BR0009780A - Processo para preparação de complexos de platina de amina - Google Patents
Processo para preparação de complexos de platina de aminaInfo
- Publication number
- BR0009780A BR0009780A BR0009780-2A BR0009780A BR0009780A BR 0009780 A BR0009780 A BR 0009780A BR 0009780 A BR0009780 A BR 0009780A BR 0009780 A BR0009780 A BR 0009780A
- Authority
- BR
- Brazil
- Prior art keywords
- pta
- halide
- reacted
- hydroxy
- platinum complexes
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- -1 amine platinum complexes Chemical class 0.000 title abstract 2
- 150000004820 halides Chemical class 0.000 abstract 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000007942 carboxylates Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 229910052697 platinum Inorganic materials 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003057 platinum Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Patente de Invenção: "PROCESSO PARA PREPARAçãO DE COMPLEXOS DE PLATINA DE AMINA". A presente invenção refere-se à área de drogas de platina. Em particular, refere-se a um processo melhorado para preparação de complexos de platina tendo fórmula geral (1a) ou (1b), compreendendo: 1a) uma primeira etapa, em que [PtA~ 4~]^ 2-^ é reagido com L sob condições apropriadas em um primeiro solvente para formar [PtA~ 3~(L)]^ -^; 1b) uma segunda etapa, em que [PtA~ 3~(L)]^ -^ é reagido com L' sob condições apropriadas em um segundo solvente para formar cis-[PtA~ 2~(L')(L)]; 1c) no caso onde Y é halogênio ou hidróxi uma terceira etapa, em que cis-[PtA^ 2^(L')(L)] é reagido com H~ 2~O~ 2~, Y~ 2~ ou oxidante contendo halogênio para formar c,t,C-[PtA~ 2~Y~ 2~(L')(L)]; no caso onde Y é éster de carbonato, carbamato ou carboxilato, uma quarta etapa, em que um intermediário, onde Y é hidróxi formado na etapa 1c), é funcionalizado com um agente de acilação apropriado; e 1d) no caso onde A não é um haleto ou é diferente do haleto original, etapas adicionais nas quais o haleto original A de um intermediário formado nas etapas 1 a ou 1b, 1c ou 1d é convertido para um diferente haleto ou novos grupos de partida A tal como hidróxi monodentado, alcóxi, carboxilato ou carboxilato bidentado, fosfonocarboxilato, difosfonato, ou sulfato; em que L, L' e Y têm o significado como definido na descrição.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12893999P | 1999-04-13 | 1999-04-13 | |
PCT/CA2000/000385 WO2000061590A1 (en) | 1999-04-13 | 2000-04-11 | Process for preparing amine platinum complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0009780A true BR0009780A (pt) | 2002-01-02 |
BR0009780B1 BR0009780B1 (pt) | 2013-09-24 |
Family
ID=22437722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0009780-2B1A BR0009780B1 (pt) | 1999-04-13 | 2000-04-11 | processo para preparar um complexo de cisplatina |
Country Status (32)
Country | Link |
---|---|
US (1) | US6518428B1 (pt) |
EP (1) | EP1165576B1 (pt) |
JP (1) | JP4756669B2 (pt) |
KR (1) | KR100711955B1 (pt) |
CN (3) | CN100460412C (pt) |
AR (1) | AR043084A1 (pt) |
AT (1) | ATE309257T1 (pt) |
AU (1) | AU770006B2 (pt) |
BG (1) | BG65429B1 (pt) |
BR (1) | BR0009780B1 (pt) |
CA (1) | CA2368849C (pt) |
