DK138369B - Fremgangsmåde til kontrolleret trinvis syntese af peptider og beskyttede derivater deraf. - Google Patents

Fremgangsmåde til kontrolleret trinvis syntese af peptider og beskyttede derivater deraf.

Info

Publication number
DK138369B
DK138369B DK341266AA DK341266A DK138369B DK 138369 B DK138369 B DK 138369B DK 341266A A DK341266A A DK 341266AA DK 341266 A DK341266 A DK 341266A DK 138369 B DK138369 B DK 138369B
Authority
DK
Denmark
Prior art keywords
peptides
protected derivatives
stepwise synthesis
controlled stepwise
synthesis
Prior art date
Application number
DK341266AA
Other languages
English (en)
Other versions
DK138369C (da
Inventor
Ralph Franz Hirschmann
Robert George Denkewalter
Erwin Frederick Schoenewaldt
John Byron Conn
Robert Gibb Strachan
Daniel Frank Veber
Harvey Schwam
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK138369B publication Critical patent/DK138369B/da
Application granted granted Critical
Publication of DK138369C publication Critical patent/DK138369C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/086General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing sulfur
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695Corticotropin [ACTH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0804Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1019Tetrapeptides with the first amino acid being basic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1021Tetrapeptides with the first amino acid being acidic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Arc Welding In General (AREA)
DK341266AA 1965-07-02 1966-07-01 Fremgangsmåde til kontrolleret trinvis syntese af peptider og beskyttede derivater deraf. DK138369B (da)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US46931065A 1965-07-02 1965-07-02
US50497865A 1965-10-24 1965-10-24
US50498265A 1965-10-24 1965-10-24
US53856066A 1966-03-30 1966-03-30
US53854266A 1966-03-30 1966-03-30
US54438066A 1966-04-22 1966-04-22
US54435866A 1966-04-22 1966-04-22
US54585766A 1966-04-28 1966-04-28
US54586266A 1966-04-28 1966-04-28
US54585566A 1966-04-28 1966-04-28
GB27965/66A GB1158721A (en) 1965-07-02 1966-06-22 Peptide synthesis

Publications (2)

Publication Number Publication Date
DK138369B true DK138369B (da) 1978-08-21
DK138369C DK138369C (da) 1979-02-05

Family

ID=27581645

Family Applications (1)

Application Number Title Priority Date Filing Date
DK341266AA DK138369B (da) 1965-07-02 1966-07-01 Fremgangsmåde til kontrolleret trinvis syntese af peptider og beskyttede derivater deraf.

Country Status (13)

Country Link
US (3) US3435046A (da)
JP (1) JPS4737921B1 (da)
AT (4) AT297677B (da)
BR (1) BR6680930D0 (da)
CH (1) CH495956A (da)
DE (8) DE1795524A1 (da)
DK (1) DK138369B (da)
FI (1) FI48184C (da)
GB (7) GB1158724A (da)
IL (6) IL34876A (da)
NO (1) NO128326B (da)
SE (4) SE345998B (da)
YU (1) YU31197B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1675379B1 (de) * 1968-01-13 1972-03-09 Roesinger Heinz Rollringdichtung fuer muffenrohr verbindungen
NL7002228A (da) * 1970-02-18 1971-08-20
FR2569111B1 (fr) * 1984-08-16 1987-04-17 Rhone Poulenc Sante Nouveaux medicaments contenant des tripeptides
DE3542784A1 (de) * 1985-12-04 1987-06-11 Hella Kg Hueck & Co Scheinwerfer fuer kraftfahrzeuge
JPH0383990A (ja) * 1989-08-28 1991-04-09 Nippon Paint Co Ltd オキサゾリジン化合物
IN184759B (da) * 1997-07-22 2000-09-23 Kaneka Corp
WO2000005247A1 (fr) * 1998-07-21 2000-02-03 Kaneka Corporation Procede de cristallisation d'un sel d'acide maleique de n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-l-alanyl-l-proline
DE19936976A1 (de) 1999-08-05 2001-02-08 Emil Siegwart Flanschverbindung von Rohren, insbesondere Luftleitungsrohren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993053A (en) * 1961-07-18 Production of n-carboxy-a-amino
US2716647A (en) * 1952-07-30 1955-08-30 Monsanto Chemicals N-carboxy anhydride of alpha-amino acids

Also Published As

Publication number Publication date
IL34876A (en) 1971-02-25
DE1795519A1 (de) 1972-01-13
IL25974A (en) 1971-02-25
IL34877A (en) 1971-03-24
AT290490B (de) 1971-06-11
SE364716B (da) 1974-03-04
IL34878A (en) 1971-02-25
YU31197B (en) 1973-02-28
GB1158724A (en) 1969-07-16
SE347512B (da) 1972-08-07
GB1158723A (en) 1969-07-16
IL34879A (en) 1971-03-24
DE1795529A1 (de) 1972-01-13
FI48184C (fi) 1974-07-10
DE1793597A1 (de) 1972-03-16
BR6680930D0 (pt) 1973-11-13
DE1795528A1 (de) 1972-01-13
SE349038B (da) 1972-09-18
NO128326B (da) 1973-10-29
GB1158722A (en) 1969-07-16
JPS4737921B1 (da) 1972-09-25
DK138369C (da) 1979-02-05
SE345998B (da) 1972-06-19
US3467667A (en) 1969-09-16
DE1795524A1 (de) 1972-01-13
GB1158727A (en) 1969-07-16
FI48184B (da) 1974-04-01
AT289105B (de) 1971-04-13
US3435046A (en) 1969-03-25
GB1158726A (en) 1969-07-16
DE1795521A1 (de) 1972-01-13
DE1795522A1 (de) 1972-01-13
AT307630B (de) 1973-05-25
DE1795523A1 (de) 1972-01-13
GB1158721A (en) 1969-07-16
IL34880A (en) 1970-11-30
GB1158725A (en) 1969-07-16
US3459760A (en) 1969-08-05
AT297677B (de) 1972-04-10
CH495956A (de) 1970-09-15

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