DK167048B1 - Stabilt interferonkompleks, farmaceutisk praeparat indeholdende dette samt fremgangsmaade til fremstilling af interferonkomplekset - Google Patents

Stabilt interferonkompleks, farmaceutisk praeparat indeholdende dette samt fremgangsmaade til fremstilling af interferonkomplekset Download PDF

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Publication number
DK167048B1
DK167048B1 DK582188A DK582188A DK167048B1 DK 167048 B1 DK167048 B1 DK 167048B1 DK 582188 A DK582188 A DK 582188A DK 582188 A DK582188 A DK 582188A DK 167048 B1 DK167048 B1 DK 167048B1
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DK
Denmark
Prior art keywords
interferon
protamine
zinc
complex
salt
Prior art date
Application number
DK582188A
Other languages
Danish (da)
English (en)
Other versions
DK582188D0 (da
DK582188A (da
Inventor
Zachary Yim
Michael A Zupon
Imtiaz A Chaudry
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DK582188D0 publication Critical patent/DK582188D0/da
Publication of DK582188A publication Critical patent/DK582188A/da
Application granted granted Critical
Publication of DK167048B1 publication Critical patent/DK167048B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK582188A 1987-02-24 1988-10-19 Stabilt interferonkompleks, farmaceutisk praeparat indeholdende dette samt fremgangsmaade til fremstilling af interferonkomplekset DK167048B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1824387 1987-02-24
US07/018,243 US4853218A (en) 1987-02-24 1987-02-24 Zinc-protamine-alpha interferon complex
US8800410 1988-02-23
PCT/US1988/000410 WO1988006456A1 (en) 1987-02-24 1988-02-23 Stable interferon complexes

Publications (3)

Publication Number Publication Date
DK582188D0 DK582188D0 (da) 1988-10-19
DK582188A DK582188A (da) 1988-10-19
DK167048B1 true DK167048B1 (da) 1993-08-23

Family

ID=21786960

Family Applications (1)

Application Number Title Priority Date Filing Date
DK582188A DK167048B1 (da) 1987-02-24 1988-10-19 Stabilt interferonkompleks, farmaceutisk praeparat indeholdende dette samt fremgangsmaade til fremstilling af interferonkomplekset

Country Status (23)

Country Link
US (1) US4853218A (pt)
EP (2) EP0281299B1 (pt)
JP (1) JPH0611712B2 (pt)
KR (1) KR940001372B1 (pt)
AT (1) ATE76580T1 (pt)
AU (1) AU608584B2 (pt)
CA (1) CA1316105C (pt)
DE (1) DE3871407D1 (pt)
DK (1) DK167048B1 (pt)
ES (1) ES2032009T3 (pt)
FI (1) FI93309C (pt)
GR (1) GR3005358T3 (pt)
HU (1) HU201881B (pt)
IE (1) IE61340B1 (pt)
IL (1) IL85523A (pt)
MX (1) MX9203328A (pt)
MY (1) MY103212A (pt)
NO (1) NO173279C (pt)
NZ (1) NZ223598A (pt)
OA (1) OA09737A (pt)
PT (1) PT86810B (pt)
WO (1) WO1988006456A1 (pt)
ZA (1) ZA881258B (pt)

