DK1716162T3 - Phosphonater, amidomonophosphonater, amidobisphosphonater til behandling af virussygdomme - Google Patents

Phosphonater, amidomonophosphonater, amidobisphosphonater til behandling af virussygdomme

Info

Publication number: DK1716162T3
Authority: DK; Denmark
Prior art keywords: phosphonates; amidomonophosphonates; amidobis; treatment; viral diseases
Prior art date: 2003-12-30

Application number

DK04815956.0T

Other languages

English (en)

Inventor

Xiaqin Cheng

Gary P Cook

Manoj C Desai

Edward Doerffler

Gong-Xin He

Choung U Kim

William A Lee

John C Rohloff

Jianying Wang

Zheng-Yu Yang

Original Assignee

Gilead Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-30

Filing date

2004-12-29

Publication date

2011-01-10

2004-12-29 Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc

2011-01-10 Application granted granted Critical

2011-01-10 Publication of DK1716162T3 publication Critical patent/DK1716162T3/da

Links

ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000003612 virological effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/664—Amides of phosphorus acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK04815956.0T 2003-12-30 2004-12-29 Phosphonater, amidomonophosphonater, amidobisphosphonater til behandling af virussygdomme DK1716162T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US53374503P	2003-12-30	2003-12-30
US59098704P	2004-07-26	2004-07-26
US60659504P	2004-09-01	2004-09-01
PCT/US2004/043969 WO2005066189A1 (en)	2003-12-30	2004-12-29	Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases

Publications (1)

Publication Number	Publication Date
DK1716162T3 true DK1716162T3 (da)	2011-01-10

Family

ID=34753695

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK04815956.0T DK1716162T3 (da)	2003-12-30	2004-12-29	Phosphonater, amidomonophosphonater, amidobisphosphonater til behandling af virussygdomme
DK10158740.0T DK2204374T3 (da)	2003-12-30	2004-12-29	Nucleosidphosphonater og analoge deraf til behandling af HPV-infektioner

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK10158740.0T DK2204374T3 (da)	2003-12-30	2004-12-29	Nucleosidphosphonater og analoge deraf til behandling af HPV-infektioner

Country Status (28)

