DK146112B - INSECTICID AGENT FOR USE IN THE FORM OF SHAMPOO - Google Patents
INSECTICID AGENT FOR USE IN THE FORM OF SHAMPOO Download PDFInfo
- Publication number
- DK146112B DK146112B DK517577AA DK517577A DK146112B DK 146112 B DK146112 B DK 146112B DK 517577A A DK517577A A DK 517577AA DK 517577 A DK517577 A DK 517577A DK 146112 B DK146112 B DK 146112B
- Authority
- DK
- Denmark
- Prior art keywords
- shampoo
- lice
- acetic acid
- oil
- diluted
- Prior art date
Links
- 239000002453 shampoo Substances 0.000 title description 33
- 239000003795 chemical substances by application Substances 0.000 title description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 60
- 241001674048 Phthiraptera Species 0.000 description 29
- 239000000203 mixture Substances 0.000 description 26
- 229960000583 acetic acid Drugs 0.000 description 20
- 238000009472 formulation Methods 0.000 description 15
- 239000000047 product Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- 241000238631 Hexapoda Species 0.000 description 11
- 238000011282 treatment Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 9
- 239000000284 extract Substances 0.000 description 9
- 235000013601 eggs Nutrition 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 244000166675 Cymbopogon nardus Species 0.000 description 7
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 7
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 description 7
- 241000255925 Diptera Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- 235000011203 Origanum Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N gamma-hexachlorocyclohexane Natural products ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 5
- 239000002917 insecticide Substances 0.000 description 5
- 229960002809 lindane Drugs 0.000 description 5
- 244000045947 parasite Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 229940085790 synthetic camphor Drugs 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000010632 citronella oil Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 240000000783 Origanum majorana Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 240000007313 Tilia cordata Species 0.000 description 3
- 239000000686 essence Substances 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- 240000008853 Datura stramonium Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 241000721662 Juniperus Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241001529744 Origanum Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241000517307 Pediculus humanus Species 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 239000010634 clove oil Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000011418 maintenance treatment Methods 0.000 description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 2
- 210000003689 pubic bone Anatomy 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 241000723347 Cinnamomum Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000272184 Falconiformes Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 231100000111 LD50 Toxicity 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 241000282346 Meles meles Species 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 241000258242 Siphonaptera Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 240000004460 Tanacetum coccineum Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- ROVGZAWFACYCSP-MQBLHHJJSA-N [2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(C\C=C/C=C)C(=O)C1 ROVGZAWFACYCSP-MQBLHHJJSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940085942 formulation r Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 231100000171 higher toxicity Toxicity 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 229960003424 phenylacetic acid Drugs 0.000 description 1
- 239000003279 phenylacetic acid Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 description 1
- 229940015367 pyrethrum Drugs 0.000 description 1
- 229940048383 pyrethrum extract Drugs 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Description
(iln (19) DANMARK \Ra/(iln (19) DENMARK \ Ra /
jftl (12, FREMLÆGGELSESSKRIFT ,,,,146112 Bjftl (12, SUBMISSION SCRIPTURE ,,,, 146112 B
tajgataiga
DIREKTORATET FOR PATENT- OG VAREMÆRKEVÆSENETDIRECTORATE OF THE PATENT AND TRADEMARKET SYSTEM
(21) Patentansøgning nr.: 5175/77 (51) Int.CI.3: A 01 N 65/00 (22) Indleveringsdag: 22 nov 1977 (41) Aim. tilgængelig: 23 ma] 1978 (44) Fremlagt:04juli983 (86) International ansøgning nr.: -(30) Prioritet: 22 nov 1976 FR 7635121 (71) Ansøger: ‘S.E.R.T.O.G.; 92200 Neuilly sur Seine, FR.(21) Patent Application No. 5175/77 (51) Int.CI.3: A 01 N 65/00 (22) Filing Date: 22 Nov 1977 (41) Aim. available: 23 May] 1978 (44) Submitted: 04 Jul983 (86) International Application No: - (30) Priority: 22 Nov 1976 FR 7635121 (71) Applicant: 'S.E.R.T.O.G .; 92200 Neuilly sur Seine, FR.
(72) Opfinder: Pierre Muvln; FR, Pierre ‘Moreau; FR.(72) Inventor: Pierre Muvln; FR, Pierre 'Moreau; FR.
(74) Fuldmægtig: Patentbureauet Hotman-Bang & Boutard_ (54) Insekticidt middel til anvendelse i form af shampoo(74) Agent: Hotman-Bang & Boutard_ (54) Insecticidal agent for use in the form of shampoo
Den foreliggende opfindelse angår et insekticidt middel til beskyttelse mod insekter og til anvendelse i form af shampoo og særligt bestemt til udryddelse og beskyttelse imod særligt modstandsdygtige O insekter, såsom lus og lopper.The present invention relates to an insecticidal agent for protection against insects and for use in the form of shampoos and particularly intended for eradication and protection against particularly resistant O insects such as lice and fleas.
MM
— Man kender forskellige forbindelser, der er i stand til at ødelæg- ^ ge denne type insekter, såsom DDT, hexaehlorcyclohexan eller lindan.Various compounds are known which are capable of destroying this type of insect, such as DDT, hexaehlorocyclohexane or lindane.
“ Disse produkter fremtræder dog generelt altid i form af pulvere, og ^ deres forhøjede toxicitet gør dem farlige at anvende ved direkte kontakt med pattedyrs hud.“However, these products generally always appear in the form of powders, and their increased toxicity makes them dangerous to use in direct contact with mammalian skin.
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Huis man tager eksemplet lus og lopper, så angriber disse landeplager netop fortrinsvis unge indiuider (børn, hundehvalpe, kattekillinger) og dermed individer, der er særligt følsomme over for toxiske substanser.If you take the example of lice and fleas, then these land plagues mainly attack young individuals (children, puppies, kittens) and thus individuals who are particularly sensitive to toxic substances.
På den anden side ved man, at visse sure forbindelser i væskeform, såsom eddikesyre, er virksomme mod insekter og parasitter, særligt når disse stoffer anvendes i opløsning med pH i nærheden af 2.On the other hand, certain acidic compounds in liquid form, such as acetic acid, are known to be effective against insects and parasites, especially when these substances are used in solution with a pH close to 2.
