DK1142566T3 - Oftalmologiske formuleringer på basis af ciclosporin, hyaluronsyre og polysorbat - Google Patents

Oftalmologiske formuleringer på basis af ciclosporin, hyaluronsyre og polysorbat

Info

Publication number: DK1142566T3
Authority: DK; Denmark
Prior art keywords: cyclosporine; polysorbate; hyaluronic acid; formulations based; ophthalmological formulations
Prior art date: 2000-04-07

Application number

DK01107223T

Other languages

English (en)

Inventor

Napoli Guido Di

Original Assignee

Medidom Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-07

Filing date

2001-03-23

Publication date

2004-02-09

2001-03-23 Application filed by Medidom Lab filed Critical Medidom Lab

2004-02-09 Application granted granted Critical

2004-02-09 Publication of DK1142566T3 publication Critical patent/DK1142566T3/da

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
108010036949 Cyclosporine Proteins 0.000 title 1
229960001265 ciclosporin Drugs 0.000 title 1
229930182912 cyclosporin Natural products 0.000 title 1
238000009472 formulation Methods 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229950008882 polysorbate Drugs 0.000 title 1
229920000136 polysorbate Polymers 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

DK01107223T 2000-04-07 2001-03-23 Oftalmologiske formuleringer på basis af ciclosporin, hyaluronsyre og polysorbat DK1142566T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH6942000		2000-04-07

Publications (1)

Publication Number	Publication Date
DK1142566T3 true DK1142566T3 (da)	2004-02-09

Family

ID=4529494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01107223T DK1142566T3 (da)	2000-04-07	2001-03-23	Oftalmologiske formuleringer på basis af ciclosporin, hyaluronsyre og polysorbat

Country Status (19)

