004-02-12 Bristol Myers Squibb Co Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso.
JP2005516986A (ja) * 2002-02-08 2005-06-09 ブリストル−マイヤーズ　スクイブ　カンパニー （オキシム）カルバモイル脂肪酸アミド加水分解酵素インヒビター
FR2843964B1 (fr) * 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
FR2850377B1 (fr) * 2003-01-23 2009-02-20 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2860514A1 (fr) * 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique

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US20070021403A1 (en) 2007-01-25
NZ550007A (en) 2010-06-25
TW200529816A (en) 2005-09-16
BRPI0508072A (pt) 2007-07-17
AU2005224140B2 (en) 2010-12-02
PL1720550T3 (pl) 2009-09-30
MA28366A1 (fr) 2006-12-01
DE602005013923D1 (de) 2009-05-28
FR2866885A1 (fr) 2005-09-02
JP2007524706A (ja) 2007-08-30
CA2554608A1 (fr) 2005-09-29
RU2006134025A (ru) 2008-04-10
WO2005089759A1 (fr) 2005-09-29
IL177534A (en) 2011-01-31
PT1720550E (pt) 2009-06-04
CY1109231T1 (el) 2014-07-02
AR047818A1 (es) 2006-02-22
ATE428417T1 (de) 2009-05-15
ES2325376T3 (es) 2009-09-02
EP1720550A1 (de) 2006-11-15
US20100279998A1 (en) 2010-11-04
JP4796046B2 (ja) 2011-10-19
RU2384569C2 (ru) 2010-03-20
HRP20090294T1 (en) 2009-06-30
ZA200606964B (en) 2008-01-30
SI1720550T1 (sl) 2009-10-31
KR20060134081A (ko) 2006-12-27
US7781590B2 (en) 2010-08-24
AU2005224140A1 (en) 2005-09-29
FR2866885B1 (fr) 2007-08-31
CN1921858A (zh) 2007-02-28
EP1720550B1 (de) 2009-04-15
IL177534A0 (en) 2006-12-10

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