DK1210123T3 - Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation - Google Patents

Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation

Info

Publication number
DK1210123T3
DK1210123T3 DK00959442.5T DK00959442T DK1210123T3 DK 1210123 T3 DK1210123 T3 DK 1210123T3 DK 00959442 T DK00959442 T DK 00959442T DK 1210123 T3 DK1210123 T3 DK 1210123T3
Authority
DK
Denmark
Prior art keywords
effective
oligodeoxynucleotides
mutation
vectors suitable
stranded oligodeoxynucleotide
Prior art date
Application number
DK00959442.5T
Other languages
English (en)
Inventor
Richard A Metz
Bruce L Frank
Debra M Walther
Original Assignee
Valigen Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valigen Us Inc filed Critical Valigen Us Inc
Application granted granted Critical
Publication of DK1210123T3 publication Critical patent/DK1210123T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
DK00959442.5T 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation DK1210123T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/384,960 US6271360B1 (en) 1999-08-27 1999-08-27 Single-stranded oligodeoxynucleotide mutational vectors
PCT/US2000/023457 WO2001015740A1 (en) 1999-08-27 2000-08-25 Single-stranded oligodeoxynucleotide mutational vectors

Publications (1)

Publication Number Publication Date
DK1210123T3 true DK1210123T3 (da) 2010-12-20

Family

ID=23519459

Family Applications (3)

Application Number Title Priority Date Filing Date
DK10008602.4T DK2266627T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK00959442.5T DK1210123T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK10008602.4T DK2266627T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer
DK10183960.3T DK2324856T3 (da) 1999-08-27 2000-08-25 Enkeltstrengede oligodeoxynukleotide mutationsvektorer

Country Status (15)

Country Link
US (3) US6271360B1 (da)
EP (3) EP2324856B1 (da)
JP (2) JP5697187B2 (da)
CN (1) CN1384759B (da)
AT (1) ATE478687T1 (da)
AU (2) AU773242C (da)
BR (1) BR0013590A (da)
CA (1) CA2382120C (da)
DE (1) DE60044876D1 (da)
DK (3) DK2266627T3 (da)
ES (3) ES2544727T3 (da)
NZ (1) NZ517942A (da)
PT (3) PT2324856E (da)
WO (1) WO2001015740A1 (da)
ZA (1) ZA200201228B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652607B2 (en) 1999-07-07 2003-11-25 The Lubrizol Corporation Concentrated emulsion for making an aqueous hydrocarbon fuel
EP1212406A1 (en) * 1999-08-20 2002-06-12 University Of Delaware Cell-free assay for plant gene targeting and conversion
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
WO2001073002A2 (en) * 2000-03-27 2001-10-04 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
US6936467B2 (en) * 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
WO2001087914A2 (en) * 2000-05-17 2001-11-22 University Of Delaware Plant gene targeting using oligonucleotides
AU2001279069A1 (en) * 2000-07-27 2002-02-13 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
US7053195B1 (en) * 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
US20040096880A1 (en) * 2001-08-07 2004-05-20 Kmiec Eric B. Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
US20030109476A1 (en) * 2001-08-07 2003-06-12 Kmiec Eric B. Compositions and methods for the prevention and treatment of Huntington's disease
EP1446503A2 (en) * 2001-09-27 2004-08-18 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
US20030207327A1 (en) * 2001-09-27 2003-11-06 Kmiec Eric B. Coisogenic eukaryotic cell collections
JP2005518817A (ja) * 2002-03-07 2005-06-30 ユニバーシティー、オブ、デラウェア ヒストン・デアセチラーゼ・インヒビタ、ラムダファージベータ蛋白、またはヒドロキシウレアを含む組成物を使用してオリゴヌクレオチド媒介性核酸配列改変を高める方法、組成物およびキット
GB0218803D0 (en) * 2002-08-13 2002-09-18 Nl Kanker I Targeted gene modification by single-standed DNA oligonucleotides
AU2003282477A1 (en) * 2002-10-07 2004-05-04 Napro Bio Therapeutics, Inc. Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
US6929917B2 (en) * 2002-11-18 2005-08-16 Pregentis Method for cloning of a rare, specifically mutated cell
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
PL2465341T3 (pl) 2006-01-12 2015-06-30 Cibus Europe Bv Mutanty EPSPS
NZ574390A (en) * 2006-06-28 2012-04-27 Coh Inc Fatty acid blends and uses therefor in fuel
EP2177605B1 (de) 2006-10-06 2014-12-10 BASF Plant Science GmbH Delta-5 Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen
US9102948B2 (en) 2006-11-17 2015-08-11 22Nd Century Limited, Llc Regulating alkaloids
BR122018070230B1 (pt) * 2007-10-05 2023-01-10 Cibus Europe B.V. Método para produção de planta resistente à herbicida
ES2653573T3 (es) * 2007-12-27 2018-02-07 Cibus Europe B.V. Mezclas de éster butílico de ácido graso
AU2009248852B9 (en) 2008-05-23 2015-08-13 Cibus Europe B.V. Production of squalene using yeast
WO2010036771A2 (en) 2008-09-26 2010-04-01 Basf Agrochemical Products B.V. Herbicide-resistant ahas-mutants and methods of use
AU2009326129B2 (en) 2008-12-12 2016-05-12 Basf Plant Science Gmbh Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
HUE034245T2 (en) * 2009-11-23 2018-02-28 Nucelis Llc Methods and preparations for the preparation of squalene using yeast
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
EP2426204A1 (en) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontaneous nodule organogenesis in plants
KR101137285B1 (ko) 2010-10-28 2012-04-20 위월드 주식회사 초소형 광대역 송수신 안테나 피더
KR20150041788A (ko) 2012-08-17 2015-04-17 다우 아그로사이언시즈 엘엘씨 식물에서의 트랜스진 발현을 위한 옥수수 비번역 영역의 용도
CN114703210A (zh) 2013-03-14 2022-07-05 希博斯美国有限公司 突变的丙二烯氧合酶2(aos2)基因
ES2921207T3 (es) 2013-03-15 2022-08-19 Cibus Us Llc Procedimientos y composiciones para aumentar la eficiencia de la modificación genética direccionada utilizando la reparación genética mediada por oligonucleótidos
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
SI2966984T1 (sl) 2013-03-15 2022-06-30 Cibus Us Llc Ciljana genska sprememba z oligonukleotidom posredovanega genskega popravka
KR20230127356A (ko) 2014-03-14 2023-08-31 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
KR20180116769A (ko) 2016-02-09 2018-10-25 시버스 유에스 엘엘씨 올리고뉴클레오타이드 매개 유전자 보수를 사용한 표적화된 유전자 변형의 효율을 증가시키기 위한 방법 및 조성물
US10584363B2 (en) 2016-06-03 2020-03-10 Takara Bio Usa, Inc. Methods of producing and using single-stranded deoxyribonucleic acids and compositions for use in practicing the same
AU2019207703A1 (en) 2018-01-09 2020-07-16 Cibus Europe B.V. Shatterproof genes and mutations