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PH26198A (en) * 1986-05-27 1992-03-18 Schering Corp Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
ES2054815T3 (es) * 1987-09-08 1994-08-16 Takeda Chemical Industries Ltd Citoquinas insolubilizadas en agua.
WO1991018927A1 (en) * 1990-06-04 1991-12-12 Schering Corporation Method for preparing interferon alpha-2 crystals
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
ES2151541T3 (es) * 1992-12-02 2001-01-01 Alkermes Inc Microesferas que contienen hormona del crecimiento de liberacion prolongada.
US5441734A (en) * 1993-02-25 1995-08-15 Schering Corporation Metal-interferon-alpha crystals
US6087324A (en) * 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
AU706180B2 (en) * 1994-07-25 1999-06-10 Alkermes Controlled Therapeutics, Inc. Controlled release of metal cation-stabilized interferon
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
CA2230494A1 (en) * 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics Inc. Composition for sustained release of an agent
EP0959873B1 (en) * 1996-12-20 2006-03-01 ALZA Corporation Gel composition and methods
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
NZ533436A (en) * 2001-11-14 2007-10-26 Alza Corp Catheter injectable depot compositons and uses thereof
WO2003041685A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Injectable depot composition
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
TWI353854B (en) 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK1539101T3 (da) * 2002-07-31 2009-04-27 Alza Corp Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
AU2003295409B2 (en) * 2002-11-06 2010-02-11 Durect Corporation Controlled release depot formulations
CA2512001A1 (en) * 2002-12-31 2004-07-22 Altus Pharmaceuticals Inc. Complexes of protein crystals and ionic polymers
SG176314A1 (en) * 2002-12-31 2011-12-29 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them
CN1822816A (zh) * 2003-05-30 2006-08-23 阿尔萨公司 可植入的弹性体储库组合物、其用途以及制备方法
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20050106214A1 (en) * 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US20050281879A1 (en) * 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
EP1976551A4 (en) * 2005-12-23 2009-12-30 Altus Pharmaceuticals Inc COMPOSITIONS COMPRISING COMPLEX PROTEIN CRYSTALS BY POLYCATIONS AND PROCESSING METHOD THEREOF
US7753077B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick for electrically operating valves
US7753078B2 (en) 2007-04-19 2010-07-13 Husco International Inc. Hybrid hydraulic joystick with an integral pressure sensor and an outlet port
JP4889782B2 (ja) * 2008-12-24 2012-03-07 株式会社マルハニチロ食品 プロタミン及び／またはその塩と酸性高分子化合物とを含む生理活性複合体及びその用途
US9050370B2 (en) * 2009-01-28 2015-06-09 Smartcells, Inc. Conjugate based systems for controlled drug delivery
EA026964B1 (ru) * 2010-11-24 2017-06-30 Дьюрект Корпорейшн Биоразлагаемая композиция для доставки лекарственного средства (варианты)
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1282504A (fr) * 1954-06-03 1962-01-27 Novo Terapeutisk Labor As Procédé de production de suspensions stables d'insuline zinc-protamine
US3912807A (en) * 1974-04-18 1975-10-14 American Home Prod Treatment of diabetes using somatostatin and insulin
IN150740B (pt) * 1978-11-24 1982-12-04 Hoffmann La Roche
NZ195980A (en) * 1980-01-08 1984-10-19 Biogen Nv Dna sequences,recombinant dna molecules and processes for producing leukocyte interferon-like polypeptides;pharmaceutical and veterinary compositions
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
DE3262575D1 (en) * 1981-12-23 1985-04-18 Schering Corp Stabilised interferon formulations and their preparation
US4605555A (en) * 1984-09-20 1986-08-12 Sun Star Kabushiki Kaisha Composition and method for treating keratosic disorder of skin and mucosa

Also Published As

Publication number Publication date
ZA881258B (en) 1988-08-23
OA09737A (en) 1993-11-30
DK582188D0 (da) 1988-10-19
KR890700359A (ko) 1989-04-24
AU1394688A (en) 1988-09-26
NO173279B (no) 1993-08-16
CA1316105C (en) 1993-04-13
MY103212A (en) 1993-05-29
MX9203328A (es) 1992-07-01
HU201881B (en) 1991-01-28
IL85523A0 (en) 1988-08-31
FI93309B (fi) 1994-12-15
DE3871407D1 (de) 1992-07-02
EP0281299A1 (en) 1988-09-07
FI93309C (fi) 1995-03-27
GR3005358T3 (pt) 1993-05-24
PT86810B (pt) 1992-05-29
NO173279C (no) 1993-11-24
FI893929A0 (fi) 1989-08-22
JPH0611712B2 (ja) 1994-02-16
IE61340B1 (en) 1994-11-02
ATE76580T1 (de) 1992-06-15
JPH03500286A (ja) 1991-01-24
DK582188A (da) 1988-10-19
ES2032009T3 (es) 1993-01-01
EP0281299B1 (en) 1992-05-27
WO1988006456A1 (en) 1988-09-07
PT86810A (pt) 1988-03-01
IL85523A (en) 1992-11-15
FI893929A (fi) 1989-08-22
NO884596L (no) 1988-10-14
AU608584B2 (en) 1991-04-11
KR940001372B1 (ko) 1994-02-21
IE880480L (en) 1988-08-24
HUT51902A (en) 1990-06-28
NO884596D0 (no) 1988-10-14
EP0375678A1 (en) 1990-07-04
US4853218A (en) 1989-08-01
NZ223598A (en) 1989-12-21

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed