DK1147103T3 - Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet - Google Patents

Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Info

Publication number
DK1147103T3
DK1147103T3 DK00901539T DK00901539T DK1147103T3 DK 1147103 T3 DK1147103 T3 DK 1147103T3 DK 00901539 T DK00901539 T DK 00901539T DK 00901539 T DK00901539 T DK 00901539T DK 1147103 T3 DK1147103 T3 DK 1147103T3
Authority
DK
Denmark
Prior art keywords
oxides
phenanthridine
pde
inhibitory activity
compounds
Prior art date
Application number
DK00901539T
Other languages
English (en)
Inventor
Dieter Flockerzi
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Hermann Amschler
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of DK1147103T3 publication Critical patent/DK1147103T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
DK00901539T 1999-01-15 2000-01-13 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet DK1147103T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity
EP00901539A EP1147103B1 (en) 1999-01-15 2000-01-13 Phenantrhridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
DK1147103T3 true DK1147103T3 (da) 2005-08-29

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00901539T DK1147103T3 (da) 1999-01-15 2000-01-13 Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet

Country Status (12)

Country Link
US (1) US6534519B1 (da)
EP (1) EP1147103B1 (da)
JP (1) JP2003502278A (da)
AT (1) ATE294793T1 (da)
AU (1) AU2290000A (da)
CA (1) CA2359449A1 (da)
DE (1) DE60019894T2 (da)
DK (1) DK1147103T3 (da)
ES (1) ES2241571T3 (da)
PT (1) PT1147103E (da)
SI (1) SI1147103T1 (da)
WO (1) WO2000042034A1 (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL205670B1 (pl) * 1999-01-15 2010-05-31 Nycomed Gmbh Nowa 6-fenylofenantrydyna, jej zastosowanie oraz lek zawierający ten związek
CA2396026A1 (en) 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
AU2001283935B2 (en) 2000-07-14 2006-07-13 Altana Pharma Ag Novel 6-heteroarylphenanthridines
DE60310576T2 (de) * 2002-08-29 2007-10-31 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
EP1658271A1 (en) * 2003-07-31 2006-05-24 ALTANA Pharma AG Novel 6-phenylphenanthridines
US20060189645A1 (en) * 2003-07-31 2006-08-24 Altana Pharma Ag Novel 6-phenylphenantridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
MXPA06002521A (es) * 2003-09-05 2006-06-20 Altana Pharma Ag Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus.
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
CN104817534A (zh) 2004-03-03 2015-08-05 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
NZ560269A (en) 2005-03-08 2010-12-24 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
ES2184077T3 (es) * 1996-03-26 2003-04-01 Altana Pharma Ag Nuevas fenantridinas sustituidas en la posicion 6.
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
TR199900856T2 (xx) 1996-11-11 1999-07-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Bron�la ilgili terapi maddeleri olarak benzonaftiridinler
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
WO1998040382A1 (en) * 1997-03-07 1998-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
PT988302E (pt) 1997-06-03 2003-07-31 Altana Pharma Ag Benzonaftiridinas
CZ293725B6 (cs) 1997-07-25 2004-07-14 Altana Pharma Ag Tetrazolové deriváty
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
ATE294793T1 (de) 2005-05-15
JP2003502278A (ja) 2003-01-21
EP1147103B1 (en) 2005-05-04
EP1147103A1 (en) 2001-10-24
US6534519B1 (en) 2003-03-18
DE60019894T2 (de) 2006-01-12
PT1147103E (pt) 2005-08-31
ES2241571T3 (es) 2005-11-01
SI1147103T1 (en) 2005-10-31
WO2000042034A1 (en) 2000-07-20
AU2290000A (en) 2000-08-01
DE60019894D1 (de) 2005-06-09
CA2359449A1 (en) 2000-07-20

Similar Documents

Publication Publication Date Title
NO20013341L (no) Fenylfenantridiner med PDE-IV inhiberende aktivitet
DK1147103T3 (da) Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet
DK0882021T3 (da) Nye phenanthridiner
EE200000033A (et) Uudsed tetrasoolderivaadid
CY1105427T1 (el) 6-αρυλφαινανφριδινες με pde-iv ανασταλτικη δραστικοτητα
AU2904300A (en) Polysubstituted 6-phenylphenanthridines with pde-iv inhibiting activity
DK1109810T3 (da) Benzonaphthydin-N-oxider med PDE3- og PDE4-inhiberende aktivitet
DK1147087T3 (da) Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet