DK0892780T3 - m-Amidinophenylanaloger som faktor Xa-inhibitorer - Google Patents
m-Amidinophenylanaloger som faktor Xa-inhibitorerInfo
- Publication number
- DK0892780T3 DK0892780T3 DK97908723T DK97908723T DK0892780T3 DK 0892780 T3 DK0892780 T3 DK 0892780T3 DK 97908723 T DK97908723 T DK 97908723T DK 97908723 T DK97908723 T DK 97908723T DK 0892780 T3 DK0892780 T3 DK 0892780T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- factor
- amidinophenyl
- analogues
- amidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Treating Waste Gases (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1210496P | 1996-02-22 | 1996-02-22 | |
US64408596A | 1996-05-09 | 1996-05-09 | |
US3682397P | 1997-02-03 | 1997-02-03 | |
PCT/US1997/002919 WO1997030971A1 (fr) | 1996-02-22 | 1997-02-18 | ANALOGUES DU M-AMIDINO PHENYLE COMME INHIBITEURS DU FACTEUR Xa |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0892780T3 true DK0892780T3 (da) | 2003-03-03 |
Family
ID=27359573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97908723T DK0892780T3 (da) | 1996-02-22 | 1997-02-18 | m-Amidinophenylanaloger som faktor Xa-inhibitorer |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0892780B1 (fr) |
AT (1) | ATE228111T1 (fr) |
AU (1) | AU2056197A (fr) |
CA (1) | CA2244851A1 (fr) |
DE (1) | DE69717268T2 (fr) |
DK (1) | DK0892780T3 (fr) |
ES (1) | ES2186874T3 (fr) |
PT (1) | PT892780E (fr) |
WO (1) | WO1997030971A1 (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
EP0880501A1 (fr) | 1996-02-02 | 1998-12-02 | Zeneca Limited | Composes heterocycliques utiles en tant qu'agents pharmaceutiques |
GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
CN1228087A (zh) * | 1996-08-14 | 1999-09-08 | 曾尼卡有限公司 | 取代的嘧啶衍生物和它们的药物用途 |
UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
US6440972B1 (en) | 1997-02-13 | 2002-08-27 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
ATE242774T1 (de) | 1997-02-13 | 2003-06-15 | Astrazeneca Ab | Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
IL134394A0 (en) * | 1997-08-27 | 2001-04-30 | Kissei Pharmaceutical | 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both |
EP1015429B1 (fr) * | 1997-09-09 | 2004-05-12 | Bristol-Myers Squibb Pharma Company | BENZIMIDAZOLINONES, BENZOXAZOLINONES, BENZOPIPERAZINONES, INDANONES ET LEURS DERIVES EN TANT QU'INHIBITEURS DU FACTEUR Xa |
DE19753522A1 (de) * | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
EP0921116B1 (fr) * | 1997-12-04 | 2003-06-18 | F. Hoffmann-La Roche Ag | Dérivés de N-(4-carbamimido-phényl)glycine amide |
PT1042287E (pt) * | 1997-12-24 | 2005-08-31 | Aventis Pharma Gmbh | Derivados de indole como inibidores do factor xa |
AU3110999A (en) | 1998-03-27 | 1999-10-18 | Du Pont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
DE19834751A1 (de) * | 1998-08-01 | 2000-02-03 | Boehringer Ingelheim Pharma | Disubstituierte bicyclische Heterocyclen, ihre Herstellung und ihre Verwendung als Arzneimittel |
EP0987274A1 (fr) * | 1998-09-15 | 2000-03-22 | Hoechst Marion Roussel Deutschland GmbH | Inhibiteurs du facteur VIIa |
NZ511927A (en) | 1998-12-14 | 2004-02-27 | F | Phenylglycine derivatives |
CA2348740A1 (fr) | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Inhibiteurs de la thrombine ou du facteur xa |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
EP1059302A1 (fr) * | 1999-06-08 | 2000-12-13 | Aventis Pharma Deutschland GmbH | Inhibiteurs de factor VIIa |
DE10027025A1 (de) * | 2000-05-31 | 2001-12-06 | Merck Patent Gmbh | Clycinamide |
UA75093C2 (en) | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
US7312235B2 (en) | 2001-03-30 | 2007-12-25 | Millennium Pharmaceuticals, Inc. | Benzamide inhibitors of factor Xa |
EP1373194B1 (fr) * | 2001-03-30 | 2007-08-01 | Millennium Pharmaceuticals, Inc. | COMPOSES DE BENZAMIDE, INHIBITEURS DU FACTOR Xa |
US7005437B2 (en) | 2001-05-22 | 2006-02-28 | Boehringer Ingelheim Pharma Kg | Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions |
DE10124867A1 (de) * | 2001-05-22 | 2002-11-28 | Boehringer Ingelheim Pharma | Substituierte Aryl- und Heteroarylderivate, deren Herstellung und deren Verwendung als Arzneimittel |
EP1415983A4 (fr) | 2001-08-09 | 2006-01-18 | Kissei Pharmaceutical | Derive de 5-amidino-n-(2-aminophenethyl)-n- hydroxybenzensulfonamide, composition medicinale le contenant et intermediaire utilise |
EP2982668A3 (fr) | 2002-12-03 | 2016-04-13 | Pharmacyclics LLC | Dérivés de 2-(2-hydroxybiphényl-3-yl)-1h-benzoimidazole-5-carboxamidine en tant qu'inhibiteurs du facteur viia inhibitors pour le traitement de maladies thromboemboliques |
WO2006047415A2 (fr) * | 2004-10-26 | 2006-05-04 | Janssen Pharmaceutica, N.V. | Composes inhibiteurs du facteurs xa |
GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物 |
JP6423372B2 (ja) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 強力なrock1およびrock2阻害剤としてのフェニルピラゾール誘導体 |
MY193649A (en) | 2013-12-20 | 2022-10-21 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2037153A1 (fr) * | 1990-03-09 | 1991-09-10 | Leo Alig | Derives de l'acide acetique |
US5481021A (en) * | 1991-03-06 | 1996-01-02 | G. D. Searle & Co. | Phenyl amidines derivatives useful as platelet aggregation inhibitors |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
HUT63609A (en) * | 1992-03-10 | 1993-09-28 | Sandoz Ag | Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds |
-
1997
- 1997-02-18 PT PT97908723T patent/PT892780E/pt unknown
- 1997-02-18 ES ES97908723T patent/ES2186874T3/es not_active Expired - Lifetime
- 1997-02-18 CA CA002244851A patent/CA2244851A1/fr not_active Abandoned
- 1997-02-18 AU AU20561/97A patent/AU2056197A/en not_active Abandoned
- 1997-02-18 DE DE69717268T patent/DE69717268T2/de not_active Expired - Fee Related
- 1997-02-18 AT AT97908723T patent/ATE228111T1/de not_active IP Right Cessation
- 1997-02-18 DK DK97908723T patent/DK0892780T3/da active
- 1997-02-18 WO PCT/US1997/002919 patent/WO1997030971A1/fr active IP Right Grant
- 1997-02-18 EP EP97908723A patent/EP0892780B1/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69717268T2 (de) | 2003-09-04 |
ATE228111T1 (de) | 2002-12-15 |
PT892780E (pt) | 2003-02-28 |
EP0892780A1 (fr) | 1999-01-27 |
AU2056197A (en) | 1997-09-10 |
EP0892780B1 (fr) | 2002-11-20 |
WO1997030971A1 (fr) | 1997-08-28 |
ES2186874T3 (es) | 2003-05-16 |
CA2244851A1 (fr) | 1997-08-28 |
DE69717268D1 (de) | 2003-01-02 |
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