DK1001752T3 - Analgetiske fremgangsmåder under anvendelse af syntetiske katalysatorer til dismutation af superoxidradikaler - Google Patents

Analgetiske fremgangsmåder under anvendelse af syntetiske katalysatorer til dismutation af superoxidradikaler

Info

Publication number
DK1001752T3
DK1001752T3 DK98929022T DK98929022T DK1001752T3 DK 1001752 T3 DK1001752 T3 DK 1001752T3 DK 98929022 T DK98929022 T DK 98929022T DK 98929022 T DK98929022 T DK 98929022T DK 1001752 T3 DK1001752 T3 DK 1001752T3
Authority
DK
Denmark
Prior art keywords
dismutation
superoxide radicals
synthetic catalysts
analgesic methods
analgesic
Prior art date
Application number
DK98929022T
Other languages
Danish (da)
English (en)
Inventor
Daniela Salvemini
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK1001752T3 publication Critical patent/DK1001752T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
DK98929022T 1997-06-20 1998-06-15 Analgetiske fremgangsmåder under anvendelse af syntetiske katalysatorer til dismutation af superoxidradikaler DK1001752T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5040297P 1997-06-20 1997-06-20
PCT/US1998/012231 WO1998058636A1 (en) 1997-06-20 1998-06-15 Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals

Publications (1)

Publication Number Publication Date
DK1001752T3 true DK1001752T3 (da) 2004-04-19

Family

ID=21965044

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98929022T DK1001752T3 (da) 1997-06-20 1998-06-15 Analgetiske fremgangsmåder under anvendelse af syntetiske katalysatorer til dismutation af superoxidradikaler

Country Status (12)

Country Link
US (2) US6180620B1 (es)
EP (1) EP1001752B1 (es)
JP (1) JP2002506445A (es)
AT (1) ATE256467T1 (es)
AU (1) AU733415B2 (es)
CA (1) CA2294155A1 (es)
DE (1) DE69820633T2 (es)
DK (1) DK1001752T3 (es)
ES (1) ES2215305T3 (es)
PT (1) PT1001752E (es)
WO (1) WO1998058636A1 (es)
ZA (1) ZA985376B (es)

