DK147858C - Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera - Google Patents

Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera

Info

Publication number: DK147858C
Authority: DK; Denmark
Prior art keywords: deoxy; fluorcytidine; fluoruridine; analogue; preparation
Prior art date: 1976-12-20

Application number

DK566777A

Other languages

English (en)

Other versions

DK566777A (da

DK147858B (da

Inventor

Alan Frederick Cook

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-12-20

Filing date

1977-12-19

Publication date

1985-06-10

1977-12-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1978-06-21 Publication of DK566777A publication Critical patent/DK566777A/da

1984-12-24 Publication of DK147858B publication Critical patent/DK147858B/da

1985-06-10 Application granted granted Critical

1985-06-10 Publication of DK147858C publication Critical patent/DK147858C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

DK566777A 1976-12-20 1977-12-19 Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera DK147858C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/752,510 US4071680A (en)	1976-12-20	1976-12-20	5'-Deoxy-5-fluoropyrimidine nucleosides
US75251076		1976-12-20

Publications (3)

Publication Number	Publication Date
DK566777A DK566777A (da)	1978-06-21
DK147858B DK147858B (da)	1984-12-24
DK147858C true DK147858C (da)	1985-06-10

Family

ID=25026612

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK566777A DK147858C (da)	1976-12-20	1977-12-19	Analogifremgangsmaade til fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte dera
DK531781A DK148745C (da)	1976-12-20	1981-11-30	Ribofuranosylderivater til anvendelse som mellemprodukter ved fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte deraf

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK531781A DK148745C (da)	1976-12-20	1981-11-30	Ribofuranosylderivater til anvendelse som mellemprodukter ved fremstilling af 5'-deoxy-5-fluorcytidin eller 5'-deoxy-5-fluoruridin eller fysiologisk tolerable syreadditionssalte deraf

Country Status (30)

