DK1326862T3 - Crystalline monohydrate of tiotropium bromide, process for its preparation and use thereof for the manufacture of a drug - Google Patents

Crystalline monohydrate of tiotropium bromide, process for its preparation and use thereof for the manufacture of a drug

Info

Publication number: DK1326862T3
Authority: DK; Denmark
Prior art keywords: drug; manufacture; preparation; tiotropium bromide; crystalline monohydrate
Prior art date: 2000-10-12

Application number

DK01983510T

Other languages

Danish (da)

Inventor

Michael Trunk

Rolf Banholzer

Peter Sieger

Peter Specht

Andreas Mathes

Christian Kulinna

Manfred Ludwig August Graulich

Helmut Meissner

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2001-09-28

Publication date

2004-11-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1326862(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-09-28 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK1326862T3 publication Critical patent/DK1326862T3/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01983510T 2000-10-12 2001-09-28 Crystalline monohydrate of tiotropium bromide, process for its preparation and use thereof for the manufacture of a drug DK1326862T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en)	2000-10-12	2001-09-28	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (1)

Publication Number	Publication Date
DK1326862T3 true DK1326862T3 (en)	2004-11-22

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01983510T DK1326862T3 (en)	2000-10-12	2001-09-28	Crystalline monohydrate of tiotropium bromide, process for its preparation and use thereof for the manufacture of a drug

Country Status (47)

Country	Link
EP (2)	EP1326862B1 (en)
JP (1)	JP3764422B2 (en)
KR (1)	KR100823860B1 (en)
CN (2)	CN100519558C (en)
AP (1)	AP1572A (en)
AR (2)	AR034389A1 (en)
AT (1)	ATE276253T1 (en)
AU (2)	AU2002214996B2 (en)
BG (1)	BG66161B1 (en)
BR (1)	BR0114584A (en)
CA (1)	CA2425539C (en)
CR (1)	CR6938A (en)
CZ (1)	CZ301841B6 (en)
DE (1)	DE50103666D1 (en)
DK (1)	DK1326862T3 (en)
DZ (1)	DZ3478A1 (en)
EA (1)	EA004381B1 (en)
EC (1)	ECSP034540A (en)
EE (1)	EE04567B1 (en)
EG (1)	EG24142A (en)
ES (1)	ES2228965T3 (en)
GE (1)	GEP20063905B (en)
HK (2)	HK1060567A1 (en)
HR (1)	HRP20030276B1 (en)
HU (1)	HU226830B1 (en)
IL (2)	IL155335A0 (en)
IS (1)	IS2339B (en)
MA (1)	MA25842A1 (en)
ME (2)	MEP40008A (en)
MX (1)	MXPA03003221A (en)
MY (1)	MY126931A (en)
NO (1)	NO328465B1 (en)
NZ (1)	NZ525733A (en)
OA (1)	OA12403A (en)
PE (1)	PE20020422A1 (en)
PL (1)	PL207870B1 (en)
PT (1)	PT1326862E (en)
RS (1)	RS50218B (en)
SA (1)	SA01220412B1 (en)
SI (1)	SI1326862T1 (en)
SK (1)	SK287009B6 (en)
TR (1)	TR200402579T4 (en)
TW (1)	TW589313B (en)
UA (1)	UA74215C2 (en)
UY (2)	UY26962A1 (en)
WO (1)	WO2002030928A1 (en)
ZA (1)	ZA200302500B (en)