De flydende produkter angriber dog ved disse pH-værdier på mærkbar måde individernes hud, således at man er nødt til at anvende dem i mere fortyndet opløsning, hvilket i betydelig grad formindsker deres virkning.However, the liquid products at these pH values noticeably attack the skin of the individuals, so that they have to be used in more dilute solution, which greatly reduces their effect.
Fra beskrivelserne til britisk patent nr. 1 001 681 og de tyske patenter nr. 266 809 og 346 596 er det kendt at anvende organiske syrer som f.eks. eddikesyre, valerianesyre og phenyleddikesyre til beskyttelse mod insekter herunder også i hårplejemiddel.From the disclosures of British Patent Nos. 1,001,681 and German Patents Nos. 266,809 and 346,596, it is known to use organic acids such as e.g. acetic acid, valeric acid and phenylacetic acid for protection against insects including in hair care products.
Fra beskrivelserne til tysk patent nr. 834 583, britisk patent nr.From the disclosures of German Patent No. 834,583, British Pat.
1 001 681 og fransk brugsmønster nr. 2 268 513 kendes anvendelsen af ekstrakter og essenser, ligesom anvendelsen af naturligt og/eller syntetisk kamfer er kendt f.eks. fra beskrivelsen til belgisk patent nr. 491 727.1 001 681 and French usage pattern No. 2 268 513, the use of extracts and essences is known, and the use of natural and / or synthetic camphor is known e.g. from the specification to Belgian Patent No. 491 727.
Det har imidlertid vist sig, at man ved kombinationen af et befugt-ningsmiddel såsom natrium-, ammonium- eller triethanolaminlaury1-sulfat, fortrinsvis natriumlaurylsulfat, i en høj koncentration, 2-6 volumen-?i eddikesyre og 0,5 - 3 volumen-% naturligt eller syntetisk planteekstrakt valgt blandt ekstrakter eller essenser af nellike, lavendel, pebermynte, merian (origanum L.), rosmarin, lind, enebær, citron, citronella, timian, pigæble (Datura stramonium), fyr, pyrethrum, pyrethrin og de essentielle olier fra ægte kanelbark eller kanelblade, opnår et middel i form af en såkaldt shampoo, der lader sig anvende til dræbning af insekter, herunder især lus, såvel på mennesker og dyr som på livløse overflader.However, it has been found that in the combination of a wetting agent such as sodium, ammonium or triethanolamine lauric sulfate, preferably sodium lauryl sulfate, at a high concentration, 2-6 volume of acetic acid and 0.5 - 3 volume volume. % natural or synthetic plant extract selected from extracts or essences of cloves, lavender, peppermint, marjoram (origanum L.), rosemary, lime, juniper, lemon, citronella, thyme, pear apple (Datura stramonium), pine, pyrethrum, pyrethrin and the essentials oils from real cinnamon bark or cinnamon leaves obtain a remedy in the form of a so-called shampoo that can be used to kill insects, especially lice, both on humans and animals as well as on lifeless surfaces.
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Denne shampoobehandling vil således forhindre re-infection med de pågældende parasitter.This shampoo treatment will thus prevent re-infection with the parasites concerned.
Det omhandlede insekticide middel er derfor ejendommeligt ved det i krav l's kendetegnede del anførte.The insecticidal agent in question is therefore peculiar to the part of claim 1.
Derudover kan man med fordel tilsætte en insektfordrivende og sår-helende forbindelse, såsom naturlig eller syntetisk kamfer, i rumfangsforhold på mellem 0,5 og 5%, fortrinsvis mellem 0,5 og 1,5¾.In addition, an insect repellent and wound healing compound, such as natural or synthetic camphor, may be added in volume ratios of between 0.5 and 5%, preferably between 0.5 and 1.5 °.
For bedre at kunne forstå fordelene og bedømme værdien af virkningen af midlerne ifølge opfindelsen skal man i det efterfølgende beskrive eksempler på fremstillingen af blandinger såvel som deres tilsvarende anvendelse ved de vigtigste anvendelsesområder og de dertil hørende behandlingsmetoder.In order to better understand the benefits and judge the value of the effect of the compositions of the invention, examples of the preparation of mixtures as well as their corresponding use in the main fields of application and the associated treatment methods will be described below.
Ved hver enkelt formulering vil man se, at indholdet af befugt-ningsmiddel er af vigtighed.With each formulation it will be seen that the content of wetting agent is important.
Man har faktisk konstateret på overraskende måde, at eddikesyrens insektdræbende virkning forøges betydeligt ved tilsætning af be-fugtningsmiddel, såsom natrium-, ammonium- eller triethanolammo-niumlaurylsulfat, de klassiske kationbaser eller sådanne ikke-ioniske forbindelser, der almindeligvis anvendes inden for området shampoos, og at de således dannede produkter har vist sig at være bemærkelsesværdigt stabile.Indeed, it has been surprisingly found that the insecticidal effect of the acetic acid is greatly increased by the addition of wetting agents such as sodium, ammonium or triethanolammonium lauryl sulfate, the classical cation bases or such nonionic compounds commonly used in the field of shampoos. and that the products thus formed have proved remarkably stable.
Denne iagttagelse kan verificeres ved hjælp af følgende test, som udføres på snudebiller, myrer, ørentviste, lus og lopper: Man fortynder til tredobbelt rumfang de produkter, der er fremstillet ifølge beskrivelserne i de efterfølgende eksempler, derpå anbringer man nogle dråber på hvert insekt, som fastholdes mellem dækglas således, at insektets legeme er omtrent 3/4 imprægneret.This observation can be verified by the following tests carried out on moth beetles, ants, eagles, lice and fleas: The products prepared according to the descriptions in the following examples are diluted to triple, then a few drops are applied to each insect, which is held between coverslips so that the insect body is approximately 3/4 impregnated.
Man måler så den tid, der er nødvendig for, at insektet ikke længere udviser bevægelser. Man sammenligner denne tid med den, der 146112 4 opnås wed hjælp af en vandig eddikesyreopløsning af tilsvarende pH.It then measures the time needed for the insect to no longer exhibit movement. This time is compared with that obtained with an aqueous acetic acid solution of similar pH.
De opnåede resultater viser, at tiderne i gennemsnit er fra 2 til 5 gange mindre under anvendelse af shampoo, end det er tilfældet med ren eddikesyre (20 - 50 sekunder i stedet for 1-3 minutter).The results obtained show that the times are on average from 2 to 5 times less using shampoo than is the case with pure acetic acid (20 - 50 seconds instead of 1-3 minutes).
EKSEMPEL 1EXAMPLE 1
Hygiejnisk shampoo virksom_mod_lus til voksne_og_børnHygienic shampoo effective_mod_lus for adults and children
De anførte mængdeforhold er rumfangsforhold.The stated volume ratios are volume ratios.
Befugtningsmiddel "Texapon'®N 40 (HENKEL) 75 til 95¾Wetting agent "Texapon'®N 40 (HENKEL) 75 to 95¾
Syntetisk kamfer 0,5 til 1,5¾Synthetic camphor 0.5 to 1.5¾
Citronella 0,5 til 1,5¾Citronella 0.5 to 1.5¾
Eddikesyre 5 til 6¾ pH 1,8 til 3,5Acetic acid 5 to 6¾ pH 1.8 to 3.5
Fremgangsmåden til fremstilling af den stabile shampoo er som følger:The procedure for producing the stable shampoo is as follows:
Man fremstiller en opløsning af befugtningsmidlet "ΤΕΧΑΡ0Ν" ® som man fortynder til 30¾ med vand under anvendelse af en beholder forsynet med en langsomtgående omrører.A solution of the wetting agent "ΤΕΧΑΡ0Ν" ® is prepared which is diluted to 30¾ with water using a container equipped with a slow stirrer.
Man tilsætter derpå den syntetiske kamfer og citronella-olien i de ovenfor angivne mængder og afventer fuldstændig opløsning.The synthetic camphor and citronella oil are then added in the above quantities and await complete dissolution.
Man tilsætter derpå langsomt ved hjælp af en dekantertragt teknisk eddikesyre, idet man overvåger pH-værdien, f.eks. ved hjælp .af et pH-meter.It is then slowly added by means of a decant funnel technical acetic acid, monitoring the pH, e.g. using a pH meter.
Man afbryder tilsætningen af eddikesyre, når pH er tæt ved 3, og man standser omrøringen efter 5 minutters forløb.The addition of acetic acid is stopped when the pH is close to 3 and the stirring is stopped after 5 minutes.
Afprøvning 1: 5 146112Test 1: 5 146112
Man har behandlet 2 børn på henholdsvis 11 og 13 år, hvis hår rummede en betydelig ansamling af voksne lus og af luseæg, ved hjælp af en shampoo, der indeholdt 1¾ syntetisk kamfer, 1?ί ci-tronella-olie, 5% eddikesyre og 93¾ "TEXAPON" fortyndet til 30¾ (pH justeret til 3).Two children aged 11 and 13, respectively, were treated whose hair contained a substantial accumulation of adult lice and lice eggs, using a shampoo containing 1¾ synthetic camphor, 1 ί ci-tronella oil, 5% acetic acid and 93¾ "TEXAPON" diluted to 30¾ (pH adjusted to 3).
En vask ved hjælp af denne shampoo blev udført en morgen kl. 9. Shampooen blev anvendt med virkning igennem 15 minutter, hvorpå der blev udført en vandvask.A wash using this shampoo was performed one morning at. 9. The shampoo was used with effect for 15 minutes, after which a water wash was performed.
Undersøgelse af hovedet viste, at der ikke længere var nogen voksne lus, og at mængden af luseæg var formindsket.Examination of the head showed that there were no longer any adult lice and that the amount of lice eggs had decreased.
En ny shampoo-vask blev udført 2, 4 og 6 dage senere, hvad der førte til, at ingen udvoksede lus kunne iagttages, antallet af luseæg var i regelmæssig aftagen.A new shampoo wash was performed 2, 4 and 6 days later, which meant that no adult lice could be observed, the number of lice eggs was in regular decline.
Fornyet vask blev udført hver uge. Efter 3 ugers forløb var luseæggene komplet forsvundet.Re-washing was performed every week. After 3 weeks the lice eggs had completely disappeared.
Afprøvning 2:Test 2:
En ung pige på 15 år var blevet opmærksom på ved badning, at lus svømmede rundt ved siden af hende. Hun blev behandlet hver aften med et pulver indeholdende 0,8¾ lindan, dækket med en hætte natten igennem og derpå vasket med en almindelig shampoo hver morgen og redt med en tættekam. Efter 5 dages forløb fandtes der stadig luseæg i håret.A young girl of 15 years old had become aware at bathing that lice were swimming around beside her. She was treated every night with a powder containing 0.8¾ of lindane, covered with a cap overnight and then washed with a regular shampoo each morning and saved with a close comb. After 5 days, lice eggs were still present in the hair.
En enkelt shampoobehandling med det i afprøvning 1 beskrevne produkt var tilstrækkelig til at befri håret for alle parasitter og derved at ophøre med den besværlige og ubehagelige behandling.A single shampoo treatment with the product described in Test 1 was sufficient to rid the hair of all parasites and thereby cease the cumbersome and unpleasant treatment.
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Afprøvning 3: 6Test 3: 6
En lille pige på 5 år havde luseæg og var i 3 uger blevet behandlet hver aften med et pulver baseret på 0,4¾ lindan og 10?» DDT.A little girl of 5 years had lice eggs and had been treated every night for 3 weeks with a powder based on 0.4¾ lindane and 10? » DDT.
Hun beholdt natten over disse insekticider i håret ved hjælp af en hætte og fik om morgenen en almindelig shampoo-behandling efterfulgt af en redning med tættekam.She kept these insecticides in her hair overnight using a cap and received a regular shampoo treatment in the morning followed by a close-comb rescue.
Denne lille blonde pige havde et særligt fint hår, og de talrige luseæg sad særdeles godt fast i håret.This little blonde girl had a particularly fine hair, and the numerous lice eggs were very well stuck in her hair.
En første behandling med det under afprøvning 1 omtalte produkt gav kun et delvist resultat. Der var nødvendigt at udføre endnu to behandlinger med produktet for at nå til total bortfjernelse af luseæggene.An initial treatment with the product mentioned in test 1 yielded only a partial result. Two more treatments were needed with the product to achieve complete removal of the lice eggs.