Country	Link
US (5)	US7553825B2 (da)
EP (2)	EP1716162B1 (da)
JP (2)	JP4949852B2 (da)
KR (2)	KR20120080240A (da)
CN (2)	CN101816664B (da)
AP (1)	AP2212A (da)
AT (1)	ATE478082T1 (da)
AU (2)	AU2004312546B2 (da)
BR (1)	BRPI0418251C1 (da)
CA (1)	CA2550222C (da)
CY (2)	CY1111050T1 (da)
DE (1)	DE602004028763D1 (da)
DK (2)	DK1716162T3 (da)
EA (1)	EA011304B1 (da)
ES (2)	ES2389602T3 (da)
HK (2)	HK1097276A1 (da)
HR (3)	HRP20060254A2 (da)
IL (1)	IL176407A (da)
IS (1)	IS2994B (da)
NO (2)	NO338001B1 (da)
NZ (1)	NZ548771A (da)
PL (3)	PL1716162T3 (da)
PT (2)	PT1716162E (da)
RS (2)	RS52433B (da)
SG (1)	SG149075A1 (da)
SI (2)	SI2204374T1 (da)
WO (1)	WO2005066189A1 (da)
ZA (1)	ZA200606049B (da)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8512718B2 (en)	2000-07-03	2013-08-20	Foamix Ltd.	Pharmaceutical composition for topical application
EP1504014B1 (en)	2002-05-13	2015-12-02	Metabasis Therapeutics, Inc.	Process for preparation of cyclic prodrugs of pmea and pmpa
CA2485702C (en) *	2002-05-13	2011-07-19	Metabasis Therapeutics, Inc.	Novel phosphonic acid based prodrugs of pmea and its analogues
IL152486A0 (en)	2002-10-25	2003-05-29	Meir Eini	Alcohol-free cosmetic and pharmaceutical foam carrier
US9265725B2 (en)	2002-10-25	2016-02-23	Foamix Pharmaceuticals Ltd.	Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8486376B2 (en)	2002-10-25	2013-07-16	Foamix Ltd.	Moisturizing foam containing lanolin
US8119150B2 (en)	2002-10-25	2012-02-21	Foamix Ltd.	Non-flammable insecticide composition and uses thereof
US9668972B2 (en)	2002-10-25	2017-06-06	Foamix Pharmaceuticals Ltd.	Nonsteroidal immunomodulating kit and composition and uses thereof
US10117812B2 (en)	2002-10-25	2018-11-06	Foamix Pharmaceuticals Ltd.	Foamable composition combining a polar solvent and a hydrophobic carrier
US7820145B2 (en)	2003-08-04	2010-10-26	Foamix Ltd.	Oleaginous pharmaceutical and cosmetic foam
US20080138296A1 (en)	2002-10-25	2008-06-12	Foamix Ltd.	Foam prepared from nanoemulsions and uses
US7700076B2 (en)	2002-10-25	2010-04-20	Foamix, Ltd.	Penetrating pharmaceutical foam
US7704518B2 (en)	2003-08-04	2010-04-27	Foamix, Ltd.	Foamable vehicle and pharmaceutical compositions thereof
US8900554B2 (en)	2002-10-25	2014-12-02	Foamix Pharmaceuticals Ltd.	Foamable composition and uses thereof
US9211259B2 (en)	2002-11-29	2015-12-15	Foamix Pharmaceuticals Ltd.	Antibiotic kit and composition and uses thereof
ES2532906T5 (es)	2002-10-25	2022-03-23	Foamix Pharmaceuticals Ltd	Espuma cosmética y farmacéutica
US8119109B2 (en)	2002-10-25	2012-02-21	Foamix Ltd.	Foamable compositions, kits and methods for hyperhidrosis
US7575739B2 (en)	2003-04-28	2009-08-18	Foamix Ltd.	Foamable iodine composition
US8486374B2 (en)	2003-08-04	2013-07-16	Foamix Ltd.	Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8795693B2 (en)	2003-08-04	2014-08-05	Foamix Ltd.	Compositions with modulating agents
CN101816664B (zh)	2003-12-30	2012-04-18	吉里德科学公司	用于治疗病毒性疾病的膦酸酯、单膦酸酰胺化物、双膦酸酰胺化物
RU2006138907A (ru) *	2004-06-08	2008-07-20	Метабазис Терапеутикс	Синтез сложных циклических эфиров с применением кислоты льюиса
WO2007002808A1 (en) *	2005-06-29	2007-01-04	Gilead Sciences, Inc.	Anti-nonmelanoma carcinoma compounds, compositions, and methods of use thereof
WO2007002912A2 (en) *	2005-06-29	2007-01-04	Gilead Sciences, Inc.	Anti-proliferative compounds, compositions, and methods of use thereof
KR101424832B1 (ko) *	2006-05-16	2014-08-06	길리애드 사이언시즈, 인코포레이티드	악성 혈액 종양 치료 방법 및 악성 혈액 종양 치료용 조성물
WO2007137196A2 (en) *	2006-05-19	2007-11-29	Threshold Pharmaceuticals, Inc.	Tubulin binding anti cancer compounds and prodrugs thereof
JP5356228B2 (ja) *	2006-07-07	2013-12-04	ギリアードサイエンシーズ，インコーポレイテッド	ｔｏｌｌ様レセプター７の調節因子
EP2046121B1 (en)	2006-07-14	2012-08-22	Stiefel Research Australia Pty Ltd	Fatty acid pharmaceutical foam
US20080260655A1 (en)	2006-11-14	2008-10-23	Dov Tamarkin	Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8636982B2 (en)	2007-08-07	2014-01-28	Foamix Ltd.	Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en)	2007-11-30	2016-09-13	Foamix Pharmaceuticals Ltd.	Foam containing benzoyl peroxide
WO2009072007A2 (en)	2007-12-07	2009-06-11	Foamix Ltd.	Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8518376B2 (en)	2007-12-07	2013-08-27	Foamix Ltd.	Oil-based foamable carriers and formulations
WO2009090558A2 (en)	2008-01-14	2009-07-23	Foamix Ltd.	Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
TWI444384B (zh) *	2008-02-20	2014-07-11	Gilead Sciences Inc	核苷酸類似物及其在治療惡性腫瘤上的用途
WO2010125470A2 (en)	2009-04-28	2010-11-04	Foamix Ltd.	Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2011013008A2 (en)	2009-07-29	2011-02-03	Foamix Ltd.	Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769625C (en)	2009-07-29	2017-04-11	Foamix Ltd.	Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en)	2009-10-02	2017-12-26	Foamix Pharmaceuticals Ltd.	Methods for accelerated return of skin integrity and for the treatment of impetigo