Country	Link
US (2)	US6677304B2 (da)
EP (1)	EP1142566B1 (da)
JP (1)	JP2001316284A (da)
CN (1)	CN1185009C (da)
AR (1)	AR028291A1 (da)
AT (1)	ATE250924T1 (da)
AU (1)	AU778858B2 (da)
BR (1)	BR0101332A (da)
CA (1)	CA2342133C (da)
CZ (1)	CZ294385B6 (da)
DE (1)	DE60100866T2 (da)
DK (1)	DK1142566T3 (da)
ES (1)	ES2206363T3 (da)
IL (1)	IL142268A (da)
PL (1)	PL201055B1 (da)
PT (1)	PT1142566E (da)
SK (1)	SK285220B6 (da)
TR (1)	TR200302105T4 (da)
ZA (1)	ZA200102769B (da)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030157161A1 (en) *	2001-05-01	2003-08-21	Angiotech Pharmaceuticals, Inc.	Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents
US20020192280A1 (en) *	2001-05-01	2002-12-19	Angiotech Pharmaceuticals, Inc.	Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents
US7354574B2 (en)	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
FR2848106B1 (fr) *	2002-12-06	2006-11-17	Oreal	Composition de teinture pour fibres keratiniques comprenant un alcool gras non oxyalkylene, un colorant d'oxydation, un polymere associatif et un amide d'une alcanolamine et d'un acide gras en c14-c30.
US7326256B2 (en) *	2002-12-06	2008-02-05	L'ORéAL S.A.	Composition for the oxidation dyeing of keratin fibers, comprising at least one non-oxyalkenylated fatty alcohol, at least one oxidation dye, at least one associative polymer, and at least one amide of an alkanolamine and a C14-C30 fatty acid
JP2004262777A (ja) *	2003-02-27	2004-09-24	Shiseido Co Ltd	アセチル化ヒアルロン酸含有眼用医薬組成物
US20050196370A1 (en) *	2003-03-18	2005-09-08	Zhi-Jian Yu	Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
AU2003228126A1 (en) *	2003-05-02	2004-11-23	Arturo Jimenez Bayardo	Method of preparing an aqueous solution of cyclosporin-a and resulting aqueous solution
US7947295B2 (en) *	2003-06-13	2011-05-24	Alcon, Inc.	Ophthalmic compositions containing a synergistic combination of two polymers
US7083802B2 (en)	2003-07-31	2006-08-01	Advanced Ocular Systems Limited	Treatment of ocular disease
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en)	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
CA2553381C (en) *	2004-01-20	2011-03-22	Allergan, Inc.	Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7135455B2 (en) *	2004-11-15	2006-11-14	Allergan, Inc	Methods for the therapeutic use of cyclosporine components
WO2006067608A1 (en) *	2004-12-22	2006-06-29	Laboratoire Medidom S.A.	Aqueous formulations based on sodium hyaluronate for parenteral use
US8663639B2 (en)	2005-02-09	2014-03-04	Santen Pharmaceutical Co., Ltd.	Formulations for treating ocular diseases and conditions
BRPI0608152A2 (pt)	2005-02-09	2009-11-10	Macusight Inc	formulações para tratamento ocular
CN100478025C (zh) *	2005-03-25	2009-04-15	中国科学院上海药物研究所	一种环孢菌素a眼用微乳制剂及其制备方法
JP5117384B2 (ja) *	2005-07-01	2013-01-16	シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ	点眼剤の形態における眼用生理学的サプリメントまたは医薬の調製のためのｌ−カルニチンまたはアルカノイルｌ−カルニチンの使用
AU2006270041B2 (en)	2005-07-18	2011-08-18	Minu, Llc	Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) *	2005-07-18	2007-01-18	Peyman Gholam A	Enhanced recovery following ocular surgery
US7501393B2 (en) *	2005-07-27	2009-03-10	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
ES2616295T3 (es)	2005-10-12	2017-06-12	Seikagaku Corporation	Agente para aplicar a mucosa y procedimiento para la producción del mismo
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
NZ568694A (en) *	2005-11-09	2011-09-30	Zalicus Inc	Method, compositions, and kits for the treatment of medical conditions
TWI468162B (zh)	2005-12-13	2015-01-11	英塞特公司	作為傑納斯激酶（ＪＡＮＵＳＫＩＮＡＳＥ）抑制劑之經雜芳基取代之吡咯并〔２，３-ｂ〕吡啶及吡咯并〔２，３-ｂ〕嘧啶
WO2007092620A2 (en)	2006-02-09	2007-08-16	Macusight, Inc.	Stable formulations, and methods of their preparation and use
US7655625B2 (en)	2006-02-13	2010-02-02	Allergan, Inc.	Methods of treating blepharospasm using cyclosporine components
US20070212420A1 (en) *	2006-03-10	2007-09-13	Bausch & Lomb Incorporated	Pharmaceutical formulations comprising polyanionic materials and zinc-based preservatives
CA2645488C (en)	2006-03-23	2014-09-02	Macusight, Inc.	Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions
WO2008002582A2 (en) *	2006-06-27	2008-01-03	Riolan Technologies, Inc.	Ultraviolet absorbing ophthalmic compositions
US9561178B2 (en) *	2006-07-25	2017-02-07	Allergan, Inc.	Cyclosporin compositions
AU2016203191B2 (en) *	2006-07-25	2018-03-01	Allergan, Inc.	Cyclosporin compositions
WO2008035246A2 (en)	2006-07-28	2008-03-27	Novagali Pharma Sa	Compositions containing quaternary ammonium compounds
CN101896160A (zh) *	2006-10-17	2010-11-24	阿勒根公司	环胞菌素组合物
JP2010522774A (ja) *	2007-03-30	2010-07-08	フォベア、ファルマスティカル、ソシエテ、アノニム	血管新生眼疾患を治療するための方法
SG10201509887UA (en)	2007-06-13	2016-01-28	Incyte Corp	Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
US8435544B2 (en)	2007-10-08	2013-05-07	Lux Biosciences, Inc.	Ophthalmic compositions comprising calcineurin inhibitors or mTOR inhibitors
EP2195033A1 (en) *	2007-10-08	2010-06-16	Fovea Pharmaceuticals SA	Aqueous ophthalmic formulations
US20100016219A1 (en) *	2008-07-19	2010-01-21	Jerry Zhang	Ophthalmic compositions containing solubilized cyclosporin
CL2009001884A1 (es) *	2008-10-02	2010-05-14	Incyte Holdings Corp	Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