EKSEMPEL 2EXAMPLE 2
Behandling_af_lopper, lus og_blodmider hos hundeTreatment_of_lopper, lice and_blood mites in dogs
Man anvender en shampoo, fremstillet som i eksempel 1, og indeholdende 6¾ eddikesyre, 1,5¾ citronella-olie og 1,5¾ nellike-olie samt 91¾ "TEXAPON" ^ fortyndet til 30¾ (pH justeret til 2).A shampoo prepared as in Example 1 was used containing 6¾ acetic acid, 1.5¾ citronella oil and 1.5¾ clove oil and 91¾ "TEXAPON" diluted to 30¾ (pH adjusted to 2).
Man behandlede en voksen grævlingehund, som var befængt med lopper.An adult badger dog treated with fleas was treated.
Man udførte en vask med en shampoo formuleret til veterinær brug som ovenfor angivet en morgen kl. 8. Klokken 12 havde hunden ikke flere lopper, og den blev ikke befængt igen i løbet af 3 dage trods ugunstige omgivelser.A wash with a shampoo formulated for veterinary use was performed as indicated above one morning at. 8. At 12 o'clock the dog had no more fleas and was not re-infested within 3 days despite unfavorable surroundings.
En vedligeholdelsesbehandling, som bestod i at forstøve en væske sammensat af en opløsning af thimianudtræk 25?ί,. vineddike 73¾ og citronella-olie 2¾ bevirkede undgåelse af enhver tilbagevenden af parasitter, indtil omgivelserne (lokaler og textiler) kun- 148112 7 ne desinficeres fuldstændigt.A maintenance treatment which consisted of atomizing a liquid composed of a solution of thyme extract 25 µl. vinegar 73¾ and citronella oil 2¾ avoided any return of parasites until the environment (rooms and textiles) could be completely disinfected.
Generelt kan man beskrive anvendelsesmåden for de ifølge opfindelsen fremstillede produkter som følger: Man udfører en shampoobehandling af de dele, der skal behandles, ved hjælp af de ovenfor beskrevne blandinger, man lader produkterne virke i en tidsperiode, der normalt befinder sig mellem 1 og 10 minutter for levende væsener og mellem 6 og 20 minutter for genstande.In general, the method of application of the products according to the invention can be described as follows: A shampoo treatment of the parts to be treated is carried out by means of the mixtures described above, the products are allowed to operate for a period of time which is usually between 1 and 10. minutes for living beings and between 6 and 20 minutes for objects.
Man skyller grundigt, hvilket bortskyller eddikesyren såvel som insekterne og parasitterne.Rinse thoroughly, which flushes the acetic acid as well as the insects and parasites.
Efter vasken konstaterer man, at produkter, der virker frastødende på insekterne, er forblevet i tilstrækkelig mængde til at beskytte mod nye infectioner.After washing, it is found that products that are repellent to the insects have remained in sufficient quantity to protect against new infections.
Man er dog i talrige tilfælde interesseret i at fortsætte behandlingen med på hinanden følgende, men adskilte vaskebehandlinger, indtil larverne er totalt forsvundet, såvel som i at anvende en vedligeholdelsesbehandling, som består i påsprøjtning eller forstøvning af diverse essenser af produkter med insektdræbende eller parasitdræbende virkning, som ovenfor angivet, med eller uden kamfer, men fortrinsvis uden eddikesyre, dvs. citronella-olie, nellikeolie, lavendelolie, pebermynteolie, merianolie, rosmarinolie, lindeolie, enebærolie, citronolie, timianolie, pigæbleolie (Datura stramonium), pyrethrumekstrakt eller ægte kanelolie.However, in many cases, one is interested in continuing the treatment with consecutive but separate washing treatments until the larvae have completely disappeared, as well as in applying a maintenance treatment consisting of spraying or atomizing various essences of insecticidal or parasitic killing products. , as indicated above, with or without camphor, but preferably without acetic acid, viz. citronella oil, clove oil, lavender oil, peppermint oil, marjoram oil, rosemary oil, linden oil, juniper oil, lemon oil, thyme oil, baby apple oil (Datura stramonium), pyrethrum extract or real cinnamon oil.
Disse besprøjtninger beskytter varigt de behandlede overflader mellem hver shampoo-behandling.These sprays permanently protect the treated surfaces between each shampoo treatment.
Man har derudover afprøvet insekticid-virkningen af en shampoo overensstemmende med den, der blev anvendt ved afprøvning 1 i eksempel 1, sammenlignet med en pulverformig lindan-blanding indeholdende 1,5 vægt-?o på følgende måde: . 8 1. Afprøvning på udvoksede lus; 146112 I en lille skål anbringes 5 cm^ ren shampoo, derpå nedlægges 5 lus (pediculus humanus). Døden indtræffer øjeblikkeligt. Efter at have overbevist sig om dette resultat udførte man et nyt forsøg, idet man efterlod lusene i shampooen i kun 10 sekunder, hvorpå man bortfjernede dem med en træstav. Man anbragte dem under en lup og konstaterede, at lusene var helt døde.In addition, the insecticide effect of a shampoo similar to that used in Test 1 of Example 1 has been tested compared to a powdered lindane mixture containing 1.5% by weight as follows:. 8 1. Test on adult lice; In a small bowl, place 5 cm 2 of pure shampoo, then put down 5 lice (pediculus humanus). Death occurs immediately. After being convinced of this result, they performed a second experiment, leaving the lice in the shampoo for only 10 seconds, then removing them with a wooden stick. They were placed under a magnifying glass and found that the lice were completely dead.
Man fortsatte på samme måde mad shampoo fortyndet til 50%, derpå til 25% med det formål at nærme sig anvendelseskoncentrationerne, som varierer mellem 25 og 100%.Similarly, food shampoo diluted to 50% was then continued to 25% for the purpose of approaching application concentrations, which vary between 25 and 100%.
Drabet af lusene er langsommere med disse to fortyndinger, og forsøget med bortfjernelse af lusene viser, at efter 30 sekunder vender lusene ikke tilbage til livet.The killing of the lice is slower with these two dilutions, and the attempt to remove the lice shows that after 30 seconds the lice do not return to life.
De samme forsøg er blevet udført på kropslusarten phthirius pubis med den samme dødelighedsprocent på 100 efter 30 sekunder. Disse forsøg er blevet gentaget i sammenligning med en pulverformig lin-danblanding indeholdende 1,5%.The same experiments have been performed on the pharyngeal phthirius pubis with the same mortality rate of 100 after 30 seconds. These experiments have been repeated in comparison with a powdered linden mixture containing 1.5%.