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US20060270639A1 (en) * 1997-06-20 2006-11-30 Daniela Salvemini Combinations of superoxide dismutase mimetics and nonsteroidal analgesic/anti-inflammatory drugs
WO1999023097A1 (en) 1997-11-03 1999-05-14 Duke University Substituted porphyrins
DK1155019T3 (da) 1999-01-25 2006-04-18 Nat Jewish Med & Res Center Substituerede porphyriner og deres terapeutiske anvendelse
ATE291446T1 (de) * 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US20020072512A1 (en) * 2000-12-08 2002-06-13 Metaphore Pharmaceuticals, Inc Method of preventing and treating HIV-mediated central nervous system damage
DE60235955D1 (de) * 2001-01-05 2010-05-27 Metaphore Pharmaceuticals Inc Zusammensetzungen und verfahren zur erhöhung der zytokin-aktivität und zur behandlung der hypotension assoziiert mit der verabreichung von zytokinen
DE60233317D1 (de) * 2001-01-19 2009-09-24 Nat Jewish Med & Res Center Medikament zum schutz in der radiotherapie
AU2002236861A1 (en) * 2001-01-26 2002-08-06 Metaphore Pharmaceuticals, Inc. Method of treatment of neurodegenerative disorders using pentaaza-macrocyclic ligand complexes
US20040137638A1 (en) 2002-03-04 2004-07-15 Slomczynska Urszula J. Chromatography of metal complexes
EP2988125B1 (en) * 2001-03-02 2019-05-08 Galera Labs, LLC Manganese(ii) pentaazacycloalkane complexes
EP1439842A4 (en) * 2001-06-01 2009-09-02 Nat Jewish Med & Res Center OXIDANT CAPTAIN FOR THE TREATMENT OF DIABETES OR FOR THE USE IN THE TRANSPLANTATION OR INDUCTION OF IMMUNOTOLERANE
WO2002100883A2 (en) * 2001-06-08 2002-12-19 Metaphore Pharmaceuticals, Inc. Libraries of conformationally constrained peptides, chiral azacrowns, and peptidomimetics and methods of making the same
CA2451602A1 (en) * 2001-06-26 2003-01-03 Metaphore Pharmaceuticals, Inc. Combination therapy of an sodm and a corticosteroid for prevention and/or treatment of inflammatory disease
CA2464528A1 (en) * 2001-11-02 2003-05-15 Elan Corporation, Plc Pharmaceutical composition
ES2319399T3 (es) * 2001-12-14 2009-05-07 Alcon, Inc. Compuestos mimeticos de la superoxido-dismutasa para el tratamiento de trastornos y enfermedades oculares.
US6933275B2 (en) * 2002-05-01 2005-08-23 The Board Of Trustees Of The Leland Stanford Junior University Protein kinase C peptides for use in withdrawal
AU2003237500A1 (en) * 2002-06-07 2003-12-22 Duke University Substituted porphyrins
US20030232784A1 (en) * 2002-06-14 2003-12-18 Benedict James J. Hyaluronic acid-associated superoxide dismutase mimics and their use in the treatment of joint pain
CA2397684A1 (en) * 2002-08-12 2004-02-12 Michael P. Murphy Mitochondrially targeted antioxidants
CA2499994C (en) * 2002-09-23 2012-07-10 Verion, Inc. Abuse-resistant pharmaceutical compositions
MXPA05005937A (es) * 2002-12-06 2005-08-18 Alcon Inc Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
BR0317026A (pt) * 2002-12-06 2005-10-25 Alcon Inc Mìmicos de superóxido dismutase para o tratamento de distúrbios e doenças oculares
KR100648618B1 (ko) * 2003-11-19 2006-11-23 주식회사 웰스킨 활성 산소 억제제
MXPA06006187A (es) * 2003-12-11 2006-08-25 Alcon Inc Imitadores de super oxido dismutasa para el tratamiento de dano retinal y de nervio optico.
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
CA2591970C (en) * 2004-12-21 2014-08-19 Metaphore Pharmaceuticals, Inc Polyethylene glycolated superoxide dismutase mimetics
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
KR100724586B1 (ko) 2005-12-09 2007-06-04 세종대학교산학협력단 수퍼옥사이드 디스뮤타아제 활성을 갖는 고리화합물
HUE044234T2 (hu) 2006-10-12 2019-10-28 Galera Labs Llc Eljárások szájnyálkahártya-gyulladás kezelésére
CA2705761C (en) 2007-11-14 2016-04-26 Kereos, Inc. Super-oxide dismutase mimetics
EP2859916B1 (en) 2008-05-22 2017-11-29 Galera Labs, LLC Combination of an antimitotic agent and a selective superoxide dismutase mimetic in antitumor therapy
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
WO2013048965A1 (en) 2011-09-26 2013-04-04 Galera Therapeutics, Llc Methods for treatment of diseases
ES2807528T3 (es) 2015-08-11 2021-02-23 Galera Labs Llc Complejos macrocíclicos pentaaza que poseen biodisponibilidad oral
WO2018152353A2 (en) 2017-02-15 2018-08-23 Galera Labs, Llc Pentaaza macrocyclic ring complexes for local intestinal delivery
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
EA201992431A1 (ru) 2017-10-13 2020-03-13 ГАЛЕРА ЛЭБЗ, ЭлЭлСи Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса
CA3090129A1 (en) 2018-01-31 2019-08-08 Galera Labs, Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent
WO2021163397A1 (en) 2020-02-13 2021-08-19 Teva Pharmaceuticals International Gmbh Solid state forms of avasopasem manganese and process for preparation thereof

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JPH0751496B2 (ja) 1986-04-02 1995-06-05 武田薬品工業株式会社 リポソ−ムの製造法
US4999347A (en) 1986-08-28 1991-03-12 Sorenson John R J Analgesic method
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JPS63313581A (ja) * 1987-06-16 1988-12-21 Ube Ind Ltd 修飾ス−パ−オキシドジスムタ−ゼ
DE69224839T2 (de) 1991-07-19 1998-10-08 Monsanto Co Mangan-Komplexe mit Stickstoff enthaltenden makrozyklischen Liganden, wirksam als Superoxiddismutasekatalysatoren.
CA2072934C (en) 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CN1088086A (zh) * 1992-12-14 1994-06-22 西北大学 一种新型的护肤保健品
US6204259B1 (en) 1993-01-14 2001-03-20 Monsanto Company Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
CN1225631A (zh) 1996-03-13 1999-08-11 孟山都公司 有歧化过氧化物催化剂效果的含氮大环配位体锰或铁配合物的生物缀合物

Also Published As

Publication number Publication date
ATE256467T1 (de) 2004-01-15
US6180620B1 (en) 2001-01-30
AU8068598A (en) 1999-01-04
DE69820633D1 (de) 2004-01-29
JP2002506445A (ja) 2002-02-26
ES2215305T3 (es) 2004-10-01
US6395725B1 (en) 2002-05-28
EP1001752A1 (en) 2000-05-24
DE69820633T2 (de) 2004-09-23
ZA985376B (en) 1999-06-21
EP1001752B1 (en) 2003-12-17
CA2294155A1 (en) 1998-12-30
WO1998058636A1 (en) 1998-12-30
AU733415B2 (en) 2001-05-17
PT1001752E (pt) 2004-05-31

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