ATE294793T1 - Phenantrhridin-n-oxides mit pde-iv hemmender wirkung - Google Patents

Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Info

Publication number
ATE294793T1
ATE294793T1 AT00901539T AT00901539T ATE294793T1 AT E294793 T1 ATE294793 T1 AT E294793T1 AT 00901539 T AT00901539 T AT 00901539T AT 00901539 T AT00901539 T AT 00901539T AT E294793 T1 ATE294793 T1 AT E294793T1
Authority
AT
Austria
Prior art keywords
oxides
phenantrhridine
pde
inhibiting effect
compounds
Prior art date
Application number
AT00901539T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE294793T1 publication Critical patent/ATE294793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Junction Field-Effect Transistors (AREA)
AT00901539T 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung ATE294793T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
ATE294793T1 true ATE294793T1 (de) 2005-05-15

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901539T ATE294793T1 (de) 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Country Status (12)

Country Link
US (1) US6534519B1 (de)
EP (1) EP1147103B1 (de)
JP (1) JP2003502278A (de)
AT (1) ATE294793T1 (de)
AU (1) AU2290000A (de)
CA (1) CA2359449A1 (de)
DE (1) DE60019894T2 (de)
DK (1) DK1147103T3 (de)
ES (1) ES2241571T3 (de)
PT (1) PT1147103E (de)
SI (1) SI1147103T1 (de)
WO (1) WO2000042034A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL205670B1 (pl) * 1999-01-15 2010-05-31 Nycomed Gmbh Nowa 6-fenylofenantrydyna, jej zastosowanie oraz lek zawierający ten związek
CA2396026A1 (en) 2000-01-11 2001-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridine-n-oxides
AU2001283935B2 (en) 2000-07-14 2006-07-13 Altana Pharma Ag Novel 6-heteroarylphenanthridines
DE60310576T2 (de) * 2002-08-29 2007-10-31 Altana Pharma Ag 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
DE60311662T2 (de) 2002-08-29 2007-10-25 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
EP1658271A1 (de) * 2003-07-31 2006-05-24 ALTANA Pharma AG Neue 6-phenylphenanthridine
US20060189645A1 (en) * 2003-07-31 2006-08-24 Altana Pharma Ag Novel 6-phenylphenantridines
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
MXPA06002521A (es) * 2003-09-05 2006-06-20 Altana Pharma Ag Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus.
CA2556086C (en) 2004-02-18 2014-04-01 Altana Pharma Ag Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors
CN104817534A (zh) 2004-03-03 2015-08-05 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
JP2007527901A (ja) * 2004-03-10 2007-10-04 アルタナ　ファルマ　アクチエンゲゼルシャフト アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用
PL1856093T3 (pl) 2005-03-02 2010-05-31 Takeda Gmbh Chlorowodorek (2R,4aR,10bR)-6-(2,6-dimetoksy-pirydyn-3-ylo)-9-etoksy-8-metoksy-1,2,3,4,4a,10b-heksahydrofenantrydyn-2-olu
NZ560269A (en) 2005-03-08 2010-12-24 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
MX2010003155A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de ciclopropil aril amida y uso de los mismos.
EP2804603A1 (de) 2012-01-10 2014-11-26 President and Fellows of Harvard College Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
ES2184077T3 (es) * 1996-03-26 2003-04-01 Altana Pharma Ag Nuevas fenantridinas sustituidas en la posicion 6.
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
TR199900856T2 (xx) 1996-11-11 1999-07-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Bron�la ilgili terapi maddeleri olarak benzonaftiridinler
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
WO1998040382A1 (en) * 1997-03-07 1998-09-17 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel tetrazoles
PT988302E (pt) 1997-06-03 2003-07-31 Altana Pharma Ag Benzonaftiridinas
CZ293725B6 (cs) 1997-07-25 2004-07-14 Altana Pharma Ag Tetrazolové deriváty
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
JP2003502278A (ja) 2003-01-21
EP1147103B1 (de) 2005-05-04
EP1147103A1 (de) 2001-10-24
US6534519B1 (en) 2003-03-18
DE60019894T2 (de) 2006-01-12
PT1147103E (pt) 2005-08-31
ES2241571T3 (es) 2005-11-01
SI1147103T1 (en) 2005-10-31
WO2000042034A1 (en) 2000-07-20
DK1147103T3 (da) 2005-08-29
AU2290000A (en) 2000-08-01
DE60019894D1 (de) 2005-06-09
CA2359449A1 (en) 2000-07-20

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