DK170891B1 - 1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem - Google Patents

1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem Download PDF

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Publication number
DK170891B1
DK170891B1 DK529987A DK529987A DK170891B1 DK 170891 B1 DK170891 B1 DK 170891B1 DK 529987 A DK529987 A DK 529987A DK 529987 A DK529987 A DK 529987A DK 170891 B1 DK170891 B1 DK 170891B1
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DK
Denmark
Prior art keywords
group
methyl
dihydropyridine
compounds
nitrophenyl
Prior art date
Application number
DK529987A
Other languages
Danish (da)
English (en)
Other versions
DK529987D0 (da
DK529987A (da
Inventor
Hiroyuki Koike
Masafumi Yoshimoto
Hiroshi Nishino
Original Assignee
Sankyo Co
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co
Publication of DK529987D0 publication Critical patent/DK529987D0/da
Publication of DK529987A publication Critical patent/DK529987A/da
Application granted granted Critical
Publication of DK170891B1 publication Critical patent/DK170891B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK529987A 1986-10-09 1987-10-09 1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem DK170891B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24025486 1986-10-09
JP24025486 1986-10-09

Publications (3)

Publication Number Publication Date
DK529987D0 DK529987D0 (da) 1987-10-09
DK529987A DK529987A (da) 1988-04-10
DK170891B1 true DK170891B1 (da) 1996-03-04

Family

ID=17056752

Family Applications (1)

Application Number Title Priority Date Filing Date
DK529987A DK170891B1 (da) 1986-10-09 1987-10-09 1,4-dihydropyridin-3,5-dicarboxylsyrederivater og fremgangsmåde til fremstilling deraf samt farmaceutisk middel indeholdende dem

Country Status (20)

Country Link
US (1) US4772596A (ja)
EP (2) EP0529702B1 (ja)
JP (1) JPS63253082A (ja)
KR (1) KR920004483B1 (ja)
CN (1) CN1017897B (ja)
AT (2) ATE94162T1 (ja)
AU (1) AU600038B2 (ja)
CA (1) CA1309098C (ja)
DE (2) DE3751978T2 (ja)
DK (1) DK170891B1 (ja)
ES (2) ES2059391T3 (ja)
FI (1) FI90543C (ja)
GR (1) GR3022301T3 (ja)
HK (2) HK1005727A1 (ja)
HU (1) HU199454B (ja)
IE (1) IE63111B1 (ja)
NO (1) NO170084C (ja)
NZ (1) NZ222106A (ja)
RU (1) RU1831476C (ja)
ZA (1) ZA877518B (ja)