Efterfølgende tabel opsummerer de fundne resultater, idet der anvendes en shampooformulering R.S. 206 bestående af (efter vægt):The following table summarizes the results found, using a shampoo formulation R.S. 206 consisting of (by weight):
Eddikesyre 4,54%Acetic acid 4.54%
Kamfer 0,76%Camphor 0.76%
NaCl 0,20%NaCl 0.20%
Citronella 0,76% "Texapon" ® 35,00%Citronella 0.76% "Texapon" ® 35.00%
Vand 58,74% 100,00% 9 U6112Water 58.74% 100.00% 9 U6112
Forsøg med pediculus humanus voksne individer:Experiments with pediculus humanus adult individuals:
Efter 10 Efter 30 Efter 2 Dødelighedsprocent_sekunder_sekunder_timer R.S. 206 ren 100* 100¾ 100¾ R.S. 206 fortyndet til 50¾ 20¾ 100¾ 100¾ R.S. 206 - fortyndet til 25¾ 0¾ 100¾ 100¾After 10 After 30 After 2 Mortality Percentage_seconds_seconds_hours R.S. 206 pure 100 * 100¾ 100¾ R.S. 206 diluted to 50¾ 20¾ 100¾ 100¾ R.S. 206 - diluted to 25¾ 0¾ 100¾ 100¾
Lindan-pulver med 1,5¾ 0¾ 0¾ 50¾Lindan powder with 1.5¾ 0¾ 0¾ 50¾
Det samme forsøg er blevet gennemført med voksne individer af phthirius pubis med identiske resultater til følge.The same experiment has been conducted with adult individuals of phthirius pubis with identical results.
EKSEMPEL 3EXAMPLE 3
Forskellige formuleringer blev afprøvet på fluer og lus. Ved afprøvning på fluer anbragte man 10 fluer i en æske med dimensionerne 20 x 15 x 10 cm og fremstillet af moskitonet over små stykker træ. Ca. 0,5 cm^ blev sprøjtet på fluerne. Man optalte antallet af dræbte fluer efter 2 timers forløb.Various formulations were tested on flies and lice. When testing on flies, 10 flies were placed in a box of dimensions 20 x 15 x 10 cm and made of mosquito net over small pieces of wood. Ca. 0.5 cm 2 was sprayed on the flies. The number of killed flies was calculated after 2 hours.
Ved afprøvning på lus blev 10 lus anbragt på en glasplade {såkaldt Petri-plade), og de blev i en periode på ca. 10 sekunder dækket med en dråbe af den væske, der skulle afprøves, hvorpå de blev skyllet med vand ved hjælp af en pipette. De efter 2 timers forløb dræbte lus blev optalt.When testing on lice, 10 lice were placed on a glass plate (so-called Petri plate) and they remained for a period of approx. 10 seconds covered with a drop of the liquid to be tested and then rinsed with water using a pipette. The lice killed after 2 hours were counted.
De afprøvede formuleringer havde følgende sammensætning:The formulations tested had the following composition:
Formulering 1.1: Eddikesyre: 4,5*, resten vand.Formulation 1.1: Acetic acid: 4.5 *, the rest water.
Formulering 1.2: "Texapon" ® ekstrakt N 40 fortyndet til 30?0's koncentration: 94*, vand: 6¾.Formulation 1.2: "Texapon" ® extract N 40 diluted to 30? 0 concentration: 94 *, water: 6¾.
Formulering 1.3: Citronellaekstrakt: 1,5*, resten vand.Formulation 1.3: Citronella extract: 1.5 *, the rest water.
Formulering 1.4: Eddikesyre: 4,5?ί, citronellaekstrakt: 1,5¾, resten vand.Formulation 1.4: Acetic acid: 4.5 µl, citronella extract: 1.5¾, the rest water.
Formulering 1.5: Eddikesyre: 4,5*, citronellaekstrakt: 1,5*, ' "Texapon"® ekstrakt N 40 fortyndet til 30*’s koncentration: 94*; pH-værdien justeret til 2,7.Formulation 1.5: Acetic acid: 4.5 *, citronella extract: 1.5 *, "Texapon" ® extract N 40 diluted to 30 * concentration: 94 *; pH adjusted to 2.7.
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Formulering 1.7: Analog med formulering 1.6, idet dog pH blev forøget til 5,5 ved tilsætning af natriumhydroxid.Formulation 1.7: Analogous to Formulation 1.6, however, the pH was raised to 5.5 by the addition of sodium hydroxide.
Formulering 1.8: Eddikesyre: 9S, citronella: 1,5?ό, idet resten bestod af "Texapon" ®ekstrakt N 40 fortyndet til 30Sa's koncentration; pH = 1.Formulation 1.8: Acetic acid: 9S, citronella: 1.5? Ό, the remainder consisting of "Texapon" ® extract N 40 diluted to 30Sa concentration; pH = 1.
Ved afprøvning med hensyn til tolerance blev en lille mængde af hver afprøvningsformulering påført huden af en kanin eller et menneske. Med hensyn til kaninen iagttog man lyserød farvning eller følsomhedsreaktion efter påføringen, idet man bedømte lyserødfarvningen eller følsomheden som værende enten "middel" eller "dårlig". Med hensyn til tolerance af de afprøvede formuleringer på menneskets hud anvendtes armen, og der føltes her en svagt brændende fornemmelse i forbindelse med formulering 1.8.In tolerance testing, a small amount of each test formulation was applied to the skin of a rabbit or human. Regarding the rabbit, pink staining or sensitivity reaction was observed after application, rating the pink stain or sensitivity as either "medium" or "poor". With respect to tolerance of the tested formulations on human skin, the arm was used, and there was a slight burning sensation in connection with formulation 1.8.
I Følgende tabellariske opstilling er opsummeret de ovenfor beskrevne afprøvninger.The following table describes the tests described above.
