DK1431284T3 - Diarylsulfidderivat, additionssalt deraf samt immunundertrykkende middel - Google Patents
Diarylsulfidderivat, additionssalt deraf samt immunundertrykkende middelInfo
- Publication number
- DK1431284T3 DK1431284T3 DK02768057T DK02768057T DK1431284T3 DK 1431284 T3 DK1431284 T3 DK 1431284T3 DK 02768057 T DK02768057 T DK 02768057T DK 02768057 T DK02768057 T DK 02768057T DK 1431284 T3 DK1431284 T3 DK 1431284T3
- Authority
- DK
- Denmark
- Prior art keywords
- diarylsulfide
- immunosuppressants
- derivatives
- addition salts
- salts
- Prior art date
Links
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 239000003018 immunosuppressive agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001297411 | 2001-09-27 | ||
JP2002216192 | 2002-07-25 | ||
PCT/JP2002/009865 WO2003029205A1 (fr) | 2001-09-27 | 2002-09-25 | Derive de sulfure de diaryle, son sel d'addition et immunosuppresseur |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1431284T3 true DK1431284T3 (da) | 2008-02-18 |
Family
ID=26623111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02768057T DK1431284T3 (da) | 2001-09-27 | 2002-09-25 | Diarylsulfidderivat, additionssalt deraf samt immunundertrykkende middel |
Country Status (15)
Country | Link |
---|---|
US (1) | US6960692B2 (pt) |
EP (1) | EP1431284B1 (pt) |
JP (2) | JP4217620B2 (pt) |
KR (1) | KR100913269B1 (pt) |
CN (1) | CN1329372C (pt) |
AU (1) | AU2002332289B2 (pt) |
BR (1) | BRPI0212894B8 (pt) |
CA (1) | CA2461212C (pt) |
CY (1) | CY1107272T1 (pt) |
DE (1) | DE60223699T2 (pt) |
DK (1) | DK1431284T3 (pt) |
ES (1) | ES2292809T3 (pt) |
MX (1) | MXPA04002679A (pt) |
PT (1) | PT1431284E (pt) |
WO (1) | WO2003029205A1 (pt) |
Families Citing this family (73)
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CN1585638A (zh) * | 2001-09-14 | 2005-02-23 | 图拉里克公司 | 被连接的联芳基化合物 |
WO2003059880A1 (fr) | 2002-01-11 | 2003-07-24 | Sankyo Company, Limited | Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant |
CN1652757B (zh) * | 2002-05-16 | 2012-02-08 | 诺瓦提斯公司 | Edg受体结合剂在癌症中的应用 |
MXPA05003080A (es) | 2002-09-19 | 2005-06-15 | Kyorin Seiyaku Kk | Derivado de amino alcohol, sales de los mismos y agentes inmunosupresores. |
PL408347A1 (pl) | 2002-09-24 | 2014-08-18 | Novartis Ag | Kombinacja, zastosowanie kombinacji oraz zastosowanie agonisty receptora S1P |
HUE028247T2 (en) | 2003-04-08 | 2016-12-28 | Novartis Ag | A solid oral composition comprising S1P receptor agonist and sugar alcohol |
ATE547395T1 (de) * | 2003-04-30 | 2012-03-15 | Novartis Pharma Gmbh | Aminopropanol-derivate als modulatoren des sphingosin-1-phosphat-rezeptors |
GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
GB0324210D0 (en) * | 2003-10-15 | 2003-11-19 | Novartis Ag | Organic compounds |
GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
JP2007186422A (ja) * | 2004-01-28 | 2007-07-26 | Astellas Pharma Inc | アリールスルフィド誘導体 |
CN1921847B (zh) | 2004-02-24 | 2010-06-16 | 三共株式会社 | 氨基醇化合物 |
EP1755680A1 (en) * | 2004-05-03 | 2007-02-28 | Novartis AG | Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor |
RU2396982C2 (ru) * | 2004-07-16 | 2010-08-20 | Киорин Фармасьютикал Ко., Лтд. | Эффективный способ использования лекарственных средств и способ предотвращения выраженности побочных эффектов |
TW200611687A (en) * | 2004-07-29 | 2006-04-16 | Sankyo Co | Pharmaceutical compositions used for immunosuppressant |
PL1773307T3 (pl) | 2004-07-30 | 2015-03-31 | Novartis Ag | Preparaty 2-amino-1,3-propanodioli i ich analogów |
US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
RU2007109207A (ru) | 2004-08-13 | 2008-09-20 | Прикис Фамэсьютикэлс, Инк. (US) | Соединения-модуляторы активности рецептора сфингозин-1-фосфата (варианты), фармацевтическая композиция, содержащая указанные соединения, и способ лечения нарушения, ассоциированного со сфингозин-1-фосфатом |
BRPI0516337A (pt) * | 2004-10-12 | 2008-04-29 | Kyorin Seiyaku Kk | processo para a produção de 2- amino-2-[4-(3-benziloxifeniltio) -2- (clorofenil} etil] - 1,3 - hidrocloreto de propanediol e hidratos dos mesmos e produtos intermerdiários para a produção dos mesmos |
SG158096A1 (en) * | 2004-11-29 | 2010-01-29 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
TWI418350B (zh) * | 2005-06-24 | 2013-12-11 | Sankyo Co | 含有ppar調節劑之醫藥組成物的用途 |
GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
PT2295049E (pt) * | 2005-09-09 | 2015-03-02 | Novartis Ag | Tratamento de doenças auto-imunes |
CA2624909C (en) | 2005-10-07 | 2013-10-01 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease |
JP5044919B2 (ja) * | 2005-10-07 | 2012-10-10 | Jnc株式会社 | ベンゼン環にアルキル基を有する化合物、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子 |
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RS53080B (en) | 2006-08-08 | 2014-06-30 | Kyorin Pharmaceutical Co. Ltd. | AMINOPHOSPHORIC ACID ETHAR DERIVATIVE AND S1P RECEPTOR MODULATOR CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
KR20100021430A (ko) | 2007-05-04 | 2010-02-24 | 노파르티스 아게 | S1p 수용체 조절제의 용도 |
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CN103396346A (zh) * | 2008-05-19 | 2013-11-20 | 杏林制药株式会社 | 光学活性氨基醇衍生物的制备方法 |
TW201000109A (en) * | 2008-05-20 | 2010-01-01 | Kyorin Seiyaku Kk | Agent for induction/maintenance of remission |
HUE030424T2 (en) * | 2008-07-23 | 2017-05-29 | Arena Pharm Inc | Substituted 1,2,3,4-tetrahydrocyclopenta [b] indol-3-ylacetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
EA019808B1 (ru) * | 2008-08-18 | 2014-06-30 | Новартис Аг | Производные аминоспиртов, предназначенные для лечения демиелинизирующих периферических невропатий |
ES2583630T3 (es) | 2008-08-27 | 2016-09-21 | Arena Pharmaceuticals, Inc. | Derivados de ácido tricíclico sustituido como agonistas del receptor S1P1 útiles en el tratamiento de trastornos autoinmunes e inflamatorios |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
SG176573A1 (en) | 2009-07-09 | 2012-01-30 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and medicines containing same as active ingredient |
CN103221391B (zh) | 2010-01-27 | 2018-07-06 | 艾尼纳制药公司 | (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法 |
JP2013521301A (ja) | 2010-03-03 | 2013-06-10 | アリーナ ファーマシューティカルズ, インコーポレイテッド | S1p1受容体修飾物質およびその結晶形の調製のためのプロセス |
MA34285B1 (fr) * | 2010-05-06 | 2013-06-01 | Novartis Ag | Traitement de maladies autoimmunes |
MX2012012925A (es) * | 2010-05-06 | 2012-12-17 | Novartis Ag | Regimen de dosificacion de derivados de sulfuro de diarilo. |
WO2012015758A2 (en) * | 2010-07-30 | 2012-02-02 | Saint Louis University | Methods of treating pain |
MX2013003945A (es) | 2010-10-08 | 2013-06-05 | Novartis Ag | Formulaciones de vitamina e como inhibidoras de sulfamida ns3. |
WO2012073249A1 (en) | 2010-12-01 | 2012-06-07 | Arch Pharmalabs Limited | A novel process for the preparation of 3-(benzyloxy)- benzenethiol, a key intermediate for the preparation of pharmaceutical drugs. |
TWI519539B (zh) | 2010-12-21 | 2016-02-01 | Kyorin Seiyaku Kk | Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof |
CN102120720B (zh) * | 2011-01-25 | 2013-05-22 | 上海华升生物科技有限公司 | 盐酸芬戈莫德的合成新方法 |
CN102863345A (zh) * | 2011-07-06 | 2013-01-09 | 中国医学科学院药物研究所 | 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
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CN103113270A (zh) * | 2012-11-26 | 2013-05-22 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-(3-苄氧基-苯基硫烷基)-2-氯-1-乙烯基苯的合成方法 |