Country	Link
US (1)	US4071680A (da)
JP (2)	JPS5834479B2 (da)
AR (2)	AR220692A1 (da)
AT (1)	AT355733B (da)
AU (1)	AU515446B2 (da)
BE (1)	BE861984A (da)
CA (1)	CA1085390A (da)
DE (1)	DE2756653C2 (da)
DK (2)	DK147858C (da)
ES (2)	ES465217A1 (da)
FI (1)	FI63946C (da)
FR (1)	FR2374334A1 (da)
GB (1)	GB1589688A (da)
GR (1)	GR70039B (da)
HK (1)	HK78284A (da)
HU (1)	HU177104B (da)
IE (1)	IE46107B1 (da)
IL (2)	IL53589A (da)
IT (1)	IT1089318B (da)
LU (1)	LU78717A1 (da)
MC (1)	MC1174A1 (da)
MY (1)	MY8500246A (da)
NL (1)	NL178878C (da)
NO (1)	NO145307C (da)
NZ (1)	NZ185965A (da)
PH (1)	PH12784A (da)
PT (1)	PT67429B (da)
SE (1)	SE440361B (da)
YU (2)	YU40688B (da)
ZA (1)	ZA777238B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU724533A1 (ru) *	1977-08-02	1980-03-30	Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср	1-(5-Фторурацилил-1) - - глюкофурануронова кислота или ее ацилзамещенный лактон,обладающие антибластическим действием
FR2428638A1 (fr) *	1978-06-15	1980-01-11	Aec Chim Organ Biolog	Nouveau derive de la xylidine-3,4, sa preparation et son utilisation
CA1135258A (en)	1979-06-15	1982-11-09	Richard D'souza	Process for the preparation of 5'deoxy-5-fluorouridine
US5077279A (en) *	1986-05-01	1991-12-31	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5084445A (en) *	1986-05-01	1992-01-28	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxy-5-methylcytidine
US4916122A (en) *	1987-01-28	1990-04-10	University Of Georgia Research Foundation, Inc.	3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5455339A (en) *	1986-05-01	1995-10-03	University Of Georgia Research Foundation, Inc.	Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US4841039A (en) *	1986-05-01	1989-06-20	Emory University	2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5190926A (en) *	1987-01-28	1993-03-02	University Of Georgia Research Foundation, Inc.	3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
CA1327358C (en) *	1987-11-17	1994-03-01	Morio Fujiu	Fluoro cytidine derivatives
US5384396A (en) *	1988-02-23	1995-01-24	The University Of Georgia Research Foundation, Inc.	Process for the deoxygenation of nucleosides
US5077280A (en) *	1988-04-12	1991-12-31	Brown University Research Foundation	Treatment of viral infections
US4987224A (en) *	1988-08-02	1991-01-22	University Of Georgia Research Foundation, Inc.	Method of preparation of 2',3'-dideoxynucleosides
US5141943A (en) *	1990-04-12	1992-08-25	Brown University Research Foundation	5-benzyl barbiturate derivatives
US5278167A (en) *	1992-05-13	1994-01-11	Brown University Research Foundation	6-pyridyl substituted pyrimidine derivatives
IT1291983B1 (it) *	1997-05-23	1999-01-25	Pro Bio Sint Srl	Prodcedimento per la preparazione di un derivato della desossiuridina
US6593467B2 (en)	1997-05-23	2003-07-15	Clariant Finance (Bvi) Limited	Process for the preparation of a deoxyuridine derivative
NZ330360A (en) *	1997-06-02	1999-03-29	Hoffmann La Roche	5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
CN1931869B (zh) *	2005-09-14	2011-05-11	上海瑞广生化科技开发有限公司	5’-脱氧-5-氟胞苷类衍生物，它的制备方法及其用途
CN105343029B (zh) *	2015-12-08	2018-10-12	上海朝晖药业有限公司	一种去氧氟尿苷胶囊及其制备方法
CA3108362A1 (en) *	2018-08-03	2020-02-06	Cellix Bio Private Limited	Compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3687931A (en) *	1970-03-19	1972-08-29	Syntex Corp	Halogenated purine and pyrimidine nucleosides and process therefor
US3928319A (en) *	1971-06-16	1975-12-23	Syntex Inc	4 -Fluoro nucleosides, novel intermediates and methods of preparing same
JPS5545560B2 (da) *	1972-11-28	1980-11-18
JPS5726278B2 (da) *	1973-03-13	1982-06-03
US3910885A (en) *	1974-03-12	1975-10-07	Syntex Inc	4-Alkoxy nucleosides and intermediates therefore

1976
- 1976-12-20 US US05/752,510 patent/US4071680A/en not_active Expired - Lifetime
1977
- 1977-12-01 CA CA292,119A patent/CA1085390A/en not_active Expired
- 1977-12-05 ZA ZA00777238A patent/ZA777238B/xx unknown
- 1977-12-12 IL IL53589A patent/IL53589A/xx unknown
- 1977-12-13 AU AU31491/77A patent/AU515446B2/en not_active Expired
- 1977-12-14 NZ NZ185965A patent/NZ185965A/xx unknown
- 1977-12-14 IE IE2536/77A patent/IE46107B1/en not_active IP Right Cessation
- 1977-12-15 FI FI773804A patent/FI63946C/fi not_active IP Right Cessation
- 1977-12-16 FR FR7738041A patent/FR2374334A1/fr active Granted
- 1977-12-16 HU HU77HO2030A patent/HU177104B/hu unknown
- 1977-12-17 GR GR55003A patent/GR70039B/el unknown
- 1977-12-19 DK DK566777A patent/DK147858C/da not_active IP Right Cessation
- 1977-12-19 LU LU7778717A patent/LU78717A1/xx unknown
- 1977-12-19 MC MC771274A patent/MC1174A1/xx unknown
- 1977-12-19 SE SE7714462A patent/SE440361B/sv not_active IP Right Cessation
- 1977-12-19 PT PT67429A patent/PT67429B/pt unknown
- 1977-12-19 GB GB52665/77A patent/GB1589688A/en not_active Expired
- 1977-12-19 NO NO774375A patent/NO145307C/no unknown
- 1977-12-19 ES ES465217A patent/ES465217A1/es not_active Expired
- 1977-12-19 NL NLAANVRAGE7714069,A patent/NL178878C/xx not_active IP Right Cessation
- 1977-12-19 AR AR270422A patent/AR220692A1/es active
- 1977-12-19 AT AT909577A patent/AT355733B/de not_active IP Right Cessation
- 1977-12-19 DE DE2756653A patent/DE2756653C2/de not_active Expired
- 1977-12-19 BE BE183559A patent/BE861984A/xx not_active IP Right Cessation
- 1977-12-19 IT IT30903/77A patent/IT1089318B/it active
- 1977-12-20 YU YU3022/77A patent/YU40688B/xx unknown
- 1977-12-20 JP JP52152463A patent/JPS5834479B2/ja not_active Expired
- 1977-12-20 PH PH20576A patent/PH12784A/en unknown
1978
- 1978-07-10 ES ES471584A patent/ES471584A1/es not_active Expired
1979
- 1979-02-08 AR AR275446A patent/AR225410A1/es active
1980
- 1980-10-20 IL IL61311A patent/IL61311A0/xx unknown
1981
- 1981-07-24 JP JP56115410A patent/JPS5936999B2/ja not_active Expired
- 1981-11-30 DK DK531781A patent/DK148745C/da not_active IP Right Cessation
1984
- 1984-10-18 HK HK782/84A patent/HK78284A/xx not_active IP Right Cessation
- 1984-12-04 YU YU2049/84A patent/YU44478B/xx unknown
1985
- 1985-12-30 MY MY246/85A patent/MY8500246A/xx unknown

