DK157844C - Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive n-alkyl-(2,6-dialkoxybenzamidometyl)-pyrrolidiner eller farmaceutisk acceptable salte deraf med syrer samt mellemprodukt til brug i fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive n-alkyl-(2,6-dialkoxybenzamidometyl)-pyrrolidiner eller farmaceutisk acceptable salte deraf med syrer samt mellemprodukt til brug i fremgangsmaaden

Info

Publication number: DK157844C
Authority: DK; Denmark
Prior art keywords: fruit; milk; mild; acid; dialcoxybenzamidomethyl
Prior art date: 1978-03-23

Application number

DK117779A

Other languages

Danish (da)

English (en)

Other versions

DK157844B (da

DK117779A (da

Inventor

Goesta Lennart Florvall

Sven Ove Oegren

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-03-23

Filing date

1979-03-22

Publication date

1990-07-30

1979-03-22 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1979-09-24 Publication of DK117779A publication Critical patent/DK117779A/da

1990-02-26 Publication of DK157844B publication Critical patent/DK157844B/da

1990-07-30 Application granted granted Critical

1990-07-30 Publication of DK157844C publication Critical patent/DK157844C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Oil, Petroleum & Natural Gas (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK117779A 1978-03-23 1979-03-22 Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive n-alkyl-(2,6-dialkoxybenzamidometyl)-pyrrolidiner eller farmaceutisk acceptable salte deraf med syrer samt mellemprodukt til brug i fremgangsmaaden DK157844C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE7803411A SE411118B (sv)	1978-03-23	1978-03-23	Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper
SE7803411		1978-03-23

Publications (3)

Publication Number	Publication Date
DK117779A DK117779A (da)	1979-09-24
DK157844B DK157844B (da)	1990-02-26
DK157844C true DK157844C (da)	1990-07-30

Family

ID=20334412

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK117779A DK157844C (da)	1978-03-23	1979-03-22	Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive n-alkyl-(2,6-dialkoxybenzamidometyl)-pyrrolidiner eller farmaceutisk acceptable salte deraf med syrer samt mellemprodukt til brug i fremgangsmaaden

Country Status (26)

Country	Link
US (1)	US4232037A (de)
EP (1)	EP0004831B1 (de)
JP (1)	JPS585910B2 (de)
AT (1)	AT374173B (de)
AU (1)	AU525475B2 (de)
CA (1)	CA1101873A (de)
CS (1)	CS226183B2 (de)
DD (1)	DD143605A5 (de)
DE (1)	DE2964774D1 (de)
DK (1)	DK157844C (de)
ES (1)	ES478871A1 (de)
FI (1)	FI73979C (de)
HK (1)	HK77085A (de)
HU (1)	HU177793B (de)
IE (1)	IE48491B1 (de)
LT (1)	LT2246B (de)
LU (1)	LU88308I2 (de)
MX (1)	MX9203148A (de)
MY (1)	MY8500407A (de)
NL (1)	NL930052I2 (de)
NO (1)	NO152414C (de)
NZ (1)	NZ189935A (de)
SE (1)	SE411118B (de)
SG (1)	SG51885G (de)
SU (1)	SU818481A3 (de)
ZA (1)	ZA79964B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8101536L (sv) *	1981-03-11	1982-09-12	Astra Laekemedel Ab	Bensamid-derivat
US4470977A (en) *	1981-06-04	1984-09-11	Adria Laboratories, Inc.	Antiemetic and antipsychotic agents
SE8205135D0 (sv) *	1982-09-09	1982-09-09	Astra Laekemedel Ab	Benzamido-derivatives
US5240957A (en) *	1984-01-31	1993-08-31	Astra Lakemedel Akteibolag	Oxysalicylamido derivatives
SE8400478D0 (sv) *	1984-01-31	1984-01-31	Astra Laekemedel Ab	Oxysalicylamido derivatives
SE8503054D0 (sv) *	1985-06-19	1985-06-19	Astra Laekemedel Ab	Catecholcarboxamides
DE3629598A1 (de) *	1986-08-30	1988-03-03	Boehringer Ingelheim Kg	3-brom-2,6-dimethoxibenzamide, ihre herstellung und verwendung
US4772459A (en) *	1986-09-09	1988-09-20	Erbamont, Inc.	Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4751236A (en) *	1987-05-20	1988-06-14	Avihou Mishniot	Method for treating genital herpes
US5154913A (en) *	1987-11-19	1992-10-13	Vanderbilt University	Radioiodinated benzamines method of their use as radioimaging agents
US5231099A (en) *	1991-04-15	1993-07-27	Du Pont Merck Pharmaceutical Company	Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs
EP0594758A1 (de) *	1991-07-15	1994-05-04	Merck & Co. Inc.	Neues verfahren zur aromatischen bromierung
US5248817A (en) *	1991-07-15	1993-09-28	Merck & Co., Inc.	Process for aromatic bromination
CN104058956A (zh) *	2014-06-04	2014-09-24	蚌埠团结日用化学有限公司	3-溴-2，6二甲氧基苯甲酸合成的生产工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DD67123A (de) *
US3342826A (en) *	1964-01-13	1967-09-19	Ile De France	Heterocyclic aminoalkyl benzamides
FR5916M (de) *	1966-01-21	1968-05-06
BE695272A (de) *	1967-03-09	1967-09-11
US3862139A (en) *	1972-06-23	1975-01-21	Delmar Chem	Heterocyclic benzamide compounds
IT1070992B (it) *	1973-12-21	1985-04-02	Italfarmaco Spa	Processo per la preparazione della i etil 2 2 metossi 5 sulfamoil benzamidometil pirrolidina
CH605793A5 (de) *	1974-03-05	1978-10-13	Ile De France
FR2294698A1 (fr) *	1974-12-18	1976-07-16	Synthelabo	Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
DE2556457C3 (de) *	1974-12-18	1981-02-12	Synthelabo S.A., Paris	N-(Pyrrolidin-2-yl-methyl)-2-methoxybenzamide, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

