CA1096771A - Complexes insectifuges - Google Patents
Complexes insectifugesInfo
- Publication number
- CA1096771A CA1096771A CA291,442A CA291442A CA1096771A CA 1096771 A CA1096771 A CA 1096771A CA 291442 A CA291442 A CA 291442A CA 1096771 A CA1096771 A CA 1096771A
- Authority
- CA
- Canada
- Prior art keywords
- volume
- shampoo
- complex according
- acetic acid
- wetting agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000002453 shampoo Substances 0.000 claims abstract description 34
- 239000000080 wetting agent Substances 0.000 claims abstract description 9
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 8
- 239000000077 insect repellent Substances 0.000 claims abstract description 7
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 5
- 229960000846 camphor Drugs 0.000 claims abstract description 5
- 229930008380 camphor Natural products 0.000 claims abstract description 5
- 239000002917 insecticide Substances 0.000 claims description 7
- 240000004784 Cymbopogon citratus Species 0.000 claims description 6
- 235000017897 Cymbopogon citratus Nutrition 0.000 claims description 6
- 239000000686 essence Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 235000005979 Citrus limon Nutrition 0.000 claims description 4
- 244000131522 Citrus pyriformis Species 0.000 claims description 4
- 244000223014 Syzygium aromaticum Species 0.000 claims description 4
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 4
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 4
- 240000002657 Thymus vulgaris Species 0.000 claims description 4
- 239000001585 thymus vulgaris Substances 0.000 claims description 4
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims description 3
- 240000008853 Datura stramonium Species 0.000 claims description 3
- 241000721662 Juniperus Species 0.000 claims description 3
- 235000013628 Lantana involucrata Nutrition 0.000 claims description 3
- 244000178870 Lavandula angustifolia Species 0.000 claims description 3
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims description 3
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 claims description 3
- 240000007673 Origanum vulgare Species 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 240000004460 Tanacetum coccineum Species 0.000 claims description 3
- ROVGZAWFACYCSP-MQBLHHJJSA-N [2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(C\C=C/C=C)C(=O)C1 ROVGZAWFACYCSP-MQBLHHJJSA-N 0.000 claims description 3
- 235000017803 cinnamon Nutrition 0.000 claims description 3
- 239000001102 lavandula vera Substances 0.000 claims description 3
- 235000018219 lavender Nutrition 0.000 claims description 3
- 229940015367 pyrethrum Drugs 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims description 2
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 244000178231 Rosmarinus officinalis Species 0.000 claims description 2
- 235000011941 Tilia x europaea Nutrition 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- 239000004571 lime Substances 0.000 claims description 2
- -1 natural or synthetic Substances 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 230000000590 parasiticidal effect Effects 0.000 claims description 2
- 240000006909 Tilia x europaea Species 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002297 parasiticide Substances 0.000 claims 1
- 241001674048 Phthiraptera Species 0.000 abstract description 15
- 244000166675 Cymbopogon nardus Species 0.000 abstract description 2
- 235000018791 Cymbopogon nardus Nutrition 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 17
- JLYXXMFPNIAWKQ-GNIYUCBRSA-N gamma-hexachlorocyclohexane Chemical compound Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl JLYXXMFPNIAWKQ-GNIYUCBRSA-N 0.000 description 11
- 229960002809 lindane Drugs 0.000 description 11
- JLYXXMFPNIAWKQ-UHFFFAOYSA-N gamma-hexachlorocyclohexane Natural products ClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl JLYXXMFPNIAWKQ-UHFFFAOYSA-N 0.000 description 10
- 210000004209 hair Anatomy 0.000 description 8
- 241000238631 Hexapoda Species 0.000 description 7
- 239000000843 powder Substances 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 244000045947 parasite Species 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000517307 Pediculus humanus Species 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 230000000749 insecticidal effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 240000007313 Tilia cordata Species 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229960000510 ammonia Drugs 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 238000011418 maintenance treatment Methods 0.000 description 2
- 210000003689 pubic bone Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 229960004418 trolamine Drugs 0.000 description 2
- 241000238876 Acari Species 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000254171 Curculionidae Species 0.000 description 1
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000699729 Muridae Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- VQXSOUPNOZTNAI-UHFFFAOYSA-N Pyrethrin I Natural products CC(=CC1CC1C(=O)OC2CC(=O)C(=C2C)CC=C/C=C)C VQXSOUPNOZTNAI-UHFFFAOYSA-N 0.000 description 1
- 241000258242 Siphonaptera Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000021425 apple cider vinegar Nutrition 0.000 description 1
- 229940088447 apple cider vinegar Drugs 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000012447 hatching Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- VJFUPGQZSXIULQ-XIGJTORUSA-N pyrethrin II Chemical compound CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VJFUPGQZSXIULQ-XIGJTORUSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 229940085790 synthetic camphor Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/44—Poaceae or Gramineae [Grass family], e.g. bamboo, lemon grass or citronella grass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
ABREGE DESCRIPTIF Nouveaux complexes insectifuges associant un agent mouillant avec 2 à 12 % en volume d'acide acétique, 0,5 à 3 % en volume de citronelle et 0,5 à 1,5 % en volume de cam-phre. Utilisation des complexes en shampooinage contre les poux et puces.ABSTRACT DESCRIPTION New insect repellent complexes combining a wetting agent with 2 to 12% by volume of acetic acid, 0.5 to 3% by volume of citronella and 0.5 to 1.5% by volume of camphor. Use of complexes in shampoo against lice and fleas.