Also Published As

Publication number	Publication date
AT355733B (de)	1980-03-25
AR225410A1 (es)	1982-03-31
IE46107L (en)	1978-06-20
HK78284A (en)	1984-10-26
DE2756653C2 (de)	1982-06-24
DK531781A (da)	1981-11-30
ATA909577A (de)	1979-08-15
AU515446B2 (en)	1981-04-02
FR2374334B1 (da)	1981-11-27
DK148745C (da)	1986-03-17
ES471584A1 (es)	1979-01-16
NO774375L (no)	1978-06-21
MY8500246A (en)	1985-12-31
PH12784A (en)	1979-08-17
SE440361B (sv)	1985-07-29
YU302277A (en)	1983-01-21
LU78717A1 (da)	1979-02-02
DE2756653A1 (de)	1978-06-22
ES465217A1 (es)	1978-12-01
YU44478B (en)	1990-08-31
MC1174A1 (fr)	1978-09-25
IL53589A (en)	1981-05-20
JPS5834479B2 (ja)	1983-07-27
GR70039B (da)	1982-07-26
JPS5395982A (en)	1978-08-22
FI773804A (fi)	1978-06-21
IL53589A0 (en)	1978-03-10
DK566777A (da)	1978-06-21
CA1085390A (en)	1980-09-09
NL178878C (nl)	1986-06-02
ZA777238B (en)	1978-09-27
JPS5936999B2 (ja)	1984-09-06
FR2374334A1 (fr)	1978-07-13
IL61311A0 (en)	1980-12-31
FI63946B (fi)	1983-05-31
PT67429A (en)	1978-01-01
PT67429B (en)	1979-12-19
FI63946C (fi)	1983-09-12
IT1089318B (it)	1985-06-18
HU177104B (en)	1981-07-28
YU40688B (en)	1986-04-30
NZ185965A (en)	1979-03-28
GB1589688A (en)	1981-05-20
YU204984A (en)	1985-08-31
AU3149177A (en)	1979-06-21
NL7714069A (nl)	1978-06-22
NO145307C (no)	1982-02-24
SE7714462L (sv)	1978-06-21
AR220692A1 (es)	1980-11-28
DK148745B (da)	1985-09-16
US4071680A (en)	1978-01-31
JPS5747000A (en)	1982-03-17
NO145307B (no)	1981-11-16
BE861984A (fr)	1978-06-19
IE46107B1 (en)	1983-02-23
DK147858B (da)	1984-12-24

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Legal Events

Date	Code	Title	Description
1998-01-26	PUP	Patent expired