CY (1) | CY1104965T1 (pt) |
CZ (1) | CZ303156B6 (pt) |
DE (1) | DE60023859T2 (pt) |
DK (1) | DK1165576T3 (pt) |
EE (1) | EE04747B1 (pt) |
ES (1) | ES2253214T3 (pt) |
HK (2) | HK1039336B (pt) |
HU (1) | HUP0200748A3 (pt) |
IL (1) | IL145671A0 (pt) |
IS (1) | IS2711B3 (pt) |
MX (1) | MXPA01010430A (pt) |
MY (1) | MY122706A (pt) |
NO (1) | NO330429B1 (pt) |
NZ (1) | NZ514736A (pt) |
PL (1) | PL202731B1 (pt) |
RU (1) | RU2245340C2 (pt) |
SK (1) | SK286374B6 (pt) |
TW (1) | TWI289565B (pt) |
UA (1) | UA71614C2 (pt) |
WO (1) | WO2000061590A1 (pt) |
ZA (1) | ZA200107965B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
MXPA01010430A (es) | 1999-04-13 | 2002-03-27 | Anormed Inc | Procedimiento para preparar complejos de aminoplatino. |
US6413953B1 (en) * | 1999-04-13 | 2002-07-02 | Anormed Inc. | Pt(IV) antitumor agent |
GB0011903D0 (en) * | 2000-05-18 | 2000-07-05 | Astrazeneca Ab | Combination chemotherapy |
US6806289B1 (en) * | 2000-07-14 | 2004-10-19 | Stephen J. Lippard | Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same |
US6894049B1 (en) | 2000-10-04 | 2005-05-17 | Anormed, Inc. | Platinum complexes as antitumor agents |
ES2308451T3 (es) | 2004-02-18 | 2008-12-01 | Gpc Biotech Ag | Satraplatino para el tratamiento de tumores resistentes o refractarios. |
CZ296459B6 (cs) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo |
ES2257178B1 (es) * | 2004-09-30 | 2007-08-16 | Universidad Autonoma De Madrid | Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral. |
US8168662B1 (en) | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8168661B2 (en) * | 2006-11-06 | 2012-05-01 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8173686B2 (en) | 2006-11-06 | 2012-05-08 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US8178564B2 (en) * | 2006-11-06 | 2012-05-15 | Poniard Pharmaceuticals, Inc. | Use of picoplatin to treat colorectal cancer |
US20110033528A1 (en) * | 2009-08-05 | 2011-02-10 | Poniard Pharmaceuticals, Inc. | Stabilized picoplatin oral dosage form |
TW200916094A (en) * | 2007-06-27 | 2009-04-16 | Poniard Pharmaceuticals Inc | Stabilized picoplatin dosage form |
US20100260832A1 (en) * | 2007-06-27 | 2010-10-14 | Poniard Pharmaceuticals, Inc. | Combination therapy for ovarian cancer |
CN101809024A (zh) * | 2007-07-16 | 2010-08-18 | 铂雅制药公司 | 吡铂的口服制剂 |
US20110052581A1 (en) * | 2008-02-08 | 2011-03-03 | Poniard Pharmaceuticals Inc. | Use of picoplatin and cetuximab to treat colorectal cancer |
KR20170005523A (ko) * | 2009-06-12 | 2017-01-13 | 포니아드 파마슈티칼즈, 인크. | 피코플라틴의 개선된 합성법 |
RU2451010C1 (ru) * | 2011-01-11 | 2012-05-20 | Закрытое Акционерное Общество "Ива Фарм" | Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия |
CN103554188B (zh) * | 2013-11-19 | 2016-03-02 | 辽宁大学 | 6-(氮杂环取代)蒽醌二氯化铂配合物及其制备方法和应用 |
CN103860539B (zh) * | 2014-04-14 | 2016-02-10 | 于迎涛 | 一种具有混合轴向配体的Pt(IV)类抗癌药物及制备方法 |
CN104231000A (zh) * | 2014-08-20 | 2014-12-24 | 山东铂源药业有限公司 | 一种抗肿瘤药物甲啶铂的合成方法 |
US10987353B2 (en) | 2016-05-04 | 2021-04-27 | The Wistar Institute Of Anatomy And Biology | Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs |
KR102137669B1 (ko) * | 2019-08-05 | 2020-07-27 | 한국과학기술연구원 | 메탄올 또는 그 전구체 합성용 촉매, 이의 제조방법 및 이를 이용한 메탄올 또는 그 전구체의 제조방법 |
