DK1389089T3 - Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighed - Google Patents
Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighedInfo
- Publication number
- DK1389089T3 DK1389089T3 DK02737899T DK02737899T DK1389089T3 DK 1389089 T3 DK1389089 T3 DK 1389089T3 DK 02737899 T DK02737899 T DK 02737899T DK 02737899 T DK02737899 T DK 02737899T DK 1389089 T3 DK1389089 T3 DK 1389089T3
- Authority
- DK
- Denmark
- Prior art keywords
- biologically active
- lipid particles
- container
- lipophilic
- solubilizing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01302841 | 2001-03-27 | ||
PCT/EP2002/003371 WO2002080883A2 (en) | 2001-03-27 | 2002-03-26 | Method and composition for solubilising a biologically active compound with low water solubility |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1389089T3 true DK1389089T3 (da) | 2009-12-21 |
Family
ID=8181836
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02737899T DK1389089T3 (da) | 2001-03-27 | 2002-03-26 | Fremgangsmådeog sammensætning til solubilisering af en biologisk aktiv forbindelse med lav vandoplöselighed |
Country Status (11)
Country | Link |
---|---|
US (2) | US20040115255A1 (da) |
EP (1) | EP1389089B1 (da) |
JP (3) | JP2004524368A (da) |
AT (1) | ATE440593T1 (da) |
AU (1) | AU2002312777B2 (da) |
CA (1) | CA2442539C (da) |
DE (1) | DE60233484D1 (da) |
DK (1) | DK1389089T3 (da) |
ES (1) | ES2332584T3 (da) |
PT (1) | PT1389089E (da) |
WO (1) | WO2002080883A2 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
BR0212833A (pt) | 2001-09-26 | 2004-10-13 | Baxter Int | Preparação de nanopartìculas de tamanho submìcron através de dispersão e de remoção de solvente ou de fase lìquida |
DE10203923B4 (de) * | 2002-01-31 | 2011-06-01 | Klinipharm Gmbh | Verfahren zur Erhöhung der Wasserlöslichkeit lipophiler Wirkstoffe, Herstellung von hochkonzentrierten wässrigen Zusammensetzungen dieser Wirkstoffe, derartige Produkte und ihre Verwendung |
JP2007507432A (ja) * | 2003-10-02 | 2007-03-29 | セムバイオシス ジェネティクス インコーポレイテッド | 活性成分を含む油体を調製するための方法 |
WO2005065677A1 (ja) * | 2004-01-09 | 2005-07-21 | Otsuka Pharmaceutical Factory, Inc. | パクリタキセルまたはドセタキセルを溶解または分散させるための脂肪乳剤 |
US7345093B2 (en) | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
US7659310B2 (en) | 2004-04-27 | 2010-02-09 | Formatech, Inc. | Methods of enhancing solubility of agents |
DK1748759T3 (da) * | 2004-04-27 | 2013-04-22 | Javeri Indu | Fremgangsmåder til at forøge hydrofobe forbindelsers opløselighed i vand af ved micellære dispersioner |
US7754230B2 (en) * | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
PT1758590E (pt) | 2004-05-19 | 2011-11-15 | Univ California | Utilização de um detergente para a remoção não cirúrgica de gordura |
US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
WO2006050327A2 (en) * | 2004-10-28 | 2006-05-11 | Alza Corporation | Lyophilized liposome formulations and method |
KR101391020B1 (ko) * | 2005-03-14 | 2014-04-30 | 가부시키가이샤 오츠까 세이야꾸 고죠 | 수난용성 약제를 함유한 약학 조성물 |
JP5342834B2 (ja) * | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
CA2910133C (en) * | 2008-05-23 | 2018-02-27 | The University Of British Columbia | Modified drugs for use in liposomal nanoparticles |
CA2737025C (en) * | 2008-09-27 | 2012-09-04 | Jina Pharmaceuticals, Inc. | Lipid based pharmaceutical preparations for oral and topical application; their compositions, methods, and uses thereof |