BR112012007473A2 (pt)	2009-10-02	2019-05-07	Foamix Ltd	composições tópicas de tetraciclina e respectivo método de uso
CN102309984B (zh) *	2011-07-22	2013-05-01	华东师范大学	一种磷酸酰胺类双功能催化剂及其合成方法
JP6113185B2 (ja)	2011-12-22	2017-04-12	ジェロン・コーポレーションＧｅｒｏｎＣｏｒｐｏｒａｔｉｏｎ	テロメラーゼ基質およびテロメア長作用因子としてのグアニンアナログ
CN107312039B (zh)	2012-08-30	2019-06-25	江苏豪森药业集团有限公司	一种替诺福韦前药的制备方法
CN107056838A (zh)	2013-03-15	2017-08-18	加利福尼亚大学董事会	无环核苷膦酸二酯
CN104804042B (zh) *	2014-01-24	2018-01-19	齐鲁制药有限公司	核苷酸膦酸酯类化合物、其药物组合物、制备方法及用途
AU2015217221A1 (en)	2014-02-13	2016-08-11	Ligand Pharmaceuticals, Inc.	Prodrug compounds and their uses
WO2015161781A1 (zh) *	2014-04-21	2015-10-29	四川海思科制药有限公司	一种核苷类似物及其中间体的制备方法
JP2017520545A (ja)	2014-07-02	2017-07-27	リガンド・ファーマシューティカルズ・インコーポレイテッド	プロドラッグ化合物およびそれらの使用
WO2016044281A1 (en) *	2014-09-15	2016-03-24	The Regents Of The University Of California	Nucleotide analogs
US20190022116A1 (en)	2014-12-26	2019-01-24	Emory University	N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto
CN107820499B (zh) *	2015-04-28	2022-11-11	鲁汶大学研究与开发部	抗病毒化合物、其制备工艺、以及其用于治疗病毒感染的用途
WO2017007701A1 (en) *	2015-07-07	2017-01-12	Merck Sharp & Dohme Corp.	Antiviral phosphodiamide compounds
TWI620754B (zh) *	2015-08-26	2018-04-11		Method for preparing amino phosphate derivative and preparation method thereof
EP3350191B9 (en)	2015-09-15	2021-12-22	The Regents of the University of California	Nucleotide analogs
WO2017100108A1 (en)	2015-12-10	2017-06-15	Merck Sharp & Dohme Corp.	Antiviral phosphodiamide prodrugs of tenofovir
WO2017106069A1 (en)	2015-12-15	2017-06-22	Merck Sharp & Dohme Corp.	Antiviral oxime phosphoramide compounds
WO2017124896A1 (zh) *	2016-01-19	2017-07-27	四川海思科制药有限公司	一种核苷类似物的磷酰胺酯前药及其应用
MX2020012139A (es)	2016-09-08	2021-01-29	Vyne Pharmaceuticals Inc	Composiciones y metodos para tratar rosacea y acne.
EP3515923A1 (en) *	2016-09-23	2019-07-31	Katholieke Universiteit Leuven	Prodrugs of fluorinated acyclic nucleoside phosphonates
EP3532069A4 (en)	2016-10-26	2020-05-13	Merck Sharp & Dohme Corp.	ARYL-AMIDE PHOSPHODIAMIDE COMPOUNDS ANTIVIRALS
WO2018119013A1 (en)	2016-12-22	2018-06-28	Merck Sharp & Dohme Corp.	Antiviral aliphatic ester prodrugs of tenofovir
EP3558322B1 (en) *	2016-12-22	2021-09-29	Merck Sharp & Dohme Corp.	Antiviral benzyl-amine phosphodiamide compounds
CN108276444A (zh) *	2017-01-06	2018-07-13	米文君	一类新的化合物及其用途
US20190374557A1 (en) *	2017-02-28	2019-12-12	Alexandre Vasilievich Ivachtchenko	Cyclobutyl (S)-2-[[[(R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phenoxy-phosphoryl]amino]-propanoates, and production process and application thereof
GB2581936B (en)	2017-12-07	2021-02-10	Univ Emory	N4-hydroxycytidine and derivatives and anti-viral uses related thereto
EP3737676B1 (en)	2018-01-09	2024-03-06	Ligand Pharmaceuticals, Inc.	Acetal compounds and therapeutic uses thereof
US11826375B2 (en)	2018-07-19	2023-11-28	Merck Sharp & Dohme Llc	Phosphinic amide prodrugs of tenofovir
WO2021202669A2 (en)	2020-04-01	2021-10-07	Reyoung Corporation	Nucleoside and nucleotide conjugate compounds and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2528490C2 (de) *	1975-06-26	1983-04-28	Henkel KGaA, 4000 Düsseldorf	Verfahren zur Herstellung saurer Protease
US4816570A (en) *	1982-11-30	1989-03-28	The Board Of Regents Of The University Of Texas System	Biologically reversible phosphate and phosphonate protective groups
US4968788A (en) *	1986-04-04	1990-11-06	Board Of Regents, The University Of Texas System	Biologically reversible phosphate and phosphonate protective gruops
ES2083580T3 (es)	1990-06-13	1996-04-16	Arnold Glazier	Profarmacos de fosforo.
ATE167679T1 (de) *	1990-09-14	1998-07-15	Acad Of Science Czech Republic	Wirkstoffvorläufer von phosphonaten
US5977061A (en) *	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use
US6312662B1 (en)	1998-03-06	2001-11-06	Metabasis Therapeutics, Inc.	Prodrugs phosphorus-containing compounds
US20030072814A1 (en) *	1999-12-16	2003-04-17	Maibach Howard I.	Topical pharmaceutical composition for the treatment of warts
JP2003519232A (ja) *	2000-01-07	2003-06-17	ウニフェルジテーレ・インステリング・アントウェルペン	プリン誘導体、その製造法およびその使用
US20020119443A1 (en) *	2000-07-21	2002-08-29	Gilead Sciences, Inc.	Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
DE10236294A1 (de) *	2001-08-17	2003-02-27	Alstom Switzerland Ltd	Gasversorgungskontrolleinrichtung einer Gasspeicherkraftanlage
CN1168449C (zh) *	2002-12-23	2004-09-29	梁有国	抗人***瘤病毒感染的药物
CN101816664B (zh)	2003-12-30	2012-04-18	吉里德科学公司	用于治疗病毒性疾病的膦酸酯、单膦酸酰胺化物、双膦酸酰胺化物