BR112023000125A2 (pt) | 2020-07-08 | 2023-04-11 | Dayton Therapeutics Ag | Satraplatina para uso no tratamento de neoplasias linfoides |
CN113402565B (zh) * | 2021-06-16 | 2023-07-28 | 中国人民解放军空军军医大学 | 一类含有泊沙康唑的四价铂配合物、制备方法及其应用 |
WO2023131524A1 (en) | 2022-01-07 | 2023-07-13 | Dayton Therapeutics Ag | Treating haematological malignancies by means of satraplatin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2060615B (en) | 1979-08-23 | 1983-06-22 | Johnson Matthey Co Ltd | Platinum-amine complexes |
US4533502A (en) | 1983-02-22 | 1985-08-06 | Rochon Fernande D | Platinum (II) compounds and their preparation |
ATE63919T1 (de) * | 1984-06-27 | 1991-06-15 | Johnson Matthey Plc | Platinkoordinationsverbindungen. |
US5244919A (en) | 1988-02-02 | 1993-09-14 | Johnson Matthey, Inc. | Pt(IV) complexes as anti-tumor agents |
GB9105037D0 (en) | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9502799D0 (en) * | 1995-02-14 | 1995-04-05 | Johnson Matthey Plc | Improvements in platinum complexes |
US5547982A (en) * | 1995-02-27 | 1996-08-20 | Johnson Matthey, Inc. | Anti-tumor platinum complexes |
JP2004500321A (ja) | 1999-03-19 | 2004-01-08 | アノーメッド インコーポレイティド | 金属錯体を含む薬学的組成物 |
MXPA01010430A (es) | 1999-04-13 | 2002-03-27 | Anormed Inc | Procedimiento para preparar complejos de aminoplatino. |
-
2000
- 2000-04-11 MX MXPA01010430A patent/MXPA01010430A/es active IP Right Grant
- 2000-04-11 PL PL351612A patent/PL202731B1/pl not_active IP Right Cessation
- 2000-04-11 CN CNB2006100093181A patent/CN100460412C/zh not_active Expired - Lifetime
- 2000-04-11 US US09/547,074 patent/US6518428B1/en not_active Expired - Lifetime
- 2000-04-11 CZ CZ20013648A patent/CZ303156B6/cs not_active IP Right Cessation
- 2000-04-11 AT AT00918620T patent/ATE309257T1/de active
- 2000-04-11 DE DE60023859T patent/DE60023859T2/de not_active Expired - Lifetime
- 2000-04-11 SK SK1468-2001A patent/SK286374B6/sk not_active IP Right Cessation
- 2000-04-11 CN CN2006101003981A patent/CN1916009B/zh not_active Expired - Lifetime
- 2000-04-11 EP EP00918620A patent/EP1165576B1/en not_active Expired - Lifetime
- 2000-04-11 IL IL14567100A patent/IL145671A0/xx not_active IP Right Cessation
- 2000-04-11 BR BRPI0009780-2B1A patent/BR0009780B1/pt not_active IP Right Cessation
- 2000-04-11 DK DK00918620T patent/DK1165576T3/da active
- 2000-04-11 RU RU2001130457/04A patent/RU2245340C2/ru not_active IP Right Cessation
- 2000-04-11 EE EEP200100536A patent/EE04747B1/xx not_active IP Right Cessation
- 2000-04-11 AU AU39510/00A patent/AU770006B2/en not_active Expired
- 2000-04-11 CA CA2368849A patent/CA2368849C/en not_active Expired - Fee Related
- 2000-04-11 WO PCT/CA2000/000385 patent/WO2000061590A1/en active IP Right Grant
- 2000-04-11 NZ NZ514736A patent/NZ514736A/xx not_active IP Right Cessation
- 2000-04-11 ES ES00918620T patent/ES2253214T3/es not_active Expired - Lifetime
- 2000-04-11 HU HU0200748A patent/HUP0200748A3/hu unknown
- 2000-04-11 CN CNB008076359A patent/CN1250559C/zh not_active Expired - Fee Related
- 2000-04-11 JP JP2000610861A patent/JP4756669B2/ja not_active Expired - Fee Related