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EP2990055B1 (en) | 2013-04-26 | 2019-06-05 | Kyoto University | Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
MA47503A (fr) | 2017-02-16 | 2021-04-21 | Arena Pharm Inc | Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales |
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EP3831370A4 (en) | 2018-07-27 | 2022-04-27 | Priothera Limited | AGENT FOR INHIBITING THE RECURRENCE OF HEMATOLOGICAL MALIGNITY IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION |
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AU2021424131A1 (en) | 2021-01-28 | 2023-07-27 | Priothera Limited | Methods of treatment with s1p receptor modulators |
EP4248958A3 (en) | 2021-01-28 | 2024-01-03 | Priothera SAS | Methods of treatment with s1p receptor modulators |
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US5284971A (en) * | 1992-07-16 | 1994-02-08 | Syntex (U.S.A.) Inc. | 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents |
DK0627406T3 (da) * | 1992-10-21 | 1999-07-12 | Taito Co | 2-Amino-1,3-propandiolforbindelser og immunundertrykkende midler |
ATE271028T1 (de) * | 1997-04-04 | 2004-07-15 | Mitsubishi Pharma Corp | 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese |
EP1431275B1 (en) * | 2001-09-27 | 2010-04-07 | Kyorin Pharmaceutical Co., Ltd. | Diaryl ether derivative, addition salt thereof, and immunosuppressant |
-
2002
- 2002-09-25 CN CNB028190629A patent/CN1329372C/zh not_active Expired - Fee Related
- 2002-09-25 JP JP2003532456A patent/JP4217620B2/ja not_active Expired - Fee Related
- 2002-09-25 BR BRPI0212894A patent/BRPI0212894B8/pt not_active IP Right Cessation
- 2002-09-25 DE DE60223699T patent/DE60223699T2/de not_active Expired - Lifetime
- 2002-09-25 PT PT02768057T patent/PT1431284E/pt unknown
- 2002-09-25 MX MXPA04002679A patent/MXPA04002679A/es active IP Right Grant
- 2002-09-25 ES ES02768057T patent/ES2292809T3/es not_active Expired - Lifetime
- 2002-09-25 KR KR1020047004284A patent/KR100913269B1/ko active IP Right Grant
- 2002-09-25 WO PCT/JP2002/009865 patent/WO2003029205A1/ja active IP Right Grant
- 2002-09-25 CA CA2461212A patent/CA2461212C/en not_active Expired - Lifetime
- 2002-09-25 AU AU2002332289A patent/AU2002332289B2/en not_active Ceased
- 2002-09-25 US US10/489,820 patent/US6960692B2/en not_active Expired - Lifetime
- 2002-09-25 EP EP02768057A patent/EP1431284B1/en not_active Expired - Lifetime
- 2002-09-25 DK DK02768057T patent/DK1431284T3/da active
-
2008
- 2008-01-25 CY CY20081100086T patent/CY1107272T1/el unknown
- 2008-10-10 JP JP2008264592A patent/JP4917589B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4917589B2 (ja) | 2012-04-18 |
US6960692B2 (en) | 2005-11-01 |
PT1431284E (pt) | 2008-01-21 |
BRPI0212894B8 (pt) | 2021-05-25 |
DE60223699T2 (de) | 2008-10-30 |
CY1107272T1 (el) | 2012-11-21 |
DE60223699D1 (en) | 2008-01-03 |
AU2002332289B2 (en) | 2007-05-10 |
MXPA04002679A (es) | 2004-07-30 |
ES2292809T3 (es) | 2008-03-16 |
CN1561331A (zh) | 2005-01-05 |
CN1329372C (zh) | 2007-08-01 |
CA2461212A1 (en) | 2003-04-10 |
EP1431284A4 (en) | 2006-03-01 |
US20040254222A1 (en) | 2004-12-16 |
CA2461212C (en) | 2010-08-17 |
BRPI0212894B1 (pt) | 2019-07-30 |
KR100913269B1 (ko) | 2009-08-21 |
JP4217620B2 (ja) | 2009-02-04 |
KR20040037107A (ko) | 2004-05-04 |
EP1431284B1 (en) | 2007-11-21 |
EP1431284A1 (en) | 2004-06-23 |
JP2009040794A (ja) | 2009-02-26 |
JPWO2003029205A1 (ja) | 2005-01-13 |
WO2003029205A1 (fr) | 2003-04-10 |
BR0212894A (pt) | 2004-10-13 |
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