146112 11 tu cn -X Ή £0 -ΟΌ'Ό'σΌΌ'^^ 0 000000014 c 010100101010=(0 c ό ο ω ο s: c ro h ιΗ O' me D ·Η MM XI Ό Ό T3 *Ό Χ3 Χ3 Ή Ο C Ο Ο Ο XJ ο Ο Ο Μ tu ι— to di οι οι ·η en en σ' «η οι ϋ ε "Ε cni CI •ΗΙ146112 11 tu cn -X Ή £ 0 -ΟΌ'Ό'σΌΌ '^^ 0 000000014 c 010100101010 = (0 c ό ο ω ο s: c ro h ιΗ O' me D · Η MM XI Ό Ό T3 * Ό Χ3 Χ3 Ή C Ο Ο Ο XJ ο Ο Ο Μ tu ι— to di οι οι · η and en σ '«η οι ϋ ε" ni cni CI • ΗΙ
Χ31 (D I I ' IΧ31 (D I I 'I
Cl I (0 4CCl I (0 4C
coi -ρ μ a a a to a mcoi -ρ μ a a a to a m
Ml CD CD f-f h ¢4 O ¢4 OMl CD CD f-f h ¢ 4 O ¢ 4 O
J3I 44 E -P 44 -p M 44 MJ3I 44 E -P 44 -p M 44 M
-□I ME DO «I Ol 1) O' HI COD'D- □ I ME DO «I Ol 1) O 'HI COD'D
• Μ 1 D Η Η·Η Μ ·Η ι—I ·Η XO MMX)• Μ 1 D Η Η · Η ι · — ι — I · XO MMX)
Ql C0“D M ‘—li—I Ή Mi—I Μ >—I f-)X3Mi—I f-iXOQ1 C0 “D M '—li — I Ή Mi — I Μ> —I f-) X3Mi — I f-iXO
hi <UD 4-) d ο ο -po-poao-tjoao 4JI crxi o .x c c dxdxcoodxcoo XI 031 (01hi <UD 4-) d ο ο -po-poao-tjoao 4JI crxi o .x c c dxdxcoodxcoo XI 031 (01
Cl »4 (4Cl »4 (4)
Ml CD QJMl CD QJ
I D 4-)I D 4-)
Ml M tt— I U_ O (4 (41 03Ml M tt— I U_ O {4 (41 03
CD I M 4-) ECD I M 4-) E
4_>l CO .Ο Μ [Λ Ο O CM VO O CM CD4_> l CO .Ο Μ [Λ Ο O CM VO O CM CD
Cl 44 a 44 Ή 1-1Cl 44 and 44 Ή 1-1
Dl C f4Dl C f4
Cl < X) CMCl <X) CM
ΟΙ 0.1 ElEl 0.1 El
οι Iοι I
XI *4 CXI * 4 C
I D MI D M
ΓΛΙ D (4ΓΛΙ D (4
I M SI M S
CD I <l- tt- O OOO CD O O OCD I <l- tt- O OOO CD O O O
"Ol oCO Μ i—li—I'—I Μ Μ Μ ι I"Ol oCO Μ i — li — I'— I Μ Μ Μ ι I
1 M O.1 M O.
tt-1 to tø 1 4-) u ctt-1 to thaw 1 4-) u c
I C S DI C S D
du < tt_ σyou <tt_ σ
C I Μ IC I Μ I
Cl (4Cl (4)
X I DX I D
hi ω 4->hi ω 4->
Ml D tt- >1 r—I D f4Ml D tt-> 1 r — I D f4
I DI D
DCI M -P E CM O O ΙΛ O ΙΛ ODCI M -P E CM O O ΙΛ O ΙΛ O
in i to .o m t-ι ήin i to .o m t-ι ή
Ml 44 83 -u 441 C 4Ml 44 83 -u 441 C 4
to I < X) CMto I <X) CM
Ml oilMl oil
14 I14 I
Dl (0 1Dl (0 1
Cl DSCl DS
>.1 M tt- uo i »roe MQ.OO OOO O O O O (0 D i—I i—I 1—I 1—I 1—I 1 I —I 1 1> .1 M tt- uo i »roe MQ.OO OOO O O O O (0 D i — I i — I 1 — I 1 — I 1 — I 1 I —I 1 1
44 ¢4 C44 ¢ 4 C
C S MC S M
< tt- (4 x r-tnoi^r-r-’ic'iao<tt- (4 x r-tnoi ^ r-r-'ic'iao
CMI-'r-CMCMCMlAMCMI'r-CMCMCMlAM
DD
r-Hr-H
DD
ε enε and
C-IC r-HCMI^<d"LA^Of^COC-IC r-HCMI ^ <d «LA ^ Of ^ CO
0 *H · ... .0 * H · ....
1 f f-ι /H 1—i r-~l I—f I—) <—I Ή *“1 146112 12 EKSEMPEL 41 f f-ι / H 1 — i r- ~ l I — f I—) <—I Ή * “1 EXAMPLE 4
Ved denne kliniske afprøvning blev anvendt en formulering betegnet som R.S. 208 med følgende sammensætning:In this clinical trial, a formulation designated as R.S. 208 having the following composition:
Eddikesyre 4,57 gAcetic acid 4.57 g
Natriumchlorid 4,87 g "Texapon" ^ N 40 36,55 gSodium Chloride 4.87 g of "Texapon" N 40 36.55 g
Merianolie (origanum) 0,76 g renset vand op til 100 gMarjoram oil (origanum) 0.76 g of purified water up to 100 g
Den pågældende shampoo blev anvendt ved behandling af 14 forskellige familier i en gennemsnitlig bymæssig bebyggelse, idet ét eller flere af familiemedlemmerne, især blandt børnene, var angrebet af lus.The shampoo in question was used in the treatment of 14 different families in an average urban settlement, with one or more of the family members, especially among the children, being attacked by lice.
I samtlige tilfælde førte anvendelse af shampoo efter de tidligere anførte retningslinier til bortfald af inficeringen, og der konstateredes ingen uheldige følgevirkninger, idet irritationen begrænsedes til enkelte utilsigtede påsprøjtninger i øjet, som hurtigt blev afhjulpet ved anvendelse af rent vand.In all cases, the use of shampoo according to the previously stated guidelines led to the discontinuation of the infection and no adverse effects were noted, as the irritation was limited to a few accidental eye springs which were quickly remedied using clean water.
Det fremstillede produkt har vist sig at være mere aktivt end en Lindan-blanding med 1,5¾.The product obtained has been found to be more active than a 1.5 Lind Lindan blend.
Lindan-blandinger med 0,4 og 0,8¾ besidder en virkning, der er u-tilstrækkelig til at blive anvendt som sammenligningsgrundlag.Lindan mixtures of 0.4 and 0.8¾ have an effect insufficient to be used as a basis of comparison.
Derudover har man konstateret den bakteriostatiske virkning af produkter ifølge opfindelsen, og dette er gjort, skønt de ikke indeholder nogen af de sædvanligt anvendte bakteriedræbende forbindelser, såsom methy1-paraoxybenzoat, men forskellige forsøg har vist, at ingen bakterier udvikles i produkterne i ren tilstand eller fortyndet til 50¾.In addition, the bacteriostatic effect of products of the invention has been found, and this has been done, although they do not contain any of the commonly used bactericidal compounds, such as methyl paraoxybenzoate, but various experiments have shown that no bacteria develop in the products in the pure state or diluted to 50¾.
Den foretagne undersøgelse til konstatering af, at blandingen var 146112 13 fri for bakterier, er blevet fortsat i betragtning af de interessante resultater, der blev opnået.The study carried out to find that the mixture was free of bacteria has been continued in view of the interesting results obtained.
Den anvendte undersøgelsesmetode var som følger med shampoo fremstillet analogt med eksempel 1: 1. Podning på almindelig gelatine 2. Inkubering i ovn ved 37°C i 48 timer og derpå i 7 dage. Resultater:The study method used was as follows with shampoo prepared analogously to Example 1: 1. Inoculation on plain gelatin 2. Incubation in oven at 37 ° C for 48 hours and then for 7 days. results:
Efter 48 timer Efter 7 dageAfter 48 hours After 7 days
Shampoo, ren 0 kolonier 0 kolonierShampoo, clean 0 colonies 0 colonies
Shampoo, fortyndet til 50% 0 kolonier 0 kolonierShampoo, diluted to 50% 0 colonies 0 colonies
Efter podning med Escherichia coli:After inoculation with Escherichia coli:
Shampoo, ren 0 kolonier 0 kolonierShampoo, clean 0 colonies 0 colonies
Shampoo, fortyndet til 50% 0 kolonier 0 kolonierShampoo, diluted to 50% 0 colonies 0 colonies
De iagttagne toxiciteter kan variere i betydelig grad, hvilket bestyrker det interessante ved, at eddikesyre forbundet synergi-stisk med et befugtningsmiddel tilfører dette en forøget insektdræbende evne, idet dog toxiciteten holder sig inden for grænser helt forenelige med produktets anvendelse i kontakt med følsomme hudlag.The toxicities observed can vary considerably, which is reinforced by the fact that acetic acid associated synergistically with a wetting agent gives this an increased insecticidal ability, although the toxicity remains within limits fully compatible with the use of the product in contact with sensitive skin layers.
Den perora'le toxicitet bestemt ved at indgive shampoo fremstillet i overensstemmelse med eksempel 1 til hanmus af arten River og med en middellegemsvægt på 25 g viser maksimal tolereret dosis på 24 ml/kg, og for lethaldosis 100 en værdi på 40 ml/kg.The oral toxicity determined by administering shampoo prepared in accordance with Example 1 to male mice of the species River and having a mean body weight of 25 g shows a maximum tolerated dose of 24 ml / kg and for the lethal dose 100 a value of 40 ml / kg.
De opnåede resultater tillader ikke at beregne en lethaldoses 50.The results obtained do not allow the calculation of a light dose 50.
Til sammenligning kan anføres, at lethaldosis 50 for lindan bestemt ved vandige blandinger indgivet peroralt til mus er ca. 300 mg/kg.In comparison, the lethal dose 50 for lindane as determined by aqueous mixtures administered orally to mice is approx. 300 mg / kg.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7635121 | 1976-11-22 | ||
FR7635121A FR2371190A1 (en) | 1976-11-22 | 1976-11-22 | INSECTIVE COMPLEXES |
Publications (3)
Publication Number | Publication Date |
---|---|
DK517577A DK517577A (en) | 1978-05-23 |
DK146112B true DK146112B (en) | 1983-07-04 |
DK146112C DK146112C (en) | 1983-11-28 |
Family
ID=9180154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK517577A DK146112C (en) | 1976-11-22 | 1977-11-22 | INSECTICID AGENT FOR USE IN THE FORM OF SHAMPOO |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS54119035A (en) |
AT (1) | AT362617B (en) |
AU (1) | AU518341B2 (en) |
BE (1) | BE861000A (en) |
CA (1) | CA1096771A (en) |
CH (1) | CH625121A5 (en) |
DE (1) | DE2752140C2 (en) |
DK (1) | DK146112C (en) |
ES (1) | ES464354A1 (en) |
FR (1) | FR2371190A1 (en) |
GB (1) | GB1593601A (en) |
GR (1) | GR70301B (en) |
LU (1) | LU78565A1 (en) |
NL (1) | NL188555C (en) |
NO (1) | NO149718C (en) |
NZ (1) | NZ185745A (en) |
OA (1) | OA08256A (en) |
PT (1) | PT67304B (en) |
SE (1) | SE7713126L (en) |
ZA (1) | ZA776910B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2553664A1 (en) * | 1983-10-25 | 1985-04-26 | Charnay Sylvie | Composition based on essential oils from plants, for destroying lice and nits |
IL74067A0 (en) * | 1985-01-16 | 1985-04-30 | Ataron Dev 1985 Ltd | Compositions containing quaternary ammonium compounds |
AU602144B2 (en) * | 1986-05-08 | 1990-10-04 | R & C Products Pty Limited | Animal repellant composition and method |
JPH01149402U (en) * | 1988-04-07 | 1989-10-17 | ||
JPH0211105U (en) * | 1988-07-04 | 1990-01-24 | ||
JPH02115107A (en) * | 1988-10-22 | 1990-04-27 | Matsushita Electric Works Ltd | Antibiotic agent |
US5288483A (en) * | 1990-04-18 | 1994-02-22 | The Procter & Gamble Company | Anti-lice treatment compositions |