2004
- 2004-12-29 CN CN2010101456719A patent/CN101816664B/zh active Active
- 2004-12-29 ES ES10158740T patent/ES2389602T3/es active Active
- 2004-12-29 AT AT04815956T patent/ATE478082T1/de active
- 2004-12-29 BR BRPI0418251A patent/BRPI0418251C1/pt active Search and Examination
- 2004-12-29 CA CA2550222A patent/CA2550222C/en active Active
- 2004-12-29 DK DK04815956.0T patent/DK1716162T3/da active
- 2004-12-29 DE DE602004028763T patent/DE602004028763D1/de active Active
- 2004-12-29 PT PT04815956T patent/PT1716162E/pt unknown
- 2004-12-29 AU AU2004312546A patent/AU2004312546B2/en active Active
- 2004-12-29 US US11/026,303 patent/US7553825B2/en active Active
- 2004-12-29 DK DK10158740.0T patent/DK2204374T3/da active
- 2004-12-29 WO PCT/US2004/043969 patent/WO2005066189A1/en active Application Filing
- 2004-12-29 PL PL04815956T patent/PL1716162T3/pl unknown
- 2004-12-29 NZ NZ548771A patent/NZ548771A/en unknown
- 2004-12-29 RS RS20120389A patent/RS52433B/en unknown
- 2004-12-29 PT PT10158740T patent/PT2204374E/pt unknown
- 2004-12-29 SI SI200431910T patent/SI2204374T1/sl unknown
- 2004-12-29 AP AP2006003675A patent/AP2212A/xx active
- 2004-12-29 ES ES04815956T patent/ES2350983T3/es active Active
- 2004-12-29 EP EP04815956A patent/EP1716162B1/en active Active
- 2004-12-29 EP EP10158740A patent/EP2204374B1/en active Active
- 2004-12-29 CN CN2004800394690A patent/CN1950383B/zh active Active
- 2004-12-29 PL PL10158740T patent/PL2204374T3/pl unknown
- 2004-12-29 SI SI200431534T patent/SI1716162T1/sl unknown
- 2004-12-29 EA EA200601263A patent/EA011304B1/ru not_active IP Right Cessation
- 2004-12-29 PL PL380828A patent/PL212403B1/pl unknown
- 2004-12-29 RS RSP-2010/0490A patent/RS51476B/en unknown
- 2004-12-29 SG SG200809660-4A patent/SG149075A1/en unknown
- 2004-12-29 KR KR1020127013492A patent/KR20120080240A/ko not_active Application Discontinuation
- 2004-12-29 JP JP2006547579A patent/JP4949852B2/ja active Active
2005
- 2005-06-29 US US11/170,325 patent/US20060046981A1/en not_active Abandoned
- 2005-06-29 US US11/170,247 patent/US20060030545A1/en not_active Abandoned
2006
- 2006-06-19 IL IL176407A patent/IL176407A/en active IP Right Grant
- 2006-06-21 IS IS8516A patent/IS2994B/is unknown
- 2006-07-19 HR HR20060254A patent/HRP20060254A2/xx not_active Application Discontinuation
- 2006-07-21 ZA ZA2006/06049A patent/ZA200606049B/en unknown
- 2006-07-28 NO NO20063479A patent/NO338001B1/no unknown
- 2006-07-31 KR KR1020067015535A patent/KR101214257B1/ko active IP Right Grant
2007
- 2007-04-30 HK HK07104599.0A patent/HK1097276A1/xx unknown
2009
- 2009-02-18 US US12/388,295 patent/US8088754B2/en active Active
- 2009-05-05 US US12/436,004 patent/US8268802B2/en active Active
2010
- 2010-11-17 CY CY20101101036T patent/CY1111050T1/el unknown
- 2010-11-18 HR HR20100626T patent/HRP20100626T1/hr unknown
2011
- 2011-01-06 HK HK11100117.5A patent/HK1146061A1/xx unknown
- 2011-01-13 AU AU2011200141A patent/AU2011200141B2/en active Active
- 2011-02-25 JP JP2011040828A patent/JP2011137029A/ja not_active Withdrawn
2012
- 2012-09-04 HR HRP20120699TT patent/HRP20120699T1/hr unknown
- 2012-09-10 CY CY20121100813T patent/CY1113103T1/el unknown
2015
- 2015-05-18 NO NO20150615A patent/NO338040B1/no unknown