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JP2005504015A (en) *	2001-06-22	2005-02-10	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	Anticholinergics, methods for their production and their use for producing pharmaceutical compositions
US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7311894B2 (en)	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
US7244415B2 (en)	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
DE10214263A1 (en) *	2002-03-28	2003-10-16	Boehringer Ingelheim Pharma	HFA suspension formulations containing an anticholinergic
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (en)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
PT2067779E (en)	2003-11-03	2013-07-25	Boehringer Ingelheim Int	Tiotropium salts, method for their production and medicinal formulas containing them
WO2005042528A1 (en) *	2003-11-03	2005-05-12	Boehringer Ingelheim International Gmbh	Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
PL1682542T3 (en) *	2003-11-03	2010-06-30	Boehringer Ingelheim Int	Novel crystalline anhydride with anticholinergic effect
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
ATE539754T1 (en)	2004-04-22	2012-01-15	Boehringer Ingelheim Int	DRUG COMBINATIONS CONTAINING BENZOXAZINES FOR THE TREATMENT OF RESPIRATORY DISEASES
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
ATE427108T1 (en)	2004-08-11	2009-04-15	Boehringer Ingelheim Pharma	MEDICINAL PRODUCTS CONTAINING ANTICHOLINERGICS FOR THE TREATMENT OF DISEASES OF THE URINARY TRACT
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
CN101043912B (en) *	2004-10-21	2012-10-31	贝林格尔·英格海姆国际有限公司	Blister for inhalers
EP1858554A2 (en) *	2005-03-09	2007-11-28	Boehringer Ingelheim International GmbH	New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
WO2006114371A1 (en)	2005-04-28	2006-11-02	Boehringer Ingelheim International Gmbh	Novel compounds for treating inflammatory diseases
AU2006243239A1 (en) *	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Crystalline forms of tiotropium bromide
WO2006117299A2 (en)	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Novel crystalline forms of tiotropium bromide
WO2006134021A2 (en) *	2005-06-15	2006-12-21	Boehringer Ingelheim International Gmbh	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
NZ566399A (en) *	2005-08-06	2011-07-29	Boehringer Ingelheim Int	Use of tiotropium salts in the treatment of severe persistant asthma
PL1917253T3 (en)	2005-08-15	2015-06-30	Boehringer Ingelheim Int	Method for producing betamimetics
TWI396541B (en)	2005-10-10	2013-05-21	Boehringer Ingelheim Int	Novel combinations of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (en) *	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Micronization process
PT1869035E (en)	2005-12-19	2013-01-10	Sicor Inc	Novel crystalline form of tiotropium bromide and process for preparation thereof
KR20080079586A (en) *	2005-12-19	2008-09-01	시코르, 인크.	Pure and stable tiotropium bromide
EA015353B1 (en) *	2006-01-04	2011-06-30	Бёрингер Ингельхайм Интернациональ Гмбх	Use of tiotropium salts in the treatment of moderate persistent asthma
EP1847543A1 (en)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidines for the treatment of inflammatory diseases
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PL2513093T3 (en)	2009-12-17	2015-03-31	Centrexion Therapeutics Corp	New ccr2 receptor antagonists and uses thereof
CA2786245A1 (en)	2010-01-29	2011-08-04	Boehringer Ingelheim International Gmbh	Substituted naphthyridines and their use as syk kinase inhibitors
US8877745B2 (en)	2010-05-12	2014-11-04	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
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2001
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/en active
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/en not_active Ceased
- 2001-09-28 EP EP01983510A patent/EP1326862B1/en not_active Expired - Lifetime
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/en not_active Expired - Lifetime
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/en unknown
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/en unknown
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/en not_active IP Right Cessation
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active Active
- 2001-09-28 HU HU0301022A patent/HU226830B1/en unknown
- 2001-09-28 AT AT01983510T patent/ATE276253T1/en active
- 2001-09-28 ES ES01983510T patent/ES2228965T3/en not_active Expired - Lifetime
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/en active IP Right Grant
- 2001-09-28 OA OA1200300107A patent/OA12403A/en unknown