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FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
EP1285655B1 (en) * 2000-04-11 2007-05-30 Sankyo Company, Limited Stabilized pharmaceutical compositions containing the calcium channel blocker azelnidipine
AU2001284413A1 (en) * 2000-08-30 2002-03-13 Sankyo Company Limited Medicinal compositions for preventing or treating heart failure
JP4546726B2 (ja) * 2002-12-24 2010-09-15 宇部興産株式会社 光学活性なジヒドロピリジン誘導体
RU2294328C2 (ru) * 2002-12-24 2007-02-27 Санкио Компани, Лимитед Оптически активные производные дигидропиридина, их применение и терапевтическое средство на их основе
EP1604664A4 (en) * 2003-01-31 2006-12-27 Sankyo Co MEDICAMENT FOR THE PREVENTION AND TREATMENT OF ARTERIOSCLEROSIS AND BLOOD HIGH PRESSURE
JP4629973B2 (ja) * 2003-09-22 2011-02-09 第一三共株式会社 光学活性シクロプロピルアミン誘導体およびその製造方法
US7569599B2 (en) 2003-12-12 2009-08-04 Daiichi Pharmaceutical Co., Ltd. Intermediates for the production of optically active cyclopropylamine derivatives and process for the production of the intermediates
CA2612384A1 (en) * 2005-06-15 2006-12-28 Elan Pharma International, Limited Nanoparticulate azelnidipine formulations
ES2404939T3 (es) * 2005-06-27 2013-05-29 Daiichi Sankyo Company, Limited Preparación farmacéutica que contiene un antagonista del receptor de la angiotensina II y un bloqueador de los canales de calcio
CN100352818C (zh) * 2005-09-23 2007-12-05 四川科伦药业股份有限公司 一种改进的制备阿折地平的方法
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
JP2008290989A (ja) * 2007-05-28 2008-12-04 Ube Ind Ltd ジヒドロピリジン誘導体の酸付加塩を含有する医薬
JP2008290988A (ja) * 2007-05-28 2008-12-04 Ube Ind Ltd 光学活性なジヒドロピリジン誘導体の酸付加塩を含有する医薬
IT1391113B1 (it) * 2008-09-30 2011-11-18 Dipharma Francis Srl Procedimento per la preparazione di azelnidipina cristallina
JP5463051B2 (ja) * 2009-02-17 2014-04-09 相模化成工業株式会社 １，４―ジヒドロピリジン誘導体の製造法
CN101863879B (zh) * 2009-04-16 2012-12-19 四川科伦药物研究有限公司 一种α晶型阿折地平的制备方法
JP2011006379A (ja) * 2009-05-26 2011-01-13 Tokuyama Corp ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝（アゼルニジピン）の再結晶方法、アゼルニジピンのイソプロピルアルコール付加体、およびアゼルニジピンの製造方法
JP2011105649A (ja) * 2009-11-18 2011-06-02 Daito Kk アゼルニジピンの結晶
JP5637710B2 (ja) * 2010-03-24 2014-12-10 株式会社トクヤマ ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
JP2012020970A (ja) * 2010-07-15 2012-02-02 Tokuyama Corp ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝の製造方法
JP5859115B2 (ja) * 2011-04-29 2016-02-10 山東軒竹医薬科技有限公司 １，４−ジヒドロピリジン−３，５−ジカルボキシラート誘導体、その調製方法及びその使用
JP5917034B2 (ja) * 2011-07-15 2016-05-11 ニプロ株式会社 カルシウムブロッカーを含有する固形医薬組成物
MX2014002163A (es) 2011-08-26 2014-09-25 Wockhardt Ltd Métodos para el tratamiento de desórdenes cardiovasculares.
CN102329259B (zh) * 2011-10-21 2013-09-18 南京工业大学 (1-二苯甲基-3-吖丁啶醇)氰基乙酸酯的制备方法
CN102382104A (zh) * 2011-11-21 2012-03-21 山东新华制药股份有限公司 α晶型阿折地平的制备方法
CN103319457B (zh) * 2012-03-20 2016-01-27 北京晶润宏达医药科技有限公司 阿折地平γ晶型的制备方法
CN108430989B (zh) * 2015-10-13 2021-10-08 轩竹生物科技有限公司 1,4-二氢吡啶-3,5-二羧酸酯衍生物的制备方法及中间体

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DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
US3935223A (en) * 1972-03-06 1976-01-27 Bayer Aktiengesellschaft 2-Amino-1,4-dihydropyridine derivatives
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JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
DE3244178A1 (de) * 1982-11-30 1984-05-30 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridinderivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
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Also Published As

Publication number Publication date
NO170084B (no) 1992-06-01
AU7953787A (en) 1988-04-14
ATE146169T1 (de) 1996-12-15
HU199454B (en) 1990-02-28
DE3751978D1 (de) 1997-01-23
JPS63253082A (ja) 1988-10-20
CN1017897B (zh) 1992-08-19
HK1005726A1 (en) 1999-01-22
NO874219L (no) 1988-04-11
KR880005078A (ko) 1988-06-27
EP0529702A1 (en) 1993-03-03
DK529987D0 (da) 1987-10-09
NZ222106A (en) 1989-12-21
ES2097859T3 (es) 1997-04-16
CN87107150A (zh) 1988-05-04
FI874451A0 (fi) 1987-10-09
ZA877518B (en) 1989-06-28
DE3751978T2 (de) 1997-07-03
FI874451A (fi) 1988-04-10
NO170084C (no) 1992-09-09
IE872706L (en) 1988-04-09
RU1831476C (ru) 1993-07-30
CA1309098C (en) 1992-10-20
ES2059391T3 (es) 1994-11-16
DK529987A (da) 1988-04-10
GR3022301T3 (en) 1997-04-30
DE3787346D1 (de) 1993-10-14
AU600038B2 (en) 1990-08-02
FI90543B (fi) 1993-11-15
EP0266922A1 (en) 1988-05-11
DE3787346T2 (de) 1994-04-21
EP0266922B1 (en) 1993-09-08
ATE94162T1 (de) 1993-09-15
US4772596A (en) 1988-09-20
HK1005727A1 (en) 1999-01-22
JPH0331715B2 (ja) 1991-05-08
EP0529702B1 (en) 1996-12-11
NO874219D0 (no) 1987-10-09
KR920004483B1 (ko) 1992-06-05
IE63111B1 (en) 1995-03-22
FI90543C (fi) 1994-02-25
HUT47268A (en) 1989-02-28

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