Description
10"6771 L'invention concerne un complexe insectifuge utili-sable notamment sous forme de shampooing, spécialement desti-né à la destruction et la prévention d'insectes particulière-ment résistants tels que les poux et les puces.
On connalt différents constituants susceptibles de détruire ce type d'insectes comme le D.D.T., l'hexachloro-cyclohexane ou le lindane. Toutefois, ces produits se présen-tent généralement sous forme de poudre et leur toxicité élevée rend dangereuse leur utilisation par contact direct avec la peau des mammifères.
Or, si l'~on prend l'exemple des poux et des puces, ces fléaux atteignent de préférence des individus jeunes, (enfants, chiots, chatons), donc des individus particulière-ment sensibles aux substances toxiques.
D'autre part, on sait que certains constituants aci-des sous la forme liquide tels que l'acide acétique, sont ac-tifs contre les insectes et parasites, notamment lorsque ces produits sont utilis~s en solution concentr~e à pH voisin de 10 "6771 The invention relates to an insect repellent complex used sand especially in the form of shampoo, specially intended born to the destruction and prevention of particular insects-resistant, such as lice and fleas.
We know different constituents likely to destroy this type of insect like DDT, hexachloro-cyclohexane or lindane. However, these products are present generally try in powder form and their high toxicity makes their use dangerous by direct contact with the skin of mammals.
Now, if we take the example of lice and fleas, these plagues preferably reach young individuals, (children, puppies, kittens), therefore particular individuals-sensitive to toxic substances.
On the other hand, it is known that certain constituents aci-in liquid form such as acetic acid, are ac-against insects and parasites, especially when these products are used in concentrated solution at a pH close to
2.
Toutefoi~, à ces pH, les produits liquides agresse-raient de fa~on sensible la peau des individus de sorte qu'on est obligé de les utiliser en solution diluée, ce qui diminue notablement leur efficacité.
L'objet de la présente invention concerne un complexe insectifuge permettant de pallier à ces inconvénients et dont l'action permet d'une part de supprimer efficacement les in-sectes et parasites et d'autre part d'en prévenir le retour sur les parties traitées.
Ce complexe, utilisable notamment sous forme de shampooing, comprend une forte proportion d'agent mouillant, tel que le lauryle sulfate de sodium, l'ammoniaque ou la tri-éthanolamine, et est remarquable en ce qu'il comporte de 1 à
,~
--1-- . ~
1096771 :
25% en volume d'au moins un acide organique possédant de 2 à
8 atomes de carbone de façon à porter le pH de l'ensemble à
une valeur inférieure à 4,5 et de préférence inférieure à 2.
Toutefoi ~, at these pHs, liquid products attack make sensitive skin of individuals so that is obliged to use them in dilute solution, which decreases notably their effectiveness.
The object of the present invention relates to a complex insect repellent to overcome these drawbacks and including the action allows on the one hand to effectively remove the in-sects and parasites and secondly to prevent their return on the treated parts.
This complex, which can be used in particular in the form of shampoo, includes a high proportion of wetting agent, such as sodium lauryl sulfate, ammonia or tri-ethanolamine, and is remarkable in that it comprises from 1 to , ~
--1--. ~
1096771:
25% by volume of at least one organic acid having from 2 to 8 carbon atoms so as to bring the pH of the whole to a value less than 4.5 and preferably less than
3,5.
En particulier, les complexes objets de l'inven-tion peuvent comporter de 2 à 12% en volume d'acide acétique, ainsi que 0,5 à 20%, plus particulièrement 0,5 à 3%, en volume de substances insecticides et/ou parasiticides issues de substances naturelles ou obtenues par synthèse, telles que les extraits ou essences de girofle, de lavande, de menthe poivrée, d'origan, de romarin, de tilleul, de genévrier, de citron, de citronelle, de thym, de Datura Stramonium, de pin, de pyrèthre, de pyréthrine et des huiles essentielles d'écorce ou de feuilles de canelle de Ceylan.
En outre, ils peuvent contenir avantageusement une substance insectifuge et cicatrisante telle que du camphre naturel ou synthétique selon des proportions en volume com~
prises entre 1,5 et 5% et de préférence entre 0,5 et 1,5%.
Pour mieux faire comprendre les avantages et mettre en valeur le mode d'action des complexes selon l'invention, on va décrire ci-après à titre non limitatif~des exemples de formulation correspondant aux applications principales des complexes ainsi que des exemples de traitements réalisés.
Pour chaque formulation, on constatera que la proportion d'agent mouillant est importante.
En effet, il a été constaté de fa,con surprenante que l'effet insecticide de l'acide acétique est considérable-ment augmenté par l'addition d'agents mouillants tels que les lauryle sulfates de sodium, d'ammoniaque ou de triëthanol-amine, les bases cationiques classiques ou les produits nonioniques utilisés classiquement dans le domaine des shampooings. -lOq6771 Cette constatation peut être vérifiée à l'aide du test suivant effectué sur des charançons, des fourmis, des pince-oreilles, des poux et des puces. On dilue en tiers en volume le produit réalisé dans les exemples ci-après décrits puis on place quelques gouttes sur chaque insecte pris entre des lamelles de fa,con à ce que le corps de l'insecte soit imprégné à peu près au trois-quarts.
On mesure alors le temps nécessaire pour que l'insecte ne soit plus parcouru de mouvements. On compare ce temps à celui obtenu à l'aide d'une solution aqueuse d'acide acét1que de pH équivalent.
Les résultats constatés montrent que les temps sont en moyenne de deux à cinq fois moindre dans le cas du sham-pooing que dans le cas de l'acide acétique pur (20 à 50 se-condes au lieu de 1 à 3 minutes).
Premier exemple: shampooing hygiénique efficace contre les poux pour adultes et enfants. Les proportions sont indiquées en volume.
-Agent mouillant Texapant ~3 ~ 40 (HENKEL) dilué à 30%.,75 à 95%
-Camphre synthétique.......................................... .0,5 à 1,5% -~
-Citronelle.. ,..................... ,....... '.,,,.................... .0,5 ~ 1,5%
-Acide acétique................. .........,.................... ,. 5 à 10%
-pH.......... ,.... ,................... ,,,,,,. ,,.,.,..... .,,..... ,.. .1,8 à 2,3.
Cas 1: On a traité deux énfants âgés respectivement de 11 et 13 ans dont les cheveux comportaient une importante colonie de poux adultes et des lentes à l'aide d'un shampooing contenant 1% de camphre synthétique, 1% d'essence de citron-nelle, 5% d'acide acétique et 93% de Texapant ~ dilu~ à 30%
(pH ajusté à 2,1), Un lavage à l'aide du shampooing est pratiqué un ma-tin à 9 heures. Le shampooing est utilisé en activit~ pendant .~
10"677~
15 minutes puis un lavage à l'eau est pratiqué.
Un examen de la tête montre qu'il ne subsiste plus aucun pou adulte et que la proportion de lentes a diminué. Un nouveau shampooing est pratiqué 2, 4, puis 6 jours plus tard quoiqu'aucun pou adulte ne soit observé. Le nombre des lentes est en régression régulière.
De nouveaux lavages sont pratiqués chaque semaine.
Au bout de 3 semaines les lentes ont totalement disparu.
Cas 2: Agée de 15 ans, une jeune fille s'est aper-çue en prenant un bain que des pous nageaient près d'elle. Ellea été traitée chaque soir avec une poudre à 0,8% de lindane, coiffée d'un bonnet toute la nuit puis lavée avec un sham-pooing ordinaire chaque matin et peignée au peigne fin. Au about de cinq jours, des lentes se trouvaient encore dans les cheveux.
Un seul shampooing avec le produit indiqué au cas 1 a suffi pour débarasser les cheveux de tous les parasites et faire cesser le traitement fastidieux et désagréable. ;
Cas 3: Une petite fille de cinq ans, depuis trois semalnes, avait des lentes et était traitée chaque soir avec une poudre à base de lindane à 0,4% et de DDT à 10%. Elle gardait le nuit entière ces insecticides dans les cheveux avec un bonnet et le matin recevait un shampooing ordinaire suivi d'un passage de peigne fin.
Cette petite fille blonde avait des cheveux parti-culièrement fins et les lentes nombreuses étaient fixées d'une façon très solide sur les cheveux.
Un premier traitement avec le produit du cas 1 ne donna qu'un résultat partiel. Il fallut,faire encore deux applications de produit pour obtenir l'élimination totale des lentes. 3.5.
In particular, the complex objects of the invention tion may contain from 2 to 12% by volume of acetic acid, as well as 0.5 to 20%, more particularly 0.5 to 3%, by volume insecticidal and / or parasiticidal substances from natural or synthetically obtained substances, such as extracts or essences of cloves, lavender, mint peppery, oregano, rosemary, linden, juniper, lemon, lemongrass, thyme, Datura Stramonium, pine, pyrethrum, pyrethrin and essential oils Ceylon bark or cinnamon leaves.
In addition, they can advantageously contain a insect repellant and healing substance such as camphor natural or synthetic in proportions by volume com ~
taken between 1.5 and 5% and preferably between 0.5 and 1.5%.
To better understand the benefits and put in value the mode of action of the complexes according to the invention, we will describe below without limitation ~ examples of formulation corresponding to the main applications of complexes as well as examples of treatments performed.
For each formulation, we will see that the proportion of wetting agent is important.
Indeed, it was found in a surprisingly con that the insecticidal effect of acetic acid is considerable-increased by the addition of wetting agents such as sodium lauryl sulphates, ammonia or triethanol-amine, conventional cationic bases or nonionic products conventionally used in the field of shampoos. -lOq6771 This can be verified using the following test performed on weevils, ants, ear clips, lice and fleas. We dilute in thirds by volume the product produced in the examples described below then place a few drops on each insect caught between strips of fa, so that the body of the insect is impregnated about three-quarters.
We then measure the time necessary for the insect is no longer traversed by movements. We compare this time to that obtained using an aqueous acid solution acetate equivalent pH.
The results observed show that the times are on average two to five times less in the case of sham-pooing that in the case of pure acetic acid (20 to 50 se-condes instead of 1 to 3 minutes).
First example: effective hygienic shampoo against lice for adults and children. The proportions are indicated in volume.
-Wetting agent Texapant ~ 3 ~ 40 (HENKEL) diluted to 30%., 75 to 95%
- Synthetic camera .......................................... .0.5 to 1.5% - ~
-Citronella .., ....................., ....... '. ,,, ........... ......... .0.5 ~ 1.5%
-Acetic acid................. .........,.................... ,. 5 to 10%
-pH .........., ...., ................... ,,,,,,. ,,.,., ...... ,, ....., .. .1.8 to 2.3.