GB0904423D0 (en) *	2009-03-14	2009-04-29	Univ Strathclyde	Improving the solubility of chemicals
SG176111A1 (en)	2009-05-22	2011-12-29	Incyte Corp	3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
EA025520B1 (ru)	2009-05-22	2017-01-30	Инсайт Холдингс Корпорейшн	N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ
ES2537385T3 (es)	2009-06-09	2015-06-08	Aurinia Pharmaceuticals Inc.	Sistemas de suministro tópico para uso oftálmico
WO2011028685A1 (en)	2009-09-01	2011-03-10	Incyte Corporation	Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
MX347851B (es)	2010-03-10	2017-05-16	Incyte Corp	Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
EP2574168B9 (en)	2010-05-21	2016-10-05	Incyte Holdings Corporation	Topical formulation for a jak inhibitor
US9034884B2 (en)	2010-11-19	2015-05-19	Incyte Corporation	Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
WO2012068450A1 (en)	2010-11-19	2012-05-24	Incyte Corporation	Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
CA2839767A1 (en)	2011-06-20	2012-12-27	Incyte Corporation	Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
TW201313721A (zh)	2011-08-18	2013-04-01	Incyte Corp	作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk)	2011-09-07	2016-06-24	Інсайт Холдінгс Корпорейшн	Способи і проміжні сполуки для отримання інгібіторів jak
US8785394B2 (en) *	2011-11-15	2014-07-22	Allergan, Inc.	Sustained action formulation of cyclosporin form 2
CN104039308B (zh) *	2011-11-15	2018-06-05	阿勒根公司	环孢菌素a形式2的可热压性悬浮液
FR2988297B1 (fr) *	2012-03-22	2014-03-28	Thea Lab	Solution ophtalmique aqueuse a base de ciclosporine a sans conservateur
US9193733B2 (en)	2012-05-18	2015-11-24	Incyte Holdings Corporation	Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
BR112015010663B1 (pt)	2012-11-15	2022-12-06	Incyte Holdings Corporation	Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo
CN105189509B (zh)	2013-03-06	2017-12-19	因赛特公司	用于制备jak抑制剂的方法及中间体
PT3019177T (pt)	2013-07-10	2020-12-30	Matrix Biology Inst	Composições de hialuronano de elevada elasticidade e suas utilizações
RS60469B1 (sr)	2013-08-07	2020-07-31	Incyte Corp	Dozni oblici sa produženim oslobađanjem za jak1 inhibitor
WO2015184305A1 (en)	2014-05-30	2015-12-03	Incyte Corporation	TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CA2955037A1 (en) *	2014-07-18	2016-01-21	Allergan, Inc.	Suspension compositions of cyclosporin a for subconjunctival and periocular injection
CN108135926A (zh)	2015-09-24	2018-06-08	基质生物研究所	高弹性透明质酸组合物及其使用方法
KR101635915B1 (ko) *	2016-02-15	2016-07-04	삼천당제약주식회사	사이클로스포린과 히알루론산 또는 이의 염을 포함하는 수용액 형태의 안과용 조성물
US20190240251A1 (en) *	2016-10-14	2019-08-08	i.com medical GmbH	Method for establishing, restoring, and preserving homeostasis of the ocular surface
US20190224275A1 (en)	2017-05-12	2019-07-25	Aurinia Pharmaceuticals Inc.	Protocol for treatment of lupus nephritis
US11766421B2 (en)	2017-09-25	2023-09-26	Surface Ophthalmics, Inc.	Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease
US10596161B2 (en)	2017-12-08	2020-03-24	Incyte Corporation	Low dose combination therapy for treatment of myeloproliferative neoplasms
WO2019152374A1 (en)	2018-01-30	2019-08-08	Incyte Corporation	Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
KR20210100005A (ko) *	2018-03-29	2021-08-13	마티 테라퓨틱스 인코포레이티드	안과 약제의 서방성 제형 및 건성 증후군 치료 용도
MX2022012285A (es)	2018-03-30	2023-08-15	Incyte Corp	Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak).
EP3902525A4 (en) *	2018-12-27	2022-09-28	Surface Ophthalmics, Inc.	OPHTHALMIC PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR SURFACE DISEASES
US20220378698A1 (en)	2019-07-12	2022-12-01	Pharmathen S.A.	Preservative free pharmaceutical composition for ophthalmic administration containing cyclosporine
CN115038443A (zh)	2019-11-22	2022-09-09	因西特公司	包含alk2抑制剂和jak2抑制剂的组合疗法
CA3173164A1 (en) *	2020-03-23	2021-09-30	Brenda K. Mann	Compositions and methods for treatment of ocular conditions
GR1010012B (el)	2020-05-12	2021-05-27	Φαρματεν Α.Β.Ε.Ε.	Φαρμακευτικο σκευασμα ελευθερο συντηρητικου για οφθαλμικη χορηγηση περιεχον κυκλοσπορινη
US11833155B2 (en)	2020-06-03	2023-12-05	Incyte Corporation	Combination therapy for treatment of myeloproliferative neoplasms
US11510930B2 (en) *	2020-08-26	2022-11-29	Somerset Therapeutics, Llc	Gatifloxacin, prednisolone, and bromfenac compositions and methods
WO2024019127A1 (ja) *	2022-07-20	2024-01-25	旭化成株式会社	ヒアルロン酸誘導体医薬組成物及び医薬組成物の製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US592048A (en) *		1897-10-19		Drill-press
DE3851152T2 (de) *	1987-09-03	1995-01-26	Univ Georgia Res Found	Cyclosporin-augenmittel.
CA1340994C (en) *	1989-09-21	2000-05-16	Rudolf Edgar Dr. Falk	Treatment of conditions and disease
JPH0558906A (ja) *	1991-09-06	1993-03-09	Sankyo Co Ltd	シクロスポリン点眼製剤
ES2098739T3 (es) *	1992-05-13	1997-05-01	Sandoz Ltd	Composiciones oftalmicas conteniendo una cyclosporin.
US5474979A (en) *	1994-05-17	1995-12-12	Allergan, Inc.	Nonirritating emulsions for sensitive tissue
RU2119351C1 (ru) *	1994-06-01	1998-09-27	Юхан Корпорейшн	Иммуносупрессорная композиция, содержащая циклоспорин, и способ ее получения
JPH1160505A (ja) *	1997-05-20	1999-03-02	Senju Pharmaceut Co Ltd	防腐組成物