- 2000-04-11 KR KR1020017013049A patent/KR100711955B1/ko not_active IP Right Cessation
- 2000-04-12 AR ARP000101696A patent/AR043084A1/es active IP Right Grant
- 2000-04-12 MY MYPI20001537A patent/MY122706A/en unknown
- 2000-06-23 TW TW089112556A patent/TWI289565B/zh not_active IP Right Cessation
- 2000-11-04 UA UA2001117756A patent/UA71614C2/uk unknown
-
2001
- 2001-09-27 ZA ZA200107965A patent/ZA200107965B/en unknown
- 2001-09-28 IS IS6092A patent/IS2711B3/is unknown
- 2001-10-12 NO NO20014957A patent/NO330429B1/no not_active IP Right Cessation
- 2001-11-08 BG BG106090A patent/BG65429B1/bg unknown
-
2002
- 2002-02-04 HK HK02100835.7A patent/HK1039336B/zh unknown
-
2006
- 2006-02-01 CY CY20061100130T patent/CY1104965T1/el unknown
-
2007
- 2007-08-01 HK HK07108382.2A patent/HK1100562A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0009780A (pt) | Processo para preparação de complexos de platina de amina | |
BR9907429A (pt) | Composto de hidrazida, processo para sua preparação e composições farmacêuticas contendo os mesmos | |
BR9915651A (pt) | Processo para a preparação de ácidos alcanossulfÈnicos. | |
EA200000711A1 (ru) | 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ | |
NO981944L (no) | Lipopolyaminer som transfeksjonsmidler samt farmas÷ytisk anvendelse derav | |
EP0992528A3 (en) | Aminofunctional silicone emulsion | |
ATE293595T1 (de) | Thyroidhormon-analoga und verfahren zu ihrer herstellung | |
BR9805031A (pt) | Compostos de naftaleno, processo para sua preparação e composições farmacêuticas contendo os mesmos. | |
BR0311410A (pt) | Composto de piperidina | |
BR9610905A (pt) | Derivados de sulfamato processo de fabricação de derivados de sulfamato e composições farmacêuticas | |
BR0007638A (pt) | Processo para determinação pós-genÈmica de estruturas atÈmicas macromoleculares | |
KR970074763A (ko) | 불소화된 비타민 d₃ 유사체 | |
BR9813217A (pt) | Tetraciclos, processo para a produção dos mesmos e preparações farmacêuticas contendo estes compostos | |
TR199800543A2 (xx) | Benziloksi ikame edilen, aniliye edilmi� N-heterosiklik bile�ikler. | |
BR9912138A (pt) | Compostos cìclicos úteis no tratamento de dislipidemia, aterosclerose e diabetes, composções farmacêuticas e processo para preparação | |
BR9807395A (pt) | Processo para preparação de tiazolidinadiona substituìda | |
KR910007923A (ko) | 3-(l-피로글루타밀)-l-티아졸리딘-4-카르복실산과 그 유도체의 제조방법 | |
DE60020130D1 (de) | Verfahren zur herstellung 3-amino-gallensaurer derivate | |
BR9902692A (pt) | Copolìmero de silano e um método para produção do mesmo | |
BR0311482A (pt) | Agente de transformação bacteriana | |
KR900003174A (ko) | 벤조푸로[3,2-c] 퀴놀린 화합물 | |
BR0114258A (pt) | Esteróides de 17alfa-fluoroalquila, processo para sua produção e composições farmacêuticas que contêm estes compostos | |
HUP0303478A2 (hu) | Eljárás N-szubsztituált 2,6-dialkil-morfolinok előállítására | |
BR9909759A (pt) | Processo para a fabricação de um composto | |
ATE277051T1 (de) | Verfahren zur herstellung von debromohymenialdisin und deren analogen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/09/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2307 DE 24-03-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |