DK167013B1 - 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer - Google Patents

4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer Download PDF

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Publication number
DK167013B1
DK167013B1 DK168488A DK168488A DK167013B1 DK 167013 B1 DK167013 B1 DK 167013B1 DK 168488 A DK168488 A DK 168488A DK 168488 A DK168488 A DK 168488A DK 167013 B1 DK167013 B1 DK 167013B1
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Prior art keywords
hydrogen
methyl
prop
ynyl
group
Prior art date
Application number
DK168488A
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Danish (da)
English (en)
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DK168488D0 (da
DK168488A (da
Inventor
Leslie Richard Hughes
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Ici Plc
Nat Res Dev
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Publication date
Application filed by Ici Plc, Nat Res Dev filed Critical Ici Plc
Publication of DK168488D0 publication Critical patent/DK168488D0/da
Publication of DK168488A publication Critical patent/DK168488A/da
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Publication of DK167013B1 publication Critical patent/DK167013B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK168488A 1987-03-25 1988-03-25 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer DK167013B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878707053A GB8707053D0 (en) 1987-03-25 1987-03-25 Anti-tumour agents
GB8707053 1987-03-25

Publications (3)

Publication Number Publication Date
DK168488D0 DK168488D0 (da) 1988-03-25
DK168488A DK168488A (da) 1988-09-26
DK167013B1 true DK167013B1 (da) 1993-08-16

Family

ID=10614570

Family Applications (1)

Application Number Title Priority Date Filing Date
DK168488A DK167013B1 (da) 1987-03-25 1988-03-25 4-oxo-6-aminomethyl-quinazolinderivater,fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende disse samt anvendelse af disse til fremstilling af laegemidler til behandling af tumorer

Country Status (17)

Country Link
US (1) US4981856A (ja)
EP (1) EP0284338B1 (ja)
JP (1) JP2577036B2 (ja)
AT (1) ATE98956T1 (ja)
AU (1) AU600105B2 (ja)
CA (1) CA1301756C (ja)
DE (1) DE3886435T2 (ja)
DK (1) DK167013B1 (ja)
ES (1) ES2061641T3 (ja)
FI (1) FI881340A (ja)
GB (2) GB8707053D0 (ja)
GR (1) GR3010208T3 (ja)
IL (1) IL85696A (ja)
NO (1) NO881300L (ja)
NZ (1) NZ224010A (ja)
PT (1) PT87074B (ja)
ZA (1) ZA881885B (ja)

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GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
EP0365763A1 (en) * 1988-09-30 1990-05-02 Agouron Pharmaceuticals, Inc. Antiproliferative cyclic compounds
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
ZA913730B (en) * 1990-05-30 1992-02-26 Ici Plc Anti-tumor compounds
GB9013615D0 (en) * 1990-06-19 1990-08-08 Wellcome Found Pharmaceutical compounds
GB9105771D0 (en) * 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
US5145854A (en) * 1991-11-27 1992-09-08 Nair Madhavan G 1-formyl-5,8,10-trideazafolates
GB9205320D0 (en) * 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
US5430148A (en) * 1992-03-31 1995-07-04 Agouron Pharmaceuticals, Inc. Antiproliferative quinazolines
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
DE4421884A1 (de) 1994-06-23 1996-01-04 Hoechst Ag Verfahren zur Herstellung von Hydroxycarbonsäureaniliden
DE4427837A1 (de) 1994-08-05 1996-02-08 Hoechst Ag Verfahren zur Herstellung von O-Acylglykolsäureaniliden
DE19504225A1 (de) 1995-02-09 1996-08-14 Hoechst Ag Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden
US5739330A (en) * 1996-02-05 1998-04-14 Hoechst Celanese Corporation Process for preparing quinazolones
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AU2002346471A1 (en) * 2001-11-20 2003-06-10 Cytokinetics, Inc. Process for the racemization of chiral quinazolinones
US7087418B2 (en) 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Pichia pastoris formate dehydrogenase and uses therefor
CA2475879A1 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Synthesis of quinazolinones
PL373412A1 (en) * 2002-05-09 2005-08-22 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods of their use for treating cellular proliferative diseases
WO2003097053A1 (en) * 2002-05-09 2003-11-27 Cytokinetics, Inc. Compounds, compositions, and methods
JP2005536475A (ja) 2002-05-23 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
EP1556357A4 (en) * 2002-06-14 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
US7211580B2 (en) * 2002-07-23 2007-05-01 Cytokinetics, Incorporated Compounds, compositions, and methods
EP1539180A4 (en) * 2002-08-21 2006-08-30 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
WO2004034972A2 (en) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
GB0317631D0 (en) * 2003-07-28 2003-08-27 Btg Int Ltd Synthetic method
WO2005041888A2 (en) * 2003-11-03 2005-05-12 Cytokinetics, Inc. Pyrimidin-4-one compounds, compositions and methods
US20050148593A1 (en) * 2003-11-07 2005-07-07 Gustave Bergnes Compounds, compositions, and methods
JP2007513154A (ja) * 2003-12-08 2007-05-24 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法
WO2009002808A2 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
DK3052485T3 (da) 2013-10-04 2021-10-11 Infinity Pharmaceuticals Inc Heterocykliske forbindelser og anvendelser deraf
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
SG11201607705XA (en) 2014-03-19 2016-10-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2065653B (en) * 1979-12-19 1983-03-09 Nat Res Dev Anti-cancer quinazoline derivatives
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents

Also Published As

Publication number Publication date
ES2061641T3 (es) 1994-12-16
NZ224010A (en) 1990-12-21
CA1301756C (en) 1992-05-26
DK168488D0 (da) 1988-03-25
GB2202847B (en) 1990-06-06
JP2577036B2 (ja) 1997-01-29
EP0284338A2 (en) 1988-09-28
ZA881885B (en) 1988-09-26
GB8805982D0 (en) 1988-04-13
AU600105B2 (en) 1990-08-02
FI881340A0 (fi) 1988-03-21
GB8707053D0 (en) 1987-04-29
DE3886435D1 (de) 1994-02-03
AU1327988A (en) 1988-09-29
FI881340A (fi) 1988-09-26
NO881300L (no) 1988-09-26
IL85696A (en) 1993-05-13
GB2202847A (en) 1988-10-05
ATE98956T1 (de) 1994-01-15
US4981856A (en) 1991-01-01
NO881300D0 (no) 1988-03-24
EP0284338A3 (en) 1989-05-17
PT87074A (pt) 1988-04-01
GR3010208T3 (ja) 1994-03-31
DK168488A (da) 1988-09-26
JPS63255270A (ja) 1988-10-21
PT87074B (pt) 1992-07-31
EP0284338B1 (en) 1993-12-22
DE3886435T2 (de) 1994-04-14

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
B1 Patent granted (law 1993)
PBP Patent lapsed