DK0888313T3 - 2,3-benzodiazepinderivater og deres anvendelse af AMPA-receptorhæmmere - Google Patents

2,3-benzodiazepinderivater og deres anvendelse af AMPA-receptorhæmmere

Info

Publication number
DK0888313T3
DK0888313T3 DK97915277T DK97915277T DK0888313T3 DK 0888313 T3 DK0888313 T3 DK 0888313T3 DK 97915277 T DK97915277 T DK 97915277T DK 97915277 T DK97915277 T DK 97915277T DK 0888313 T3 DK0888313 T3 DK 0888313T3
Authority
DK
Denmark
Prior art keywords
alkyl
hydrogen
optionally substituted
cycloalkyl
group
Prior art date
Application number
DK97915277T
Other languages
English (en)
Inventor
Istvan Ling
Gizella Abraham
Sandor Solyom
Tamas Hamori
Istvan Tarnawa
Pal Berzsenyi
Ferenc Andrasi
Emese Csuzdi
Marta Szoellosy
Antal Simay
Istvan Pallagi
Katalin Horvath
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0888313T3 publication Critical patent/DK0888313T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK97915277T 1996-02-01 1997-01-29 2,3-benzodiazepinderivater og deres anvendelse af AMPA-receptorhæmmere DK0888313T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604920A DE19604920A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
PCT/DE1997/000225 WO1997028135A1 (de) 1996-02-01 1997-01-29 2,3-benzodiazepinderivate und deren verwendung als ampa-rezeptoren-hemmer

Publications (1)

Publication Number Publication Date
DK0888313T3 true DK0888313T3 (da) 2002-07-15

Family

ID=7785065

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97915277T DK0888313T3 (da) 1996-02-01 1997-01-29 2,3-benzodiazepinderivater og deres anvendelse af AMPA-receptorhæmmere

Country Status (14)

Country Link
US (1) US6200970B1 (da)
EP (1) EP0888313B1 (da)
JP (1) JP2000505793A (da)
AT (1) ATE216373T1 (da)
AU (1) AU2285997A (da)
CA (1) CA2244777C (da)
DE (2) DE19604920A1 (da)
DK (1) DK0888313T3 (da)
ES (1) ES2175386T3 (da)
HU (1) HUP9901473A3 (da)
MX (1) MX9806171A (da)
PT (1) PT888313E (da)
WO (1) WO1997028135A1 (da)
ZA (1) ZA97850B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
EP2177520A1 (en) 2000-06-12 2010-04-21 Eisai R&D Management Co., Ltd. 1,5-Di(aryl or heteroaryl)-3-halo-2(1H)-pyridones as intermediates for the preparation of AMPA receptor inhibitors
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
AU2003263357B2 (en) * 2002-09-13 2009-02-26 Motac Neuroscience Limited Treatment of basal ganglia-related movement disorders with 2,3-benzodiazepines
WO2004026299A1 (en) * 2002-09-17 2004-04-01 Motac Neuroscience Limited Treatment of dyskinesia
US20040141152A1 (en) * 2002-09-27 2004-07-22 Marino Joseph A. Apparatus and method for conducting vision screening
US6858605B2 (en) * 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
WO2007077469A1 (en) * 2005-12-30 2007-07-12 Egis Gyógyszergyár Optical isomers of dihydro-2,3-benzodiazepines and their stereoselective synthesis
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
EA201590356A1 (ru) * 2012-08-16 2015-07-30 Байер Фарма Акциенгезельшафт 2,3-бензодиазепины
AU2014220838A1 (en) 2013-02-19 2015-09-10 Bayer Pharma Aktiengesellschaft Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
WO2015121268A1 (de) * 2014-02-14 2015-08-20 Bayer Pharma Aktiengesellschaft 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren
AU2019395288A1 (en) 2018-12-14 2021-09-23 Eisai R&D Management Co., Ltd. Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU208429B (en) 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof

Also Published As

Publication number Publication date
DE19604920A1 (de) 1997-08-07
WO1997028135A1 (de) 1997-08-07
ZA97850B (en) 1997-08-04
AU2285997A (en) 1997-08-22
HUP9901473A3 (en) 2001-07-30
PT888313E (pt) 2002-09-30
CA2244777A1 (en) 1997-08-07
ES2175386T3 (es) 2002-11-16
CA2244777C (en) 2006-11-07
ATE216373T1 (de) 2002-05-15
US6200970B1 (en) 2001-03-13
JP2000505793A (ja) 2000-05-16
HUP9901473A2 (hu) 1999-09-28
EP0888313A1 (de) 1999-01-07
DE59707062D1 (de) 2002-05-23
MX9806171A (es) 1998-10-31
EP0888313B1 (de) 2002-04-17

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