US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
CA2781529C (en) | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes comprising docetaxel |
US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
US20170340563A1 (en) * | 2009-09-23 | 2017-11-30 | Curirx Inc. | Methods for the Preparation of Liposomes Comprising Drugs |
CN101926757B (zh) | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
KR101546171B1 (ko) * | 2010-12-08 | 2015-08-20 | 에프. 호프만-라 로슈 아게 | 달세트라피브의 리포좀 제제 |
EP2675460A4 (en) | 2011-02-18 | 2014-07-09 | Kythera Biopharmaceuticals Inc | TREATMENT OF FAT TISSUE UNDER CHIN |
US8653058B2 (en) | 2011-04-05 | 2014-02-18 | Kythera Biopharmaceuticals, Inc. | Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits |
WO2013176223A1 (ja) * | 2012-05-23 | 2013-11-28 | 国立大学法人大阪大学 | 炎症性疾患治療用医薬組成物 |
EP2682106A1 (en) | 2012-07-03 | 2014-01-08 | Phares Pharmaceutical Research N.V. | Method of solubilizing biologically active compounds |
IL259246B1 (en) | 2015-12-07 | 2024-07-01 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Preparations for oral administration that include at least one cannabinoid, a method for their preparation and use |
US10722466B2 (en) | 2016-10-28 | 2020-07-28 | Les Laboratoires Servier | Liposomal formulation for use in the treatment of cancer |
CA3063395A1 (en) * | 2017-05-12 | 2018-11-15 | Curinanorx, Llc | Methods for the preparation of liposomes comprising drugs |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1202370B (it) * | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti |
JPH0753661B2 (ja) * | 1984-03-08 | 1995-06-07 | フアレス フアーマスーチカル リサーチ エヌブイ | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 |
CA1338702C (en) * | 1987-03-05 | 1996-11-12 | Lawrence D. Mayer | High drug:lipid formulations of liposomal- antineoplastic agents |
US5616334A (en) * | 1987-03-05 | 1997-04-01 | The Liposome Company, Inc. | Low toxicity drug-lipid systems |
MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
US5811119A (en) * | 1987-05-19 | 1998-09-22 | Board Of Regents, The University Of Texas | Formulation and use of carotenoids in treatment of cancer |
WO1989002265A1 (en) * | 1987-09-07 | 1989-03-23 | Teijin Limited | Medicine-containing fat emulsion of the type prepared immediately before use and process for preparing medicine-containing fat emulsion |
IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
US5741513A (en) * | 1990-02-08 | 1998-04-21 | A. Natterman & Cie. Gmbh | Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it |
US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
ATE138803T1 (de) * | 1990-07-31 | 1996-06-15 | Liposome Co Inc | Anhäufung von aminosäuren und peptiden in liposomen |
EP0687684A4 (en) * | 1993-03-04 | 1998-03-04 | Kanto Ishi Pharma Co Ltd | COMPOUND ASSOCIATED WITH LEWIS SYSTEM, PROCESS FOR OBTAINING THIS COMPOUND AND ANTI-INFLAMMATORY |
DE19609538A1 (de) * | 1996-03-11 | 1997-09-18 | Basf Ag | Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung |
CA2160118A1 (en) * | 1993-05-21 | 1994-12-08 | Patrick L. Ahl | Reduction of liposome-induced adverse physiological reactions |
EP0633024A1 (en) * | 1993-07-09 | 1995-01-11 | Ciba-Geigy Ag | Topically administrable zinc phthalocyanine compositions |
US5415869A (en) * | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
