DK0821682T3 - Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset - Google Patents

Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset

Info

Publication number
DK0821682T3
DK0821682T3 DK96914957T DK96914957T DK0821682T3 DK 0821682 T3 DK0821682 T3 DK 0821682T3 DK 96914957 T DK96914957 T DK 96914957T DK 96914957 T DK96914957 T DK 96914957T DK 0821682 T3 DK0821682 T3 DK 0821682T3
Authority
DK
Denmark
Prior art keywords
pct
phenyl
disorders
sec
alkyl
Prior art date
Application number
DK96914957T
Other languages
English (en)
Inventor
Lene Teuber
Frank Waetjen
Yoshimasa Fukuda
Osamu Ushiroda
Toshiro Sasaki
Original Assignee
Neurosearch As
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As, Meiji Seika Kaisha filed Critical Neurosearch As
Application granted granted Critical
Publication of DK0821682T3 publication Critical patent/DK0821682T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
DK96914957T 1995-04-21 1996-04-19 Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset DK0821682T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK46095 1995-04-21
DK74195 1995-06-27
PCT/EP1996/001649 WO1996033191A1 (en) 1995-04-21 1996-04-19 Benzimidazole compounds and their use as modulators of the gabaa receptor complex

Publications (1)

Publication Number Publication Date
DK0821682T3 true DK0821682T3 (da) 2000-12-04

Family

ID=26064049

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96914957T DK0821682T3 (da) 1995-04-21 1996-04-19 Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset

Country Status (28)

Country Link
US (1) US5922725A (da)
EP (1) EP0821682B1 (da)
JP (1) JP3171852B2 (da)
KR (1) KR100283363B1 (da)
CN (1) CN1089762C (da)
AT (1) ATE194836T1 (da)
AU (1) AU699623B2 (da)
BR (1) BR9608056A (da)
CA (1) CA2218552C (da)
CZ (1) CZ287538B6 (da)
DE (1) DE69609413T2 (da)
DK (1) DK0821682T3 (da)
EE (1) EE04308B1 (da)
ES (1) ES2150671T3 (da)
GR (1) GR3034558T3 (da)
HK (1) HK1018048A1 (da)
HU (1) HU224031B1 (da)
IS (1) IS2020B (da)
MX (1) MX9708147A (da)
NO (1) NO314502B1 (da)
NZ (1) NZ307532A (da)
PL (1) PL184020B1 (da)
PT (1) PT821682E (da)
RU (1) RU2136676C1 (da)
SK (1) SK282105B6 (da)
TR (1) TR199701219T1 (da)
UA (1) UA54394C2 (da)
WO (1) WO1996033191A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU726447B2 (en) 1996-10-21 2000-11-09 Neurosearch A/S 1-phenyl-benzimidazole compounds and their use as BAGA-A receptor modulators
WO1998019165A1 (en) * 1996-10-25 1998-05-07 Neurosearch A/S A method for the identification of compounds with anxiolytic potential
GB9702524D0 (en) * 1997-02-07 1997-03-26 Merck Sharp & Dohme Therapeutic agents
CA2304379A1 (en) * 1997-10-10 1999-04-22 Neurosearch A/S Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use
AU1224499A (en) * 1997-12-09 1999-06-28 Neurosearch A/S Chemical compounds for use as anxiolytic agents and a method for the identification of anxiolytic compounds
EP1097918A4 (en) * 1998-07-15 2003-04-02 Meiji Seika Kaisha PROCESS FOR THE PRODUCTION OF 2-NITRO-FLUOROBENZENES SUBSTITUTED IN POSITION 4
AU764479B2 (en) * 1998-10-29 2003-08-21 Bristol-Myers Squibb Company Compounds derived from an amine nucleus that are inhibitors of IMPDH enzyme
US6627624B1 (en) 1999-04-02 2003-09-30 Neurogen Corporation Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6380210B1 (en) 1999-04-02 2002-04-30 Neurogen Corporation Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6281237B1 (en) 1999-04-02 2001-08-28 Neurogen Corporation N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
WO2000078728A1 (en) * 1999-06-22 2000-12-28 Neurosearch A/S Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
JP2004501109A (ja) 2000-05-24 2004-01-15 メルク　シャープ　エンド　ドーム　リミテッド Ｇａｂａ受容体に対するリガンドとしての３−フェニル−イミダゾ−ピリミジン誘導体
TWI248936B (en) * 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
WO2002076983A1 (en) * 2001-03-23 2002-10-03 Merck Sharp & Dohme Limited Imidazo-pyrimidine derivatives as ligands for gaba receptors
JP2006516626A (ja) * 2003-01-28 2006-07-06 スミスクライン ビーチャム コーポレーション 化学的化合物
DE602004011914T2 (de) 2003-04-03 2008-06-12 Neurosearch A/S Benzimidazole derivate und ihre anwendung als gaba a rezeptor komplex modulatoren
AU2004226179A1 (en) 2003-04-03 2004-10-14 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABA-a receptor complex
TWI391381B (zh) * 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
WO2010055126A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
US8278460B2 (en) * 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
ES2927086T3 (es) 2017-09-28 2022-11-02 Cstone Pharmaceuticals Suzhou Co Ltd Derivado de anillo condensado como inhibidor del receptor A2A

