DK1567652T3 - Nye neomycin-phosphotransferasegener og fremgangsmåde til selektion af höjtproducerende rekombinante celler - Google Patents
Nye neomycin-phosphotransferasegener og fremgangsmåde til selektion af höjtproducerende rekombinante cellerInfo
- Publication number
- DK1567652T3 DK1567652T3 DK03812157T DK03812157T DK1567652T3 DK 1567652 T3 DK1567652 T3 DK 1567652T3 DK 03812157 T DK03812157 T DK 03812157T DK 03812157 T DK03812157 T DK 03812157T DK 1567652 T3 DK1567652 T3 DK 1567652T3
- Authority
- DK
- Denmark
- Prior art keywords
- neomycin phosphotransferase
- recombinant cells
- producing recombinant
- selecting high
- phosphotransferase genes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01095—Kanamycin kinase (2.7.1.95), i.e. neomycin-kanamycin phosphotransferase
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10256081 | 2002-11-29 | ||
| DE10330686A DE10330686A1 (de) | 2002-11-29 | 2003-07-08 | Neue Neomycin-Phosphotransferase-Gene und Verfahren zur Selektion von Hochproduzierenden rekombinanten Zellen |
| PCT/EP2003/013203 WO2004050884A2 (de) | 2002-11-29 | 2003-11-25 | Neue neomycin-phosphotransferase-gene und verfahren zur selektion von hochproduzierenden rekombinanten zellen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1567652T3 true DK1567652T3 (da) | 2007-11-26 |
Family
ID=32471486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03812157T DK1567652T3 (da) | 2002-11-29 | 2003-11-25 | Nye neomycin-phosphotransferasegener og fremgangsmåde til selektion af höjtproducerende rekombinante celler |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1567652B1 (ja) |
| JP (1) | JP4344325B2 (ja) |
| KR (1) | KR101149777B1 (ja) |
| AT (1) | ATE371035T1 (ja) |
| AU (1) | AU2003302689B2 (ja) |
| BR (1) | BR0316525A (ja) |
| CA (1) | CA2507664C (ja) |
| DE (1) | DE50308030D1 (ja) |
| DK (1) | DK1567652T3 (ja) |
| ES (1) | ES2293096T3 (ja) |
| MX (1) | MXPA05005481A (ja) |
| WO (1) | WO2004050884A2 (ja) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| FR2897068B1 (fr) * | 2006-02-03 | 2008-04-18 | Biomethodes Sa | Kanamycine kinase ii amelioree et utilisations de celle-ci |
| US20080124760A1 (en) | 2006-07-26 | 2008-05-29 | Barbara Enenkel | Regulatory Nucleic Acid Elements |
| EP1975228A1 (en) | 2007-03-28 | 2008-10-01 | Fachhochschule Mannheim | Polynucleotides for enhancing expression of a polynucleotide of interest |
| WO2010074080A1 (ja) * | 2008-12-22 | 2010-07-01 | 国立大学法人北海道大学 | 動物細胞を用いて外来遺伝子由来タンパク質を大量に生産するための発現ベクター、およびその利用 |
| JP4525863B1 (ja) | 2009-06-05 | 2010-08-18 | 東洋紡績株式会社 | 高生産性細胞の樹立のための発現ベクター及び高生産性細胞 |
| JP4491808B1 (ja) * | 2009-06-05 | 2010-06-30 | 東洋紡績株式会社 | 高発現細胞の効率的な選別に有用な薬剤選択マーカー遺伝子発現カセット |
| JP4547643B1 (ja) * | 2009-06-05 | 2010-09-22 | 東洋紡績株式会社 | クローニングに最適化された発現ベクター |
| US20120258496A1 (en) | 2010-09-27 | 2012-10-11 | Boehringer Ingelheim International Gmbh | Production of low fucose antibodies in h4-ii-e rat cells |
| BR112014010198B1 (pt) | 2011-10-28 | 2022-12-06 | Prothena Biosciences Limited | Anticorpos humanizados que reconhecem alfa-sinucleína |
| US8790644B2 (en) | 2012-01-27 | 2014-07-29 | Neotope Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| WO2013182553A2 (en) | 2012-06-06 | 2013-12-12 | Boehringer Ingelheim International Gmbh | CELL ENGINEERING USING RNAs |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| WO2014102103A2 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within a signal peptide |
| WO2014102101A1 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
| JP6674888B2 (ja) | 2013-03-13 | 2020-04-01 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
| US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| US9850302B2 (en) | 2013-07-12 | 2017-12-26 | Prothena Biosciences Limited | Antibodies that recognize IAPP |
| WO2015004633A1 (en) | 2013-07-12 | 2015-01-15 | Neotope Biosciences Limited | Antibodies that recognize islet-amyloid polypeptide (iapp) |
| US11191832B2 (en) | 2013-11-19 | 2021-12-07 | Prothena Biosciences Limited | Monitoring immunotherapy of Lewy body disease from constipation symptoms |
| WO2015136471A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-laminin4 antibodies specific for lg1-3 |
