DK1254162T3 - Kahalalid F og beslægtede forbindelser - Google Patents

Kahalalid F og beslægtede forbindelser

Info

Publication number
DK1254162T3
DK1254162T3 DK01904169T DK01904169T DK1254162T3 DK 1254162 T3 DK1254162 T3 DK 1254162T3 DK 01904169 T DK01904169 T DK 01904169T DK 01904169 T DK01904169 T DK 01904169T DK 1254162 T3 DK1254162 T3 DK 1254162T3
Authority
DK
Denmark
Prior art keywords
kahalalid
related compounds
kahalalide
leads
preparing
Prior art date
Application number
DK01904169T
Other languages
English (en)
Inventor
Fernando Albericio
Ernest Giralt
Jose Carlos Jimenez
Angel Lopez
Ignacio Manzanares
Ignacio Rodrigues
Miriam Royo
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of DK1254162T3 publication Critical patent/DK1254162T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Detergent Compositions (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
DK01904169T 2000-02-09 2001-02-09 Kahalalid F og beslægtede forbindelser DK1254162T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds
PCT/GB2001/000576 WO2001058934A2 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds

Publications (1)

Publication Number Publication Date
DK1254162T3 true DK1254162T3 (da) 2008-01-02

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01904169T DK1254162T3 (da) 2000-02-09 2001-02-09 Kahalalid F og beslægtede forbindelser

Country Status (28)

Country Link
US (2) US7482429B2 (da)
EP (3) EP1829889A3 (da)
JP (1) JP5188665B2 (da)
KR (1) KR100871489B1 (da)
CN (2) CN1422278A (da)
AT (1) ATE371667T1 (da)
AU (1) AU783542B2 (da)
BG (1) BG65926B1 (da)
BR (1) BR0108213A (da)
CA (1) CA2399187C (da)
CY (1) CY1106992T1 (da)
CZ (1) CZ304258B6 (da)
DE (1) DE60130192T2 (da)
DK (1) DK1254162T3 (da)
ES (1) ES2292558T3 (da)
GB (1) GB0002952D0 (da)
HK (1) HK1047290A1 (da)
HU (1) HUP0301817A3 (da)
IL (2) IL150981A0 (da)
MX (1) MXPA02007760A (da)
NO (1) NO331847B1 (da)
NZ (1) NZ520488A (da)
PL (1) PL207121B1 (da)
PT (1) PT1254162E (da)
RU (1) RU2280039C2 (da)
SK (1) SK11242002A3 (da)
UA (1) UA76949C2 (da)
WO (1) WO2001058934A2 (da)

Families Citing this family (24)

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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
HUP0600031A3 (en) 2000-10-31 2012-02-28 Pharma Mar Kahalalide formulations and their use
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
WO2009052379A2 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Improved antitumoral treatments
AU2009209541A1 (en) * 2008-01-30 2009-08-06 Pharma Mar, S.A. Improved antitumoral treatments
MX2010009782A (es) * 2008-03-07 2010-09-30 Pharma Mar Sa Tratamientos antitumorales mejorados.
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
CA3207643A1 (en) * 2015-09-23 2017-03-30 XWPharma Ltd. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
BR112019020464A2 (pt) 2017-03-30 2020-04-28 Xw Laboratories Inc. compostos derivados de heteroarila bicíclica, composição farmacêutica compreendendo os ditos compostos, adesivo transdérmico compreendendo a dita composição e uso terapêutico dos compostos e composição
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
EP3856719B1 (en) 2018-09-30 2023-06-07 XWPharma Ltd. Compounds as neuronal histamine receptor-3 antagonists and uses thereof
TW202136194A (zh) 2019-12-20 2021-10-01 香港商凱瑞康寧有限公司 ４－纈胺醯氧基丁酸的合成方法
AU2021292406B2 (en) 2020-06-18 2024-03-14 XWPharma Ltd. Controlled release granulations of water-soluble active pharmaceutical ingredients
JP2023537192A (ja) 2020-06-18 2023-08-31 エックスダブリューファーマ リミテッド 水溶性医薬品有効成分の医薬造粒物
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
JP2023544420A (ja) 2020-10-05 2023-10-23 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物
EP4308086A1 (en) 2021-03-19 2024-01-24 XWPharma Ltd. Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative
WO2023205233A1 (en) * 2022-04-21 2023-10-26 Zevra Therapeutics, Inc. Gamma-hydroxybutyrate delivering compounds and processes for making and using them

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US4943533A (en) * 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
JPS6178719A (ja) * 1984-09-25 1986-04-22 Tanabe Seiyaku Co Ltd 総合輸液剤
GR870129B (en) * 1987-01-27 1987-02-04 Giatzidis Ippokratis Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis
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JP3854306B2 (ja) * 1991-03-06 2006-12-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヒト化及びキメラモノクローナル抗体
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GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
CA2406743A1 (en) * 2000-04-28 2001-11-08 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
US6440465B1 (en) * 2000-05-01 2002-08-27 Bioderm, Inc. Topical composition for the treatment of psoriasis and related skin disorders
HUP0600031A3 (en) 2000-10-31 2012-02-28 Pharma Mar Kahalalide formulations and their use
US20050054555A1 (en) 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

Also Published As

Publication number Publication date
BG65926B1 (bg) 2010-05-31
CY1106992T1 (el) 2012-09-26
PL207121B1 (pl) 2010-11-30
PL356800A1 (en) 2004-07-12
KR20020092951A (ko) 2002-12-12
US20080318849A1 (en) 2008-12-25
EP1254162B1 (en) 2007-08-29
IL150981A0 (en) 2003-02-12
EP2258715A1 (en) 2010-12-08
MXPA02007760A (es) 2002-10-23
CN101597326A (zh) 2009-12-09
AU3208601A (en) 2001-08-20
HUP0301817A3 (en) 2011-10-28
JP2003522198A (ja) 2003-07-22
NO20023749L (no) 2002-10-07
CA2399187A1 (en) 2001-08-16
US20040214755A1 (en) 2004-10-28
WO2001058934A2 (en) 2001-08-16
GB0002952D0 (en) 2000-03-29
CZ20022740A3 (cs) 2003-01-15
DE60130192T2 (de) 2008-05-21
US7482429B2 (en) 2009-01-27
NO20023749D0 (no) 2002-08-08
NZ520488A (en) 2005-03-24
BR0108213A (pt) 2003-03-05
EP1254162A2 (en) 2002-11-06
HUP0301817A2 (hu) 2003-09-29
CN1422278A (zh) 2003-06-04
NO331847B1 (no) 2012-04-23
RU2002123877A (ru) 2004-01-10
CN101597326B (zh) 2014-07-09
AU783542B2 (en) 2005-11-10
BG107020A (bg) 2003-05-30
HK1047290A1 (en) 2003-02-14
JP5188665B2 (ja) 2013-04-24
IL150981A (en) 2013-05-30
CZ304258B6 (cs) 2014-02-05
DE60130192D1 (de) 2007-10-11
EP1829889A2 (en) 2007-09-05
ES2292558T3 (es) 2008-03-16
WO2001058934A3 (en) 2002-03-21
RU2280039C2 (ru) 2006-07-20
SK11242002A3 (sk) 2003-06-03
CA2399187C (en) 2011-04-19
KR100871489B1 (ko) 2008-12-05
EP1829889A3 (en) 2007-09-26
UA76949C2 (en) 2006-10-16
ATE371667T1 (de) 2007-09-15
PT1254162E (pt) 2007-12-03

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