DK1569929T3 - Forbindelser og fremgangsmåder til behandling eller forebyggelse af flavi-virusinfektioner - Google Patents
Forbindelser og fremgangsmåder til behandling eller forebyggelse af flavi-virusinfektionerInfo
- Publication number
- DK1569929T3 DK1569929T3 DK03767343.1T DK03767343T DK1569929T3 DK 1569929 T3 DK1569929 T3 DK 1569929T3 DK 03767343 T DK03767343 T DK 03767343T DK 1569929 T3 DK1569929 T3 DK 1569929T3
- Authority
- DK
- Denmark
- Prior art keywords
- treating
- compounds
- methods
- flavivirus infections
- preventing flavivirus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43196402P | 2002-12-10 | 2002-12-10 | |
| PCT/CA2003/001912 WO2004052885A1 (en) | 2002-12-10 | 2003-12-09 | Compounds and methods for the treatment or prevention of flavivirus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1569929T3 true DK1569929T3 (da) | 2010-08-16 |
Family
ID=42828817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03767343.1T DK1569929T3 (da) | 2002-12-10 | 2003-12-09 | Forbindelser og fremgangsmåder til behandling eller forebyggelse af flavi-virusinfektioner |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1569929B9 (da) |
| JP (1) | JP4926403B2 (da) |
| AT (1) | ATE466856T1 (da) |
| AU (1) | AU2003291885A1 (da) |
| BR (1) | BR0316771A (da) |
| CA (1) | CA2508990C (da) |
| DK (1) | DK1569929T3 (da) |
| MX (1) | MXPA05006196A (da) |
| NZ (1) | NZ540799A (da) |
| WO (1) | WO2004052885A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004061746A1 (de) * | 2004-12-22 | 2006-07-06 | Bayer Healthcare Ag | Alkinyl-substituierte Thiophene |
| US7569600B2 (en) | 2005-05-13 | 2009-08-04 | Virochem Pharma Inc. | Compounds and methods for the treatment of prevention of Flavivirus infections |
| US20090136448A1 (en) * | 2005-12-22 | 2009-05-28 | John Andrew Corfield | Antiviral 2-Carboxy-Thiophene Compounds |
| WO2008017688A1 (en) * | 2006-08-11 | 2008-02-14 | Smithkline Beecham Corporation | 2-carboxy thiophene derivatives as anti-viral agents |
| WO2008043791A2 (en) * | 2006-10-13 | 2008-04-17 | Smithkline Beecham Corporation | Thiophene derivatives for treating hepatitis c |
| EP2559692A1 (en) | 2006-11-15 | 2013-02-20 | Virochem Pharma Inc. | Thiophene analogues for the treatment or prevention of Flavivirus infections |
| ES2381410T3 (es) | 2007-05-04 | 2012-05-28 | Vertex Pharmceuticals Incorporated | Terapia de combinación paa el tratamiento de infecciones por VHC |
| GB0712393D0 (en) * | 2007-06-26 | 2007-08-01 | Smithkline Beecham Corp | Compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| BRPI1006825A2 (pt) | 2009-01-09 | 2019-04-24 | Univ Texas | compostos pró-neurogênicos |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| PE20120666A1 (es) | 2009-07-21 | 2012-06-01 | Gilead Sciences Inc | Inhibidores de los virus flaviviridae |
| ES2559437T3 (es) * | 2009-09-09 | 2016-02-12 | Gilead Sciences, Inc. | Inhibidores de virus de la familia Flaviviridae |
| CA2781614A1 (en) * | 2009-11-25 | 2011-06-09 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
| US8524764B2 (en) * | 2010-01-15 | 2013-09-03 | Gilead Sciences, Inc. | Inhibitors of Flaviviridae viruses |
| PL2523950T3 (pl) | 2010-01-15 | 2017-09-29 | Gilead Sciences, Inc. | Inhibitory wirusów flaviviridae |
