DK148189A - Fremgangsmaade til fremstilling af phenolsubstituerede gem-diphosphonatderivater - Google Patents
Fremgangsmaade til fremstilling af phenolsubstituerede gem-diphosphonatderivaterInfo
- Publication number
- DK148189A DK148189A DK148189A DK148189A DK148189A DK 148189 A DK148189 A DK 148189A DK 148189 A DK148189 A DK 148189A DK 148189 A DK148189 A DK 148189A DK 148189 A DK148189 A DK 148189A
- Authority
- DK
- Denmark
- Prior art keywords
- phenol
- procedure
- preparation
- diphosphonate derivatives
- substituted gem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3865—Polyphosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/4043—Esters of poly(thio)phosphonic acids containing sulfur substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1239/88A CH675422A5 (da) | 1988-03-31 | 1988-03-31 | |
CH123988 | 1988-03-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK148189D0 DK148189D0 (da) | 1989-03-28 |
DK148189A true DK148189A (da) | 1989-10-17 |
DK173936B1 DK173936B1 (da) | 2002-02-25 |
Family
ID=4205733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198901481A DK173936B1 (da) | 1988-03-31 | 1989-03-28 | Phenolsubstituerede gem-diphosphonatderivater, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger indeholdende disse |
Country Status (25)
Country | Link |
---|---|
US (2) | US5043330A (da) |
EP (1) | EP0339237B1 (da) |
JP (1) | JPH0822865B2 (da) |
KR (1) | KR0147830B1 (da) |
CN (2) | CN1024555C (da) |
AR (1) | AR247569A1 (da) |
AT (1) | ATE84040T1 (da) |
AU (1) | AU612475B2 (da) |
CA (1) | CA1338495C (da) |
CH (1) | CH675422A5 (da) |
DE (2) | DE68904104T2 (da) |
DK (1) | DK173936B1 (da) |
ES (1) | ES2011210T3 (da) |
FI (1) | FI92933C (da) |
GR (2) | GR900300002T1 (da) |
HU (1) | HU203556B (da) |
IE (1) | IE62692B1 (da) |
IL (1) | IL89649A (da) |
MY (1) | MY103850A (da) |
NO (1) | NO891317L (da) |
NZ (1) | NZ228516A (da) |
PH (1) | PH27603A (da) |
PT (1) | PT90175B (da) |
ZA (1) | ZA892126B (da) |
ZW (1) | ZW3789A1 (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0377894A (ja) * | 1989-08-18 | 1991-04-03 | Toray Ind Inc | メチレンジホスホン酸化合物 |
JPH05163150A (ja) * | 1991-05-13 | 1993-06-29 | E R Squibb & Sons Inc | アテローム性動脈硬化症の抑制・治療剤 |
US5157027A (en) * | 1991-05-13 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Bisphosphonate squalene synthetase inhibitors and method |
CA2067974A1 (en) * | 1991-05-13 | 1992-11-14 | Scott A. Biller | Method for lowering cholesterol employing a phosphonomethylphosphinate squalene synthetase inhibitor |
WO1993005052A1 (fr) * | 1991-09-05 | 1993-03-18 | Toray Industries, Inc. | Derive d'acide methanediphosphonique, sa production et son utilisation comme remede |
EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
JPH06172372A (ja) * | 1991-11-06 | 1994-06-21 | Takeda Chem Ind Ltd | スクアレン合成酵素阻害剤およびその用途 |
FR2683529B1 (fr) * | 1991-11-12 | 1994-02-04 | Bretagne Occidentale Universite | Composes pharmaceutiques gem-diphosphonates analogues du cis-platine. |
CH683996A5 (fr) * | 1992-03-05 | 1994-06-30 | Symphar Sa | Dérivés aminophosphonates substitués, leur procédé de préparation et compositions pharmaceutiques les contenant. |
WO1994001442A1 (en) * | 1992-07-10 | 1994-01-20 | Toray Industries, Inc. | Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof |
US5332728A (en) * | 1992-11-23 | 1994-07-26 | Bristol-Myers Squibb Company | Method for treating a fungal infection |
US5434288A (en) * | 1992-12-01 | 1995-07-18 | Monsanto Company | PLA2 inhibitors |
ZA941088B (en) * | 1993-02-19 | 1995-09-27 | Symphar Sa | Substituted ketophosphonates the processes for their preparation and pharmaceutical compositions containing them |
JP2546067B2 (ja) * | 1993-02-25 | 1996-10-23 | 東レ株式会社 | メタンジホスホン酸化合物の製造方法 |
US5419845A (en) * | 1994-03-15 | 1995-05-30 | Basf Corporation | Perfluorinated gemdiphosphonates as corrosion inhibitors for antifreeze coolants and other functional fluids |
ES2196075T3 (es) * | 1994-08-24 | 2003-12-16 | Toray Industries | Procedimiento para producir un compuesto del acido metanodifosfonico. |
CH690163A5 (fr) * | 1995-07-28 | 2000-05-31 | Symphar Sa | Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers. |
GB9603637D0 (en) * | 1996-02-21 | 1996-04-17 | Smithkline Beecham Plc | Process |
AU2783397A (en) * | 1996-05-15 | 1997-12-05 | University Of Sheffield, The | Isopentenyl pyrophosphate isomerase (ipi) and/or prenyl transferase inhibitors |
US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
ES2241139T3 (es) | 1997-05-14 | 2005-10-16 | Atherogenics, Inc. | Un monoeter de probucol y procedimientos para la inhibicion de la expresion de vcam-1. |
US7008645B2 (en) | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
IL125336A0 (en) * | 1998-07-14 | 1999-03-12 | Yissum Res Dev Co | Compositions for inhibition and treatment of restinosis |