- 2001-09-28 UA UA2003054185A patent/UA74215C2/en unknown
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/en active Pending
- 2001-09-28 PT PT01983510T patent/PT1326862E/en unknown
- 2001-09-28 SI SI200130219T patent/SI1326862T1/en unknown
- 2001-09-28 IL IL15533501A patent/IL155335A0/en active IP Right Grant
- 2001-09-28 CN CNB018171435A patent/CN1221549C/en not_active Ceased
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 PL PL366041A patent/PL207870B1/en unknown
- 2001-09-28 DK DK01983510T patent/DK1326862T3/en active
- 2001-09-28 RS YU27303A patent/RS50218B/en unknown
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/en unknown
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/en active IP Right Grant
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 EE EEP200300171A patent/EE04567B1/en unknown
- 2001-09-28 EA EA200300457A patent/EA004381B1/en not_active IP Right Cessation
- 2001-09-28 DE DE50103666T patent/DE50103666D1/en not_active Expired - Lifetime
- 2001-09-28 SK SK436-2003A patent/SK287009B6/en not_active IP Right Cessation
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/en active IP Right Grant
- 2001-09-28 EP EP04016877A patent/EP1468998A1/en not_active Withdrawn
- 2001-09-28 AU AU1499602A patent/AU1499602A/en active Pending
- 2001-10-02 SA SA01220412A patent/SA01220412B1/en unknown
- 2001-10-09 EG EG20011058A patent/EG24142A/en active
- 2001-10-09 TW TW090124963A patent/TW589313B/en active
- 2001-10-10 UY UY26962A patent/UY26962A1/en not_active Application Discontinuation
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/en active IP Right Grant
- 2001-10-12 AR ARP010104782A patent/AR034389A1/en active Pending
2003
- 2003-03-26 CR CR6938A patent/CR6938A/en unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/en active Active
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/en unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/en unknown
- 2003-04-09 IS IS6772A patent/IS2339B/en unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-10 HR HR20030276A patent/HRP20030276B1/en not_active IP Right Cessation
- 2003-04-11 NO NO20031694A patent/NO328465B1/en not_active IP Right Cessation
2004
- 2004-05-20 HK HK04103583A patent/HK1060567A1/en not_active IP Right Cessation
2006
- 2006-06-07 HK HK06106478.2A patent/HK1086557A1/en not_active IP Right Cessation
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/en unknown
2013
- 2013-07-11 UY UY34901A patent/UY34901A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
EG24142A (en)	2008-08-06
HUP0301022A3 (en)	2005-12-28
JP2004526668A (en)	2004-09-02
DE50103666D1 (en)	2004-10-21
TW589313B (en)	2004-06-01
HK1060567A1 (en)	2004-08-13
EP1326862A1 (en)	2003-07-16
ECSP034540A (en)	2003-07-25
AR034389A1 (en)	2004-02-25
ES2228965T3 (en)	2005-04-16
WO2002030928A1 (en)	2002-04-18
HU226830B1 (en)	2009-11-30
UY26962A1 (en)	2002-06-20
EA004381B1 (en)	2004-04-29
KR20030042008A (en)	2003-05-27
GEP20063905B (en)	2006-08-25
CN1733761A (en)	2006-02-15
NZ525733A (en)	2005-01-28
NO328465B1 (en)	2010-02-22
MEP40008A (en)	2011-02-10
MXPA03003221A (en)	2004-12-03
PL207870B1 (en)	2011-02-28
BG66161B1 (en)	2011-09-30
HRP20030276A2 (en)	2005-02-28
IL155335A0 (en)	2003-11-23
YU27303A (en)	2006-05-25
AU2002214996B2 (en)	2007-03-15
SK287009B6 (en)	2009-09-07
CN100519558C (en)	2009-07-29
AP1572A (en)	2006-02-13
CN1221549C (en)	2005-10-05
EE200300171A (en)	2003-06-16
ME00243B (en)	2011-05-10
NO20031694L (en)	2003-04-11
EP1326862B1 (en)	2004-09-15
RS50218B (en)	2009-07-15
AP2003002775A0 (en)	2003-03-31
EP1468998A1 (en)	2004-10-20
JP3764422B2 (en)	2006-04-05
ATE276253T1 (en)	2004-10-15
CZ301841B6 (en)	2010-07-07
OA12403A (en)	2006-04-18
HUP0301022A2 (en)	2003-10-28
CA2425539A1 (en)	2003-04-11
AR068527A2 (en)	2009-11-18
AU1499602A (en)	2002-04-22
SK4362003A3 (en)	2003-08-05
UY34901A (en)	2015-02-27
SA01220412B1 (en)	2006-11-05
SI1326862T1 (en)	2005-02-28
MY126931A (en)	2006-10-31
EA200300457A1 (en)	2003-10-30
MA25842A1 (en)	2003-07-01
UA74215C2 (en)	2005-11-15
IS2339B (en)	2008-02-15
CR6938A (en)	2004-10-28
ZA200302500B (en)	2004-04-22
BR0114584A (en)	2003-08-26
TR200402579T4 (en)	2004-12-21
HRP20030276B1 (en)	2006-02-28
CA2425539C (en)	2007-04-03
CN1469877A (en)	2004-01-21
BG107687A (en)	2003-09-30
IL155335A (en)	2009-02-11
DZ3478A1 (en)	2002-04-18
IS6772A (en)	2003-04-09
PL366041A1 (en)	2005-01-24
NO20031694D0 (en)	2003-04-11
PE20020422A1 (en)	2002-06-28
HK1086557A1 (en)	2006-09-22
KR100823860B1 (en)	2008-04-21
EE04567B1 (en)	2005-12-15
PT1326862E (en)	2004-11-30

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