Also Published As

Publication number	Publication date
EA011304B1 (ru)	2009-02-27
CY1113103T1 (el)	2016-04-13
CN101816664B (zh)	2012-04-18
AU2011200141A1 (en)	2011-02-03
PL380828A1 (pl)	2007-03-19
US20060046981A1 (en)	2006-03-02
CY1111050T1 (el)	2015-06-11
BRPI0418251B1 (pt)	2019-09-24
ATE478082T1 (de)	2010-09-15
DK2204374T3 (da)	2012-09-10
HRP20060254A2 (en)	2006-10-31
HK1146061A1 (en)	2011-05-13
ES2389602T3 (es)	2012-10-29
JP4949852B2 (ja)	2012-06-13
AP2006003675A0 (en)	2006-08-31
IS2994B (is)	2018-03-15
CN101816664A (zh)	2010-09-01
AP2212A (en)	2011-03-01
BRPI0418251A (pt)	2007-04-17
EP2204374B1 (en)	2012-06-13
US20090291922A1 (en)	2009-11-26
ZA200606049B (en)	2008-01-08
US20090149400A1 (en)	2009-06-11
AU2011200141B2 (en)	2012-02-16
HRP20120699T1 (hr)	2012-09-30
WO2005066189A1 (en)	2005-07-21
US20060030545A1 (en)	2006-02-09
CA2550222A1 (en)	2005-07-21
PL1716162T3 (pl)	2011-02-28
NZ548771A (en)	2010-05-28
HRP20100626T1 (hr)	2011-03-31
JP2007517065A (ja)	2007-06-28
EP1716162A1 (en)	2006-11-02
PL2204374T3 (pl)	2012-11-30
EP1716162B1 (en)	2010-08-18
NO338001B1 (no)	2016-07-18
HK1097276A1 (en)	2007-06-22
PT2204374E (pt)	2012-09-17
BRPI0418251C1 (pt)	2021-05-25
EP2204374A1 (en)	2010-07-07
SG149075A1 (en)	2009-01-29
RS52433B (en)	2013-02-28
ES2350983T3 (es)	2011-01-28
NO20150615L (no)	2005-07-01
US7553825B2 (en)	2009-06-30
RS51476B (en)	2011-04-30
CN1950383B (zh)	2010-06-09
PT1716162E (pt)	2010-11-24
CA2550222C (en)	2013-05-28
CN1950383A (zh)	2007-04-18
US20050222090A1 (en)	2005-10-06
JP2011137029A (ja)	2011-07-14
IS8516A (is)	2006-06-21
EA200601263A1 (ru)	2006-12-29
BRPI0418251B8 (pt)	2019-10-08
KR101214257B1 (ko)	2012-12-21
IL176407A (en)	2012-12-31
AU2004312546B2 (en)	2010-10-14
SI2204374T1 (sl)	2012-09-28
US8088754B2 (en)	2012-01-03
IL176407A0 (en)	2006-10-05
SI1716162T1 (sl)	2010-12-31
DE602004028763D1 (de)	2010-09-30
AU2004312546A1 (en)	2005-07-21
US8268802B2 (en)	2012-09-18
PL212403B1 (pl)	2012-09-28
KR20060129360A (ko)	2006-12-15
NO20063479L (no)	2006-10-02
NO338040B1 (no)	2016-07-25
KR20120080240A (ko)	2012-07-16

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