Case 1: Two elderly children were treated respectively 11 and 13 year olds with significant hair colony of adult lice and nits using shampoo containing 1% synthetic camphor, 1% lemon essence-nelle, 5% acetic acid and 93% Texapant ~ diluted ~ 30%
(pH adjusted to 2.1), Washing with shampoo is done a ma-tin at 9 a.m. The shampoo is used in activity during . ~
10 "677 ~
15 minutes then washing with water is carried out.
Examination of the head shows that it no longer remains no adult lice and the proportion of nits has decreased. A
new shampoo is performed 2, 4, then 6 days later although no adult louse is observed. The number of nits is in regular regression.
New washes are performed every week.
After 3 weeks the nits have completely disappeared.
Case 2: A 15-year-old girl discovered seen while taking a bath that lice were swimming near her. It was treated each evening with a 0.8% lindane powder, wearing a cap all night and then washing with a sham-ordinary fist every morning and combed with a fine comb. At after five days, nits were still in the hair.
A single shampoo with the product indicated in the case 1 was enough to rid the hair of all parasites and stop the tedious and unpleasant treatment. ;
Case 3: A five-year-old girl for three semalnes, had nits and was treated each evening with a powder based on 0.4% lindane and 10% DDT. She kept these insecticides in their hair overnight with a hat and in the morning received an ordinary shampoo followed by a fine comb passage.
This little blond girl had parti-especially fine and numerous nits were fixed very solidly on the hair.
A first treatment with the product of case 1 does not gave only a partial result. We had to do two more product applications to achieve total elimination nits.
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Deuxième exemple: traitement des puces, poux et tiques chez les chiens.
On a utilisé un shampooing contenant 6% d'acide acé-tique, 1,5% de citronelle et 1,5% d'essence de girofle et 91%
de Texapant ~ dilué à 30% (pH ajusté à 2).
On traite un chien adulte de race Teckel infesté de puces.
Un lavage avec un shampooing de formule vétérinaire ~-ci-dessus est pratiqué un matin à 8 heures. A 12 heures le ;~
chien ne présente plus de puces et n'est plus contaminé pen- -dant 3 jours malgré un environnement défavorable.
Un traitement d'entretien consistant à pulvériser -une lotion constitu~e d'une solution de d~coction de thym à
25%, de vinaigre de cidre à 73% et de 2% de citronelle permet d'éviter tout retour des parasites jusqu'à désinfection com-plète de l'environnement (locaux et tissus) à l'aide des pro-duits de l'exemple 3.
Troisième exemple: Traitement de locaux et tissus.
On a utilisé un shampooing composé de 10% d'acide acétique, 2% d'essence de citronelle et 2% de camphre (pH
ajusté à 1,8).
' Dans une pièce inoccupée depuis quelques temps et mal fermée, comportant des objets disparates et des tissus, une pro-lifération de puces a été constatée.
Après rangement des objets, le tapis recouvrant une partie du sol et de carrelage sont aspergés avec le shampooing dilué dans deux fois son volume d'eau. Deux heures plus tard, les puces ne donnent plus signe de vie.
De la meme façon, on a traité avec succès des man-teaux, couvertures et paniers à chien en les traitant avec dessolutions de 5 cm3 de shampooing pour un litre d'eau.
, ,~. ._. A 5 D'une façon gén~rale, le mode d'action des produits objets de l'invention est le suivant: on pratique un shampooing des parties à traiter à l'aide des complexes décrits ci-dessus, on laisse les produits agir pendant une durée généralement com-prise entre une à dix minutes pour les individus et entre cinq à vingt minutes pour les objets.
On rince abondamment ce qui entraîne l'acide acétique ou ses équivalents ainsi que les inséctes et les parasites.
Après le lavage, on constate que les. produits répul-sifs des insectes restent en quantité suffisante pour protéger ~
contre de nouvelles infections. ;
Toutefois, dans de nombreux cas, on a intérêt à con-tinuer le traitement par les lavages successifs espacés jus-qu'à disparition complète des larves ainsi qu'à appliquer un traitement d'entretien comprenant des pulvérisations ou sprays des différentes essences de produits insecticides ou parasiti- :
cides cités plus haut, avec ou sans camphre mais de préférence ~
sans acide acétique, c'est-à-dire de citronelle, d'essence de .
girofle, de lavande, de menthe poivrée, d'origan, de romaxin, de tilleul, de genévrier, de citron, de thym, de Datura Stra-monium, de pyrèthre ou d'huile essentielle de canelle de Cey- : :
lan.
Ces pulvérisations protègent.durablement les suje s entre chaque shampooing. .
On a d'autre part comparé l'action d'insecticide du shampooing conforme à celui utilisé dans le cas 1 de l'exemple 1, par rapport à une préparation de lindane en poudre à 15% en poids de la façon suivante: :
1. Essais sur pou adulte:
Dans une coupelle, on met 5 cm3 de shampooing pur, puis on y dépose 5 poux (pediculus humanus). La mort est im-.. . . .. . .. . . .. .. . .. .
~09677~
médiate. Afin d'être certain du résultat, un autre essai a été fait en laissant seulement 10 secondes les poux dans le shampooing, en les retirant avec une baguette en bois. On les met sous une loupe et on constate la mort effective des poux.
On opère de la même manière avec le shampooing di-~ -*-lué à 50% puis à 25% afin de se rapprocher des concentrations d'utilisation qui varient de 25 à 100%.
La mort des poux est plus lente avec ces deux di-lutions et le test de r~cupération des poux montre qu'après ;
30 secondes, les poux ne reviennent pas à la vie.
Les même essais sont pratiqués sur l'èspèce phtiriuspubis avec le m & e pourcentage de mortalité de 100% après 30 secondes. Ces essais sont repris en comparaison avec une pré-paration de lindane en poudre à 15%. -Le tableau ci-après résume les résultats obtenus:
Essais sur pediculus humanus adultes:
Pourcentaqe de-mortalité:
Après Après Après - 0 secondes 30 secondes 2 heures R.S. 206 * pur 100% 100% 100%
R.S. 206 dilué à 50% 20% 100% 100%
R.S. 206 dilué à 25% 0% 100% 100%
Lindane poudre à 15% 0% 0% 50%
Le même essai a été effectué sur adultes de phtirius pubis avec des résultats identiques.
2. Essais sur lentes de pediculus humanus: ~ -Il a été très difficile de savoir si les lentes ont bien été tu~es par le produit car pour être certain de leur * R.S. 206 signifie Rabi et Solabo ~o. 206, qui est un numéro dans la série des produits mis aux point par les Laboraboires Rabi et Solabo.
; ~7~
., . ~ . , ~
~Q"6771 mort, il faut attendre 2 à 5 semaines; le fait de séparer la lente du cheveu sur lequel elle est collée peut être le facteur de destruction.
L'essai suivant a été pratiqué: Sur un enfant por-teur de lentes, 10 cheveux avec des lentes ont éte retirés et placés dans des coupelles avec les;produits d'essais ou de l'eau, pendant une durée de 15 minutes puis conservés à une température de 22.
Certaines lentes dans le shampooing sont séparées du cheveu, d'autres restent coll~es. Les observations ont port~
sur cinq semaines et les résultats ont été les suivants:
Observations sur l'éclosion des lentes:
lère semaine 2ème 3ème 4ème 5ème R.S. 206 pur 0 0 0 0 0 R.S. 206 dilué à 50% 0 0 0 0 0 Lindane poudre à 15% 0 0 0 0 0 Le même essai a été effectué sur des lentes de phtirius pubis avec des résultats identiques.
Le produit est donc plus actif qu'une formulation de lindane à 15%, Les formulations de lindane à 0,4 et 0,8% ont une ac-tion insuffisante pour être utilisées comme élément de compa- ;
ralson .
D'autre part, l'action bactériostatique des produits selon l'invention a été v~rifiée et ceci bien qu'ils ne con-tiennent aucun des bact~ricides habituellement utilisés, tels que paraoxybenzoate de méthyle mais divers essais ont montré
qu'aucune bactérie ne se développait dans le produit pur ou dilué à 50%.
L'étude faite pour vérifier que la préparation était exempte de bactéries a ét~ poursuivie devant les résultats in-téressants obtenus.
La technique utilisée a ét~ la suivante avec le shampooing de l'exemple 1:
1) Ensemencement sur gélose ordinaire, 2) Conservation en étuve à 37 pendant 48 heures puis pendant sept jours.
Résultats:
Après 48 heures Après 7 jours Shampooing pur 0 colonie 0 colonie Shampooing dilué à 50% 0 colonie 0 colonie Après ensemencement avec escherichia coli:
Après 48 heures Après 7 jours -Shampooing pur 0 colonie 0 colonie -~
Shampooing dilué à 50% 0 colonie 0 colonie Enfin, les toxicités relevées peuvent varier de fa- -~con importante, ce qui renforce l'int~rêt de l'acide acétique associé en synergie avec un agent mouillant lui conférant un pouvoir insecticide accru tout en maintenant sa toxicité dans des limites tout à fait compatibles avec son utilisation, en 20 contact avec des épidermes sensibles.
En effet, la toxicité P.O. obtenue par administra- -tion du shampooing conforme à l'exemple 1 à des souris RIVER
mâles de poids moyen 25 grammes, indique pour dose maximale tolérée 24 ml/kg et pour dose léthale 100, une valeur de 40 ml/kg.
Les résultats ne permettent pas d'~valuer une dose léthale 50. Par comparaison, on peut rappeler que la dose léthale 50 pour lindane observée avec des préparations aqueuses administrée par voie orale à des souris est à peu près de 300 mg/kg.
Enfin, l'étude de la tolérance locale cutanée a per-. .. ~
~ '.
_g _ lOq6771 mis de déterminer l'indice d'irritation primaire de 0,3 donc faible, les essais d'application répétée sur l'oreille de sou-ris ont permis de conclure que le shampooing n'était pas irri-tant et les applications répétées sur le pelage du lapin ont montré une excellente tolérance.
Seuls les essais au niveau occulaire font penser que le shampooing peut être irritant mais que cette action irrita-tive est très faible après une dilution correspondant à
l'utilisation du produit.
D'autres applications et variantes de l'invention se-ront aisément réalis~es par l'homme de l'art sans pour cela sortir du cadre de l'invention, notamment en substituant des équivalents avec différents produits décrits ci-dessus, par exemple en remplaçant l'acide acétique par des acides homolo-gues, mais il a été constaté que les résultats obtenus pouvaient être sensiblement inférieurs, en particulier avec les acides propionique et caprilique.
. . -4-~.
109677 ~
Second example: treatment of fleas, lice and ticks in dogs.
A shampoo containing 6% acetic acid was used tick, 1.5% lemongrass and 1.5% clove essence and 91%
Texapant ~ diluted to 30% (pH adjusted to 2).
An adult Dachshund dog infested with fleas.
Washing with a veterinary shampoo ~ -above is practiced one morning at 8 o'clock. At 12 noon on; ~
dog no longer has fleas and is no longer contaminated during -for 3 days despite an unfavorable environment.
A maintenance treatment consisting of spraying -a lotion consisting of a solution of thyme coction to 25%, 73% apple cider vinegar and 2% lemon grass allows avoid any return of parasites until disinfection of the environment (premises and fabrics) using of Example 3.
Third example: Treatment of premises and fabrics.
We used a shampoo composed of 10% acid acetic, 2% citronella essence and 2% camphor (pH
adjusted to 1.8).
'' In a room that has been vacant for some time closed, with disparate objects and fabrics, a pro-flea longevity has been noted.
After storing the objects, the carpet covering a part of the floor and tiles are sprayed with shampoo diluted in twice its volume of water. Two hours later, fleas no longer give any sign of life.
Likewise, we have successfully treated dogs, blankets and baskets by treating them with solutions of 5 cm3 of shampoo for one liter of water.
,, ~. ._. AT 5 In general, the mode of action of the products objects of the invention is as follows: a shampoo is practiced parts to be treated using the complexes described above, the products are left to act for a duration generally taken between one to ten minutes for individuals and between five twenty minutes for objects.
Rinse thoroughly which results in acetic acid or its equivalents as well as insects and parasites.
After washing, we see that the. repul-insects stay in sufficient quantity to protect ~
against new infections. ;
In many cases, however, there is interest in con-continue treatment by successive washes spaced until until the larvae have completely disappeared and apply a maintenance treatment including sprays or sprays different species of insecticide or parasitic products:
cides mentioned above, with or without camphor but preferably ~
without acetic acid, i.e. lemon grass, essence.
cloves, lavender, peppermint, oregano, romax, lime, juniper, lemon, thyme, Datura Stra-monium, pyrethrum or Cey cinnamon essential oil::
lan.
These sprays permanently protect the suje s between each shampoo. .
We also compared the insecticide action of shampoo in accordance with that used in case 1 of the example 1, compared to a 15% powdered lindane preparation in weight as follows::
1. Tests on adult louse:
In a cup, put 5 cm3 of pure shampoo, then 5 lice (pediculus humanus) are deposited there. Death is im-... . ... ... . .. ... ...
~ 09677 ~
mediate. In order to be certain of the result, another test was been done leaving only 10 seconds the lice in the shampoo, removing them with a wooden stick. We put them under a magnifying glass and we observe the actual death of lice.
We operate in the same way with the shampoo di- ~ - * -50% and then 25% in order to get closer to the concentrations of use which vary from 25 to 100%.
Lice death is slower with these two di-lutions and the lice recovery test shows that after;
30 seconds, lice do not come back to life.
The same tests are performed on the phtiriuspubis species with the same percentage mortality of 100% after 30 seconds. These tests are repeated in comparison with a pre-15% lindane powder coating. -The table below summarizes the results obtained:
Adult pediculus humanus trials:
Percentage of mortality:
After after after - 0 seconds 30 seconds 2 hours RS 206 * pure 100% 100% 100%
RS 206 diluted to 50% 20% 100% 100%
RS 206 diluted to 25% 0% 100% 100%
Lindane powder 15% 0% 0% 50%
The same test was carried out on adults of phtirius pubis with identical results.
2. Tests on nits of pediculus humanus: ~ -It was very difficult to know whether the nits had well been you ~ are by the product because to be certain of their * RS 206 means Rabi and Solabo ~ o. 206 which is a number in the series of products developed by Laboraboires Rabi and Solabo.
; ~ 7 ~
.,. ~. , ~
~ Q "6771 dead, wait 2 to 5 weeks; separating the the hair on which it is stuck may be the factor of destruction.
The following test was performed: On a child bearing 10 hairs with nits were removed and placed in cups with; test or water, for a period of 15 minutes and then stored at temperature of 22.
Some nits in the shampoo are separated from the hair, others remain glued. The observations focused on over five weeks and the results were as follows:
Observations on the hatching of nits:
1st week 2nd 3rd 4th 5th RS 206 pure 0 0 0 0 0 RS 206 diluted to 50% 0 0 0 0 0 Lindane 15% powder 0 0 0 0 0 The same test was carried out on nits of phtirius pubis with identical results.
The product is therefore more active than a formulation of 15% lindane, 0.4 and 0.8% Lindane formulations have an insufficient to be used as a comparison element;
ralson.
On the other hand, the bacteriostatic action of the products according to the invention has been verified and this although they do not none of the bacteria commonly used, such as as methyl paraoxybenzoate but various tests have shown that no bacteria were growing in the pure product or diluted to 50%.
The study made to verify that the preparation was bacteria-free has been sued in front of the results interesting obtained.
The technique used was the following with the shampoo from Example 1:
1) Inoculation on ordinary agar, 2) Storage in an oven at 37 for 48 hours then for seven days.
Results:
After 48 hours After 7 days Pure shampoo 0 colony 0 colony Shampoo diluted to 50% 0 colony 0 colony After seeding with escherichia coli:
After 48 hours After 7 days -Pure shampoo 0 colony 0 colony - ~
Shampoo diluted to 50% 0 colony 0 colony Finally, the toxicities noted can vary in a way -~ important con, which strengthens the int ~ stop acetic acid associated in synergy with a wetting agent giving it a increased insecticidal power while maintaining its toxicity in limits entirely compatible with its use, in 20 contact with sensitive epidermis.
In fact, the PO toxicity obtained by administra- -tion of the shampoo according to Example 1 to RIVER mice males of average weight 25 grams, indicated for maximum dose tolerated 24 ml / kg and for lethal dose 100, a value of 40 ml / kg.
The results do not allow to assess a dose lethal 50. By comparison, it can be recalled that the dose lethal 50 for lindane observed with aqueous preparations given orally to mice is approximately 300 mg / kg.
Finally, the study of local skin tolerance has helped . .. ~
~ '.
_g _ lOq6771 put to determine the primary irritation index of 0.3 so weak, repeated application tests on the ear of sou-ris allowed to conclude that the shampoo was not irri-so many and repeated applications on the rabbit's coat have showed excellent tolerance.
Only eye level tests suggest that the shampoo can be irritating but that this irritating action tive is very weak after a dilution corresponding to the use of the product.
Other applications and variants of the invention are will easily be made by those skilled in the art without doing so depart from the scope of the invention, in particular by substituting equivalent with different products described above, by example by replacing acetic acid with homolo-but it was found that the results obtained could be significantly lower, especially with propionic and caprilic acids.
. .
Claims (8)
par le fait qu'il comprend 75 à 95% en volume d'un agent mouillant dilué, et 2 à 12% en volume d'acide acétique, le pH
du shampooing étant inférieur à 3,5. 8. Essentially characterized insecticide shampoo by the fact that it comprises 75 to 95% by volume of an agent diluted wetting agent, and 2 to 12% by volume of acetic acid, the pH
shampoo being less than 3.5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR7635121 | 1976-11-22 | ||
FR7635121A FR2371190A1 (en) | 1976-11-22 | 1976-11-22 | INSECTIVE COMPLEXES |
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CA1096771A true CA1096771A (en) | 1981-03-03 |
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ID=9180154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA291,442A Expired CA1096771A (en) | 1976-11-22 | 1977-11-22 | Complexes insectifuges |
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JP (1) | JPS54119035A (en) |
AT (1) | AT362617B (en) |
AU (1) | AU518341B2 (en) |
BE (1) | BE861000A (en) |
CA (1) | CA1096771A (en) |
CH (1) | CH625121A5 (en) |
DE (1) | DE2752140C2 (en) |
DK (1) | DK146112C (en) |
ES (1) | ES464354A1 (en) |
FR (1) | FR2371190A1 (en) |
GB (1) | GB1593601A (en) |
GR (1) | GR70301B (en) |
LU (1) | LU78565A1 (en) |
NL (1) | NL188555C (en) |
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Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2553664A1 (en) * | 1983-10-25 | 1985-04-26 | Charnay Sylvie | Composition based on essential oils from plants, for destroying lice and nits |
IL74067A0 (en) * | 1985-01-16 | 1985-04-30 | Ataron Dev 1985 Ltd | Compositions containing quaternary ammonium compounds |
AU602144B2 (en) * | 1986-05-08 | 1990-10-04 | R & C Products Pty Limited | Animal repellant composition and method |
JPH01149402U (en) * | 1988-04-07 | 1989-10-17 | ||
JPH0211105U (en) * | 1988-07-04 | 1990-01-24 | ||
JPH02115107A (en) * | 1988-10-22 | 1990-04-27 | Matsushita Electric Works Ltd | Antibiotic agent |
US5288483A (en) * | 1990-04-18 | 1994-02-22 | The Procter & Gamble Company | Anti-lice treatment compositions |
AU7656891A (en) * | 1990-04-18 | 1991-11-11 | Procter & Gamble Company, The | Anti-lice treatment compositions |
AU659625B2 (en) * | 1991-01-18 | 1995-05-25 | Clilco, Ltd. | Lice-repellant compositions |
US5227163A (en) * | 1991-01-18 | 1993-07-13 | Clilco, Ltd. | Lice-repellant compositions |
WO1994016665A2 (en) * | 1993-01-25 | 1994-08-04 | Seleznev, Alexandr Georgievich | Agent to combat lice infestation |
FR2732591B1 (en) * | 1995-04-07 | 1997-06-13 | Benwaiche Joseph | PEST CONTROL SHAMPOO |
DE19631596A1 (en) * | 1996-08-05 | 1998-02-12 | Henkel Kgaa | Washing process |
