DK1409506T3 - Fremgangsmåder og sammensætninger til RNAi-formidlet inhibering af genekspression i pattedyr - Google Patents
Fremgangsmåder og sammensætninger til RNAi-formidlet inhibering af genekspression i pattedyrInfo
- Publication number
- DK1409506T3 DK1409506T3 DK02761123.5T DK02761123T DK1409506T3 DK 1409506 T3 DK1409506 T3 DK 1409506T3 DK 02761123 T DK02761123 T DK 02761123T DK 1409506 T3 DK1409506 T3 DK 1409506T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- compositions
- mammals
- rnai
- gene expression
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 241000124008 Mammalia Species 0.000 title abstract 3
- 108091030071 RNAI Proteins 0.000 title abstract 3
- 230000009368 gene silencing by RNA Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000014509 gene expression Effects 0.000 title abstract 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 108091027967 Small hairpin RNA Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000004055 small Interfering RNA Substances 0.000 abstract 2
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108020004459 Small interfering RNA Proteins 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920002477 rna polymer Polymers 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30741101P | 2001-07-23 | 2001-07-23 | |
US36066402P | 2002-02-27 | 2002-02-27 | |
PCT/US2002/022869 WO2003010180A1 (en) | 2001-07-23 | 2002-07-19 | Methods and compositions for rnai mediated inhibition of gene expression in mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1409506T3 true DK1409506T3 (da) | 2012-08-06 |
Family
ID=26975733
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02761123.5T DK1409506T3 (da) | 2001-07-23 | 2002-07-19 | Fremgangsmåder og sammensætninger til RNAi-formidlet inhibering af genekspression i pattedyr |
DK10178509.5T DK2280070T3 (da) | 2001-07-23 | 2002-07-19 | Fremgangsmåde og sammensætninger til brug for RNAi-formidlet inhibering af genekspression i pattedyr |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10178509.5T DK2280070T3 (da) | 2001-07-23 | 2002-07-19 | Fremgangsmåde og sammensætninger til brug for RNAi-formidlet inhibering af genekspression i pattedyr |
Country Status (10)
Country | Link |
---|---|
US (3) | US20030153519A1 (da) |
EP (2) | EP1409506B1 (da) |
JP (4) | JP2005508306A (da) |
AT (1) | ATE556720T1 (da) |
CA (2) | CA2454183C (da) |
DK (2) | DK1409506T3 (da) |
ES (2) | ES2386775T3 (da) |
HK (1) | HK1065562A1 (da) |
PT (1) | PT2280070E (da) |
WO (1) | WO2003010180A1 (da) |
Families Citing this family (76)
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US10590418B2 (en) * | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
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-
2002
- 2002-07-19 PT PT101785095T patent/PT2280070E/pt unknown
- 2002-07-19 AT AT02761123T patent/ATE556720T1/de active
- 2002-07-19 CA CA2454183A patent/CA2454183C/en not_active Expired - Lifetime
- 2002-07-19 CA CA2936534A patent/CA2936534C/en not_active Expired - Lifetime
- 2002-07-19 WO PCT/US2002/022869 patent/WO2003010180A1/en active Application Filing
- 2002-07-19 DK DK02761123.5T patent/DK1409506T3/da active
- 2002-07-19 EP EP02761123A patent/EP1409506B1/en not_active Expired - Lifetime
- 2002-07-19 DK DK10178509.5T patent/DK2280070T3/da active
- 2002-07-19 ES ES02761123T patent/ES2386775T3/es not_active Expired - Lifetime
- 2002-07-19 JP JP2003515539A patent/JP2005508306A/ja not_active Withdrawn
- 2002-07-19 ES ES10178509.5T patent/ES2546829T3/es not_active Expired - Lifetime
- 2002-07-19 EP EP10178509.5A patent/EP2280070B1/en not_active Expired - Lifetime
- 2002-07-19 US US10/200,002 patent/US20030153519A1/en not_active Abandoned
-
2004
- 2004-10-16 HK HK04108019.6A patent/HK1065562A1/xx not_active IP Right Cessation
-
2010
- 2010-11-08 JP JP2010249697A patent/JP6055164B2/ja not_active Expired - Lifetime
-
2013
- 2013-07-12 US US13/941,262 patent/US10517887B2/en not_active Expired - Fee Related
-
2014
- 2014-09-16 JP JP2014187281A patent/JP2015044809A/ja active Pending
-
2016
- 2016-08-17 JP JP2016159918A patent/JP6247355B2/ja not_active Expired - Lifetime
-
2019
- 2019-12-20 US US16/723,744 patent/US20200246370A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1409506A1 (en) | 2004-04-21 |
JP2011093906A (ja) | 2011-05-12 |
US20030153519A1 (en) | 2003-08-14 |
JP6247355B2 (ja) | 2017-12-13 |
WO2003010180A1 (en) | 2003-02-06 |
CA2936534A1 (en) | 2003-02-06 |
EP2280070A1 (en) | 2011-02-02 |
JP2017008084A (ja) | 2017-01-12 |
CA2454183C (en) | 2016-09-06 |
CA2454183A1 (en) | 2003-02-06 |
JP6055164B2 (ja) | 2016-12-27 |
US10517887B2 (en) | 2019-12-31 |
US20200246370A1 (en) | 2020-08-06 |
US20130312126A1 (en) | 2013-11-21 |
EP2280070B1 (en) | 2015-05-20 |
ATE556720T1 (de) | 2012-05-15 |
HK1065562A1 (en) | 2005-02-25 |
ES2386775T3 (es) | 2012-08-30 |
DK2280070T3 (da) | 2015-08-24 |
JP2005508306A (ja) | 2005-03-31 |
ES2546829T3 (es) | 2015-09-29 |
JP2015044809A (ja) | 2015-03-12 |
PT2280070E (pt) | 2015-10-29 |
EP1409506B1 (en) | 2012-05-09 |
CA2936534C (en) | 2021-01-26 |
EP1409506A4 (en) | 2004-11-17 |
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