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2731844B2 (ja) * 1987-04-22 1998-03-25 ザ・ユニヴァーシティー・オブ・コネチカット 哺乳動物の細胞にポリヌクレオチドを導入するキャリア及び水溶性高分子複合体並びにその導入方法
ES2099718T3 (es) * 1990-07-02 1997-06-01 Hoechst Ag Analogos de oligonucleotidos con uniones internucleotidicas de 3'-3' o 5'-5' terminales.
AU681997B2 (en) 1991-09-05 1997-09-18 University Of Connecticut, The Targeted delivery of poly- or oligonucleotides to cells
US5808044A (en) * 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5556959A (en) 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
WO1995015972A1 (en) 1993-12-09 1995-06-15 Thomas Jefferson University Compounds and methods for site-directed mutations in eukaryotic cells
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
WO1996040271A1 (en) * 1995-06-07 1996-12-19 Yale University Treatment of hemoglobinopathies
US5908777A (en) * 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
FR2736926B1 (fr) 1995-07-19 1997-08-22 Rhone Poulenc Agrochimie 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene
US5760012A (en) 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US5888983A (en) 1996-05-01 1999-03-30 Thomas Jefferson University Method and oligonucleobase compounds for curing diseases caused by mutations
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
CA2282729A1 (en) * 1997-02-26 1998-09-03 The General Hospital Corporation Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of alzheimer's disease
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
WO1998049350A1 (en) 1997-04-30 1998-11-05 Regents Of The University Of Minnesota In vivo use of recombinagenic oligonucleobases to correct genetic lesions in hepatocytes
GB9711015D0 (en) 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
US5986086A (en) * 1997-06-20 1999-11-16 Amersham Pharmacia Biotech Inc. Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides
KR20010022652A (ko) 1997-08-05 2001-03-26 키메라젠, 인크. 식물에서 국소적인 유전자변형을 유발하기 위한 혼성 이중나선올리고뉴클레오티드의 용도
AU1526199A (en) 1997-11-18 1999-06-07 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
WO2016028625A1 (en) 2014-08-21 2016-02-25 Corning Incorporated Methods for preventing blisters in laminated glass articles and laminated glass articles formed therefrom