AU7656891A (en) * | 1990-04-18 | 1991-11-11 | Procter & Gamble Company, The | Anti-lice treatment compositions |
AU659625B2 (en) * | 1991-01-18 | 1995-05-25 | Clilco, Ltd. | Lice-repellant compositions |
US5227163A (en) * | 1991-01-18 | 1993-07-13 | Clilco, Ltd. | Lice-repellant compositions |
WO1994016665A2 (en) * | 1993-01-25 | 1994-08-04 | Seleznev, Alexandr Georgievich | Agent to combat lice infestation |
FR2732591B1 (en) * | 1995-04-07 | 1997-06-13 | Benwaiche Joseph | PEST CONTROL SHAMPOO |
DE19631596A1 (en) * | 1996-08-05 | 1998-02-12 | Henkel Kgaa | Washing process |
FR2759546A1 (en) * | 1997-02-19 | 1998-08-21 | Soc Et De Rech De Travaux D Or | Use of citronella components as insecticides |
US20030194454A1 (en) | 1998-07-28 | 2003-10-16 | Bessette Steven M. | Pesticidal compositions containing rosemary oil and wintergreen oil |
GB2347082A (en) * | 1999-02-24 | 2000-08-30 | Margaret Mary Seale | Treatment or prevention of parasitic infection using acetic acid |
GB2355404A (en) * | 1999-08-20 | 2001-04-25 | Polyatomic Apheresis Res Ltd | Vinegar for treating parasites |
WO2001032133A2 (en) * | 1999-11-05 | 2001-05-10 | Nature Plus Inc. | Improved nit removal product |
WO2001060163A2 (en) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Plant essential oils cointaining pediculicidal compositions |
SE0103401D0 (en) * | 2001-10-12 | 2001-10-12 | Natalie Fresia | Means against lice as well as vermin |
EP1954142B1 (en) * | 2005-11-18 | 2017-04-19 | Wild Child | Pediculicide/ovicide composition |
US20130280350A1 (en) * | 2010-06-08 | 2013-10-24 | Sequent Scientific Limited | Herbal topical formulation |
NO344832B1 (en) * | 2018-11-02 | 2020-05-18 | Inakva As | Composition for use in the prevention or treatment of attacks or infection of parasites on fish |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1589866A (en) * | 1924-11-17 | 1926-06-22 | Siegler Edouard Horace | Insecticide and process of preparing the same |
US2788308A (en) * | 1953-07-07 | 1957-04-09 | Irving L Ochs | Topical non-aqueous acetic compositions |
DE1105549B (en) * | 1957-07-06 | 1961-04-27 | Johannes Roedger Dr Med | Disinfecting detergents and cleaning agents |
NL279632A (en) * | 1962-02-09 | 1964-11-25 | ||
US3650964A (en) * | 1968-05-13 | 1972-03-21 | Basf Wyandotte Corp | Low foam anionic acid sanitizer compositions |
GB1249674A (en) * | 1968-11-28 | 1971-10-13 | Exxon Research Engineering Co | Novel agricultural compositions and leaf-desiccating method |
GB1438946A (en) * | 1972-06-15 | 1976-06-09 | Nat Res Dev | Control of fungi |
GB1438945A (en) * | 1972-06-15 | 1976-06-09 | Nat Res Dev | Control of fungi |
DD111633A1 (en) * | 1974-01-16 | 1975-03-05 | ||
US3969258A (en) * | 1974-10-10 | 1976-07-13 | Pennwalt Corporation | Low foaming acid-anionic surfactant sanitizer compositions |
-
1976
- 1976-11-22 FR FR7635121A patent/FR2371190A1/en active Granted
-
1977
- 1977-11-18 ZA ZA00776910A patent/ZA776910B/en unknown
- 1977-11-21 SE SE7713126A patent/SE7713126L/en not_active Application Discontinuation
- 1977-11-21 PT PT67304A patent/PT67304B/en unknown
- 1977-11-21 BE BE1008527A patent/BE861000A/en not_active IP Right Cessation
- 1977-11-21 GR GR54846A patent/GR70301B/el unknown
- 1977-11-21 NO NO773986A patent/NO149718C/en unknown
- 1977-11-22 DE DE2752140A patent/DE2752140C2/en not_active Expired - Lifetime
- 1977-11-22 CA CA291,442A patent/CA1096771A/en not_active Expired
- 1977-11-22 NZ NZ185745A patent/NZ185745A/en unknown
- 1977-11-22 GB GB48564/77A patent/GB1593601A/en not_active Expired
- 1977-11-22 AU AU30837/77A patent/AU518341B2/en not_active Expired
- 1977-11-22 AT AT834877A patent/AT362617B/en not_active IP Right Cessation
- 1977-11-22 CH CH1425377A patent/CH625121A5/en not_active IP Right Cessation
- 1977-11-22 DK DK517577A patent/DK146112C/en not_active IP Right Cessation
- 1977-11-22 JP JP13952777A patent/JPS54119035A/en active Granted
- 1977-11-22 NL NLAANVRAGE7712875,A patent/NL188555C/en not_active IP Right Cessation
- 1977-11-22 LU LU78565A patent/LU78565A1/xx unknown
- 1977-11-22 ES ES464354A patent/ES464354A1/en not_active Expired
- 1977-11-23 OA OA56323A patent/OA08256A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO149718C (en) | 1984-06-13 |
SE7713126L (en) | 1978-05-23 |
AT362617B (en) | 1981-06-10 |
FR2371190A1 (en) | 1978-06-16 |
NO149718B (en) | 1984-03-05 |
BE861000A (en) | 1978-05-22 |
DK517577A (en) | 1978-05-23 |
GR70301B (en) | 1982-09-06 |
ES464354A1 (en) | 1978-12-01 |
JPS54119035A (en) | 1979-09-14 |
ATA834877A (en) | 1980-10-15 |
NL188555C (en) | 1992-08-03 |
JPS6113443B2 (en) | 1986-04-14 |
CA1096771A (en) | 1981-03-03 |
CH625121A5 (en) | 1981-09-15 |
AU3083777A (en) | 1979-05-31 |
AU518341B2 (en) | 1981-09-24 |
PT67304A (en) | 1977-12-01 |
DK146112C (en) | 1983-11-28 |
NL188555B (en) | 1992-03-02 |
LU78565A1 (en) | 1978-04-20 |
DE2752140C2 (en) | 1994-02-10 |
NO773986L (en) | 1978-05-23 |
PT67304B (en) | 1979-04-20 |
FR2371190B1 (en) | 1981-06-19 |
OA08256A (en) | 1987-10-30 |
NL7712875A (en) | 1978-05-24 |
ZA776910B (en) | 1978-09-27 |
GB1593601A (en) | 1981-07-22 |
DE2752140A1 (en) | 1978-05-24 |
NZ185745A (en) | 1980-08-26 |
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PBP | Patent lapsed |