| KR20160131073A (ko) | 2014-03-12 | 2016-11-15 | 프로테나 바이오사이언시즈 리미티드 | Lg4-5에 대해 특이적인 항-라미닌4 항체 |
| TW201623331A (zh) | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子（ｍｃａｍ）抗體類及使用彼等之相關方法 |
| WO2015136469A1 (en) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| JP6744856B2 (ja) | 2014-04-08 | 2020-08-19 | プロセナ・バイオサイエンシズ・リミテッド | α−シヌクレインを認識する抗体を含む血液脳関門シャトル |
| TWI769570B (zh) | 2015-01-28 | 2022-07-01 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI718121B (zh) | 2015-01-28 | 2021-02-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| TWI786505B (zh) | 2015-01-28 | 2022-12-11 | 愛爾蘭商普羅佘納生物科技有限公司 | 抗甲狀腺素運送蛋白抗體 |
| WO2017046774A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017046776A2 (en) | 2015-09-16 | 2017-03-23 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of giant cell arteritis, polymyalgia rheumatica or takayasu's arteritis |
| WO2017149513A1 (en) | 2016-03-03 | 2017-09-08 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| WO2017153953A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| WO2017153955A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| KR102533675B1 (ko) | 2016-05-02 | 2023-05-22 | 프로테나 바이오사이언시즈 리미티드 | 타우 인식 항체 |
| EA201892417A1 (ru) | 2016-05-02 | 2019-05-31 | Протена Биосайенсис Лимитед | Антитела, распознающие тау |
| FI3452507T3 (fi) | 2016-05-02 | 2022-12-15 | Tau-immuunihoito | |
| WO2017208210A1 (en) | 2016-06-03 | 2017-12-07 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| JP7076711B2 (ja) | 2016-07-02 | 2022-05-30 | プロセナ バイオサイエンシーズ リミテッド | 抗トランスサイレチン抗体 |
| EP3478715A2 (en) | 2016-07-02 | 2019-05-08 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| JP7017013B2 (ja) | 2016-07-02 | 2022-02-08 | プロセナ バイオサイエンシーズ リミテッド | 抗トランスサイレチン抗体 |
| WO2018093331A1 (en) * | 2016-11-16 | 2018-05-24 | Agency For Science, Technology And Research | Attenuated glutamine synthetase as a selection marker |
| CN110881274A (zh) | 2017-05-02 | 2020-03-13 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| CA3076313A1 (en) | 2017-09-28 | 2019-04-04 | Prothena Biosciences Limited | Dosing regimes for treatment of synucleinopathies |
| KR20210094610A (ko) | 2018-11-26 | 2021-07-29 | 포티 세븐, 인코포레이티드 | c-Kit에 대한 인간화 항체 |
| BR112021016947A2 (pt) | 2019-03-03 | 2021-11-03 | Prothena Biosciences Ltd | Anticorpos que reconhecem tau |
| WO2021207401A1 (en) * | 2020-04-07 | 2021-10-14 | Io Biosciences, Inc. | Nucleic acid constructs comprising gene editing multi-sites |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04179485A (ja) * | 1990-11-09 | 1992-06-26 | Junichi Miyazaki | 新規ベクターおよび該ベクターを用いて高発現形質転換細胞を選択する方法 |
| JP2004179485A (ja) | 2002-11-28 | 2004-06-24 | Matsushita Electric Ind Co Ltd | プリント配線板の製造方法及びプリント配線板 |
-
2003
- 2003-11-25 DE DE50308030T patent/DE50308030D1/de not_active Expired - Lifetime
- 2003-11-25 MX MXPA05005481A patent/MXPA05005481A/es active IP Right Grant
- 2003-11-25 DK DK03812157T patent/DK1567652T3/da active
- 2003-11-25 ES ES03812157T patent/ES2293096T3/es not_active Expired - Lifetime
- 2003-11-25 WO PCT/EP2003/013203 patent/WO2004050884A2/de active IP Right Grant
- 2003-11-25 AU AU2003302689A patent/AU2003302689B2/en not_active Ceased
- 2003-11-25 AT AT03812157T patent/ATE371035T1/de active
- 2003-11-25 JP JP2004570678A patent/JP4344325B2/ja not_active Expired - Lifetime
- 2003-11-25 KR KR1020057009681A patent/KR101149777B1/ko active IP Right Grant
- 2003-11-25 EP EP03812157A patent/EP1567652B1/de not_active Expired - Lifetime
- 2003-11-25 BR BR0316525-6A patent/BR0316525A/pt active Pending
- 2003-11-25 CA CA2507664A patent/CA2507664C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE50308030D1 (de) | 2007-10-04 |
| EP1567652B1 (de) | 2007-08-22 |
| AU2003302689A1 (en) | 2004-06-23 |
| AU2003302689B2 (en) | 2009-02-05 |
| WO2004050884A2 (de) | 2004-06-17 |
| CA2507664A1 (en) | 2004-06-17 |
| ES2293096T3 (es) | 2008-03-16 |
| KR101149777B1 (ko) | 2012-06-11 |
| BR0316525A (pt) | 2005-10-04 |
| KR20050085202A (ko) | 2005-08-29 |
| MXPA05005481A (es) | 2005-07-25 |
| JP2006507842A (ja) | 2006-03-09 |
| CA2507664C (en) | 2010-09-07 |
| JP4344325B2 (ja) | 2009-10-14 |
| WO2004050884A3 (de) | 2004-07-15 |
| EP1567652A2 (de) | 2005-08-31 |
| ATE371035T1 (de) | 2007-09-15 |
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