1978
- 1978-03-23 SE SE7803411A patent/SE411118B/sv unknown
1979
- 1979-02-28 ZA ZA79964A patent/ZA79964B/xx unknown
- 1979-03-01 CA CA322,555A patent/CA1101873A/en not_active Expired
- 1979-03-05 EP EP79850013A patent/EP0004831B1/de not_active Expired
- 1979-03-05 DE DE7979850013T patent/DE2964774D1/de not_active Expired
- 1979-03-08 US US06/018,784 patent/US4232037A/en not_active Expired - Lifetime
- 1979-03-19 FI FI790922A patent/FI73979C/fi not_active IP Right Cessation
- 1979-03-19 AU AU45219/79A patent/AU525475B2/en not_active Ceased
- 1979-03-19 NZ NZ189935A patent/NZ189935A/en unknown
- 1979-03-20 NO NO790934A patent/NO152414C/no unknown
- 1979-03-22 DK DK117779A patent/DK157844C/da not_active IP Right Cessation
- 1979-03-22 DD DD79211750A patent/DD143605A5/de not_active IP Right Cessation
- 1979-03-22 CS CS791902A patent/CS226183B2/cs unknown
- 1979-03-22 ES ES478871A patent/ES478871A1/es not_active Expired
- 1979-03-22 SU SU792739699A patent/SU818481A3/ru active
- 1979-03-22 HU HU79AA924A patent/HU177793B/hu not_active IP Right Cessation
- 1979-03-23 AT AT0217779A patent/AT374173B/de not_active IP Right Cessation
- 1979-03-23 JP JP54033429A patent/JPS585910B2/ja not_active Expired
- 1979-08-08 IE IE630/79A patent/IE48491B1/en not_active IP Right Cessation
1985
- 1985-07-01 SG SG518/85A patent/SG51885G/en unknown
- 1985-10-10 HK HK770/85A patent/HK77085A/xx not_active IP Right Cessation
- 1985-12-30 MY MY407/85A patent/MY8500407A/xx unknown
1992
- 1992-06-23 MX MX9203148A patent/MX9203148A/es unknown
1993
- 1993-06-10 NL NL930052C patent/NL930052I2/nl unknown
- 1993-06-16 LU LU88308C patent/LU88308I2/fr unknown
- 1993-09-06 LT LTRP936A patent/LT2246B/xx unknown

Also Published As

Publication number	Publication date
JPS585910B2 (ja)	1983-02-02
US4232037A (en)	1980-11-04
NO790934L (no)	1979-09-25
ZA79964B (en)	1980-06-25
FI73979B (fi)	1987-08-31
AU525475B2 (en)	1982-11-11
NO152414B (no)	1985-06-17
DK157844B (da)	1990-02-26
LU88308I2 (fr)	1994-05-04
EP0004831A2 (de)	1979-10-17
EP0004831B1 (de)	1983-02-16
DD143605A5 (de)	1980-09-03
SU818481A3 (ru)	1981-03-30
NO152414C (no)	1985-09-25
DE2964774D1 (en)	1983-03-24
CS226183B2 (en)	1984-03-19
SE411118B (sv)	1979-12-03
HU177793B (en)	1981-12-28
FI73979C (fi)	1987-12-10
SG51885G (en)	1986-01-24
AU4521979A (en)	1979-09-27
MX9203148A (es)	1992-07-01
ES478871A1 (es)	1979-07-01
NL930052I1 (nl)	1993-09-01
JPS54154730A (en)	1979-12-06
HK77085A (en)	1985-10-18
SE7803411L (sv)	1979-09-24
NZ189935A (en)	1984-07-06
CA1101873A (en)	1981-05-26
LT2246B (lt)	1993-11-15
IE48491B1 (en)	1985-02-06
AT374173B (de)	1984-03-26
IE790630L (en)	1979-09-23
DK117779A (da)	1979-09-24
MY8500407A (en)	1985-12-31
NL930052I2 (nl)	1994-01-03
ATA217779A (de)	1983-08-15
EP0004831A3 (en)	1979-10-31
FI790922A (fi)	1979-09-24

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Legal Events

Date	Code	Title	Description
1993-09-13	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1993 00051, 930630
1994-12-05	CTFF	Application for supplementary protection certificate (spc) filed	Free format text: CA 1993 00051, 930630
1997-11-17	PBP	Patent lapsed