| WO2012006070A1 (en) * | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
| JP6126528B2 (ja) | 2010-07-07 | 2017-05-10 | ザ・ボード・オブ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・テキサス・システムＴｈｅ Ｂｏａｒｄ Ｏｆ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｔｅｘａｓ Ｓｙｓｔｅｍ | 神経新生促進化合物 |
| CA2808291A1 (en) * | 2010-08-17 | 2012-02-23 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
| TW201307334A (zh) | 2010-12-17 | 2013-02-16 | Cocrystal Discovery Inc | Ｃ型肝炎病毒聚合酶抑制劑 |
| US8741946B2 (en) | 2011-07-13 | 2014-06-03 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| WO2013016501A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Formulations of thiophene compounds |
| WO2014055142A1 (en) | 2012-06-20 | 2014-04-10 | Cocrystal Discovery, Inc. | Inhibitors of hepatitis c virus polymerase |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| CA2882826A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| US9902713B2 (en) | 2013-11-11 | 2018-02-27 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| TWI731854B (zh) | 2015-03-23 | 2021-07-01 | 美商共結晶製藥公司 | Ｃ型肝炎病毒聚合酶之抑制劑 |
| MX2020011912A (es) | 2018-05-09 | 2021-01-29 | Cocrystal Pharma Inc | Terapia de combinacion para el tratamiento del virus de la hepatitis c (vhc). |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005170A1 (en) * | 1993-08-13 | 1995-02-23 | Warner-Lambert Company | Methods of inhibiting hiv and inhibiting the activation of hiv |
| US5734081A (en) * | 1994-08-05 | 1998-03-31 | Warner-Lambert Company | Arylthio compounds |
| EP1202733B1 (en) * | 1999-08-12 | 2005-10-05 | Pharmacia Italia S.p.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| WO2002085899A1 (en) * | 2001-04-19 | 2002-10-31 | Vertex Pharmaceuticals Incorporated | Heterocyclyldicarbamides as caspase inhibitors |
| JP2005500287A (ja) * | 2001-06-11 | 2005-01-06 | シャイアー バイオケム インコーポレイテッド | Ｆｌａｖｉｖｉｒｕｓ感染の処置または予防のための化合物および方法 |
| US6881741B2 (en) * | 2001-06-11 | 2005-04-19 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of Flavivirus infections |
-
2003
- 2003-12-09 DK DK03767343.1T patent/DK1569929T3/da active
- 2003-12-09 WO PCT/CA2003/001912 patent/WO2004052885A1/en active Application Filing
- 2003-12-09 NZ NZ540799A patent/NZ540799A/en not_active IP Right Cessation
- 2003-12-09 AU AU2003291885A patent/AU2003291885A1/en not_active Abandoned
- 2003-12-09 AT AT03767343T patent/ATE466856T1/de active
- 2003-12-09 CA CA2508990A patent/CA2508990C/en not_active Expired - Fee Related
- 2003-12-09 EP EP03767343A patent/EP1569929B9/en not_active Expired - Lifetime
- 2003-12-09 MX MXPA05006196A patent/MXPA05006196A/es active IP Right Grant
- 2003-12-09 JP JP2004557712A patent/JP4926403B2/ja not_active Expired - Fee Related
- 2003-12-09 BR BR0316771-2A patent/BR0316771A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2508990C (en) | 2013-05-28 |
| EP1569929A1 (en) | 2005-09-07 |
| ATE466856T1 (de) | 2010-05-15 |
| EP1569929B1 (en) | 2010-05-05 |
| JP2006510636A (ja) | 2006-03-30 |
| NZ540799A (en) | 2008-09-26 |
| BR0316771A (pt) | 2005-10-25 |
| MXPA05006196A (es) | 2006-01-27 |
| AU2003291885A1 (en) | 2004-06-30 |
| JP4926403B2 (ja) | 2012-05-09 |
| CA2508990A1 (en) | 2004-06-24 |
| EP1569929B9 (en) | 2011-09-14 |
| WO2004052885A1 (en) | 2004-06-24 |
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