2001
- 2001-03-23 TR TR2003/02105T patent/TR200302105T4/xx unknown
- 2001-03-23 DE DE60100866T patent/DE60100866T2/de not_active Expired - Lifetime
- 2001-03-23 EP EP01107223A patent/EP1142566B1/fr not_active Expired - Lifetime
- 2001-03-23 AT AT01107223T patent/ATE250924T1/de active
- 2001-03-23 DK DK01107223T patent/DK1142566T3/da active
- 2001-03-23 ES ES01107223T patent/ES2206363T3/es not_active Expired - Lifetime
- 2001-03-23 PT PT01107223T patent/PT1142566E/pt unknown
- 2001-03-26 AR ARP010101408A patent/AR028291A1/es not_active Application Discontinuation
- 2001-03-27 CA CA2342133A patent/CA2342133C/en not_active Expired - Fee Related
- 2001-03-27 IL IL142268A patent/IL142268A/en not_active IP Right Cessation
- 2001-03-27 US US09/818,213 patent/US6677304B2/en not_active Expired - Fee Related
- 2001-04-04 ZA ZA200102769A patent/ZA200102769B/xx unknown
- 2001-04-04 CZ CZ20011229A patent/CZ294385B6/cs not_active IP Right Cessation
- 2001-04-04 AU AU33404/01A patent/AU778858B2/en not_active Ceased
- 2001-04-05 SK SK460-2001A patent/SK285220B6/sk not_active IP Right Cessation
- 2001-04-06 JP JP2001109077A patent/JP2001316284A/ja active Pending
- 2001-04-06 BR BR0101332-7A patent/BR0101332A/pt active Search and Examination
- 2001-04-06 CN CNB011124849A patent/CN1185009C/zh not_active Expired - Fee Related
- 2001-04-06 PL PL346926A patent/PL201055B1/pl unknown
2003
- 2003-11-21 US US10/721,007 patent/US6953776B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ZA200102769B (en)	2001-10-05
TR200302105T4 (tr)	2004-02-23
PL346926A1 (en)	2001-10-08
AU778858B2 (en)	2004-12-23
US20040106546A1 (en)	2004-06-03
CA2342133C (en)	2011-02-01
US20010041671A1 (en)	2001-11-15
CZ294385B6 (cs)	2004-12-15
IL142268A (en)	2007-08-19
EP1142566B1 (fr)	2003-10-01
IL142268A0 (en)	2002-03-10
US6677304B2 (en)	2004-01-13
CA2342133A1 (en)	2001-10-07
CZ20011229A3 (cs)	2001-11-14
ES2206363T3 (es)	2004-05-16
SK285220B6 (sk)	2006-09-07
AR028291A1 (es)	2003-04-30
PL201055B1 (pl)	2009-03-31
DE60100866T2 (de)	2004-07-29
JP2001316284A (ja)	2001-11-13
DE60100866D1 (de)	2003-11-06
US6953776B2 (en)	2005-10-11
BR0101332A (pt)	2001-11-06
EP1142566A1 (fr)	2001-10-10
CN1317342A (zh)	2001-10-17
AU3340401A (en)	2001-10-11
CN1185009C (zh)	2005-01-19
SK4602001A3 (en)	2001-11-06
ATE250924T1 (de)	2003-10-15
PT1142566E (pt)	2004-02-27