FR2759546A1 (en) * | 1997-02-19 | 1998-08-21 | Soc Et De Rech De Travaux D Or | Use of citronella components as insecticides |
US20030194454A1 (en) | 1998-07-28 | 2003-10-16 | Bessette Steven M. | Pesticidal compositions containing rosemary oil and wintergreen oil |
GB2347082A (en) * | 1999-02-24 | 2000-08-30 | Margaret Mary Seale | Treatment or prevention of parasitic infection using acetic acid |
GB2355404A (en) * | 1999-08-20 | 2001-04-25 | Polyatomic Apheresis Res Ltd | Vinegar for treating parasites |
WO2001032133A2 (en) * | 1999-11-05 | 2001-05-10 | Nature Plus Inc. | Improved nit removal product |
WO2001060163A2 (en) | 2000-02-17 | 2001-08-23 | Ecosmart Technologies, Inc. | Plant essential oils cointaining pediculicidal compositions |
SE0103401D0 (en) * | 2001-10-12 | 2001-10-12 | Natalie Fresia | Means against lice as well as vermin |
EP1954142B1 (en) * | 2005-11-18 | 2017-04-19 | Wild Child | Pediculicide/ovicide composition |
US20130280350A1 (en) * | 2010-06-08 | 2013-10-24 | Sequent Scientific Limited | Herbal topical formulation |
NO344832B1 (en) * | 2018-11-02 | 2020-05-18 | Inakva As | Composition for use in the prevention or treatment of attacks or infection of parasites on fish |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1589866A (en) * | 1924-11-17 | 1926-06-22 | Siegler Edouard Horace | Insecticide and process of preparing the same |
US2788308A (en) * | 1953-07-07 | 1957-04-09 | Irving L Ochs | Topical non-aqueous acetic compositions |
DE1105549B (en) * | 1957-07-06 | 1961-04-27 | Johannes Roedger Dr Med | Disinfecting detergents and cleaning agents |
NL279632A (en) * | 1962-02-09 | 1964-11-25 | ||
US3650964A (en) * | 1968-05-13 | 1972-03-21 | Basf Wyandotte Corp | Low foam anionic acid sanitizer compositions |
GB1249674A (en) * | 1968-11-28 | 1971-10-13 | Exxon Research Engineering Co | Novel agricultural compositions and leaf-desiccating method |
GB1438946A (en) * | 1972-06-15 | 1976-06-09 | Nat Res Dev | Control of fungi |
GB1438945A (en) * | 1972-06-15 | 1976-06-09 | Nat Res Dev | Control of fungi |
DD111633A1 (en) * | 1974-01-16 | 1975-03-05 | ||
US3969258A (en) * | 1974-10-10 | 1976-07-13 | Pennwalt Corporation | Low foaming acid-anionic surfactant sanitizer compositions |
-
1976
- 1976-11-22 FR FR7635121A patent/FR2371190A1/en active Granted
-
1977
- 1977-11-18 ZA ZA00776910A patent/ZA776910B/en unknown
- 1977-11-21 SE SE7713126A patent/SE7713126L/en not_active Application Discontinuation
- 1977-11-21 PT PT67304A patent/PT67304B/en unknown
- 1977-11-21 BE BE1008527A patent/BE861000A/en not_active IP Right Cessation
- 1977-11-21 GR GR54846A patent/GR70301B/el unknown
- 1977-11-21 NO NO773986A patent/NO149718C/en unknown
- 1977-11-22 DE DE2752140A patent/DE2752140C2/en not_active Expired - Lifetime
- 1977-11-22 CA CA291,442A patent/CA1096771A/en not_active Expired
- 1977-11-22 NZ NZ185745A patent/NZ185745A/en unknown
- 1977-11-22 GB GB48564/77A patent/GB1593601A/en not_active Expired
- 1977-11-22 AU AU30837/77A patent/AU518341B2/en not_active Expired
- 1977-11-22 AT AT834877A patent/AT362617B/en not_active IP Right Cessation
- 1977-11-22 CH CH1425377A patent/CH625121A5/en not_active IP Right Cessation
- 1977-11-22 DK DK517577A patent/DK146112C/en not_active IP Right Cessation
- 1977-11-22 JP JP13952777A patent/JPS54119035A/en active Granted
- 1977-11-22 NL NLAANVRAGE7712875,A patent/NL188555C/en not_active IP Right Cessation
- 1977-11-22 LU LU78565A patent/LU78565A1/xx unknown
- 1977-11-22 ES ES464354A patent/ES464354A1/en not_active Expired
- 1977-11-23 OA OA56323A patent/OA08256A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO149718C (en) | 1984-06-13 |
SE7713126L (en) | 1978-05-23 |
AT362617B (en) | 1981-06-10 |
FR2371190A1 (en) | 1978-06-16 |
NO149718B (en) | 1984-03-05 |
BE861000A (en) | 1978-05-22 |
DK517577A (en) | 1978-05-23 |
GR70301B (en) | 1982-09-06 |
ES464354A1 (en) | 1978-12-01 |
JPS54119035A (en) | 1979-09-14 |
ATA834877A (en) | 1980-10-15 |
NL188555C (en) | 1992-08-03 |
JPS6113443B2 (en) | 1986-04-14 |
CH625121A5 (en) | 1981-09-15 |
AU3083777A (en) | 1979-05-31 |
AU518341B2 (en) | 1981-09-24 |
PT67304A (en) | 1977-12-01 |
DK146112C (en) | 1983-11-28 |
NL188555B (en) | 1992-03-02 |
LU78565A1 (en) | 1978-04-20 |
DE2752140C2 (en) | 1994-02-10 |
NO773986L (en) | 1978-05-23 |
PT67304B (en) | 1979-04-20 |
FR2371190B1 (en) | 1981-06-19 |
OA08256A (en) | 1987-10-30 |
DK146112B (en) | 1983-07-04 |
NL7712875A (en) | 1978-05-24 |
ZA776910B (en) | 1978-09-27 |
GB1593601A (en) | 1981-07-22 |
DE2752140A1 (en) | 1978-05-24 |
NZ185745A (en) | 1980-08-26 |
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Effective date: 19980303 |