AU681036B2 (en) * | 1994-05-23 | 1997-08-14 | B. Braun Medical, Inc. | Formulation preparation device |
JP2740153B2 (ja) * | 1995-03-07 | 1998-04-15 | エフ・ホフマン−ラ ロシユ アーゲー | 混合ミセル |
US6447800B2 (en) * | 1996-01-18 | 2002-09-10 | The University Of British Columbia | Method of loading preformed liposomes using ethanol |
US6096336A (en) * | 1996-01-30 | 2000-08-01 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
WO1998018492A1 (fr) * | 1996-10-25 | 1998-05-07 | Yoshitomi Pharmaceutical Industries Ltd. | Procede pour empecher la precipitation de medicaments |
ATE240088T1 (de) * | 1996-12-13 | 2003-05-15 | Vesifact Ag | Kosmetische präparate in form einer nanodispersion |
GB9726916D0 (en) * | 1997-12-19 | 1998-02-18 | Danbiosyst Uk | Nasal formulation |
AU4650899A (en) * | 1998-07-10 | 2000-02-01 | Welfide Corporation | Kit of drug-containing preparation to be prepared before using and resolvent therefor |
DE19843968A1 (de) * | 1998-09-24 | 2000-04-13 | Hans Dietl | Taxane enthaltende pharmazeutische Zubereitung zur intravenösen Applikation und Verfahren zu ihrer Herstellung |
US6682758B1 (en) * | 1998-12-22 | 2004-01-27 | The United States Of America As Represented By The Department Of Health And Human Services | Water-insoluble drug delivery system |
DK2266537T3 (da) * | 1999-04-01 | 2014-12-15 | Talon Therapeutics Inc | Sammensætninger til behandling af cancer |
US20030144570A1 (en) * | 1999-11-12 | 2003-07-31 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
US20020001613A1 (en) * | 2000-02-08 | 2002-01-03 | Susan Niemiec | Method of manufacturing liposomes |
-
2002
- 2002-03-26 ES ES02737899T patent/ES2332584T3/es not_active Expired - Lifetime
- 2002-03-26 DE DE60233484T patent/DE60233484D1/de not_active Expired - Lifetime
- 2002-03-26 AU AU2002312777A patent/AU2002312777B2/en not_active Ceased
- 2002-03-26 CA CA2442539A patent/CA2442539C/en not_active Expired - Fee Related
- 2002-03-26 AT AT02737899T patent/ATE440593T1/de not_active IP Right Cessation
- 2002-03-26 EP EP02737899A patent/EP1389089B1/en not_active Expired - Lifetime
- 2002-03-26 DK DK02737899T patent/DK1389089T3/da active
- 2002-03-26 PT PT02737899T patent/PT1389089E/pt unknown
- 2002-03-26 WO PCT/EP2002/003371 patent/WO2002080883A2/en active IP Right Grant
- 2002-03-26 JP JP2002578922A patent/JP2004524368A/ja not_active Withdrawn
-
2003
- 2003-09-26 US US10/670,504 patent/US20040115255A1/en not_active Abandoned
-
2008
- 2008-01-02 US US12/003,849 patent/US20080131499A1/en not_active Abandoned
-
2009
- 2009-08-28 JP JP2009199056A patent/JP2010013461A/ja active Pending
-
2012
- 2012-07-24 JP JP2012163789A patent/JP2012207042A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1389089A2 (en) | 2004-02-18 |
ES2332584T3 (es) | 2010-02-09 |
JP2004524368A (ja) | 2004-08-12 |
AU2002312777A2 (en) | 2002-10-21 |
DE60233484D1 (de) | 2009-10-08 |
CA2442539C (en) | 2011-11-08 |
JP2012207042A (ja) | 2012-10-25 |
EP1389089B1 (en) | 2009-08-26 |
WO2002080883A2 (en) | 2002-10-17 |
US20080131499A1 (en) | 2008-06-05 |
WO2002080883A3 (en) | 2003-12-11 |
ATE440593T1 (de) | 2009-09-15 |
AU2002312777B2 (en) | 2007-07-05 |
CA2442539A1 (en) | 2002-10-17 |
JP2010013461A (ja) | 2010-01-21 |
US20040115255A1 (en) | 2004-06-17 |
PT1389089E (pt) | 2009-11-30 |
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