Publication	Publication Date	Title
DK1142566T3 (da)	2004-02-09	Oftalmologiske formuleringer på basis af ciclosporin, hyaluronsyre og polysorbat
BR0115810B1 (pt)	2011-10-18	composições cosméticas, dermatológicas e farmacêuticas isentas de tensoativos.
ZA200407868B (en)	2005-04-26	17alpha-Alkyl-17beta-oxy-estratrienes, uses thereof and pharmaceutical preparations.
AU2003245252A8 (en)	2003-11-17	Enhanced sulfated polysaccharide formulations, methods and preparations and their uses thereof
ITTO20010005A1 (it)	2001-07-11	Formulazione farmaceutica.
NO20033556L (no)	2003-10-09	Farmasöytiske formuleringer
EE200300544A (et)	2004-02-16	4-anilinokinoliin-3-karboksamiidid, nende kasutamine ning valmistamine
ITTO20000779A0 (it)	2000-08-04	Composizioni farmaceutiche.
IS6263A (is)	2002-02-08	Lyfjasamsetningar, sem innihalda trípeptíð
EP1435894A4 (en)	2005-07-06	CYTOPROTECTIVE COMPOUNDS, METHODS AND PHARMACEUTICAL AND COSMETIC FORMULATIONS
DE60132957D1 (de)	2008-04-10	Spielablaufverfahren, Spielsystem, und Server
DE60132232D1 (de)	2008-02-14	Servicefähige technologie
ITRM20030363A0 (it)	2003-07-24	Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico diesse.
FR2833599B1 (fr)	2004-01-30	Polysaccharide amphotere, composition et utilisation
NO20022022L (no)	2002-04-29	N-guanidinoalkylamider, deres fremstilling, deres anvendelse og farmasöytiske preparater omfattende disse
NL1020435A1 (nl)	2002-10-25	Heupprothese.
DE60144456D1 (de)	2011-05-26	DibenzoÄb,fÜazepin-Derivate und ihre Herstellung
DE60222900D1 (de)	2007-11-22	Uv-abschirmende peptid-flavonoid konjugate
IT1311568B1 (it)	2002-03-13	Arnese da cucina per agitare, sbattere e smuovere.
GB0217548D0 (en)	2002-09-11	Four human zinc-finger-containing proteins:MDZ3.MDZ4,MDZ7 and MDZ12
FR2814361B1 (fr)	2002-12-20	Prothese de genou, totale et modulaire
IT1318654B1 (it)	2003-08-27	Composizioni farmaceutiche comprendenti agenti antiinfiammatori e lorousi.
ZA200205556B (en)	2003-07-11	Pharmaceutical compositions and their preparation.
林何	2001	On Thought Patterns and Translation
IT1317719B1 (it)	2003-07-15	Elastomeri termoplastici e procedimento per la loro preparazione.