DE602005013923D1 - Derivate von piperidinylalkylcarbamaten, herstellungsverfahren davon und verwendung derselben als faah-enzym-inhibitoren - Google Patents

Derivate von piperidinylalkylcarbamaten, herstellungsverfahren davon und verwendung derselben als faah-enzym-inhibitoren

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Publication number
DE602005013923D1
DE602005013923D1 DE602005013923T DE602005013923T DE602005013923D1 DE 602005013923 D1 DE602005013923 D1 DE 602005013923D1 DE 602005013923 T DE602005013923 T DE 602005013923T DE 602005013923 T DE602005013923 T DE 602005013923T DE 602005013923 D1 DE602005013923 D1 DE 602005013923D1
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Germany
Prior art keywords
derivatives
manufacturing
enzyme inhibitors
alkyl carbamates
faah enzyme
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DE602005013923T
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Inventor
Ahmed Abouabdellah
Garcia Antonio Almario
Christian Hoornaert
Jean Jeunesse
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Sanofi Aventis France
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Sanofi Aventis France
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Publication of DE602005013923D1 publication Critical patent/DE602005013923D1/de
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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DE602005013923T 2004-02-26 2005-02-25 Derivate von piperidinylalkylcarbamaten, herstellungsverfahren davon und verwendung derselben als faah-enzym-inhibitoren Active DE602005013923D1 (de)

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FR0401952A FR2866885B1 (fr) 2004-02-26 2004-02-26 Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique
PCT/FR2005/000452 WO2005089759A1 (fr) 2004-02-26 2005-02-25 Derives de piperidinylalkylcarbamates, leur preparation et leur application comme inhibiteurs de l’enzyme faah

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FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique
FR2866888B1 (fr) * 2004-02-26 2006-05-05 Sanofi Synthelabo Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
WO2007005510A1 (en) 2005-06-30 2007-01-11 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
US20090111778A1 (en) * 2005-11-18 2009-04-30 Richard Apodaca 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase
CA2632030A1 (en) 2005-12-15 2007-06-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2081905B1 (de) 2006-07-28 2012-09-12 Boehringer Ingelheim International GmbH Sulfonyl verbindungen als cb2 rezeptor modulatoren
JP5030114B2 (ja) 2006-09-25 2012-09-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体をモジュレートする化合物
JP5492092B2 (ja) 2007-11-07 2014-05-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を調節する化合物
CA2730037A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
CA2737639A1 (en) 2008-09-25 2010-04-01 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the cb2 receptor
FR2941696B1 (fr) * 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945531A1 (fr) * 2009-05-12 2010-11-19 Sanofi Aventis Derives de 7-aza-spiro°3,5!nonane-7-carboxylates, leur preparation et leur application en therapeutique
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US8383615B2 (en) 2009-06-16 2013-02-26 Boehringer Ingelheim International Gmbh Azetidine 2-carboxamide derivatives which modulate the CB2 receptor
US8383651B2 (en) 2009-09-22 2013-02-26 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
US9315454B2 (en) 2010-01-15 2016-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
WO2011109324A1 (en) 2010-03-05 2011-09-09 Boehringer Ingelheim International Gmbh Tetrazole compounds which selectively modulate the cb2 receptor
US8846936B2 (en) 2010-07-22 2014-09-30 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the CB2 receptor
EP2803668A1 (de) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Neuartige (Cyano-dimethyl-methyl)-isoxazole und -[1,3,4]-thiadiazole

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DE3235565A1 (de) * 1982-09-25 1984-03-29 Boehringer Ingelheim KG, 6507 Ingelheim Piperidinderivate, ihre herstellung und verwendung
AU740588B2 (en) * 1997-11-24 2001-11-08 Scripps Research Institute, The Inhibitors of gap junction communication
MXPA03009850A (es) * 2001-04-27 2004-02-12 Bristol Myers Squibb Co Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso.
EP1472215A4 (de) * 2002-02-08 2007-05-09 Bristol Myers Squibb Co Inhibitoren der (oxim)carbamoyl fettsäureamidhydrolase
FR2843964B1 (fr) * 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
FR2850377B1 (fr) * 2003-01-23 2009-02-20 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2860514A1 (fr) * 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
FR2866886B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique

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EP1720550B1 (de) 2009-04-15
AR047818A1 (es) 2006-02-22
ATE428417T1 (de) 2009-05-15
WO2005089759A1 (fr) 2005-09-29
IL177534A (en) 2011-01-31
AU2005224140B2 (en) 2010-12-02
AU2005224140A1 (en) 2005-09-29
KR20060134081A (ko) 2006-12-27
DK1720550T3 (da) 2009-08-10
US20070021403A1 (en) 2007-01-25
ZA200606964B (en) 2008-01-30
FR2866885B1 (fr) 2007-08-31
MA28366A1 (fr) 2006-12-01
HRP20090294T1 (en) 2009-06-30
CA2554608A1 (fr) 2005-09-29
ES2325376T3 (es) 2009-09-02
IL177534A0 (en) 2006-12-10
RU2006134025A (ru) 2008-04-10
BRPI0508072A (pt) 2007-07-17
NZ550007A (en) 2010-06-25
RU2384569C2 (ru) 2010-03-20
PL1720550T3 (pl) 2009-09-30
EP1720550A1 (de) 2006-11-15
FR2866885A1 (fr) 2005-09-02
PT1720550E (pt) 2009-06-04
US20100279998A1 (en) 2010-11-04
US7781590B2 (en) 2010-08-24
TW200529816A (en) 2005-09-16
JP4796046B2 (ja) 2011-10-19
SI1720550T1 (sl) 2009-10-31
CN1921858A (zh) 2007-02-28
CY1109231T1 (el) 2014-07-02

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