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE163290T1 (de) * 1991-06-24 1998-03-15 Neurosearch As Imidazol-verbindungen, verfahren zu ihrer herstellung und ihre anwendung
US5158969A (en) * 1991-08-21 1992-10-27 Neurosearch A/S Indole derivatives as potassium channel blockers
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
AU675484B2 (en) * 1993-03-24 1997-02-06 Neurosearch A/S Benzimidazole compounds, their use and preparation

Also Published As

Publication number Publication date
PL184020B1 (pl) 2002-08-30
EE04308B1 (et) 2004-06-15
PT821682E (pt) 2000-11-30
AU699623B2 (en) 1998-12-10
HUP9802272A2 (hu) 1999-09-28
PL322944A1 (en) 1998-03-02
TR199701219T1 (xx) 1998-03-21
WO1996033191A1 (en) 1996-10-24
KR100283363B1 (ko) 2001-03-02
DE69609413T2 (de) 2000-11-23
SK282105B6 (sk) 2001-11-06
EE9700282A (et) 1998-06-15
EP0821682A1 (en) 1998-02-04
HK1018048A1 (en) 1999-12-10
SK140697A3 (en) 1998-05-06
IS2020B (is) 2005-06-15
NO974843D0 (no) 1997-10-20
KR19990007940A (ko) 1999-01-25
MX9708147A (es) 1997-12-31
CA2218552A1 (en) 1996-10-24
RU2136676C1 (ru) 1999-09-10
NZ307532A (en) 1999-03-29
ATE194836T1 (de) 2000-08-15
CN1182425A (zh) 1998-05-20
IS4593A (is) 1997-10-17
CA2218552C (en) 2002-04-16
CN1089762C (zh) 2002-08-28
EP0821682B1 (en) 2000-07-19
ES2150671T3 (es) 2000-12-01
CZ329197A3 (cs) 1998-03-18
HUP9802272A3 (en) 2002-02-28
JP3171852B2 (ja) 2001-06-04
AU5690696A (en) 1996-11-07
GR3034558T3 (en) 2001-01-31
NO974843L (no) 1997-12-15
DE69609413D1 (de) 2000-08-24
NO314502B1 (no) 2003-03-31
UA54394C2 (uk) 2003-03-17
HU224031B1 (hu) 2005-05-30
US5922725A (en) 1999-07-13
BR9608056A (pt) 1999-11-30
JPH11511734A (ja) 1999-10-12
CZ287538B6 (en) 2000-12-13

Similar Documents

Publication Publication Date Title
DK0821682T3 (da) Benzimidazolforbindelser og deres anvendelse som modulatorer af gaba-a-receptorkomplekset
CA2218493A1 (en) Benzimidazole compounds and their use as modulators of the gabaa receptor complex
DE69739733D1 (de) 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors
NO921944L (no) Benzofuran-derivater
NO961404L (no) 4-indolylpiperazinyl-derivater
DE69402935T2 (de) Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
TR200200969T2 (tr) Karbonilamino türevlerinin CNS bozukluklarına karşı kullanılması
DK0847384T3 (da) Carbamoylcarboxylsyreamider
MX9708096A (es) Compuestos de bencimidazol y su uso para preparar composiciones utiles como moduladores del complejo receptor de gabaa.
DK0651747T3 (da) Carbostyrilderivater