AUPQ872800A0 (en) * | 2000-07-12 | 2000-08-03 | Heart Research Institute, The | Compositions and methods for treating cardiovascular disorders |
GB0019272D0 (en) * | 2000-08-04 | 2000-09-27 | Symphar Sa | Pharmaceutical compounds |
AU2002320025A1 (en) * | 2001-04-11 | 2002-11-11 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
AU2002337862A1 (en) * | 2001-10-18 | 2003-04-28 | Ilex Products, Inc. | Methods of treating skin with diphosphonate derivatives |
US20060009423A1 (en) * | 2002-02-19 | 2006-01-12 | Eric Joseph Niesor | Phosphonate-phosphate and diphosphonate apolipoprotein e modulators |
WO2003094851A2 (en) * | 2002-05-11 | 2003-11-20 | Ilex Products, Inc. | 1,1- and 1,2-bisphosphonates as apoliprotein e modulators |
WO2004064781A2 (en) * | 2003-01-14 | 2004-08-05 | Adam Heller | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs |
US10517883B2 (en) | 2003-06-27 | 2019-12-31 | Zuli Holdings Ltd. | Method of treating acute myocardial infarction |
EP2001486A4 (en) * | 2006-03-17 | 2010-12-29 | Univ Illinois | BIPHOSPHONATE COMPOUNDS AND CORRESPONDING METHODS |
AU2008230861A1 (en) * | 2007-03-26 | 2008-10-02 | Salutria Pharmaceuticals, Llc | Methods and compositions of derivatives of probucol for the treatment of diabetes |
WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
US9993427B2 (en) | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
WO2016063297A1 (en) * | 2014-10-21 | 2016-04-28 | Council Of Scientific & Industrial Research | Alkylidene phosphonate esters as p-glycoprotein inducers |
WO2018236221A2 (en) * | 2017-06-03 | 2018-12-27 | Can Holding B.V. | DISSOLUTION OF NEURODEGENERATIVE PEPTIDE DEPOSITION |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA777769A (en) * | 1963-03-18 | 1968-02-06 | H. Roy Clarence | Substituted methylene diphosphonic acid compounds and detergent compositions |
DE1302557B (da) * | 1963-04-09 | 1971-08-26 | ||
US4416877A (en) * | 1979-02-13 | 1983-11-22 | Symphar S.A. | Anti-atherosclerotic pharmaceutical compositions containing diphosphonate compounds |
GB2043072B (en) * | 1979-02-13 | 1983-11-23 | Symphar Sa | Diphosphonate compounds |
FR2531088B1 (fr) * | 1982-07-29 | 1987-08-28 | Sanofi Sa | Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation |
CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
US6259935B1 (en) * | 1997-06-24 | 2001-07-10 | Matsushita Electrical Industrial Co., Ltd. | Electro-mechanical-acoustic transducing device |
-
1988
- 1988-03-31 CH CH1239/88A patent/CH675422A5/fr not_active IP Right Cessation
-
1989
- 1989-03-13 IE IE80289A patent/IE62692B1/en not_active IP Right Cessation
- 1989-03-14 US US07/323,334 patent/US5043330A/en not_active Expired - Lifetime
- 1989-03-15 ZW ZW37/89A patent/ZW3789A1/xx unknown
- 1989-03-16 MY MYPI89000332A patent/MY103850A/en unknown
- 1989-03-16 EP EP89104656A patent/EP0339237B1/en not_active Expired - Lifetime
- 1989-03-16 DE DE8989104656T patent/DE68904104T2/de not_active Expired - Fee Related
- 1989-03-16 DE DE198989104656T patent/DE339237T1/de active Pending
- 1989-03-16 ES ES89104656T patent/ES2011210T3/es not_active Expired - Lifetime
- 1989-03-16 AT AT89104656T patent/ATE84040T1/de not_active IP Right Cessation
- 1989-03-17 IL IL8964989A patent/IL89649A/en not_active IP Right Cessation
- 1989-03-21 ZA ZA892126A patent/ZA892126B/xx unknown
- 1989-03-22 CA CA000594468A patent/CA1338495C/en not_active Expired - Fee Related
- 1989-03-28 DK DK198901481A patent/DK173936B1/da not_active IP Right Cessation
- 1989-03-29 NZ NZ228516A patent/NZ228516A/en unknown
- 1989-03-29 NO NO89891317A patent/NO891317L/no unknown
- 1989-03-29 AR AR89313527A patent/AR247569A1/es active
- 1989-03-30 PT PT90175A patent/PT90175B/pt not_active IP Right Cessation
- 1989-03-30 FI FI891538A patent/FI92933C/fi not_active IP Right Cessation
- 1989-03-30 HU HU891595A patent/HU203556B/hu not_active IP Right Cessation
- 1989-03-30 KR KR1019890004076A patent/KR0147830B1/ko not_active IP Right Cessation
- 1989-03-30 CN CN89101830A patent/CN1024555C/zh not_active Expired - Fee Related
- 1989-03-30 CN CN93116289A patent/CN1086820A/zh active Pending
- 1989-03-30 AU AU32243/89A patent/AU612475B2/en not_active Ceased
- 1989-03-31 PH PH38417A patent/PH27603A/en unknown
- 1989-03-31 JP JP1083855A patent/JPH0822865B2/ja not_active Expired - Fee Related
-
1991
- 1991-06-07 GR GR90300002T patent/GR900300002T1/el unknown
- 1991-07-31 US US07/738,430 patent/US5128331A/en not_active Expired - Lifetime
-
1993
- 1993-03-23 GR GR930400629T patent/GR3007442T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ATS | Application withdrawn | ||
PBP | Patent lapsed | ||
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
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