Also Published As

Publication number Publication date
US7060500B2 (en) 2006-06-13
CA2382120A1 (en) 2001-03-08
US6479292B1 (en) 2002-11-12
ZA200201228B (en) 2003-05-28
EP2324856A1 (en) 2011-05-25
JP2012184246A (ja) 2012-09-27
ES2542530T3 (es) 2015-08-06
AU2004205139A1 (en) 2004-09-16
JP5697187B2 (ja) 2015-04-08
ATE478687T1 (de) 2010-09-15
AU7076700A (en) 2001-03-26
AU773242C (en) 2005-04-07
US20040023392A1 (en) 2004-02-05
PT1210123E (pt) 2010-11-30
PT2324856E (pt) 2015-09-03
ES2544727T3 (es) 2015-09-03
DE60044876D1 (de) 2010-10-07
PT2266627E (pt) 2015-08-25
EP2266627B1 (en) 2015-04-22
DK2266627T3 (da) 2015-06-15
JP2003508451A (ja) 2003-03-04
EP2266627A1 (en) 2010-12-29
CN1384759A (zh) 2002-12-11
AU2004205139B2 (en) 2008-01-10
JP5813571B2 (ja) 2015-11-17
US6271360B1 (en) 2001-08-07
BR0013590A (pt) 2002-05-07
NZ517942A (en) 2004-07-30
DK2324856T3 (da) 2015-08-03
EP1210123A1 (en) 2002-06-05
EP1210123A4 (en) 2004-08-18
ES2358292T3 (es) 2011-05-09
AU773242B2 (en) 2004-05-20
WO2001015740A1 (en) 2001-03-08
EP2324856B1 (en) 2015-05-06
CN1384759B (zh) 2013-05-22
EP1210123B1 (en) 2010-08-25
CA2382120C (en) 2013-10-29

Similar Documents

Publication Publication Date Title
DK1210123T3 (da) Enkeltstrengede oligodeoxynucleotidvektorer egnede til mutation
US5565350A (en) Compounds and methods for site directed mutations in eukaryotic cells
EP2267139A3 (en) Methods and means for obtaining modified phenotypes
ATE412054T1 (de) Delta-endotoxin gene und verfahren zu ihrer verwendung
CN108291218A (zh) 核酸酶非依赖性靶向基因编辑平台及其用途
WO2019103442A3 (ko) CRISPR/Cpf1 시스템을 이용한 유전체 편집용 조성물 및 이의 용도
CY1109161T1 (el) Dna που κωδικοποιει συνθαση δεοξυ-υπουσινης φυτου, διαγονιδιακα φυτα και μεθοδος ελεγχου γηρασμου και προγραμματισμενου θανατου κυτταρουσε φυτα
WO2005021585A3 (en) Axmi-003, a delta-endotoxin gene and methods for its use
PT2143792E (pt) Arn cíclico em cadeia simples, e método para a sua produção
EP0827410A4 (en) METHOD FOR INTRODUCING AND EXPRESSING GENES IN ANIMAL CELLS
MX2007009206A (es) Axmi-018, axmi-020 y axmi-021, una familia de genes de delta-endotoxina y metodos para su uso.
MX2010003891A (es) Genes sinteticos que codifican cry1ac.
AR061661A1 (es) Gen de epsp sintetasa que confiere resistencia a herbicidas
CA3152931A1 (en) Modulation of microbiota compositions using targeted nucleases
AP9901469A0 (en) Protein kinases and uses thereof.
KR102679001B1 (ko) 신규의 개량된 염기 편집 또는 교정용 융합단백질 및 이의 용도
WO2001087914A3 (en) Plant gene targeting using oligonucleotides
MXPA02012557A (es) Composiciones y metodos para la modificacion de la expresion del gen.
CN102899352B (zh) 一种利用反义寡核苷酸沉默拟南芥内源miRNA的方法
MXPA02004782A (es) Genes del empequenecimiento del sorgo y metodos de uso.
DE60130465D1 (de) Mutierte muskelspezifische enhancer
EP0777730A4 (en) DNA VECTOR FOR BONE-SPECIFIC GENE EXPRESSION
Chang et al. Production of Thrombopoietin Gene Targeted Clones by Homologous Recombination at-casein Locus of Primary Bovine Ear Skin Fibroblasts
BR9708855A (pt) Cromossomas artificiais, usos dos mesmos e processos para preparar cromossomas artificiais
ATE159048T1 (de) Modifizierung des zellmetabolismus durch extrazellulöse nukleasen